courses specifications - delta univ

Courses Specifications

Pharmacognosy Courses

2016-2017

Faculty of Pharmacy


Delta University

for Science and Technology

Faculty of Pharmacy, Delta University for Science and Technology

1

Dept. of Pharmacognosy

Botany ....................................................................................................................... 2

Pharmacognosy-1 ..................................................................................................... 7

Pharmacognosy-2 ................................................................................................... 13

Phytochemistry-1 ................................................................................................... 19

Phytochemistry-2 ................................................................................................... 24

Faculty of Pharmacy


Delta University



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Botany

1. Basic Information:

Course title: Botany

Course code: PG 111

Department: Pharmacognosy

Program on which the course is given: B. Pharm.

Faculty: Pharmacy

University: Delta University for Sciences and Technology

Academic level: First Level Fall Semester 2016-2017

Specialization: Basic

Prerequisite: None

Credit hours: Lecture:2 Practical:1 Total:3

Approval date: 06/08/2016

2. Course Aims:

Providing the student with basic knowledge of the field of botany, and the skills necessary

for further studies in the field of medicinal plants and pharmacognosy, phytochemistry and

phytotherapy.

3. Intended Learning Outcomes (ILOs):

a. Knowledge and understanding:

At the end of this course, student should be able to:

A1

a1 Describe the characters of plant cell and different tissues and organs and list the

differences between their structures.

a2 Describe different morphological and anatomical structures found in each plant

organ in different stages of the plant life.

a3 Illustrate how the morphological and anatomical structure can be modified

according to the habitat and function.

a4 Recognize the importance of taxonomy in identification and classification of

medicinal plants.

b. Intellectual Skills:


B13

b1

Distinguish different plant cell types plant tissues and apply acquired

knowledge to identify different plant tissues and organs based on anatomical

characters.

b2 Write a full scheme for description of different plant organs.

b3 Classify plant samples according to their morphological and anatomical

characters.

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c. Professional and Practical Skills:


C2 c1 Handle and dispose chemicals safely

C8 c2 Manipulate pharmaceutical instruments and equipment safely and efficiently

(microscopes, pipettes, slides and cover slips, ………etc.)

C11

c3 Develop the required skills to prepare and identify histological tissues of the plant

using the microscope.

c4 Apply acquired information to describe morphological characters of real life

samples.

c5 Integrate different morphological and anatomical aspects to conclude a scientific

classification of plants.

d. General and Transferable Skills:


D2 d1 Retrieve pharmaceutical and other drug information resources

D3 d2 Work effectively as a part of a team and independently to perform the required tasks.

D5 d3 Develop information technology (IT) skills

D9 d4 Acquire effective time-management skills.

4. Contents:

4.1.Lectures:

Week

No. Topic

No. of

hours

1. Plant cell structure and function + Ergastic cell contents 2

2. plant tissues: Dermal, ground vascular and secretory tissues 2

3. Anatomy of primary plant organs. 2

4. Anatomy of primary plant organs + Anatomy of secondary plant

organs. 2

5. Habitat of plant and animals and introduction to morphology of

leaves 2

6. Morphology of leaves 2

7. Midterm exam --

8. Morphology of stems 2

9 Morphology of roots 2

10. Morphology of flowers 2

11. Types of placentation and types of inflorescences 2

12. Introduction to plant taxonomy 2

13. revision 2

14. Final Exam

15. 24

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4.2.Practical:

Week

No. Topics

No. of

hours

1. Plant cell structure and function + Ergastic cell contents 1

2. plant tissues: Dermal, ground vascular and secretory tissues 1

3. Anatomy of primary plant organs 1

4. Anatomy of primary plant organs + Anatomy of secondary plant

organs. 1

5. Introduction to morphology of leaves 1

6. Morphology of leaves 1

7. Midterm exam ---

8. Morphology of stems 1

9. Morphology of roots and second Quiz 1

10. Morphology of flowers 1

11. Types of placentation and types of inflorescences 1

12. Revision 1

13. Practical Exam 1

14. Final Exam

15. 12

5. Teaching and Learning Methods:

5.1. Lectures

5.2. Practical work

5.3 Homework

6. Student Assessment Methods:

6.1.Assessment methods:

1. Quizzes to assess knowledge, understanding and intellectual skills

2. Course work

and mid-term

exam

to assess knowledge, understanding, intellectual skills, general skills

3. Practical

exam to assess professional and Practical and transferable and general skills

4. Written exam to assess knowledge, understanding and intellectual skills

6.2.Assessment schedule:

