corr report, 2012: cst annual general meeting s. joseph kim, md, phd, frcpc vice president, corr...
TRANSCRIPT
CORR Report, 2012:CST Annual General Meeting
S. Joseph Kim, MD, PhD, FRCPC
Vice President, CORR Board of Directors
Friday, February 24, 2012
1
Outline
• Donor activity
• Waiting list statistics
• Transplant activity
• Transplant outcomes
2
Donor Activity
3
4
Deceased Donor Rate (PMP), by Year
2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
2
4
6
8
10
12
14
16
Ra
te p
er
Mill
ion
Po
pu
lati
on
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
5
Deceased Donor Rate (PMP), by Region
2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
5
10
15
20
25
30
35
B.C. Alta. Sask. Man. Ont. Que. N.B. N.S./P.E.I. N.L.
Ra
te p
er
Mill
ion
Po
pu
lati
on
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
6
Deceased Donor Rate (PMP), by Region
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Deceased Donor 13.4 12.9 13.3 12.9 12.7 14.1 14.7 14.4 14.4 13.6
Province
B.C. 9.1 7.3 9.4 7.4 5.9 8.4 8.8 12.3 7.2 10.8
Alta. 17.0 17.3 11.4 16.2 14.1 14.8 13.7 11.4 10.6 8.9
Sask. 15.0 12.0 17.1 9.0 15.1 10.1 14.0 12.8 12.6 12.5
Man. 7.8 9.5 10.3 6.0 5.1 11.0 12.6 11.6 11.5 15.4
Ont. 10.8 11.3 11.6 12.3 11.8 13.6 15.5 13.6 16.7 15.1
Que. 18.3 16.8 19.0 18.0 17.8 18.2 18.2 19.5 17.6 15.1
N.B. 22.7 14.7 16.0 13.3 21.3 13.3 17.4 10.7 14.7 10.6
N.S./P.E.I. 9.7 11.8 11.8 9.6 13.9 20.3 15.0 17.1 16.0 20.1
N.L. 28.7 27.0 19.3 9.7 13.6 23.5 9.9 15.8 13.8 9.8
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
7
Deceased Donor Rate (PMP), by Age Group
2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
5
10
15
20
25
30
0 - 17 Years 18 - 39 Years 40 - 49 Years 50 - 54 Years 55 - 59 Years
Ra
te p
er
Mill
ion
Po
pu
lati
on
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
8
Donor Rate (PMP), by Donor Source (Deceased Versus Living)
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Deceased Donor 13.4 12.9 13.3 12.9 12.7 14.1 14.7 14.4 14.4 13.6
Living Donor 14.4 14.1 13.7 14.9 15.6 17 16.8 16.4 15.3 16.3
1
3
5
7
9
11
13
15
17Ra
te p
er M
illio
n Po
pula
tion
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
9
Living Donor Rate (PMP), by Region
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
West 18.4 18.5 17.2 19.8 17.9 19.8 21.2 17.4 15.7 19.6
Ontario 16.2 15.9 15.4 17.3 19.8 21.7 20.6 21.2 21.1 20
Quebec 6.2 6 7.1 5.8 6.7 6.8 6 7 5.2 7
Atlantic 15 12 12 11.1 12.8 13.7 12.5 16.7 14.1 12.4
3
8
13
18
23
Rate
per
Mill
ion
Popu
latio
n
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
10
Number of Canadian Organ Donors, by Donor Source
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Deceased 417 405 421 412 411 461 485 481 487 465
Living 447 441 435 475 504 556 554 546 515 557
100
300
500
700
900
1,100
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
11
Number of Solid Organ Transplants, by Donor Source
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Deceased 1338 1348 1361 1307 1361 1519 1588 1530 1577 1546
Living 445 441 435 472 502 555 554 546 515 557
250
750
1,250
1,750
2,250
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
12
Deceased Donor Organ Utilization
2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
10
20
30
40
50
60
70
80
90
100
kidney1 kidney2 liver heart lungSourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Canada Deceased Donation, 2001 to 20112011: DD = 517, NDD = 449, DCD = 68 (13%)Record year for Canada in both total DD and DCD activity
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 20110
100
200
300
400
500
600DCDNDD
13
Sources2001 to 2010: Canadian Organ Replacement Register, Canadian Institute for Health Information; 2011: Personal Communication, Dr. S. Joseph Kim.
