contact lens anterior eye 2014; p377

8/17/2019 Contact Lens Anterior Eye 2014; p377

1/5

Contact Lens & Anterior Eye37 (2014) 377–381

Contents lists available at ScienceDirect

Contact Lens & Anterior Eye

j ournal homepage: www.elsevier .com/ locate /c lae

Soft contact lens fitting after intrastromal corneal ring segmentimplantation to treat keratoconus

J. Carballo-Alvareza,∗, M.C. Puella, R. Cuiñab, D. Diaz-Valleb, J.M. Vazqueza, J.M. Benitez-del-Castillob

a Applied Vision Research Group, Faculty of Optics, Universidad Complutense de Madrid, 28037Madrid, Spainb Hospital Clinico SanCarlos, 28037Madrid, Spain

a r t i c l e i n f o

Article history:

Received 3 December 2013

Received in revised form 1 June 2014

Accepted 4 June 2014

Keywords:

Keratoconus

Intrastromal rings

Soft toric contact lens

Piggy back

a b s t r a c t

Purpose: To assess the feasibility of fitting a lathed soft toric contact lens (STCL) after the implant of

intrastromal corneal ring segments (ICRSs) to treat keratoconus.

Methods: Sixmonths after ICRS implantation, 47 eyes of 47patients (18–45years)were fittedwith a STCL.

In each eye, we determined refractive error, uncorrected (UDVA) and corrected distance visual acuity

(CDVA), and keratometry and asphericity measures. The outcome of STCL fitting was defined according

to CDVA as successful (≤0.2 logMAR) or unsuccessful (>0.2 logMAR). Patients in the unsuccessful group

were refitted with a piggy-back (PB) system. The above variables and the change in CDVA observed after

STCL and PB lens fitting from spectacle CDVAwere compared in the two groups.

Results: STCL fitting was successful in 75%, 66.66% and 0% of the ICRS implanted eyes with stages I–III

keratoconus, respectively. Spectacle-CDVAwas 1.5 lines better andmean corneal powerwas 3.62D lower

in the successful STCL group. In this group, the difference in cylinder axis between spectacles and STCL

was 24.25◦ lower. PB refitting achieved a PB-CDVA ≤0.2 logMAR in all cases. A similar difference in the

CDVA change achieved by contact lenses versus spectacles was observed in the successful STCL and PB

refitted groups.

Conclusion: STCL fitting is a feasible option in a large proportion of patients implanted with ICRS. When

these lenses are unsatisfactory, a PB system is a good alternative.© 2014 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

1. Introduction

Keratoconus occurswhenthecornea thins andgradually bulges

to acquire the shape of a cone. The outcome of corneal thinning

andprotrusion is regularor irregularastigmatism,high-order aber-

rations and vision loss [1]. The surgical implant of intrastromal

corneal ring segments (ICRSs) flattens the cone and reinforces the

cornea [2,3], and this reduces astigmatism and corneal high-order

aberrations (HOAs) in patients with clear corneas. These effects

of ICRS are the consequence of regularization of the corneal sur-

face. Following ICRS placement, good visual acuity is commonly

achieved using a rigid gas permeable (RGP) lens. RGP lenses are

able to mask much of the corneal aberration present by replacing

the irregular corneawith theregular refractive surfaces of the RGP

∗ Corresponding author at: Faculty of Optics, Complutense University ofMadrid,

Department of Optics II (Optometry and Vision), Calle Arcos del Jalon 118, 28037

Madrid, Spain. Tel.: +34913946887.

E-mail addresses: [email protected], [email protected] (J. Carballo-Alvarez).

andtear lens [4]. Carrasquillo [5] andShetty [6] reported thattoler-

ance to RGP lenses was improved after ICRS implantation, though

other authors have described the opposite trend [7,8]. According

to Reinstein et al., complications are possible due tomodifications

to the stroma and epithelium in the ring zone [9]. They showed

changes in epithelial thickness over and around the ring implant.

Also thespace occupying effectof the ICRS showedforwardarching

of stromal tissue, whereas theposterior surface is similarly arched

inward. Other studies [10,11] haveshown that the piggy-back sys-

tem,whereby a RGP lens is fitted over a soft contact lens, is a safe

waytoachieve corneal integrityandgoodcenteringof theRGPlens.