Assessment 1 Quizzes 3rd week

Assessment 2 Mid-term and course work 7th week

Assessment 3 Practical 13th week

Assessment 4 Written 14th &15th weeks

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6.3.Weighing of Assessments:

Mid-Term Exam & course work 25

Final-Term Exam 50

Practical Exam 25

Total 100%

7. List of References:

No. Reference Type

1. Berg, L. "Introductory Botany, plants, people and the environment" Thomson

Higher Education, USA (2008). Textbook

2. Kar K.R., Misra M.N. and Kabi, T. "Text Book on Fundamentals of Botany"

New Delhi (2005). Textbook

3. Simpson, M “Plant Systematics”, Elsevier publishing, Canada (2006) Textbook

4. Dikison, W. "Integrative Plant Anatomy" Harcourt Academic Press, USA (2000). Textbook

5. National geography T.V

channel

8. Matrix of course contents versus ILOs:

No. Course contents Study

Week

ILOs

knowledge and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. Cell structure and function. 1 a1 b1 c1, c2, c3 d2

2. Ergastic cell contents- plant

tissues 2 a1 b1 c2, c3 d2

3. Anatomy of primary plant

organs. 3 a2 b1 c2, c3 d2

4. Anatomy of secondary plant

organs. 4 a2 b1 c2, c3 d2

5. Habitat of plants and

animals 5 a3 b3 c5 d1, d3

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6. Morphology of plant leaves 6 a2 b2 c4 d2, d4

7. Morphology of plant leaves 8 a2 b2 c4 d2, d4

8. Morphology of plant stems 9 a2 b2 c4 d2, d4

9. Morphology of plant roots 10 a2 b2 c4 d2, d4

10. Morphology of plant

flowers 11 a2

b2

b3 c1 d2, d4

11. Introduction to Plant

taxonomy 12 a4 b3 c5 d1, d3,

Name Signature

Course Coordinator: Prof. Dr. Amani M. Marzouk

Head of Department: Prof. Dr. Fathy K. El Fiky

Approval Date 06/08/2016

Faculty of Pharmacy


Delta University



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Pharmacognosy-1


Course title: Pharmacognosy-1

Course code: PG 212



Faculty: Pharmacy


Academic level: Second level Spring Semester 2016/2017

Specialization: Pharmaceutical

Prerequisite: Botany (PG 111)

Credit hours: Lecture: 2 Practical: 1 Total: 3


2. Course Aims:

Providing the student with an overview of the concept of pharmacognosy and the importance

of using drugs of natural origin for treating diseases and also the skills to identify, evaluate and

prescribe a crude drug for treating disease and predict their toxicity, any health hazards

concerning their misuse and abuse and interactions if any.




A1.

a1 Discuss the pharmaceutical importance of leaves, flowers, barks and woods.

a2 List the different active constituents and their chemical classes for the studied

crude drugs and how to identify them chemically.

a3 Identify the different organs morphologically and under the microscope

A16. a4 Recognize the toxic profile of certain crude drugs and their interactions and

incompatibilities if any.

A22. a5 Recognize the proper medical and pharmaceutical terminology and abbreviation

in the relevant context.



B9. b1 Select the proper drug s for various disease conditions

B15. b2 Estimate health hazards concerning drug abuse and misuse.

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C2 c1 Handle and dispose chemicals safely

C3. c2 Employ proper and safe dispensing, storage and disposal of pharmaceutical

preparations

C8. c3 Manupilate pharmaceutical instruments and equipment safely and efficiently


C9. c4 Raise public awareness on rational use of drugs and social health hazardsof drug

abuse and misuse.

C11.

c5

Develop the practical skills of microscopically examining and identifying

different crude drugs in sections and powdered forms and testing chemically for

different active constituents

c6 Apply the acquired scientific knowledge to write full schemes and monographs

for other drugs under investigation.



D2.

d1 Retrieve pharmaceutical and other drug information resources

D3.

d2 Work effectively as a part of a team and independently to perform the required

tasks.

D5. d3 Develop information technology (IT) skills

D6.

d4 Develop the skills required for continued self- professional development and self

l-earning

D9. d5 Acquire effective time-management skills.

