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TRANSCRIPT
Copper Catalyzed Aerobic Oxidative
C-H Functionalizations
Contents
2
1. Introduction
2. C-H oxidation initiated by single-electron transfer
3. C-H oxidation that resemble organometallic reaction
4. Organometallic copper (Ⅲ) chemistry relevant to C-H oxidation reactions
5. Application to artificial transformation of amino acid 6. Summary
Contents
3
1. Introduction
2. C-H oxidation initiated by single-electron transfer
3. C-H oxidation that resemble organometallic reaction
4. Organometallic copper (Ⅲ) chemistry relevant to C-H oxidation reactions
5. Application to artificial transformation of amino acid 6. Summary
1-1. Copper
4
1-2. Oxygen
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1-3. Cu/O2 system
6
Contents
7
1. Introduction
2. C-H oxidation initiated by single-electron transfer
3. C-H oxidation that resemble organometallic reaction
4. Organometallic copper (Ⅲ) chemistry relevant to C-H oxidation reactions
5. Application to artificial transformation of amino acid 6. Summary
2-1. Dimerization of naphthol derivative
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2-1. Dimerization of naphthol derivative
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2-1. Dimerization of naphthol derivative
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2-1. Dimerization of naphthol derivative
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2-1. Dimerization of naphthol derivative
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2-1. Dimerization of naphthol derivative
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2-2. Chlorination and bromination of arene
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2-2. Chlorination and bromination of arene
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2-2. Chlorination and bromination of arene
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2-3. Cyclization of anilides to give oxindole
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2-3. Cyclization of anilides to give oxindole
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2-3. Cyclization of anilides to give oxindole
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Contents
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1. Introduction
2. C-H oxidation initiated by single-electron transfer
3. C-H oxidation that resemble organometallic reaction
4. Organometallic copper (Ⅲ) chemistry relevant to C-H oxidation reactions
5. Application to artificial transformation of amino acid 6. Summary
3-1. Oxidative trifluoromethylation of terminal alkyne
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3-1. Oxidative trifluoromethylation of terminal alkyne
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Contents
23
1. Introduction
2. C-H oxidation initiated by single-electron transfer
3. C-H oxidation that resemble organometallic reaction
4. Organometallic copper (Ⅲ) chemistry relevant to C-H oxidation reactions
5. Application to artificial transformation of amino acid 6. Summary
4-1. Mechanism of formation of Cu(Ⅲ) species
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4-1. Mechanism of formation of Cu(Ⅲ) species
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4-1. Mechanism of formation of Cu(Ⅲ) species
4-2. Reactivity of Cu(Ⅲ) species
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4-2. Reactivity of Cu(Ⅲ) species
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4-2. Mechanism of Reaction of Cu(Ⅲ) species
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Contents
30
1. Introduction
2. C-H oxidation initiated by single-electron transfer
3. C-H oxidation that resemble organometallic reaction
4. Organometallic copper (Ⅲ) chemistry relevant to C-H oxidation reactions
5. Application to artificial transformation of amino acid 6. Summary
5-1. Innovative method of remedy
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5-2. Target residue = Tyrosine
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5-3. Tyrosyl radical ～Alzheimer‘s disease～
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5-3. Tyrosyl radical ～Alzheimer‘s disease～
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5-3. Tyrosyl radical ～Alzheimer‘s disease～
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5-3. Tyrosyl radical ～Alzheimer‘s disease～
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5-3. Tyrosyl radical ～Alzheimer‘s disease～
5-4. Product of tyrosine oxidation
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5-4-1. Proposed mechanism
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5-5. Application to artificial transformation of
Tyr with Cu/O2
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Contents
41
1. Introduction
2. C-H oxidation initiated by single-electron transfer
3. C-H oxidation that resemble organometallic reaction
4. Organometallic copper (Ⅲ) chemistry relevant to C-H oxidation reactions
5. Application to artificial transformation of amino acid 6. Summary
6. Summary
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Reference
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