corporate presentation - inmed pharmaceuticals inc

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:INM www.inmedpharma.com Corporate Presentation OCTOBER 2021

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Page 1: Corporate Presentation - InMed Pharmaceuticals Inc

:INM

www.inmedpharma.com

Corporate Presentation

OCTOBER 2021

Page 2: Corporate Presentation - InMed Pharmaceuticals Inc

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This presentation contains forward-looking statements and forward-looking information within the meaning of applicable securities laws (collectively, “forward-looking statements”) including, among others, statements concerning: unlocking the full potential of cannabinoid pharmaceuticals; anticipated clinical development activities, timelines, catalysts, and milestones; the potential benefits of product candidates; anticipated revenue and market opportunities; and the continued availability of key personnel. All statements other than statements of historical fact are statements that could be deemed forward-looking statements.

With respect to the forward-looking information contained in this presentation, the Company has made numerous assumptions regarding, among other things: the proposed transaction with BayMedica occurring on the terms described in this news release if at all; the proposed transaction with BayMedica completing and the anticipated results and potential of BayMedica’s business and the combination of BayMedica’s business with InMed’s business occurring; continued and timely positive preclinical and clinical efficacy data; the speed of regulatory approvals; demand for the Company’s products; continued availability of key personnel; continued access to sufficient capital to fund operations; and continued economic and market stability.

These statements are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and other factors that could cause actual results to differ materially from those described in the forward-looking statements. These risks and uncertainties include, among others: the possibility that clinical trials will not be successful, or be completed, or confirm earlier clinical trial results; risks associated with obtaining funding from third parties; risks related to the timing and costs of clinical trials; key personnel may become unable to serve the Company; the need for receipt of regulatory approvals; and economic and market conditions may worsen. Readers are cautioned that the foregoing list is not exhaustive. A more complete discussion of the risks and uncertainties facing InMed’s stand-alone business is disclosed in InMed’s Annual Report on Form 10-K and other filings with the Security and Exchange Commission on www.sec.gov.

The Company undertakes no obligation to update the forward-looking statements contained herein or to reflect events or circumstances occurring after the date hereof, except as required by law.

Forward Looking Statements

Page 3: Corporate Presentation - InMed Pharmaceuticals Inc

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InMed: Two Key Pillars

Rare Cannabinoid Manufacturing

Pharmaceutical

Consumer Health & Wellness

A global leader in the manufacturing and clinical development of rare-cannabinoids

Pharmaceutical Development

Programs

Drug Development

Novel Cannabinoid Analogs

Page 4: Corporate Presentation - InMed Pharmaceuticals Inc

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The Opportunity & Challenge of Rare Cannabinoids

Note: lists are not exhaustive

140+ Rare Cannabinoids 2–20%<1%

THC CBD CBD CBD

Major Cannabinoids

CBN, CBGA, CBGV, CBGVA, THCV, THCVA, CBC, CBCV, CBCVA, CBDV, CBT CBCA,

CBNA…

• The 140+ rare cannabinoids occur in extremely low amounts in the cannabis plant

• The cost of extracting sufficient quantities of these cannabinoids can be prohibitive

• The challenge is how to manufacture sufficient quantity & purity to investigate, and potentially commercialize, rare cannabinoid-based therapies

CBG

Page 5: Corporate Presentation - InMed Pharmaceuticals Inc

Rare Cannabinoid Manufacturing

Page 6: Corporate Presentation - InMed Pharmaceuticals Inc

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Leader in a variety of cannabinoid manufacturing approaches

Why the BayMedica Acquisition is Transformational

Acquiring

Create Market Leader in Manufacturing

Increase Commercial Opportunity

Enhance management breadth & depth of expertise

Expand pharmaceutical opportunities

Substantial addressable market in nutraceuticals and consumer health and wellness sectors with immediate revenue streams

Extensive suite of new naturally occurring rare cannabinoids and cannabinoid analogs for pharmaceutical development

Decades of multi-faceted pharma R&D and manufacturing expertise brought by new management members

Creates a pure-play cannabinoid (CB) company with unparalleled, multi-faceted manufacturing capacity and strong clinical expertise

Page 7: Corporate Presentation - InMed Pharmaceuticals Inc

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• Pharmaceutical-grade, proprietary approach for synthesized cannabinoids (IntegraSynTM)

• Focused on therapeutic application of rare cannabinoids for the treatment of diseases with high unmet medical needs