Soft contact lenses offer certain advantages over RGP lenses such

as comfort, better psychological acceptance and improved corneal

integrity. Other lens modalities used on irregular corneas includ-

ingscleral RGP, high thicknesssoft contact lensesorhybridcontact

lenses are an alternative option in contact lens fitting after ICRS

implantation [12].

By correcting or inducing aberrations, it is possible to change

the natural aberration pattern of the eye. Increased HOA impair

visual function [13] and the accommodation response [14]. In

http://dx.doi.org/10.1016/j.clae.2014.06.001

1367-0484/© 2014 British Contact Lens Association. Publishedby Elsevier Ltd. All rightsreserved.

http://localhost/var/www/apps/conversion/tmp/scratch_1/dx.doi.org/10.1016/j.clae.2014.06.001http://www.sciencedirect.com/science/journal/13670484http://www.elsevier.com/locate/claemailto:[email protected]:[email protected]://localhost/var/www/apps/conversion/tmp/scratch_1/dx.doi.org/10.1016/j.clae.2014.06.001http://localhost/var/www/apps/conversion/tmp/scratch_1/dx.doi.org/10.1016/j.clae.2014.06.001mailto:[email protected]:[email protected]://crossmark.crossref.org/dialog/?doi=10.1016/j.clae.2014.06.001&domain=pdfhttp://www.elsevier.com/locate/claehttp://www.sciencedirect.com/science/journal/13670484http://localhost/var/www/apps/conversion/tmp/scratch_1/dx.doi.org/10.1016/j.clae.2014.06.001


2/5

378 J. Carballo-Alvarez et al. / Contact Lens & Anterior Eye 37 (2014) 377–381

theory, the full correction of HOA, as pursued when RGP lenses

are fitted, improves visual acuity over a large range of luminances

and contrast polarities (black letters on white background, and

white letters on black background) [15], and also improves con-

trast sensitivity [16,17] and performance at functional visual tasks

[18]. However, previous studies have shown that the visual acuity

achieved using a soft contact lens is often better than the outcome

predicted by aberrometry coefficients [19] such as the root mean

square (RMS). In addition, a relatively large extent of HOA is still

observedafterfittingRGP lenses, andthistranslatestoworsevisual

performance[20,21]attributableto factors such as irregularposte-

rior cornea effects [22], interactions between aberrations [23], the

post surgery tear film or neural adaptation [24,25]. It is thus pos-

sible that contact lenses that only partly correct anterior corneal

surface HOA, such as soft toric contact lenses (STCLs), may offer a

good visual outcome and could thus be an alternative to RGP in

casesof an irregularcornea. Aspreviously observed ineyeswith an

irregular cornea [5,26–28], ourclinical experience indicates that in

some patients, STCL, besides offering high comfort, lead to a better

visual acuity than that predictedby corneal HOA indicators.

Few studies have addressed the issue of contact lenses fitting

in ICRS implanted keratoconic eyes [6–8,10,11,28] andmost have

examined only a small numberof eyes. Some studies have investi-

gatedtheuseof soft contact lenses ineyeswith keratoconusand anirregularcornea.The resultsof thesestudiesindicate thatmostHOA

variables are reduced [27,29], although posterior corneaHOAper-

sist [30], andverticalcomaand sphericalaberrationparametersare

modified[31,32].Duetotheirgreaterdiameterthan thecornea,soft

contact lens centering could be easier in ICRS-implanted corneas

than in keratoconic eyes given the centered apex and regular sur-

faceproducedaftersurgeryevenwhenused totreatadvancedstage

disease.

The aim of this study was to assess the feasibility of fitting

lathedsoft contact lenses in47eyes implantedwithKeraRing ICRS.

Spectacle-corrected distance visual acuity (CDVA) and refraction

andcornealvariableswerecomparedineyessuccessfullyorunsuc-

cessfullyfittedwithsoft toric (STCL)orspheric(SSCL) contactlenses

and eyes refittedwith a piggy-back lens system.Wealsocomparedthe change relative to spectacle CDVA produced after fitting each

type of contact lens.