14
Province 2006 2007 2008 2009 2010 2011
B.C. 0 0 2 0 1 7
Alta. 0 0 1 1 1 3
Ont. 4 17 30 37 35 42
Que. 0 4 7 5 7 13
N.S. 0 1 2 0 2 2
Total 4 22 42 43 46 67
Donation After Cardiac Death, by Province, 2006 to 2011
Sources2001 to 2006: Canadian Organ Replacement Register, Canadian Institute for Health Information; 2011: Personal Communication, Dr. S. Joseph Kim.
Waiting List Statistics
15
16
Number of Wait-Listed Transplant Candidates, by Organ Type
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Kidney 3027 3014 2963 2875 2872 2759 2962 2963 3179 2732 3362
Liver 338 454 559 569 667 713 723 635 587 551 501
Kid-Pan 128 172 122 120 101 132 113 126 98 56 107
Heart 89 125 103 131 125 96 87 115 131 136 135
Heart-Lung 177 163 150 172 181 239 252 243 282 245 310
250
750
1,250
1,750
2,250
2,750
3,250
3,750
4,250
4,750
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
17
Duration of Dialysis Prior to First Kidney Transplant, by Province, 2008 to 2010
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
18
Number of Wait-Listed Kidney Transplant Candidates and Death Rates on the Waiting List
2%
7%
13%
18%
22%
28%
33%
38%
43%
48%
250
750
1,250
1,750
2,250
2,750
3,250
3,750
Prop
ortio
n of
Dea
ths
on W
ait
List
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
19
Number of Wait-Listed Liver Transplant Candidates and Death Rates on the Waiting List
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
Liver
338 454 559 569 667 713 723 635 587 551 501
Deaths
0.17230769230769
2
0.16426512968299
7
0.16173570019723
9
0.18083182640144
7
0.14656488549618
3
0.20114122681883
0.17391304347826
1
0.11047345767575
3
0.15834767641996
6
0.15716753022452
5
0.22424242424242
5
50150250350450550650750
2%7%13%18%22%28%33%38%43%48%
Pro
po
rtio
n o
f D
eath
s o
n W
ait
List
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
20
Number of Wait-Listed Heart Transplant Candidates and Death Rates on the Waiting List
10
30
50
70
90
110
130
150
3%
8%
13%
18%
23%
28%
33%
38%
43%
48%
Prop
ortio
n of
Dea
ths
on W
ait L
ist
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
21
Number of Wait-Listed Lung Transplant Candidates and Death Rates on the Waiting List
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
Lung
177 163 150 172 181 239 252 243 282 245 310
Deaths
0.128048780487806
0.172839506172839
0.153846153846155
0.1812
5
0.233695652173913
0.2160804020100
5
0.1827411167512
7
0.176954732510289
0.187234042553192
0.186440677966102
0.1875
2575
125175225275325
2%
13%
22%
33%
43%
Pro
po
rtio
n o
f D
ea
ths
on
Wa
it L
ist
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
22
Number of Wait-Listed Kidney–Pancreas Transplant Candidates and Death Rates on the Waiting List
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
Kid-Pan
128 172 122 120 101 132 113 126 98 56 107
Deaths
0.0084745762711864
9
0.0189873417721519
0.025
0.0425531914893617
0.046875
0.0212765957446808
0.0306122448979592
0.0530973451327434
0.0615384615384615
0.0937500000000004
0.161290322580645
10
50
90
130
170
2%
13%
22%
33%
43%
Pro
po
rtio
n o
f D
ea
ths
on
Wa
it L
ist
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Transplant Activity
23
24
Number of Kidney Transplants, by Donor Type
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Living 399 399 400 416 441 487 483 478 458 493
Deceased 663 636 657 611 615 712 769 738 766 755
100
300
500
700
900
1,100
1,300
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
25
Proportion of Kidney Transplants, by Donor Type
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Living 399 399 400 416 441 487 483 478 458 493
Deceased 663 636 657 611 615 712 769 738 766 755
5%
15%
25%
35%
45%
55%
65%
75%
85%
95%
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
26
Kidney Transplants, by Year and Donor Type, 2001 to 2010
2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
100
200
300
400
500
600
700
800
Kidney Only, First Graft, Deceased Donor Kidney Only, First Graft, Living Donor
Kidney Combination, First Graft, Deceased Donor† Re-Transplants
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
28
Number of Kidney Transplants, by Donor Type and Re-Transplant Status
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
29
Deceased Donor Kidney Transplants, by Year and Province, 2001 to 2010
2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
50
100
150
200
250
300
350
B.C.Alta.Sask.Man.Ont.Que.N.S.