• Strong preclinical/clinical evidence for two lead indications in dermatology and ocular diseases

• Highly experienced team in pharma drug development

• Nasdaq-listed, access to financial markets

• Proprietary manufacturing platforms for naturally occurring rare cannabinoids for the consumer Health and Wellness marketplace

• Sector-leading capabilities in synthetic biology and chemical synthesis

• Novel cannabinoid analogs for pharma R&D

• Early and growing revenue stream in nutraceuticals, more than $2.5M cumulative sales, 35%+ QoQ growth over last year

• Leader in large batch production of the rare cannabinoid CBC– currently 200kg batches with ability to scale to metric tonnes

• Poised to launch additional high-margin rare cannabinoids for bulk B2B sales in next 6-12 months

A Cannabinoid Pharmaceutical Company Manufacturer and Supplier to the Consumer Health & Wellness Market

Create shareholder value by combining complementary business models

Page 8: Corporate Presentation - InMed Pharmaceuticals Inc

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Unparalleled Cannabinoid Manufacturing Expertise

• Preferred for complex structures at very large scale

• Potential for high yield, lower COGS at volume

• Well suited for consumer health and wellness products

• Yeast (BayMedica) and bacteria (InMed) expertise.

Biosynthesis

No one manufacturing approach fits all: Multiple avenues to select most effective manufacturing method based on target cannabinoid and appropriate quality specifications for the desired market segment

• Preferred for CBs with simple structure and CB analog R&D

• Potential for less equipment / lower capital requirements

• Potentially easier validation

• Important component of secondary IntegraSyn™cannabinoid differentiation step

Chemical synthesis IntegraSyn™

• Utilizes very high efficiency, biosynthesis derived enzymes

• Flexibility to shift from production of one cannabinoid to a range of cannabinoids

• Commonly available and cost-efficient starting materials

• Easy to scale-up to mass production

• Shorter production time

• Higher yield = lower COGS

Page 9: Corporate Presentation - InMed Pharmaceuticals Inc

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IntegraSyn™: Biosynthesis Evolved

IntegraSyn™ is InMed’s flexible, integrated manufacturing system to efficiently produce bioidentical, pharmaceutical-grade cannabinoids

• Recently achieved 5 g/L cannabinoid yield, a commercially viable yield that significantly exceeds currently reported industry yields

• Advancing program to large commercial-scale production

• Lowering overall manufacturing costs through process optimization• Enables a cost-effective solution to rare cannabinoid production

Enzyme Crude

Cannabinoid Mixture

Commercially-viable

Cannabinoid

Purified Cannabinoid

Mixture

Page 10: Corporate Presentation - InMed Pharmaceuticals Inc

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Growing Revenue from Current Commercial Product – Cannabichromene (CBC)

Supplements

FunctionalFood & Beverage

Prodiol® CBC

Nutra

ceut

icals

Multiple Wholesale Markets in Consumer Health and Wellness

● Consumer health and wellness focus

● Currently manufactured at a large scale to food-gradeGMP; sold wholesale B2B

● Currently 200kg batches with ability to scale to metric tonnes

● Over $2.5M cumulative sales, 35%+ QoQ growth over last year

● Non-intoxicating; not scheduled by DEA

Features of BayMedica ProDiol® CBC

Animal

Health

Cosm

etics

Page 11: Corporate Presentation - InMed Pharmaceuticals Inc

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BayMedica Manufacturing Expertise in Rare CBs for Consumer Health & Wellness

140+ Rare CannabinoidsRequires synthetic manufacturing

for commercial viability

CBC

CBDV THCV

CBGV CBGVA CBT

CBN

CBy CBzCBx

Major CannabinoidsEasy to extract

from plant

< 1%

2-20%

Stage of Development

CBD

THC

Advancing multiple rare cannabinoids to commercialization

Commercial

Pre-Launch / Scale-up in process

Commercial synthesis in development

Future products

CBG

Page 12: Corporate Presentation - InMed Pharmaceuticals Inc

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Cannabinoid Synthesis Demand Expected to Drive Exponential Market Growth

Global cannabinoid synthesis market estimated to grow from $10B in 2025 to $115B by 2040

Source: Raymond James, Sept 2020

0

20

40

60

80

100

120

2020 2025 2030 2035 2040

$115B

$60B

$31B

$10B$200M

Page 13: Corporate Presentation - InMed Pharmaceuticals Inc

INM-755 and INM-088

Cannabinoid Drug Development Programs

Page 14: Corporate Presentation - InMed Pharmaceuticals Inc

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Global Leader in Cannabinol (CBN) Therapeutic Development