2. Patients and methods

The final sample included47eyes of 47patients (20women, 27

men) aged 18–45 years, who had been implanted with KeraRing

ICRS (Mediphacos, Brazil) withanoptic zoneof 5mmusing aman-

ual technique as described in ourprevious study [33]. Surgery was

performed at theHospital Clinico San Carlos, Madrid.

The study protocol adhered to the tenets of the Declaration of

Helsinki and Spanish legislation and was approved by the Ethics

Committee of the Hospital Clínico San Carlos, Madrid. Written

informedconsentwasobtainedfromallofpatientsbefore thestudy

outset.

2.1. Clinical procedures

Keratoconus was stage I in 12 of the eyes (25.5%), stage II

in 21 eyes (44.8%) and stage III in 14 eyes (29.7%) according

Amsler–Krumeich classification. Six months after surgery, all the

patients underwent an ophthalmic examination at the Faculty of

OpticsandOptometry, UniversidadComplutensedeMadrid. In this

exam,measurements of uncorrected (UDVA)andcorrected(CDVA)

distance visual acuity were made using a trial frame and trial

lens set by the same optometrist. The topographic variables mea-

sured using the Pentacam (Oculus, Germany) were: keratometric

cylinder (K-cyl) and mean keratometric values (KM3) in diopters

(D) for the central 3mm. Asphericity was estimated at 4.5mm

(Q45).

Visual acuitywasmeasured with best spectacle correction and

after contact lens fitting under photopic (85cd/m2) luminance

conditions, using Bailey–Lovie logMAR letter Charts [34] at high

contrast (96%).

All thepatientswere fittedwith lathedsoft toric contact lenses

(STCLs). The lens material was hioxyfilcon Awith a 59% water con-

tent andmodulusof 0.30MPA(Mark EnnovyLaboratories,Madrid).

Thecenter thickness measured for−3.00Dwas 0.14mm. Theback

lens surface has a spherical 10.00mm diameter optic zone. Prism

characteristics are inferior base 0.92 prismatic diopters and diam-

eter 14.50mm.Theinitial base curve (BC)was calculated(between

8.00 and 8.60 in 0.30mm steps) by the manufacturer from the

central keratometric radius at 3mm. Initial lens power was cal-

culated from the refraction, taking distometry into account when

necessary. After 2h of fitting, lens centering was assessed. When

required the BCwas changed to better center the lenswith a rota-

tion under 5◦. Next, we over-refracted and if a VA improvement

was observed a new STCL was prepared based on the lens power

plus the over-refraction,with a newsphere, cylinderandaxis. This

process was repeated to check for a VA improvement and if this

occurred another newlens was prepared andtheprocess repeatedup to two more times.

In 4 of the47eyes, thecalculation after over-refraction resulted

in a cylinder lower than−0.75D. These eyes were therefore fitted

with a lathedsoft sphericalcontact lens (SSCL). In the remaining43

eyes, an STCL was used and 2 study groups established according

to CDVA: a group of 22 successfully fitted eyes (VA better or equal

to 0.2 logMAR, better than the European Driving Standard), and a

group of 21 eyes unsuccessfully fitted with STCL (VA worse than

0.2logMAR). Eyes in theunsuccessfully STCL fitted group were re-

fitted with a piggy-back (PB) system consisting of a RGP lens over

a daily disposable soft contact lens. The RGP lens (Lenticon Lab-

oratories, Madrid) had a 5mm-diameter spherical optic zone and

an outer zone with an aspherical curve which was 0.60–1.00mm

flatter. The most peripheral band was 1mm wide, with a curveof 12.60mm. Overall lens diameter ranged from 8.70 to 9.40mm.

The material used was HDS (Paragon, USA) with a Dk of 58. The

daily disposable contact lens used was an omafilcon-A aspheri-

cal lens of 8.70mm BC, sphere +0.50 and diameter 14.20mm. The

friction coefficient of this material is 0.09±0.033 at 0 cycles [35]

determining thatmovement of theRPG lens is independent of soft

lens movement. This type of lens was selected since its thickness

(0.09mm at −3.00D) is similar to that of a conventional contact

lens,and itstopographyrevealedamoreregularsurface facilitating

RPG fitting.

