coxiella virus & qfever

8/18/2019 Coxiella Virus & Qfever

1/19

SHUBHANGI PATIL

ROLL NO : 109

COXIELLA VIRUS &QFEVER


2/19

INTRODUCTION

Coxiella is a ge!s "# G$%e a'(e)ia i (*e #a+i,- "#C".ie,,a'eae / T*ese e)e a+e a#(e) He)a, Rea C".21903$19456 7 a A+e)i'a i","gis(/

C.Burnetti is i(s ",- s8e'ies & is (*e 'a!sa(i%e age( #")Q#e%e)/


3/19

ORPHOLOG & CHARACTERISTICS

; S+a,,7 G)a+$ega(i%e7 8,e"+")8*i''"''"a'i,,!s< ",iga(e i()a'e,,!,a) a'(e)i!+(*a( )e8,i'a(es i +a')"8*ages a

+""'-(es/

; O)e): Legi"e,,a,es< Fa+i,-: C".ie,,a'eae

; Si=e: 0/>$1/? ++ i ,eg(* a 0/?$0/> ++ ii(*

; N!',ei' a'i: C".ie,,a ge"+e is


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P*-si'"'*e+i'a, 8)"8e)(ies:•

Resis(a( (" *ea(7 ," ") *ig* 8H7 0/s"i!+ *-8"'*,")i(e7 UV i))aia(i"7 ae%i)"+e(a, '"i(i"s7 s!'* asesi''a(i"7 e.()e+e (e+8e)a(!)es7 a

s!,ig*(7 e'a!se "# (*e 8)ese'e "# as8")e$,i@e s(age/

• Re8")(e (" s!)%i%e #") 3$10 +"(*s "

"", a( 1$ ?0C7 #") +")e (*a 1 +"(*" #)es* +ea( i '", s(")age7 a #") >0+"(*s i s@i+ +i,@ a( )""+ (e+8e)a(!)e/


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; T*e +i')"")gais+ *as (" a(igei' #")+s: 8*aseI a 8*ase II/ P*ase I is (*e *ig*,- i#e'(i"!s #")+#"! i a(!)e a *as i(a'( ,i8"8",-sa''*a)ie2LPS6 " (*e 'e,, +e+)ae7 *e)eas 8*ase II is,a")a(")-$g)"7 a((e!a(e7 a%i)!,e( i ai+a,s7a *as ()!'a(e LPS/

; I#e'(e 'e,,s '"(ai ? s()!'(!)a, #")+s "# (*ea'(e)ia: ,a)ge 'e,, %a)ia( 2LCV6 ") %ege(a(i%e #")+s7a s+a,, 'e,, %a)ia( 2SCV6 ") '"ese #")+s/SCV )e,ease !)ig ,-sis "# i#e'(e 'e,,s )es!,( i(*e s8")e$,i@e #")+ #"! i (*e e%i)"+e(/


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•

C/ !)e((i as see i TE i(* '"ese '*)"+a(i /


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QFEVER•

Des')ie i 19 - E/ H/ De))i'@ i aa(("i) ")@e)si A!s()a,ia as a isease "# !@" ")igi a7(*e)e#")e7 (e)+e !e)- #e%e)/

• Is",a(e i 193 - B!)e( a F)ee+a *"ie(ie (*e ")gais+ as a Ri'@e((sia s8e'ies/

• C". a Da%is is",a(e (*e 8a(*"ge #)"+ (i'@s i"(aa i 194 a es')ie i(s ()as+issi"/ T*eage( as "'ia,,- a+e C".ie,,a !)e(ii i 19>4/

• N" ,"ge) )ega)e as ',"se,- )e,a(e (" Ri'@e((sias8e'ies/

• C,assie as Ca(eg")- B i"(e))")is+ age( - (*eCDC/


8/19

•Ve'(") a Rese)%"i) I%",%e:

; Rese)%"i)s #") *!+a i#e'(i" i',!e"+es(i'a(e )!+ia(s7 8)i+a)i,- 'a((,e7s*ee87 a g"a(s/

; Ji,,i#e 'a a,s" e i#e'(e7 as e,, as"+es(i' ai+a,s s!'* as 'a(s a "gs/

; Ti'@s +a- e i%",%e i ()as+issi"

a+"g ai+a,s !( a)e )a)e,- i%",%e i()as+issi" (" *!+as/


9/19

SOURCES OF HUAN INFECTION

; I#e'(i" 'a!se - i*a,a(i" "# ae)"s",s ")'"(a+ia(e !s(s '"(aiig ai)$")e a'(e)ia e)i%e#)"+ i#e'(e )!+ia(s ") (*ei) 8)"!'(s/ A sig,ei*a,e ")gais+ +a- 8)"!'e ',ii'a, i,,ess/

; Ba'(e)ia a)e s*e i +i,@7 !)ie7 a #e'es "# i#e'(e

ai+a,s/ Hig* !+e)s "# ")gais+s i (*e a+i"(i' K!isa 8,a'e(a !)ig i)(*ig 2e/g/7 109 a'(e)iag8,a'e(a6