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
31
Living Donor Kidney Transplants, by Year and Province, 2001 to 2010
1 2 3 4 5 6 7 8 9 100
50
100
150
200
250
B.C.Alta.Sask.Man.Ont.Que.N.S.
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
33
Number of Kidney Transplants, by Diagnosis, 2001 to 2010
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Diabetes 153 157 193 139 155 171 219 217 206 229
Glomerulonephritis 379 343 366 387 324 390 363 342 367 385
Renal vascular dis-ease
77 71 79 86 80 102 98 98 94 94
Pyelo 87 95 85 96 75 89 113 88 77 77
PKD 120 115 104 113 149 157 162 151 154 134
Other 196 190 178 156 215 219 213 232 228 236
Unknown 50 64 52 50 58 71 84 88 98 93
5%
25%
45%
65%
85%
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
34
Kidney Transplant Recipients, by Age Group and End-Stage Renal Disease Diagnosis, 2010
Age 18–44 Age 45–54 Age 55–64 Age 65+0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
UnknownOtherDMHTN/VascPKDPyeloGN
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
35
Number of Pre-Emptive Kidney Transplants, 2001 to 2010
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
10
20
30
40
50
60
70
80
0-17 18-44 45-54 55-64 65-70 71+
37
Number of Kidney Transplants, by Centre, 2010
A B C D E F G H I J K L M N O P Q R S T U V W X Z
Number of trans-plants
1 1 1 3 3 3 4 12 15 27 39 50 51 52 55 62 70 78 78 80 82 97 99 132
153
10
30
50
70
90
110
130
150
170
Nu
mb
er
of
Kid
ne
y T
ran
sp
lan
ts
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
38
Proportion of Kidney Transplants, Deceased Versus Living Donors, 2010
A B C D E F G H I J K L M N O P Q R S T U V W X Z
Deceased donor 0 0 1 2 0 3 4 4 12 14 29 19 34 33 49 47 40 61 43 46 53 59 45 84 73
Living donor donor 1 1 0 1 3 0 0 8 3 13 10 31 17 19 6 15 30 17 35 34 29 38 54 48 80
5%
15%
25%
35%
45%
55%
65%
75%
85%
95%
Living donor donor Deceased donor
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
39
Number of Liver Transplants, by Age, Donor Type and Re-Transplant Status
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Combination Liver Transplants, Canada, 2001 to 2010
40SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Number of Heart Transplants, by Age, Donor Type and Re-Transplant Status
41
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Number of Lung Transplants, by Age, Donor Type and Re-Transplant Status
42
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Number of Lung Transplants, by Age, Donor Type and Re-Transplant Status
43
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
44
Number of Pancreas and Islet Transplants
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Transplant Outcomes
45
46
Total Graft Survival, First Kidney, by Donor Type, 2001 to 2010
Log Rank P < 0.0001
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
Living donor Deceased donor
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Donortype Tx 1year 2years 3years 4years 5yearsLiving donor 100.0 97.0 95.2 93.8 91.5 89.5Deceased donor 100.0 93.0 90.2 87.1 84.6 81.2
47
Death-Censored Graft Survival, First Kidney, by Donor Type, 2001 to 2010
Log Rank P < 0.0001
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
Living donor Deceased donor
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Diagnosis Tx 1year 2years 3years 4years 5yearsLi vi ng donor 100.0 97.5 96.5 95.7 94.3 93.0Deceased donor 100.0 95.2 93.6 91.9 90.4 88.5
48
Patient Survival, First Kidney, by Donor Type, 2001 to 2010
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