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Introduction to pharmacognosy: History of treating with herbs and important

definitions in pharmacognosy. 2

2. Introduction to pharmacognosy: preparation of crude drugs (collection, cultivation,

drying, packaing andstoring). 2

3. Introduction to pharmacognosy: adultration of crude drugs and outline of the

chemistry of crude drugs. 2

4. Introduction to leaves; Macro and micromorphological study of examples for the

medicinally used leaves: buchu, Eucalyptus, rosemary, peppermint and tea leaves. 2

5. solanaceous leaves( belladonna, Datura, Hyoscyamus), other leaves as coca,

Jaborandi and boldo. 2

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6. Senna (Indian, Alexandrian and other allied leaves), Digitalis purpurea and

Digitalis lanata leaves 2

7. Mid-Term exam --

8. Introduction to flowers; Macro and micromorphological study of examples for

medicinally used flowers s: Pyrethrum, German and Roman Chamomiles, Arnica,

santonica,

2

9. Saffron, safflower and clove. 2

10. Introduction to barks; Macro and micromorphological study of examples for

medicinally used barks: cinnamon, cassia and canella barks. 2

11. Cinchona, cascarilla, frangula, and pomegranate barks. 2

12. Introduction to woods; Macro and micromorphological study of examples for

medicinally used woods: Quassia, guaiacum, sandal, logwood and juniper woods.

Galls.

2

13. Discussion of the search topics assignments 2

14. Final Exam

15. 24

4.2.Practical:

Week

No. Topics

No. of

hours

1. Introduction to morphology and anatomy of leaves and Macro and

micromorphological study of Senna leaflets. 1

2. Macro and micromorphological study of Digitalis leaves 1

3. Macro and micromorphological study of solanaceous leaves (Hyoscyamus,

Datura and Belladona). 1

4. Macro and micromorphological study of solanaceous leaves (Hyoscyamus,

Datura and Belladona). 1

5. Macro and micromorphological study of Eucalyptus and Rosemary leaves 1

6. Revision and marking of practical notes 1

7. Mid-Term exam --

8. Macro and micromorphological study of German Chamomile, Pyrethrum and

Calendula 1

9. Macro and micromorphological study of Clove Buds and Hibisucs flowers 1

10. Macro and micromorphological study of Cinnamon bark 1

11. Macro and micromorphological study of Quassia wood and Aleppo galls 1

12. General chemical tests for the major classes of secondary metabolites present in

plants and general revision. 1


14. Final Exam

15. 12

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5.1. Lectures

5.2. Practical sessions

5.3. Search topic assignment and group discussion




2. Mid-term exam

and course work to assess knowledge, understanding, intellectual skills and general skills.

3. Practical exam to assess professional and practical skills

4. Written exam to assess knowledge, understanding, intellectual and professional skills

5. Oral exam to assess knowledge, understanding, intellectual skills and general skills


Assessment 1 Quizzes 4th and 12th weeks

Assessment 2 Mid-term 7th week


Assessment 4 Oral 14th &15th weeks




Final-Term Exam 40

Oral Exam 10

Practical Exam 25

Total 100%


No. Reference Type

1. Reference Textbook

2. Trease G.E. and Evans W.C., “Pharmacognosy”, William C.

Evans Edenburgh, London, New York, Philadelphia, Sydney,

Tornoto. 16th Ed. (2009).

Textbook

3. WHO monographs Periodical

4. www.nih.gov, www.herbalgram.com Website

5. National geography T.V channel

http://www.nih.gov/

http://www.herbalgram.com/

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week

ILOs

knowledge and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1.

Introduction to

pharmacognosy: History

of treating with herbs and

important definitions in

pharmacognosy.

1 a1, a5 c2 d1, d3, d4

2.

Introduction to

pharmacognosy:

preparation of crude drugs

(collection, cultivation,

drying, packaing and

storing).

2 a1, a5 c2 d1, d3, d4

3.

Introduction to

pharmacognosy:

adultration of crude drugs

and outline of the

chemistry of crude drugs.

3 a1, a5 c2 d1, d3, d4

4.

Introduction to leaves;

Macro and

micromorphological study

of examples for the

medicinally used leaves:

buchu, Eucalyptus,

rosemary, peppermint and

tea leaves.

4 a1-a5 b1-b2 c1, c3-c6 d2, d4, d5

5.

solanaceous leaves

(belladonna, datura, hyo-

scyamus), other leaves as

coca, Jaborandi and boldo.

5 a1-a5 b1-b2 c1, c3-c6 d2, d4, d5

6.

Senna (Indian,

Alexandrian and other

allied leaves), Digitalis

purpurea and Digitalis

lanata leaves

6

a1-a5

b1-b2 c1, c3-c6 d2, d4, d5

7.