• CBN programs in dermatology & ocular diseases

• First to advance CBN into clinical trial

• Phase 2 studies underway for CBN topical cream in 7 countries

• 30+ preclinical pharmacology and toxicologystudies

• Multiple patents filed

Cannabinol (CBN)

Page 15: Corporate Presentation - InMed Pharmaceuticals Inc

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INM 755: Epidermolysis Bullosa (EB)

• Epidermolysis bullosa (EB) is a group of rare genetic skin diseases characterized by fragile skin that blisters easily from minimal friction that causes shearing of the skin layers.

• The most common form is EB Simplex (EBS),~55% of all EB patients.

• The total EB population is estimated to be between 12,500 and 25,000 in the United States.

• No therapies approved specifically for the treatment of EB wounds and other symptoms.

• INM-755 is being developed for symptomatic relief in all EB patients and may have further utility in enhancing skin integrity in subset of EBS patients.

Photograph of Dystrophic EB

Page 16: Corporate Presentation - InMed Pharmaceuticals Inc

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INM-755: Positive Top-Line Results

• On intact skin (Study 101, n=22 healthy adult volunteers, 14 days): • Majority of subjects in all groups had no events on most days• Slightly higher incidence and severity of erythema (redness) and

scaling (flaking skin) in groups receiving active creams compared to vehicle cream

• Local reactions mostly mild or moderate and resolved without intervention

• Drug concentrations in the blood were very low in the high-dose group

• On epidermal wounds (Study 102, n=8 healthy adult volunteers, 14 days):• No differences in local reactions compared to controls • No adverse effects of INM-755 creams on wound healing

INM-755 Creams Safe & Well Tolerated on Intact Skin and Epidermal Wounds

Clinical Trial Applications (CTA’s) filed in multiple countries for Phase 2 in EB

Austria, Israel, Serbia, France, Germany, Greece, Spain and Italy

Phase 2 Clinical Trial in EB Initiated in 3Q 2021

Page 17: Corporate Presentation - InMed Pharmaceuticals Inc

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INM-088: Potential Roles for CBN in Glaucoma

• Direct neuroprotection for the retina and optic nerve, independent of intraocular pressure (IOP) reduction

• Reduce IOP in the affectedeyes via increased fluid drainage

Target Effects of CBN

Build Up of Aqueous

Humor Fluid

Optic Nerve

Pressure

Retina

Several cannabinoids demonstrate increased drainage, leading to reduced IOP

Glaucoma Market:• Est. 76M people worldwide• Est. US$11.B by 2027

InMed data suggest CBN is the cannabinoid of choice for neuroprotection in the eye

Page 18: Corporate Presentation - InMed Pharmaceuticals Inc

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InMed data suggest CBN is the cannabinoid of choice for neuroprotection in the eye

• In vitro studies demonstrated CBN protects the retinal ganglion cells from cell death under elevated pressure conditions

• In vitro studies indicated that CBN may be able to reduce intraocular pressure

• CBN appears to have a wide therapeutic window for neuroprotection

• Studies compared CBN with several other cannabinoids

0

50

100

150

200

Palp Conj Bulb Conj Cornea Sclera Aqueous Iris Lens Vitreous Retina RPE

Distribution of INM-088 formulation in Rabbit Ocular Tissues

Con

cent

ratio

n (n

g/g)

Ocular tissue distribution of INM-088 formulation in vivo

Page 19: Corporate Presentation - InMed Pharmaceuticals Inc

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Pharmaceutical Programs: High-Level Time/Event Schedule

2021 - 2022

ü Completed ü In-progress

ü Report results from 755-102-HV

ü Finalize and file regulatory submissions (CTAs) for 755-201-EB trial

ü Finalize manufacturing methods and process to support 755-201-EB

ü Produce clinical trial supplies

ü Initiate 755-201-EB trial in multiple European jurisdictions

ü Engage leading ocular clinical research organization to develop clinical game plan

ü Scale-up INM-088 drug product (CBN+MiDROPS®)

ü Publish key CBN data in peer-reviewed journal

Conduct non-GLP dose ranging studies

Complete pre-IND package and FDA Pre-IND Meeting (if needed)

Initiate toxicology studies (2021-22) in preparation for clinical trials

INM-755: EB INM-088: Glaucoma

ü Conduct KOL meetings and initial data screening to support 2nd indication for INM-755