After1monthofwearingthecontactlensesfinallyfitted,corneal

integrity was checked in a slit-lamp biomicroscopy exam using

sodiumfluorescein to compare the topographicmapwith the map

obtained before lens fitting.In addition, the topographic mapwas compared with the map

obtained before lens fitting.

2.2. Statistical analysis

The normality of data was checked using the Kolmogorov–

Smirnov test,which indicated a normaldistributionof allvariables.

The Wilcoxon rank-sum test was used to compare spectacle-

correctedvisual/refractiveand topographicoutcomesbetween the

successful and unsuccessful STCL fitting groups, mean changes in

visual/refractive outcomes between spectacles and fitted contact

lenses in both STCL fitting groups, and the mean CDVA change

produced in response to contact lens fitting for the STCL versus

the PB fitted eyes. Visual and refractive variables were compared


3/5

J. Carballo-Alvarez et al. / Contact Lens & Anterior Eye 37 (2014) 377–381 379

Table 1

Patient data after ICRS implantation. Mean± SD.

Sphere (D) −2.18 ± 4.75

Cylinder (D) −3.11 ± 1.90

UDVA (logMAR) 0.74 ± 0.38

CDVA (logMAR) 0.25 ± 0.15

KM3 (D) 47.70 ± 4.65

Q45 −1.69 ± 1.45

UDVA: uncorrected distance visual acuity; CDVA: corrected distance visual acuity;

KM3: mean corneal power in the 3.00mm central zone; Q45: mean asphericity inthe4.5mmdiameter central corneal zone.

betweenspectacles andcontact lenses using theStudent’s t -testfor

paireddata. All statistical testswere performedusing Statgraphics

CenturionXVI software. Significancewas set at p


4/5

380 J. Carballo-Alvarez et al. / Contact Lens & Anterior Eye 37 (2014) 377–381

Fig.1. LogMARCDVA(mean, SD)forspectaclesand each ofthe contact lensesfitted.

* A statistically significantdifference.

Fig. 2. Percentages of each type of contact lens finally fitted according to kerato-

conus stage prior to ICRS implantationsurgery.

3.4. Comparing spectacle CDVA and DVA corrected using the

different contact lenses

We then went on to compare mean logMAR CDVA values

obtained for spectacles versus each of the different contact lenses

fitted (Fig. 1). The mean logMAR CDVA increase produced after

contact lens fitting was 0.07±0.09logMAR in the STCL group

( p=0.003). Nodifferenceswere detected according to keratoconus

stage prior to surgery. In the eyes fitted with a PB system, the

mean logMAR CDVA increase was 0.23±0.16logMAR ( p=0.00),

again with no effects of prior keratoconus stage. Finally, the mean

increase produced in CDVA was 0.14±0.12logMAR in the SSCL

group. This variable was 1.15logMAR lines higher in the PB than

the STCL group ( p=0.003).

Fig. 2 shows the percentages of eyes finally fitted with each

contact lens type according to the keratoconus stage prior to ICRS

implantation: forstageI, 1 eye(8.33%) receiveda SSCL,9 (75%)eyesa STCL and 2 eyes (16.66%) a PB system; for stage II, 1 eye (4.76%)

received a SSCL, 14 eyes (66.66%) a STCL and 6 eyes (28.57%) a PB

system; and for stage III, 2 eyes (14.28%) received a SSCL and 12

eyes (85.71%) a PB system.

In no eye were significant effects of 1 month’s wear of each

type of contact lens produced on corneal surface integrity and the

topographicmap.

4. Discussion

Only a few studies have addressed contact lens fitting in ICRS

implantedkeratoconic eyes, andmost have examined only a small

number of eyes [7,8,10,28]. Several studies have shown that cus-

tomized soft contact lenses [30,37,38] used to correct HOA in

aberrated eyes offer visual benefits over their use in normal eyes.

However, some authors [29,39]warn that the visual benefit for an

abnormal eyeismore sensitive todecentrationand rotationof cus-

tomized optics compared to normal eyes. In the present study, we

usednon-customized lathedsoftcontactlenses.Thelathe-cutelab-

orationmethodgives riseto a lenswithprecise,highlyreproducible

propertiesinducingminimalrotation, translationanddecentration

[20,29,40]. Further benefits of these soft contact lenses are an easy

manufacturing process thereby reducing costs, their easy access,

alongwith acceptable comfort and simplehandling for the patient.