Introduction to flowers;

Macro and

micromorphological study

of examples for

8 a1-a5 b1-b2 c1, c3-c6 d2, d4, d5

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medicinally used flowers

s: Pyrethrum, German and

Roman Chamomiles,

Arnica, santonica,

8. Saffron, safflower &clove. 9 a1-a5 b1-b2 c1, c3-c6 d2, d4, d5

9.

Introduction to barks;

Macro and micromorpho-

logical study of examples

for medicinally used

barks: cinnamon, cassia

&canella barks.

10 a1-a5

b1-b2 c1, c3-c6 d2, d4, d5

10.

Cinchona, cascarilla,

frangula, &pomegranate

barks.

11 a1-a5 b1-b2 c1, c3-c6 d2, d4, d5

11.

Introduction to woods;

Macro and micro-

morphological study of

examples for medicinally

used woods: Quassia,

guaiacum, sandal,

logwood &juniper woods.

Galls.

12 a1-a5 b1-b2 c1, c3-c6 d2, d4, d5

Name Signature

Course Coordinator: Prof Dr. Amani M. Marzouk



Faculty of Pharmacy


Delta University



13

Pharmacognosy-2


Course title: Pharmacognosy-2

Course code: PG 313



Faculty: Pharmacy


Academic level: Third level Fall Semester 2016- 2017


Prerequisite: Pharmacognosy-1



2. Course Aims:

Providing students with the knowledge related to drugs of plant sources from different

organs such as seeds, fruits, subterranean organs and unorganized drugs, which are

reputed to be used in folk medicine and have curative values or use in the pharmaceutical

industry. The students should be familiar with the morphological and histological

characters of the studied plant organs, their detection, adulteration, identification either

entire or in powdered form, their active constituents and uses and any health hazards

concerning their misuse and abuse and interactions if there is any.




A1.

a1 Acquire knowledge about the pharmaceutical importance of seeds, fruits,

subterranean organs and unorganized drugs.

a2 List the different active constituents and their chemical classes for the studied

crude drugs and how to test for them chemically.

a3 Identify the different organs morphologically and under the microscope

A16. a4 Recognize the toxic profile of certain crude drugs and their interactions and

incompatibilities if any

A22. a5 Recognize the proper medical and pharmaceutical terminology and abbreviation

in the relevant context.

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B9.

b1 Integrate acquired information to safely selecting crude drugs and avoiding

dangerous interactions.

b2 Identify other drugs outside his main study, predict possible medicinal uses and

determine their conformation with pharmacopeial monographs.

B15. b3 Estimate health hazards concerning drug abuse and misuse.



C2. c1 Handle and dispose chemicals safely

C8. c2 Manupilate pharmaceutical instruments and equipment safely and efficiently


C9. c3 Raise public awareness on rational use of drugs and social health hazardsof drug

abuse and misuse.

C11.

c4

Develop the practical skills of microscopically examining and identifying

different crude drugs in sections and powdered forms and testing chemically for

different active constituents.

c5 Apply the acquired scientific knowledge to write full schemes and monographs

for other drugs under investigation.



D2. d1 Retrieve pharmaceutical and other drug information resources

D3. d2 Work effectively as a part of a team and independently to perform the required tasks.

D5. d3 Develop information technology (IT) skills

D6. d4 Develop the skills required for continued self- professional development and self-

learning


4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Introduction to seeds 2

2. Macro and micromorphological study of examples for the medicinally used

seeds : Linseed, Nux vomica 2


seeds : cardamom, calabar beans, black and white mustards, 2

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seeds: Strophanthus, nutmeg and mace and fenugreek. 2

5. Introduction to fruits; Macro and micromorphological study of examples for

the medicinally used fruits: Ammi vesnaga and Ammi majus. 2

6. Macro and micromorphological study of the medicinally used fruits:

anise, and fennel, coriander, and star anise 2

7. Mid-Term exam ---

8. Macro and micromorphological study of the medicinally used fruits:

capsicum, black pepper and colocynth. 2

9.

Introduction to subterranean organs;

Macro and micromorphological study of examples for medicinally used

subterranean organs as: Ginger and curcuma and rhubarb.