; C"(a'( i(* '"(a+ia(e "", ") "(*e) #"+i(es

; Iges(i" "# !8as(e!)i=e '"(a+ia(e ai)- 8)"!'(s2)a)e6

; Se.!a, ()as+issi" is 8"ssi,e


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IUNOHISTOLOGIC SLIDE

C/!)e((i i )ese'(e 'a)ia' %a,%e "# a 50 -) +a i(*Q#e%e) e"'a)i(is a( Ca-ee / ""',"a, a(i"- &*e+a(".-,i e)e !se (" s(ai (*e s8e'i+e/


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I'!a(i" Pe)i":

• Ve)- e8ee( " "se< es(i+a(e a( ?0 a-s 2)age:

1>$9 a-s6Li@e,i*"" "# C,ii'a, Disease:

• Less (*a 0 a)e s-+8("+a(i'

A($Ris@ P"8!,a(i"s:

•

Fa)+e)s7 %e(e)ia)ias7 ") (*"se *" *a,e 8"(e(ia,,-i#e'(e ,i%es("'@7 es8e'ia,,- ai+a,s gi%ig i)(*

• D!)ig (*e ?003$?010 "!()ea@ i (*e Ne(*e),as78e)s"s ,i%ig i(*i @+ "# ai)- g"a( #a)+s / A")(i"a%es i g"a(s *a%e ee '")+e as (*e 8)i+a)-

s"!)'e "# *!+a i#e'(i"< "$ai)- s*ee8 #a)+s *a%eee i%",%e (" a ,esse) e.(e(/ Li%ig i(*i @+ "#i#e'(e #a)+s *as a''"!(e #") 9 "# 'ases / T*e)e,a(i%e )is@ "# i#e'(i" i# )esiig i(*i ? @+ %s M @+"# i#e'(e #a)+s is 1/


12/19

PATHOGENESIS•

T*e ID0 2(*e "se eee (" i#e'( 0 "#e.8e)i+e(a, s!e'(s6 is "e %ia i*a,a(i"< i/e/7i*a,a(i" "# "e ")gais+ i,, -ie, isease i 0"# (*e 8"8!,a(i"/ T*is is a e.()e+e,- ,"

i#e'(i"!s "se 2",- 1$10 ")gais+s )e!i)e67+a@ig C. burnetii "e "# (*e +"s( i#e'(i"!s @"")gais+s/ Disease "''!)s i (" s(ages: a a'!(es(age (*a( 8)ese(s i(* *eaa'*es7 '*i,,s7 a)es8i)a(")- s-+8("+s7 a a isii"!s '*)"i'

s(age/• T*e a'(e)ia !se a (-8e IVB se')e(i" s-s(e+ @"as I'+D"( 2i()a'e,,!,a) +!,(i8,i'a(i" e#e'( i")gae,,e ()a'@ig gees6 (" ie'( ee'(")

8)"(eis 'a,,e A@ 8)"(eis i(" (*e *"s(/ T*ese


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CLINICAL FEATURES

• A'!(e isease is '*a)a'(e)i=e - *ig* #e%e) 2!s!a,,-M>0C6 a *eaa'*e 2!s!a,,- )e()"$")i(a,6/T*e#e%e) ,as(s a88)".i+a(e,- 3$1> a-s/ O(*e) sigs as-+8("+s +a- i',!e *a,,!'ia(i"s7 ia))*ea7

eig*( ,"ss7 #a'ia, 8ai7 a s8ee'* i+8ai)+e(/ A)as* is )a)e,- "se)%e i Q #e%e)/

; Pe!+"ia ") *e8a(i(is is see i +")e se%e)e a'!(ei#e'(i"s/ I#)e!e(,- 'a!ses 8e)i'a)i(is7+-"'a)i(is/ Ne!)","gi'a, +ai#es(a(i"s 'a "''!) ia'!(e ") '*)"i' i#e'(i"7 !( (*ei) #)e!e'- isea(e/

; E"'a)i(is is (*e +"s( i+8")(a( +ai#es(a(i" "#'*)"i' i#e'(i"/ I#e'(i"s "# %as'!,a) 8)"s(*eses a

ae!)-s+s7 "s(e"+-e,i(is7 *e8a(i(is7 i(e)s(i(ia,


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; a- 8)"g)ess (" '*)"i'i(- i a88)".i+a(e,-? "# (*"se i#e'(e i# !()ea(e7 i *i'*'ase (*e #)e!e'- "# +")(a,i(- i')eases/C*)"i' isease is ee as Q #e%e) ,as(ig

M5 +"(*s/ ; C*)"i' Q #e%e) 8)e"+ia(,- "''!)s iii%i!a,s i(* !e),-ig %a,%!,a) *ea)(

isease7 %as'!,a) ae!)-s+s7 ") %as'!,a)g)a#(s +ai#es(ig 8)i+a)i,- as '!,(!)e$ega(i%e e"'a)i(is/


