CREATING POSSIBLE

Aaron Wolfe, CEO | Adam Blanden, CSO

Presentation version 5.6

1

Company at a glanceManagement: Aaron Wolfe (CEO), Adam Blanden (CSO)

Raise: $350k seed round

Current Funding: $297,500

Summary: recombiPure is a streamlined solution to protein chemistry

Market: $2.3B/year opportunity

Stage: Seed stage

Entity Type: Delaware C corp.

Founded: Q1 2017

Strategic Partnerships: 8,400 ft2

wet lab/office (through Ichor Therapeutics)

IP status: 3 pending patents (1 exclusive license from SUNY Upstate, 2 intramural), rep. by Dorsey & Whitney, LLP

2

MBP Tag

6his Tag

Bead

A CB

D

A. Fluorescent antibody

B. Purification/labeling tag

C. Column resin

D. Solubility tag

Requires multiple vendors, lacks shelf-life, and high prices!

3

Protein chemistry is not streamlined

$10 billion1 in annual waste▪ Complicated, unreliable technologies

▪ Data is often not reproducible

▪ Required boutique solutions are:

- non-interchangeable

- expensive

- fragile

4

1Weller. Quality Issues of Research Antibodies. Analytical Chemistry Insights 2016:11 21–27 doi:10.4137/ACI.S31614.

The basis of our technology is a robust two-part protein tag

▪ Stable (extremophile origin)

▪ Soluble (expression enhancer)

▪ Inexpensive to produce (up to 1/1000th of the cost)

▪ Strong (antibody level affinity)

▪ Small (less bulky)

▪ Flexibility (diverse applications)

▪ Proprietary

RP-tag (large)

RP-tag (small)

5

We can use these tags tostreamline protein chemistry tools

RP-tag (large)

RP-tag (small)

6

F

Bead

Bead

F

Plate orSPR chip

Plate orSPR chip

Mix&

Match

RP-tag (large) RP-tag (small)

7

RP-tag (large) RP-tag (small)

Mix&

match

F

Bead

Bead

F

Plate orSPR chip

Plate orSPR chip

Alone or in combination, these pieces offer a

functionally superior and streamlined solutionto replace existing products/kits used in every life

science lab in the world…

8

Just a few examples…▪ Affinity chromatography (shown here)

▪ IP/pulldown kit

▪ ELISA kit

▪ Western blot kit

▪ Immunocytochemistry

9

The RP system binds tighter than antibodies and is target specific

10

The RP system is robust enoughto survive repeat boiling

11

• RP system• 6xhis antibody

Beta testers and clients (current)

12

13

$200k(seed)

2016 2017 2018

$97,500(pre-seed)

Proof-of-concept

- Solubility tag- Genetic engineering of

RP(large) and RP(small)- Patent licensing

Product development

- Optimize RP tags- Develop kit prototypes- Patent filing (x2)- Beta testing- Identify market strategy- Secure distributors- Online store soft launch

Distribution

- Product extension- International distribution- Execute market strategy

Development summary

$350k(add. seed)

14

Ready for testing:• IP/Pulldown

4-6 weeks:• Affinity Chromatography• ELISA

8-16 weeks:• Western Blot• Immunocytochemistry

Next step: beta test

Meet the teamExecutive team

Research support

Justin ApplegateJustin Cox

Ashleigh CrawfordConnor McGuiganJacob MontalvanMeegan Sleeper

A rowdy group of aspiring scientists trying to make a change in the

world of antibodies… one protein interaction at a time.

15

CEO Aaron J Wolfe

Co-Founder

PhD candidate, SU (ABD)

VP Marketing – DCN, Ltd.

VC Biotech Consultant

5 peer-reviewed papers

2 licensed patents

CSO Adam R. Blanden

Co-Founder

MD/PhD candidate, Upstate

NIH Fellow, biophysics

10 licensed patents

10 peer-reviewed papers

Contact

Aaron Wolfe, CEO

2521 US Route 11 LaFayette, NY 13084

(315) 380-4700 | Ajwolfe@fingerlakesbio.com

Website (under construction)

www.recombipure.com

16