Living donor Deceased donor
Log Rank P < 0.0001
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Donortype Tx 1year 2years 3years 4years 5yearsLi vi ng donor 100.0 99.4 98.7 98.1 97.1 96.2Deceased donor 100.0 97.7 96.3 94.7 93.5 91.7
49
Total Graft Survival, First Kidney, by Age Group, 2001 to 2010
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
>=65 years 50 - 64 years 35 - 49 years 18 - 34 years
Log Rank P < 0.0001
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Agegroup Tx 1year 2years 3years 4years 5years>=65 years 100.0 91.6 87.9 84.2 80.2 76.3
50 - 64 years 100.0 94.0 91.6 88.6 86.7 83.935 - 49 years 100.0 96.3 94.3 92.9 90.8 88.418 - 34 years 100.0 94.8 92.6 90.7 87.3 84.3
0 -17 years 100.0 96.2 93.5 91.7 90.4 87.8
50
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
>=65 years 50 - 64 years 35 - 49 years 18 - 34 years
Death-Censored Graft Survival, First Kidney, by Age Group, 2001 to 2010
Log Rank P < 0.0001
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Agegroup Tx 1year 2years 3years 4years 5years>=65 years 100.0 95.6 94.6 93.2 92.6 91.2
50 - 64 years 100.0 96.0 94.9 93.5 92.6 91.735 - 49 years 100.0 96.9 95.7 94.8 93.4 91.618 - 34 years 100.0 95.2 93.1 91.4 88.2 85.4
0 -17 years 100.0 96.6 94.0 92.3 90.9 88.3
51
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
>=65 years 50 - 64 years 35 - 49 years 18 - 34 years
Patient Survival, First Kidney, by Age Group, 2001 to 2010
Log Rank P < 0.0001
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Agegroup Tx 1year 2years 3years 4years 5years>=65 years 100.0 95.8 92.9 90.3 86.6 83.6
50 - 64 years 100.0 98.0 96.5 94.8 93.6 91.435 - 49 years 100.0 99.3 98.6 98.0 97.2 96.518 - 34 years 100.0 99.6 99.4 99.1 99.0 98.7
0 -17 years 100.0 99.6 99.4 99.4 99.4 99.4
52
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
Diabetes Glomerulonephritis Polycystic kidney diseasePyelonephritis Renal vascular disease OtherUnknown
Total Graft Survival, First Kidney, by End-Stage Renal Disease Diagnosis, 2001 to 2010
Log Rank P < 0.0001
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Diagnosis Tx 1year 2years 3years 4years 5yearsDi abetes 100.0 92.9 90.2 86.4 83.5 79.7Glomerulonephri ti s 100.0 95.0 92.7 90.6 88.1 85.4Polycysti c ki dney di sease 100.0 94.9 91.5 89.0 87.3 84.5Pyelonephri ti s 100.0 96.4 95.3 94.0 92.2 90.0Renal vascular di sease 100.0 95.0 92.6 90.6 87.5 85.3Other 100.0 92.9 90.2 87.3 84.3 81.2Unknown 100.0 94.0 92.6 91.3 88.5 86.5
53
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
Diabetes Glomerulonephritis Polycystic kidney disease Pyelonephritis
Renal vascular disease Other Unknown
Death-Censored Graft Survival, First Kidney, by End-Stage Renal Disease Diagnosis, 2001 to 2010
Log Rank P = 0.0023
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Diagnosis Tx 1year 2years 3years 4years 5yearsDi abetes 100.0 96.0 94.9 93.4 92.1 90.4Glomerulonephri ti s 100.0 96.1 94.4 93.2 91.5 89.5Polycysti c ki dney di sease 100.0 96.1 94.2 92.8 91.5 89.7Pyelonephri ti s 100.0 97.2 96.6 95.6 94.8 94.1Renal vascular di sease 100.0 96.4 95.5 93.4 91.1 89.5Other 100.0 95.5 94.2 93.1 91.8 90.5Unknown 100.0 95.2 93.9 93.2 90.6 89.8
54
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
Diabetes Glomerulonephritis Polycystic kidney diseasePyelonephritis Renal vascular disease OtherUnknown
Patient Survival, First Kidney, by End-Stage Renal Disease Diagnosis, 2001 to 2010
Log Rank P < 0.0001