2

10. Macro and micromorphological study of examples for medicinally used

subterranean organs as: liquorice, Ginseng and Rauwolfia. 2

11. Macro and micromorphological study of examples for medicinally used

subterranean organs as: Krameria, Ipecac, senega and galangal. 2

12. Unorganized drugs of medicinal uses such as: Gums, dried extracts and latex 2

13. Unorganized drugs of medicinal uses such as: resins and resin combinations 2

14. Final Exam

15. 24

4.2.Practical:

Week

No. Topics

No. of

hours

1. Macro and micromorphological study of examples for the medicinally

used seeds: cardamom and nutmeg 1


used seeds : Fenugreek and black mustard 1


used seeds : linseed and 1


used seeds: nux vomica and marking of practical notes 1

5. Revision 1


used fruits : Anise and fennel 1

7. Mid-Term exam --


used fruits: corainder, Ammi visnaga and capsicum 1

9.

Examples for Unorganized drugs: Gums, gelatin, aloes and resins and

resin combinations and general chemical tests for the major classes of

secondary metabolites present in plants.

1

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10. Examples for medicinally used subterranean organs: ginger, curcuma,

rhubarb and liquorice 1

11. Revision on subterranean organs and marking of practical notes 1

12. Final revision (seeds, fruits, subterranean and unorganized drugs) 1


14. Final Exam

15. 12


5.1. Lectures

5.2. Practical sessions

5.3. Assignment and group discussion



Quizzes to assess knowledge, understanding and intellectual skills

Mid-term exam

and course work to assess knowledge, understanding and intellectual skills.

Practical exam to assess professional and practical skills

Written exam to assess knowledge, understanding, intellectual and professional skills

Oral exam to assess knowledge, understanding, intellectual skills and general skills


Assessment 1 Quizzes 4th and 10th weeks







Final-Term Exam 40

Oral Exam 10

Practical Exam 25

Total 100%

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No. Reference type

1.

- Trease G.E. and Evans W.C., “Pharmacognosy”,

William C. Evans Edenburgh, London, New York,

Philadelphia, Sydney, Tornoto. 16th Ed. (2009).

textbook

- Fundamentals Pharmacognosy and Phytotherapy (by M.

Heinrich et al), Chirchil Livingston publishing company

(2004).

2. WHO monographs periodical

3. www.nih.gov, www.herbalgram.com website

4. National geography T.V channel



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1. Introduction to seeds 1 a1, a5

c5, c6. d1

2.

Macro and

micromorphological study of

examples for the medicinally

used seeds : Linseed, Nux

vomica

2 a1, a3, a5 b1-b3 c1, c3-c6 d2, d4, d5

3.

Macro and



used seeds : cardamom,

calabar beans, black and

white mustards,

3 a1, a3, a5 b1-b3 c1, c3-c6. d2, d5

4.

Macro- and



used seeds: Strophanthus,

nutmeg and mace and

fenugreek.

4 a1, a3, a5 b1-b3 c1, c3-6 d2, d5

http://www.nih.gov/

http://www.herbalgram.com/

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5.

Introduction to fruits; Macro

and micromorphological

study of examples for the

medicinally used fruits:

Ammi vesnaga and Ammi

majus.

5 a1- a5 b1-b3 c1, c3-c6 d1, d2, d5

6.

Macro- and


the medicinally used fruits:

anise, and fennel, coriander,

and star anise

6 a1- a5 b1-b3 c1, c3-c6 d2, d5

7.

Macro- and


the medicinally used fruits:

capsicum, black pepper and

colocynth.

8 a1- a5 b1-b3 c1, c3-c6 d2, d4, d5

8.

Introduction to subterranean

organs;

Macro and



used subterranean organs as:

Ginger and curcuma.

9 a1- a5 b1-b3 c1, c3-6 d2, d5

9.

Macro and




rhubarb and licorice

10 a1- a5 b1-b3 c1, c3-c6 d2, d5

10.

Macro and




Krameria, Ipecac, senega

and galangal.

11 a1- a5 b1-b3 c1, c3-c6 d2, d5

11.

Unorganized drugs of

medicinal uses such as:

Gums, dried extracts and

latex

12 a1-a2, a4-a5 b1 c1, c2, c4 d1-d5

12.

Unorganized drugs of

medicinal uses such as:

resins and resin

combinations

13 a1-a2, a4-a5 b1 c1, c2, c4 d1-d5

Name Signature

Course Coordinator: Prof. Dr. Amani M. Marzouk

Head of Department: Prof. Dr. Fathy K. Elfiky


Faculty of Pharmacy


Delta University



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Phytochemistry-1 1. Basic Information:

Course title: Phytochemistry-1

Course code: PG321



Faculty: Pharmacy


Academic level: Third level Spring Semester 2016- 2017


Prerequisite: Organic Chemistry-2 (PC 211)



2. Course Aims:

Providing the students with the knowledge of the chemistry of plant constituents and methods

of screening for active constituents, physico-chemical properties of different classes as

volatile oils, carbohydrates, bitter principles, resins, resin combinations and tannins. The

student will acquire adequate information about medicinally used representatives.