Page 20: Corporate Presentation - InMed Pharmaceuticals Inc

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Extensive Patent Protection for Combined Company

• Full commercial rights to IntegraSyn™ manufacturing approach

• Patent applications covering the biosynthetic pathway and semi-synthetic production of both natural cannabinoids and analogs

• A growing library of new analogs targeting diverse diseases

• Combined entity with 12 patent families (7 – manufacturing, 5 – product/formulations)

Major opportunity for expansion of patent portfolio of new chemical entities

Page 21: Corporate Presentation - InMed Pharmaceuticals Inc

Corporate

Page 22: Corporate Presentation - InMed Pharmaceuticals Inc

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Bringing Together a Depth of Cannabinoid Expertise

Eric A. Adams, MIBSChief Executive Officer

Bruce S. Colwill, CPA, CAChief Financial Officer

Alexandra Mancini, MScSVP, Clinical and Regulatory Affairs

30+ years of experience in global biopharma leadershipin BusDev, S&M with enGene, QLT, Abbott, Fresenius

25+ years of financial leadership: General Fusion, Entrée Resources, Neuromed Pharma

30+ years of global biopharma R&D experience: Sirius Genomics, Inex Pharmaceuticals, and QLT

Michael Woudenberg, PEngVP, CMC

Eric Hsu, PhDSVP, Preclinical R&D

20+ years of engineering, scale-up and GMP manufacturing experience: Phyton Biotech, Arbutus

Biopharma, 3M and Cardiome Pharma

20+ years of scientific leadership experience in gene transfer technologies, formulation and process

development: enGene Inc.

Extensive experience in pharma R&D, cannabinoid/ API manufacturing, clinical and regulatory affairs, biotech strategic planning, product sales & marketing, and capital markets

Phil Barr, PhDVP, Discovery Research

Charles Marlowe, PhDVP, Chemistry

20+ years strategic planning/ execution with LEK Consulting(Biogen Idec, Amgen, Genentech) Hamilton BioVentures

35+ years R&D leadership at Arriva Pharma (Founder)and Chiron. >50 issued patents; > 200 publications.

30+ years R&D discovery-to-FDA approval: MillenniumPharma, COR, Chiron, Takeda,Dow Chemical, Exelixis.

Jim Kealy, PhDVP, Synthetic Biology

Chris Meiering, PhDVP , Commercialization Operations

25+ years in synthetic biology and tech development at Amyris, Intrexon and Kosan Biosciences

15+ years of scientific R&D and 20+ yearsof entrepreneurial leadership at Zuke’s Pet Nutrition

Shane Johnson, MDSVP and General Manager BayMedica

Page 23: Corporate Presentation - InMed Pharmaceuticals Inc

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Financial SnapshotINM

Previous Close (2021-10-13) US$1.47

52-week High3 US$8.94

52-week Low3 US$1.43

Avg. Daily Volume (Trailing 50 Days) 255,584

Market Cap, I/O (2021-10-13) US$17.8 M2

Shares I/O 14.2 M2

Options (June 30, 2021) 0.9 M

Warrants 6.5 M

Fully Diluted Shares (2021-10-13) 21.6M

Cash and Short-term Investments (June 30, 2021) $7.4 M1

(1) Excluding estimated net proceeds of $11M from July 2, 2021 private placement(2) Includes common shares subject to pre-funded warrant exercises. Market Cap reflects fully exercised pre-funded warrants.(3) Includes historical OTCQX Listing

Page 24: Corporate Presentation - InMed Pharmaceuticals Inc

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Launch new cannabinoids into the consumer & health and wellness space

Long-term Growth Strategy

Accelerate Revenue Growth

Advance Drug Development

Enhance Long-Term Shareholder Value

Expand Pharmaceutical Opportunities

Deliver clinically proven CBN-based drugs for unmet medical needs in dermatology and ocular diseases

Identify and assess suite of new CB analogs for therapeutic drug development

Continue to assess all strategic opportunities for the business, including potential partnering, collaboration and licensing

Advancing a global leader in the manufacturing and development of rare cannabinoids

Page 25: Corporate Presentation - InMed Pharmaceuticals Inc

U N L O C K I N G T H E P O T E N T I A L O FC A N N A B I N O I D M E D I C I N E S

:INM

www.inmedpharma.com

Colin ClancySenior Director,

Investor Relations

[email protected]+1-604-416-0999

Thank you!