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TREATENT

D".-'-',ie #") ? ee@s 2a'!(e i,,ess6 a".-'-',ie i '"+ia(i" i(**-)".-'*,")"!ie 28)e#e))e #") '*)"i'i#e'(i"6/ Ri#a+8i a K!")"!i","es*a%e ee !se i(* ".-'-',ie #") '*)"i'i#e'(i"s !( a)e ,ess ee'(i%e (*a

*-)".-'*,")"!ie/ A(ii"(i' ()ea(+e( #")14 +"(*s (" se%e)a, -ea)s is )e!i)e #")'*)"i' i#e'(i"7 e8eig " (*e )egi+e!se/


16/19

QVAX VACCINE•

Q$VAX is a 8!)ie s!s8esi" "# #")+a,i$ia'(i%a(e7 C".ie,,a !)e(ii 8)e8a)e #)"+ (*e P*ase IHe=e),ig s()ai "# (*e ")gais+ g)" i (*e -",@sa's "# e+)-"a(e eggs/ E.'ess egg 8)"(eis a)e)e+"%e - #)a'(i"a(i" a !,()a'e()i#!ga(i"/ Ea),-

a(i"- )es8"se (" (*e %a''ie is 8)e"+ia(,- i(*(*e Ig s!',ass< IgG a(i"ies a88ea) ,a(e)/ A,(*"!g*(*e se)"'"%e)si" )a(e is ," 20$406 a a(i"-,e%e,s a)e ()asie(7 'e,, +eia(e i++!i(- e%e,"8s/

T*e !)a(i" "# 8)"(e'(i%e i++!i(- #",,"ig

i++!isa(i" is !@"7 !( is e,ie%e (" e ie.'ess "# %e -ea)s/ Re%a''ia(i" +!s( e%e) e!e)(a@e !e (" (*e 8"ssii,i(- "# se%e)e*-8e)sesi(i%i(- )ea'(i"s /


17/19

PREVENTION• Educate the public on sources of infection.

• Appropriately dispose of placenta, birth products, fetalmembranes, and aborted fetuses at facilities housing sheepand goats.

• Restrict access to barns and laboratories used in housingpotentially infected animals.

• Use only pasteurised milk and milk products.

• Use appropriate procedures for bagging, autoclaving, andashing of laboratory clothing.

• !accinate "here possible# individuals engaged in researchith pregnant sheep or live C. burnetii .

• $uarantine imported animals.

• Ensure that holding facilities for sheep should be locatedaay from populated areas. Animals should be routinelytested for antibodies to C. burnetii , and measures shouldbe implemented to prevent air%o to other occupied areas.

• Counsel persons at highest risk for developing chronic $

fever, especially persons ith pre&existing cardiac valvular


18/19

SOURCES

*((8s:/aa/")g(+eiD"'!+e(scoxiellaburnetii/8#

• *((8s:e/i@i8eia/")gi@iCoxiella burnetii

• /''/g"%#e%e)

•

*((8:/'s,/'"+/a!"'s945Q$Va.PIV>TGA$A88)"%e$13?0a!a)-?0?01>/8#

https://www.aabb.org/tm/eid/Documents/coxiellaburnetii.pdfhttps://www.aabb.org/tm/eid/Documents/coxiellaburnetii.pdfhttps://www.aabb.org/tm/eid/Documents/coxiellaburnetii.pdfhttps://en.wikipedia.org/wiki/Coxiella_burnetiihttps://en.wikipedia.org/wiki/Coxiella_burnetiihttps://en.wikipedia.org/wiki/Coxiella_burnetiihttp://www.cdc.gov/qfever/http://www.csl.com.au/docs/39/836/Q-Vax_PI_V4_TGA-Approved-17%20January%202014.pdfhttp://www.csl.com.au/docs/39/836/Q-Vax_PI_V4_TGA-Approved-17%20January%202014.pdfhttp://www.csl.com.au/docs/39/836/Q-Vax_PI_V4_TGA-Approved-17%20January%202014.pdfhttp://www.csl.com.au/docs/39/836/Q-Vax_PI_V4_TGA-Approved-17%20January%202014.pdfhttp://www.csl.com.au/docs/39/836/Q-Vax_PI_V4_TGA-Approved-17%20January%202014.pdfhttp://www.csl.com.au/docs/39/836/Q-Vax_PI_V4_TGA-Approved-17%20January%202014.pdfhttp://www.cdc.gov/qfever/http://www.cdc.gov/qfever/https://en.wikipedia.org/wiki/Coxiella_burnetiihttps://en.wikipedia.org/wiki/Coxiella_burnetiihttps://en.wikipedia.org/wiki/Coxiella_burnetiihttps://en.wikipedia.org/wiki/Coxiella_burnetiihttps://en.wikipedia.org/wiki/Coxiella_burnetiihttps://www.aabb.org/tm/eid/Documents/coxiellaburnetii.pdfhttps://www.aabb.org/tm/eid/Documents/coxiellaburnetii.pdfhttps://www.aabb.org/tm/eid/Documents/coxiellaburnetii.pdfhttps://www.aabb.org/tm/eid/Documents/coxiellaburnetii.pdf


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THAN OU