A1 a1 Identify the basic principles of all aspects of the chemistry of natural products

A2 a2 Recognize the physico-chemical properties of drugs (of natural origins) and

various substances used in preparation of medicines.

A3

a3

Understand principles of qualitative and quantitative determination of plant

active constituents (such as volatile oils, carbohydrates, Bitter principles, resins,

resin combinations and tannins).

a4 Define the basis of phytochemical screening of medicinal plants for their active

constituents.

A4 a5 Enumerate the theories of isolation, synthesis, purification, identification and

standardization of natural products.

A13 a6

Recall the chemical and pharmacological properties of drug including

chemistry, nomenclature, mechanisms of action, therapeutic uses, dosageand

contraindications, adverse drug reactions, and drug interactions.

A22 a7 Recognize the proper pharmaceutical and medical terminology and

abbreviations.

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B3. b1 Determine suitable methods of analysis and quality control of drugs as raw

material, in dosage forms and in biological fluids.

B5. b2

Design appropriate methods for isolation, synthesis, purification, identification

and standardization of various chemicals and pharmaceutical compounds (of

natural origin).

B13. b3 Interpret experimental data based on relevant principles.



C2 c1 Handle and dispose chemicals, biological and pharmaceutical preparations safely.

C4 c2 Select appropriate methods for extraction, isolation, synthesis, purification,

identification and standardization of active substances from different origins.

C8 c3

Manipulate pharmaceutical instruments and equipment safely and efficiently and

solve commonly encountered problems in pharmaceutical manufacturing

processes.

C9 c4 Select the proper drugs for various disease conditions

C11 c5 Conduct experimental and research studies, including: presentation, analysis and

interpretation of the results.



D2 d1 Retrieve pharmaceutical, clinical and other drug information resources.

D3 d2 Work effectively as a part of a team to perform the required tasks.

D5 d3 Develop information technology (IT) skills.

D6 d4 Develop the skills required for continued self-professional development and

self-learning.

D9 d5 Acquire effective time-management skills.

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Carbohydrates, occurrence, significance, biosynthesis , classification and

identification 2

2. Carbohydrates of medicinal and pharmaceutical importance: sugar alcohols,

monosaccharides and disaccharides 2

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3. Homopolysaccharides and heteropolysaccharides 2

4. Bitter principles and other miscellaneous natural products: Furanochromones,

Furancoumarins 2

5. Sesquiterpenes and lignans 2

6. Miscellaneous Natural products 2

7. MIDTERM EXAM --

8. Essential oils, distribution and occurrence, physiological significance and effects

and side effects. 2

9. Methods of extraction of volatile oils, Chemistry of volatile oils, classification and

biogenesis. 2

10. Terpene hydrocarbons, alcohols and esters. 2

11. Terpene aldehydes, ketones, and phenols. 2

12. Oxides, peroxides and miscellaneous. 2

13. Revision 2

14. Final Exam

15. 24

4.2.Practical:

Week

No. Topics

No. of

hours

1. Qualitative Tests of Monosaccharides 1

2. Qualitative Tests of Disaccharides 1

3. Qualitative Tests of Polysaccharides 1

4. Revision on Carbohydrates 1

5. Final Carbohydrates practical exam 1

6. Assay of Clove oil 1

7. Mid-Term exam --

8. Assay of volatile oil containing peroxide 1

9. Assay of volatile oil containing oxide 1

10. Assay of bitter almond oil by Hydroxylamine method 1

11. Assay of volatile oil by bisulfite method 1

12. Revision 1


14. Final Exam

15. 12


5.1 Lectures

5.2 Practical sessions

5.3 Homework

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2. Midterm and course work to assess knowledge, understanding, intellectual, transferable and

general skills

3. Practical exam to assess professional and practical and general skills

4. Written exam to assess knowledge, understanding, intellectual and professional

skills

5. Oral exam to assess knowledge, understanding, intellectual and general skills


Assessment 1 Quiz 5th and 12th weeks


Assessment 3 Practical 5th and 13th weeks





Final-Term Exam 40

Oral Exam 10

Practical Exam 25

Total 100%


No. Reference type

1. Text book of Pharmacognosy and Phytochemistry. Biren Shah. Elsevier,

India. 2nd Edition (2013) Text book

2. Trease G.E and Evans W.C.,''pharmaconosy'', william C. Evans. Edenburgh,

London, new york, philadelphia, sydney, toronto , 16th ED,(2009) textbook

3. Natural product chemistry. A Mechanistic Biosynthetic and Ecological

Approach. 2nd ed., by kurt B.C. Torsell, 1997. textbook

4.