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Diagnosis Tx 1year 2years 3years 4years 5yearsDi abetes 100.0 96.8 95.0 92.6 90.7 88.2Glomerulonephri ti s 100.0 98.9 98.2 97.2 96.3 95.4Polycysti c ki dney di sease 100.0 98.8 97.1 95.9 95.3 94.2Pyelonephritis 100.0 99.2 98.7 98.3 97.3 95.6Renal vascular disease 100.0 98.5 97.0 97.0 96.1 95.2Other 100.0 97.3 95.8 93.7 91.9 89.8Unknown 100.0 98.8 98.5 98.0 97.6 96.4
55
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
2005 - 2007 2002 - 2004 1999 - 2001
Total Graft Survival, First Kidney, by Transplant Era, 2001 to 2010
Log Rank P = 0.18
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Era Tx 1year 2years 3years 4years 5years2005 - 2007 100.0 94.7 92.0 89.5 87.7 85.12002 - 2004 100.0 94.2 91.8 89.2 86.2 83.51999 - 2001 100.0 93.3 91.0 89.5 87.1 83.5
56
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
2005 - 2007 2002 - 2004 1999 - 2001
Death-Censored Graft Survival, First Kidney, by Transplant Era, 2001 to 2010
Log Rank P = 0.062
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Era Tx 1year 2years 3years 4years 5years2005 - 2007 100.0 96.5 94.8 93.4 92.2 90.62002 - 2004 100.0 96.0 94.7 93.4 91.6 90.01999 - 2001 100.0 94.9 93.6 92.6 91.2 89.2
57
Tx 1 year 2 years 3 years 4 years 5 years50
60
70
80
90
100
2005 - 2007 2002 - 2004 1999 - 2001
Patient Survival, First Kidney, by Transplant Era, 2001 to 2010
Log Rank P = 0.40
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Era Tx 1year 2years 3years 4years 5years2005 - 2007 100.0 98.2 97.0 95.8 95.1 94.02002 - 2004 100.0 98.1 97.0 95.5 94.1 92.81999 - 2001 100.0 98.3 97.2 96.6 95.6 93.6
58
Liver Transplant Survival, by Age Group, 2001 to 2010
Log Rank P =0.07
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
0 1 2 3 4 5
0-17 100 85.33 81.59 78.84 78.16 78.16
18-34 100 87.39 85.91 84.21 82.82 80.39
35-49 100 85.28 81.21 79.8 77.21 73.65
50-64 100 85.4 81.82 79.25 77.28 75.76
65+ 100 81.71 78.08 76.31 72.82 71
55
65
75
85
95
Years From Transplant
Cum
ulati
ve P
roba
bilit
y of
Sur
viva
l
59
Liver Transplant Survival, by Donor Type, 2001 to 2010
Log Rank P =0.27
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
0 1 2 3 4 5
Living 100 87.43 84.22 81.72 80.28 77.93
Deceased 100 85.24 81.68 79.49 77.41 75.4
55
65
75
85
95
Years From Transplant
Cum
ulati
ve P
roba
bilit
y of
Sur
viva
l
60
Heart Transplant Survival, by Age Group
0 1 2 3 4 5
0-17 100 87.4 86.21 85.19 84.57 83.87
18-34 100 84.02 83.35 83.35 83.35 82.35
35-49 100 84.06 82.17 81.73 81.2 79.13
50-64 100 88.56 87.21 86.01 83.78 82.13
65+ 100 77.89 77.89 76.57 76.57 75.01
55
65
75
85
95
Years From Transplant
Cum
ulati
ve P
roba
bilit
y of
Sur
viva
l
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
61
Lung Transplant Survival, by Age Group
Tx 1 2 3 4 5
0-17 100 82.79 72.07 68.47 68.47 63.2
18-34 100 86.65 80.21 73.23 68.44 66.12
35-49 100 88.29 81.68 74.14 69.49 64.59
50-64 100 83.87 77.64 72.65 67.98 65.95
65+ 100 83.39 72.95 66.86 63.04 63.04
55
65
75
85
95
Years From Transplant
Cum
ulati
ve P
roba
bilit
y of
Sur
viva
l
SourceCanadian Organ Replacement Register, 2012, Canadian Institute for Health Information.
Summary and Conclusions
62
• Gains in deceased donation activity in some regions; activity stagnant in others
• Donation after cardiac death continues to be a promising means to expand the deceased donor pool
• Ongoing mismatch between supply and demand for all solid organ transplants
• Relative stability in number of solid organ donors and transplants over the last several years
• Favourable outcomes for recipients of solid organ transplants
Questions
63