congratulation rehabilitation and palliative care in denmark€¦ · congratulation rehabilitation...
TRANSCRIPT
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Congratulation Rehabilitation and Palliative care in Denmark
Adjunct professor, SDU Professor of health services research NIHR Senior Investigator University of Exeter Medical School, England
Adjunct professor, SDU Professor of medical sociology Wellcome Trust Investigator University of Glasgow, Scotland
INTERNATIONAL EXPERTS
Professor David Clark Professor Rod Taylor
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National Knowledge Centre for Rehabilitation and Palliative care
Rehabilitation and palliative care From my heart to cancer and back
Ann-Dorthe Zwisler
Professor, MD, cardiologist University of Southern Denmark
From evidence to clinical practice
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Rehabilitation Centre, Beitostölen 1987 - Take off for Oslo
2017 – Opening of centre
1987 1997 2007 2017
What is taking you so long?
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1987 1997 2007 2017
Model
Steen Olauf
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Outline of presentation
• From student to medical doctor – from student to researcher (1987)
• Rehabilitation in coronary disease – from evidence to practice (1997)
• Rehabilitation in complex cardiac diseases (2007)
• Rehabilitation and palliative care – future directions (2017)
1987 1997 2007 2017
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1987 1995
Being a student – becoming a medical doctor
Lars Iversen, Professor, Medical sociology Article on closure of a shipbuilding yard and impact on workers health
1986
Medical student - - - - - - - - - - -
Student of political science and administration
1991
Mitochondria are known as the powerhouses of the cell.
Beitostölen Rehabilitation Centre , Norway Life threatening disease and return to work – return to a normal life
1997
Health is
"a state of physical, mental, and social well-being and not merely the absence of disease
or infirmity (skavanker). ”
WHO 1946
Paradigm shift in health care From ‘machine-error’ to bio-psychosocial interventions
Min
or
thes
is
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1987 1995
Working as student research-assistance
1986 1991 1997
National Institute of Clinical Epidemiology (later National Institute of Public Health)
Finn Kamper Jørgensen Mette Madsen Knud Juel
Health service research based on surveys: - Children's Health at school start (68 communities) - Children's vaccination-program - Health at the workplace LEGO
Bispebjerg Hospital (Central administration) WHO - Health promotion hospital
Health service research : - Re-hospitalisation and Length of stay in medical wards - Smoke free hospital – smoking cessation
National recommendations Cardiac rehabilitation
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Rehabilitation in coronary heart disease From evidence to clinical practice in Denmark
1997 2007 2017
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• Asperin 300 mg straks
• ADP-receptorblockers
• Heparin 10.000 IE iv.
‘Minutes counts’
CAG: LAD stenosis Acute PCI: 1 vessel disease
Clinical presentation of coronary heart disease
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0
100
200
300
400
1995 2000 2001 2002 2003 2004 2005 2006 2008 2009 2010
Causes of death (2 most common) agestandardised pr. 100.000 inhabitants
Cancer
Heart disease
From life-treathening to chronic disease
Aproximately cornoary heart disease: Incidence - 14.000 IHD / year (new hospitalisations) Prevalence – 240.000
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Living with coronary heart disease
• CHD is a major cause of death and disability in developed countries with myocardial infarction as one of the main presentations • Incidence is declining in the western world, but is expected to raise world-wide to 32 million people by 2030
Disabilities
• Loss of physical functioning due to complication to disease,
low physical activity level, anxiety to perform exercise
• Mental distress: 20-30% depression – 15-25% anxiety (HADS)
• High risk lifestyle (smoking, dietary habits, low physical activity level)
• Approximately 20-30% leaves the labor market
• Health related quality of life is impaired
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Currative care Functional capacity
Time Lifetreathening disease
Disease trajectory
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Outline and terminology
Adapted from Storm et al. Ugeskr læger; 2002;164:2876-81
Palliative care
Prevention
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History of rehabilitation in coronary disease
1950 1960 1970 1980 1990 2000 2010
USA: Exercise training to prevent loss of function due to lengthy hospitalisations
USA: Out-patient phase II exercise training to ensure return to work
Lifestyle intervention and education (Daily physical activity, dietary advice and smoking cession)
Psychosocial support to meet psychological aspects
Comprehensive rehabilitation
Clinical recommendations
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Prolonged implementation curve
Zwisler et al. Scan J Pub Health,2005
Diffusion of innovation theory : Innovators – early adoptors – early majority – late majority – laggards
First recommendations in Denmark
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Does it have to take so long?