phytochmistry

Natural products research

chromatographia

Phytochemical analysis

Periodicals

Faculty of Pharmacy


Delta University



23



week

ILOs

knowledge and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1. Carbohydrates, occurrence,

significance, biosynthesis ,

classification and identification

1 a1, a3-a7 b2, b3 c2 d1, d3, d4

2.

Carbohydrates of medicinal

and pharmaceutical

importance: sugar alcohols,

monosaccharides and

disaccharides

2 a2-a7 b2-b3 c1, c2, c5 d2, d5

3. Homopolysaccharides and

heteropolysaccharides 3 a2-a7 b2-b3 c1, c2, c5 d1, d3, d4

4.

Bitter princples and other

miscellaneous natural products:

Furanochromones,

Furancoumarins

4 a2, a5-a7 b2 c2, c3 d1, d3, d4,

d5

5. Sesuiterpenes and lignans 5 a2, a5-a7 b2 c2 d1

6. Miscellaneous N.P. 6 a2, a5-a7 b2 c2 d1

7.

Essential oils, distribution and

occurrence, physiological

significance and effects and

side effects.

8 a1, a6-a7 b2 c4 d2, d5

8.

Methods of extraction of

volatile oils, chemistry of

volatile oils, classification and

biogenesis.

9 Aa2, a5 b1-b3 c1-c3, c5 d2, d5

9. Terpene hydrocarbons,

alcohols and esters. 10 a2, a3,a6 b1, b2 c2 d2, d5

10. Terpene aldehydes, ketones,

and phenols. 11 a2, a3, a4,a6 b1, b2 c1-c3, c5 d2, d5

11. Oxides, peroxides and

miscellaneous. 12 a2, a3, a4,a6 b1, b2 c1-c3, c5 d2, d5

Name Signature

Course Coordinator: Prof. Dr. Fathy K. El Fiky



Faculty of Pharmacy


Delta University



24

Phytochemistry-2 1. Basic Information:

Course title: Phytochemistry-2

Course code: PG 422



Faculty: Pharmacy


Academic level: Fourth level Fall semester 2016/2017


Prerequisite: phytochemistry-1 (PG 321)



2. Course Aims:

The course provides the students with an understanding of the chemical constituents of crude drugs

(alkaloids, glycosides, hallucinating and anticancer drugs found in different compound classes) and the

skills in extraction, separation, chemical structures, identification, quantitative determination,

medicinal uses and structure activity relationship of phyto-constituents.




A1 a1 Discuss principles and applications of phytochemistry in synthesis, isolation,

purification and identification of plant active constituents.

A2 a2 Recognize the physico-chemical properties of drugs (of natural origin as alkaloids,

glycosides, hallucinating and anticancer drugs).

A3

a3 Understand principles of qualitative and quantitative determination of plant active

constituents (such as alkaloids, glycosides, hallucinating and anticancer drugs).

a4 Define the basis of phytochemical screening of medicinal plants for their active

constituents.

A4 a5 Enumerate the theories of isolation, synthesis, purification, identification and

standardization of natural products.

A13 a6

Recall the chemical and pharmacological properties of drug (of natural origin)

including chemistry, nomenclature, mechanisms of action, therapeutic uses,

biotransformation, dosage, contraindications, adverse drug reactions, and drug

interactions.

Faculty of Pharmacy


Delta University



25



B3. b1 Determine suitable methods of analysis and quality control of drugs as raw

material, in dosage forms and in biological fluids.

B5. b2

Design appropriate methods for isolation, synthesis, purification, identification and

standardization of various chemical compounds (plant active constituents such as

alkaloids, glycosides, hallucinating and anticancer drugs found in different

compound classes).

B13. b3

Interpret experimental data based on relevant principles.



C2. c1 Handle and dispose chemicals safely.

C4. c2

Select appropriate methods for extraction, isolation, synthesis, purification,

identification and standardization of active substances (of plant origin).

C8. c3 Manipulate pharmaceutical instruments and equipment safely and efficiently.

