Course syllabus

Course title Neurosurgical diseases from the perspective of clinical neuropsychology

Instructor’s name Aleksandra Bala, PhD

Contact details aleksandra.bala@gmail.com

Affiliation Faculty of Psychology, University of Warsaw Department of Neurosurgery, Public Central Teaching Hospital

Course format Seminar

Number of hours 14h

Number of ECTS credits 2 ECTS

Brief course description During classes, students will learn about the most common neurosurgical disorders and (neuro)psychological problems of patients with particular conditions.

Full course description During classes, students will learn about the most common neurosurgical disorders as well as methods used in the neuropsychological diagnosis in a neurosurgery clinic. We will talk about possible psychological and neuropsychological consequences of various brain dysfunctions. We will analyze recent experimental papers concerning functioning of patients with CNS diseases. Case studies will be also analyzed.

Learning outcomes 1. Basic knowledge about neurosurgical diseases. 2. Basic ability to define the most common cognitive and affective

problems of patients with various conditions. 3. Basics of neuropsychological diagnosis in neurosurgical patients.

Learning activities and teaching methods

The course will have a format of lectures, discussions and short students’ presentations. During classes students will also analyze case studies in smaller groups and present it to the others.

List of topics/classes and bibliography

List of topics: a. Introduction: neuropsychologist in a neurosurgery department –

specifics of work. b. Neurosurgical conditions:

a. Traumatic brain injury b. Intracranial aneurysms and vascular malformations. c. Intracranial tumors d. Hydrocephalus e. Epilepsy

c. Final exam

Each condition will be introduced with a lecture followed by students’ presentations of research papers concerning one of the topics. Each class will end up with a discussion and a common summary of what we have learned.

Bibliography: Louis, E.D., Mayer, S.A., Rowland, L.P. (2015). Merritt’s Neurology (13th ed.). New York: Wolters Kluwer Specific subsections of ‘Merritt’s Neurology’ for each topic:

a. Traumatic brain injury

Section V. Neurotrauma 45 Concussion James M. Noble and John F. Crary 46 Traumatic Brain Injury Neeraj Badjatia, Gunjan Y. Parikh, and Stephan A. Mayer

b. Intracranial aneurysms and vascular malformations.

Section IV. Cerebrovascular Diseases 38 Intracerebral Hemorrhage Stephan A. Mayer, Fred Rincon, and J.P. Mohr 39 Subarachnoid Hemorrhage Stephan A. Mayer, Gary L. Bernardini, and Robert A. Solomon 41 Vascular Malformations J.P. Mohr and John Pile-Spellman

c. Intracranial tumors

Section XIII. Neuro-Oncology 96 Gliomas Mikael L. Rinne and Patrick Y. Wen 97 Metastatic Tumors Enid Choi, Graeme Woodworth, and Minesh P. Mehta 98 Tumors of the Meninges Thomas J. Kaley Section IX. CNS Infections 61 Acute Bacterial Meningitis and Infective Endocarditis Burk Jubelt and Barnett R. Nathan 65 Parasitic Infections Gustavo C. Román

d. Hydrocephalus Section XIV. Hydrocephalus and Cerebral Edema 106 Hydrocephalus Michelle L. Ghobrial, Leon D. Prockop, and Fred Rincon

e. Epilepsy Section VIII. Epilepsy and Paroxysmal Disorders 58 Epilepsy Carl W. Bazil, Shraddha Srinivasan, and Timothy A. Pedley

Articles for students’ presentations a. Traumatic brain injury

Albrecht, M.A., Masters, C.L., Ames, D., Foster, J.K., The AIBL Research Group. (2016). Impact of Mild Head Injury on Neuropsychological Performance in Healthy Older Adults: Longitudinal Assessment in the AIBL Cohort. Frontiers in Aging Neuroscience, 8, 105.

Libin, A.V., Scholten, J., Schladen, M.M., Danford, E., Shara, N., Penk, W., Grafman, J., Resnik, L., Bruner, D., Cichon, S., Philmon, M., Tsai, B., Blackman, M., Dromerick, . (2015). Executive functioning in TBI from rehabilitation to social reintegration: COMPASS goal, a randomized controlled trial, Military Medical Research, 2, 32.

Max. J.E. (2014). Neuropsychiatry of Pediatric Traumatic Brain Injury. Psychiatric Clinics of North America, 37, 125–140.Multani,

N., Goswami, R., Khodadadi, M., Ebraheem, A., Davis, K.D., Tator, C.H., Wennberg, R., Mikulis, D.J., Ezerins, L., Tartaglia, M.C. (2016). The association between white-matter tract abnormalities, and neuropsychiatric and cognitive symptoms in retired professional football players with multiple concussions. Journal of Neurology, 263, 1332-1341.

b. Intracranial aneurysms and vascular malformations.

da Costa, L., Dunkley, B.T., Bethune, A., Robertson, A., Keller, A., Pang, E.W. (2016). Increased Frontal Lobe Activation After Aneurysmal Subarachnoid Hemorrhage. Stroke, 47, 2503-10.