Sørensen R et al. Br J Clin Pharmacol 2008;66,875-884
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Cabana et al. JAMA. 1999;282(15):1458-1465.
Barriers to adherence to clinical recommendations?
==>> The DANREHAB trial was initiated in 1999 A large RCT (N=770 patients)
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1998 - A 5 days residential rehabilitation stay formed the basis for Development of the DANREHAB 6 weeks out-patient program
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Randomised Clinical trail (RCT)
Consented
n = 770
CR
n = 380
UC
n = 390
Registry data
n = 380100%
Registry data
n = 390100%
12 month-clinical-follow-up
Clinical visit
n = 32084%
Clinical visit
n = 30278%
Drop out
N = 60
Drop out
n = 88
P = 0.03
3 years register follow-up
Zwisler et al. Am Heart J, 2008
Complex intervention UK Medical Research Council. 2000.
Cardiac rehabilitation 6 weeks out-patient program
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Colleges statements on Rehabilitation Not for cardiologists
Nurse-religion
PCI surgeon
Only for ‘losers’ not able to do anything else
Cardiologist senior consultant
Hmm.. I do the operation – The patient will be
perfectly well!
Cardiac surgeon
We include the topic due to political
reasons
Teaching cardiologist
Who will man ‘The coffee club’
Cardiologist Responsible for the manning
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Days
Composite outcome measure*
UC
CR
Even
t ra
te
Hazard ratio = 0.92 95% CI (0.75–1.13) P = 0.40
* Death, myocardial infarction, acute first time re-admission due to heart disease which ever came first
Zwisler et al. Am Heart J, 2008
Zwisler et al. ESC, 2008
Register-based 3 years follow-up
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0
2.000
4.000
6.000
8.000
10.000
0 1 2 3
P=0.04
UC
CR
Total Length-of-stay (all admissions)
LOS UC CR
Total 9.099 6.847
Range (1–217) (1–94)
Mean 6.2 5.4
Reduction 25%
Length-of-stay (LOS) – cost saving intervention
Years
Zwisler et al. ESC, 2008
Register-based 3 years follow-up
0
2000
4000
6000
8000
Elective Acute
CR UC
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Patient satisfied – however no effect on HRQL
0
20
40
60
80
100
Very
dissatisfied
Dissatisfied Satisfied Very satisfied
CR
UC
%
How satisfied have you been with the follow-up services offered within the past 12 months?
P<0.01
[Cardiac rehabilitation – a health technology assessment]. National Board of Health, Denmark, 2006
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Treatment rationale and outcome in rehabilitation Focus on quality of life
Initiated studies – Region Sjælland and Holbæk sygehus Development and validation on HeartQol core-disease questionaire
Hospital anxiety and depression scale HADS Prevention of re-hospitalisation, Psychosocial support
Quality of life in haematological cancer with focus on MPN
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1997 2000 2005 2007 2013
The DANREHAB trial (Heart Foundation)
Initiation of clinical database (DCS Working group)
National Clinical Guidelines (National Board of Health)
Clinical database running
From guidelines to clinical practice in coronary disease
National recommendations (Heart foundation and Ministry of Health)
Health Technology assessment (National Board of Health)
2017
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Zwisler et al. EJCPR, 2011
From
To =>>
Quality assurance in rehabilitation
2007 2017
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Goal % Achived % 95% CI 1a: Deltagelse * 35 No 29 (28-29) 1b: Vedholdende deltagere ** 75 No 65 (63-68) 2a: 80% af træningssessioner 70 No 68 (65-71) 2b: 10% stigning funktionstest 80 No 69 (65-72) 3: Rygestop 60 No 50 (45-55) 4: Diætbehandling *** *** 32 (30-35) 5: Reduktion af LDL kolesterol 60 No 58 (55-60) 6: Blodtryk 70 No 60 (57-62) 7: Screening for diabetes 90 Yes 94 (93-96) 8: Screening for depression 80 Yes 61 (57-64) 9: Antitrombotisk behandling 95 Yes 95 (94-96) 10: Statinbehandling 80 Yes 95 (94-96) 11: Betablokadebehandling 80 Yes 80 (77-82)
Danish Cardiac rehabilitation Database (DHRD)
Not aviable for public
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Cardiac Rehabilitation from Denmark going global
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From Balgladesh to Denmark and back
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Rehabilitation in complex cardiac diseases The CopenHeart trials
2007 2017
Research question: Can recommendations for specific diseases i.e. CHD be transferred to other cardiac conditions?