C9. c4 Raise public awareness on rational use of drugs and social health hazards of

abused and misused drugs of natural origin.

C11. c5 Conduct experimental and research studies, including: presentation, analysis and

interpretation of the results.



D2. d1 Retrieve pharmaceutical, clinical and other drug information resources.

D3. d2 Work effectively as a part of a team to perform the required tasks.

D5. d3 Develop information technology (IT) skills.

D6. d4 Develop the skills required for continued self-professional development and self-

learning.


4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Introduction and extraction of alkaloids 2

2. Classification of alkaloids 2

3. Pyridine and piperidine alkaloids 2

4. Alkaloidal amines and tropane alkaloids 2

5. Quinoline and isoquinoline alkaloids 2

Faculty of Pharmacy


Delta University



26

6. Indole , imidazole , steroidal and purine alkaloids 2


8. Introduction of medicinal glycosides, Alcoholic and phenolic

glycosides 2

9. Aldehydic and cyanogenic glycosides 2

10. Anthracene and steroidal glycosides 2

11. Coumarin , chromone , sulpher containing and alkaloidal glycosides 2

12. Flavanoid glycosides - 2

13. Saponins and tannins 2

14. Final Exam

15. 24

4.2.Practical:

Week

No. Topics

No. of

hours

1. Introduction to alkaloids chemistry + quinine identification 1

2. Identification of caffeine 1

3. Identification of ephedrine and papaverine 1

4. Identification of atropine 1

5. Identification of pilocarpine 1

6. Identification of strychnine and brucine 1


8. Introduction to column chromatography + planner chromatography 1

9. Separation of tropane alkaloids using TLC 1

10. isolation of different dyes using paper chromatography 1

11. isolation of different dyes using column chromatography 1

12. Revision on alkaloid identification 1


14. Final Exam

15. 12


5.1 Lectures

5.2 Practical sessions

5.3 Homework

Faculty of Pharmacy


Delta University



27



6. Midterm and course work to assess knowledge, understanding, intellectual and general skills


8. Practical exam to assess professional and practical and general skills

9. Written exam to assess knowledge, understanding, intellectual and professional skills

10. Oral exam to assess knowledge, understanding, intellectual and general skills



Assessment 2 Quiz 12th week





Mid-Term Examination and course work 25

Final-Term Examination 40

Oral Examination 10

Practical Examination 25

Total 100%


No. Reference type

5. Text book of Pharmacognosy and Phytochemistry. Biren Shah. Elsevier,

India. 2nd Edition (2013) Text book

6. Trease G.E and Evans W.C.,''pharmaconosy'', william C. Evans. Edenburgh,

London, new york, philadelphia, sydney, toronto , 16th ED,(2009) textbook

7. Natural product chemistry. A Mechanistic Biosynthetic and Ecological

Approach. 2nd ed., by kurt B.C. Torsell, 1997. textbook

8.

phytochmistry

Natural products research

chromatographia

Phytochemical analysis

Periodicals



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1 Introduction and extraction

of alkaloids 1 a1, a2, a5 b2 c1-c3 d1

2 Classification of alkaloids 2 a1, a2, a6 b1 c2 d1

Faculty of Pharmacy


Delta University



28

3 Pyridine and piperidine

alkaloids 3 a2, a6 b1, b3 c2 d6

4 Alkaloidal amines and

tropane alkaloids 4 a2-a4, a6 b1, b3 c1-c3, c5 d2, d3, d5

5 Quinoline and isoquinoline

alkaloids 5 a2, a6 b1, b3 c4,c3, c5 d1

6 Indole , imidazole , steroidal

and purine alkaloids 6 a2, a5, a6 b1- b3 c1-c3, c5 d2, d3, d5

7 Introduction to medicinal

glycosides 8 a1, a2, a6 b1, b3 c2 d1, d3, d4

8

Alcoholic and phenolic

glycosides, Aldehydic and

cyanogenic glycosides

9 a1, a2, a6 b1, b3 c2, c5 d1

9 Anthracene and steroidal

glycosides 10 a1, a2, a6 b1, b3 c2, c5 d1, d3

10

Coumarin , chromone ,

sulpher containing and

alkaloidal glycosides

11 a1, a2, a6 b1- b3 c2, c5 d1, d3

11 Flavanoid glycosides -

saponins and tannins 12 a1, a2, a6 b1, b3 c2 d1, d3

Name Signature

Course Coordinator: Prof. Dr. Fathy K. El Fiky



courses specifications - delta univ

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