Murray, A.L., Dally, M., Jeffreys, A., Hwang, P., Anderson, J.F. (2014). Neuropsychological outcomes of stereotactic radiotherapy for cerebral arteriovenous malformations. Journal of Clinical Neuroscience, 21, 601-606.

Preiss, M., Netuka, D., Koblihova, J., Bernardova, L., Charvat, F., Kratochvilova, D., Benes, V. (2012). Quality of Life 1 Year after Aneurysmal Subarachnoid Hemorrhage in Good Outcome Patients Treated by Clipping or Coiling. Journal of Neurological Surgery, 73, 217–223.

Shibahashi, K., Morita, A., Kimura, T. (2014). Does a Craniotomy for Treatment of Unruptured Aneurysm Affect Cognitive Function? Neurologia Medico-chirurgica, 54, 786-93.

c. Intracranial tumors

Gehring, K., Taphoorn, M.J., Sitskoorn, M.M., Aaronson, N.K. (2015). Predictors of subjective versus objective cognitive functioning in patients with stable grades II and III glioma. Neurooncology Practice, 2, 20-31.

Greene-Schloesser, D., Robbins, M.E. (2012). Radiation-induced cognitive impairment-from bench to bedside. Neurooncology, Suppl 4, iv37-44.

Madhusoodanan, S., Ting, M.B., Farah, T., Ugur, U. (2015). Psychiatric aspects of brain tumors: A review. World Journal of

Psychiatry, 5, 273-85.

Talacchi, A., Santini, B., Casartelli, M., Monti, A., Capasso, R., Miceli, G. (2013). Awake surgery between art and science. Part II: language and cognitive mapping. Functional Neurology, 28, 223 – 239.

d. Hydrocephalus

Behrens, A., Eklund, A., Elgh, E., Smith, C., Williams, M.A., Malm, J. (2014). A computerized neuropsychological test battery designed for idiopathic normal pressure hydrocephalus. Fluids and Barriers of the CNS, 11, 22.

Kiefer, M., Unterberg, A., (2012). The differential diagnosis and treatment of normal-pressure hydrocephalus. Deutsches Arztebltt International, 109, 15-25

Junkkari, A., Häyrinen, A., Rauramaa, T., Sintonen, H., Nerg, O., Koivisto, A.M., Roine, R.P., Viinamäki, H., Soininen, H., Luikku, A., Jääskeläinen, J.E., Leinonen, V. (2016). Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study. European Journal of Neurology [Epub ahead of print].

Peterson, K.A., Savulich, G., Jackson, D., Killikelly, C., Pickard, J.D., Sahakian, B.J. (2016). The effect of shunt surgery on neuropsychological performance in normal pressure hydrocephalus: a systematic review and meta-analysis. Journal of Neurology, 263, 1669-1677.

e. Epilepsy

Benuzzi, F., Zamboni, G., Meletti, S., Serafini, M., Lui, F., Baraldi, P., Duzzi, D., Rubboli, G., Tassinari, C,A., Nichelli, P.F. (2014). Recovery from emotion recognition impairment after temporal lobectomy. Frontiers in Neurology, 5, 92.

Brown, F.C., Westerveld, M., Langfitt, J.T., Hamberger, M., Hamid, H., Shinnar, S., Sperling, M.R., Devinsky, O., Barr, W., Tracy, J., Masur, D., Bazil, C.W., Spencer, S.S. (2014). Influence of anxiety on memory performance in temporal lobe epilepsy. Epilepsy and Behavior, 31, 19-24.

Meneses, R.F., Pais-Ribeiro, J.L., da Silva, A.M., Giovagnoli, A.R. (2009). Neuropsychological predictors of quality of life in focal epilepsy. Seizure, 18, 313-9

Sidhu, M.K., Stretton, J., Winston, G.P., McEvoy, A.W., Symms, M., Thompson, P.J., Koepp, M.J., Duncan, J.S. (2016). Memory network plasticity after temporal lobe resection: a longitudinal functional imaging study. Brain, 139, 415-30.

Assessment methods and criteria

1. Presentation (25%) Students will prepare presentations of research papers related to the topics of the classes. Each Student will present at least one paper (number of presentations per person depends on the number of Students attending this course so it will be determined at the first day of classes). After the brief presentation (up to 10 minutes) we will discuss it with the group.

2. Final exam (75%) The exam will consist of a number of questions regarding neurosurgical diseases and treatment as well as neuropsychological status of patients with particular conditions. There will be three types of questions: a) multiple choice questions b) true/false sentences c) short answer questions

Attendance rules Up to one unexcused absence is permitted. Missing more than 2 classes results in course failure.

Prerequisites Completed courses on Neuropsychology and Clinical Neuropsychology

Academic honesty Students must respect the principles of academic integrity. Cheating and plagiarism (including copying work from other students, internet or other sources) are serious violations that are punishable and instructors are required to report all cases to the administration.

Basket Will be filled out by WISP admin

Remarks