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Sexual dysfunction
Organisation,
Economic og user-
perspective
Exercise and
Quality of life
The CopenHeart Trials
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Re
QUAL before intervention:
Pre-study
QUAN
QUAN
QUAL post measure
Fin
al interp
retation
based
on
Q
UA
N an
d Q
UA
L results
Intervention
QUAN Survey
register-based pre-study
Randomised Control Trial
Economic evaluation
Cochrane review
Mechanistic studies
Organisation Economic evaluation
QUAN
Mixed methods
2007 2017
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Mode of delivery
Rigshospitalet – psychoeducation + initiation of exercise training
Then by choise:
• Home-based training
• Local setting community or hospital
21 communities participate in CopenHeart
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The CopenHeart Team and partners
Hjertecenteret, Rigshospitalet
Gentofte Hospital, Kardiologisk afdeling P Roskilde sygehus, Kardiologisk afdeling
Region Sjælland CopenHearts kommunale træningscentre
og samarbejds-sygehuse/hospitaler
Statens Institut for Folkesundhed, SDU CTU, Rigshospitalet
CopenRehab, KU PH Metropol
REHPA
CorusFit, Vertic 1 PostDoc, 6 PhD Thesis, 5 masterproject
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Sexual dysfunction
Organisation,
Economic og user-
perspective
Exercise and
Quality of life
The CopenHeart Trials
120 154 210 147 196
= 827 patients enrolled
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Rehabilitation and palliative care REHPA
Future directions?
2017 and beyond
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Rehabilitation and palliative care on the national budget Improving cancer care trajectory - 2012
Overall aim of the centre • To strengthen clinical research in rehabilitation and palliation • To ensure that research is transferred rapidly into cross-professional and cross-sectorial clinical practice to the benefits of patients and society
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Research in clinical practice
Research in clinical practice
Research in clinical practice
Research in clinical practice
Cardiac rehabilitation and palliative care
Cancer rehabilitation and palliative care
Pulmonary rehabilitation and palliative care
NN rehabilitation and palliative care
Generic topics and aspects of interests
2012 2017
Cancer and other diseases with high mortality
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• How to integrate rehabilitation and palliative care
• Content and delivery of across sectors
• Needs assessment ? Intervention for all or only some patients?
• What is the proper outcomes of rehabilitation
• Spouse involvement and interventions
• Patient and public involvement (PPI)
• Patient Reported Outcomes (PRO)
• Quality assurance
• How to reach vulnerable patients? I.e. migrants, social inequity
• Rehabilitation and palliative care in low and middle-income countries
• Many, many more questions needs to be adressed
Current topics to address across diagnosis
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Rehabilitation Centre, Beitostölen 1987 - Take off for Oslo
2017 – Opening of centre
1987 1997 2007 2017
Collaboration and support
We support you
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1997 2007 2017
DIKE – nu SIF
Bispebjerg hospital
Holbæk sygehus
Roskilde sygehus
Rigshospitalet
Gentofte sygehus
RKKP – Dansk Hjerterehabiliteringsdatabase
Region Sjælland
Herlev sygehus
6 kommune samarbejdet Sundhedsministeriet/SST
KL DEFACTUM
Kræftens Bekæmpelse Hjerteforeningen
DSR
Danske fysioterapeuter
Afdeling R Odense universitetshospital
CopenRehab DSI – nu KORA
DCS
Kliniske diætister
PAVI
RcDallund
SDU
CTU
Dedicated collaborators - dear colleges
PH Metropol
Ibrahim Cardiac Hospital Dahka, Bangaldesh
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‘De hvide mænd’
Mennesket ved Havet – Svend Viig Hansen – Esbjerg 1995
Det hele menneske
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2017
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