When spectacle visual outcomes were compared in the suc-

cessfully and unsuccessfully STCL fitted groups, mean spectacle

CDVA was significantly better in the successful than the unsuc-

cessful group and mean corneal power in the central 3mm was

also lower in the successful group. Accordingly, eyes successfully

fittedwith a STCLweremoreoftenthoseatamoderatestageofker-

atoconus (Fig. 2) or those in which the surgery outcome had been

more satisfactory. The good STCL-CDVA observed in this group of

eyesmaybeattributed totheirbetterspectacleCDVAortoagreater

VA improvement produced after contact lens fitting.

The refractive powers of the fitted soft contact lenses were not

as predicted by spectacle power and vertex distance. As shown in

Table 3, the contact lenses did not show the expected more posi-

tive power than spectaclepowerinmany cases, althoughtherewashigh variabilitybetweeneyes.A possibleexplanationfor this is that

the optical quality of the eye plus contact lens, besides depending

on the opticsof the eye,will alsodepends on the optical properties

of the lens and its interaction with the cornea and tear film (prob-

ably the power of the lacrimal lens is related to themodulus of the

contact lens andis possible tochange thefinalpowerwithdifferent

materials). Further influential factors include partial correction of

anterior corneal surface HOAby the soft contact lens, interactions

between low and high order aberrations at the two corneal sur-

faces, and finally rotation and translation effects. In our study, the

successfully STCL fitted group showed a flatter BC and in no case

was a BC of 8.00mmneeded for improved fitting. This could have

determined better interaction between the contact lens, tear film

and corneal surface.Ourresults indicate that thebetterCDVAwere usually detected

when only minor changes to the cylinder axis had to made to the

new lens according to the over-refraction performed on the first

STCL fitted, althoughsphereandcylinder powerhadto bechanged.

This occurs more frequently in cases of a flatter cornea and lower

spectacle refraction. Thus, themean difference between the cylin-

deraxesof the spectacles andfinalSTCLfittedwasonly4.50±9.99◦

in the successfully STCL fittedgroup. In contrast, in the unsuccess-

fully STCL fitted group, although the refraction over the first STCL

fitted achieved a substantially better VA, the new calculated STCL

didnot show thesamegoodresult, especiallywhen therewas a sig-

nificant difference between the spectacle and STCL axes (Table 3).

Similarly,Nepomuceno et al. [28] describeda caseofa patientwith

Intacsfittedwith amoldedsoft toric contact lens. Spectacle refrac-tion was −1.25 sphere, −5.00 cylinder and VA was 0.12logMAR.

However, final contact lens power was −2.00 sphere,−1.25 cylin-

der, VA was −0.08logMAR and BC 8.70mm. In agreement with

our findings, STCL refractive power and the significantly improved

VAwere not those expected for soft contact lenses in eyes with a

regular cornea.

Results for our patients refitted with a piggy-back system

revealed this tobea goodoptionwhenSTCLfittingdid not achieve

a logMAR VA better than 0.2. In effect, this option mostly corre-

sponded to the eyes at themore advancedkeratoconus stageswith

greater HOA, inwhichsurgery hada reduced regularizingandflat-

tening effect. The mean increase in CDVA after PB fitting did not

varysignificantly fromthatobservedfor theSTCL, thoughoutcomes

werehighlyvariablebetweeneyes. It shouldbenoted thathandling


5/5
http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0200http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0195http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0190http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0185http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0180http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0175http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0170http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0165http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0160http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0155http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0150http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0145http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0140http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0135http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0130http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0125http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0120http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0115http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0110http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0105http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0100http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0095http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0090http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0085http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0080http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0075http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0070http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0065http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0060http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0055http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0050http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0045http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0040http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0035http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0030http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0025http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0020http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0015http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0010http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0005http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0005http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0005http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0005http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0005http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0005http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0005http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0005http://refhub.elsevier.com/S1367-0484(14)00053-8/sbref0005

contact lens anterior eye 2014; p377

Documents