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Controls of the Cell Cycle

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Controls of the Cell Cycle. External Chemical Physical. Internal. Ex. At M phase checkpoint. Chemical signals essential nutrient growth factors. Density-dependent inhibition crowded cells stop dividing. Cells must be attached to a substratum - PowerPoint PPT Presentation

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Page 1: Controls of the Cell Cycle

Controls of the Cell Cycle

Page 2: Controls of the Cell Cycle

Internal ExternalExternalChemical Chemical PhysicalPhysical

Page 3: Controls of the Cell Cycle

Ex. At M phase checkpoint

Page 4: Controls of the Cell Cycle

Chemical signals

essential nutrientgrowth factors

Page 5: Controls of the Cell Cycle

1. Density-dependent inhibition

• crowded cells stop dividing

Page 6: Controls of the Cell Cycle
Page 7: Controls of the Cell Cycle

Cells must be attached to a substratum

ex. inside of a culture jar or ECMof a tissue

Page 8: Controls of the Cell Cycle

Don’t respond to body’s control mechanisms

Divide excessively

Don’t exhibit density-dependent inhibition

Page 9: Controls of the Cell Cycle

“Immortal”

HeLa cells

Page 10: Controls of the Cell Cycle

Diverse

Gene alteration

Page 11: Controls of the Cell Cycle
Page 12: Controls of the Cell Cycle

Worst 5 Foods

www.copperwiki.org/index.

Page 13: Controls of the Cell Cycle

HOW CANCER CELLS HOW CANCER CELLS SPREADSPREAD

Page 14: Controls of the Cell Cycle

Transformation (normal cell to cancer cell)

Tumor (mass of abnormal cells w/in normal tissue)

Benign tumor

Malignant tumor / cancer

Metastasis

How

Cancer

Cells

Spread

Page 15: Controls of the Cell Cycle
Page 16: Controls of the Cell Cycle
Page 17: Controls of the Cell Cycle
Page 18: Controls of the Cell Cycle

1. High-energy radiation

For localized tumor

Destroys DNA in cancer cells

Page 19: Controls of the Cell Cycle

2.Chemotherapy

For metastatic tumors

For actively dividing cells

Side effects

Page 20: Controls of the Cell Cycle

To summarize…To summarize…


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