Sudden Cardiac Arrest in Children and Adolescents: Where Do We Stand on Implementing a Screening Program with ECGs?

C O N G E N I T A L C A R D I O L O G Y T O D A YTimely News and Information for BC/BE Congenital/Structural Cardiologists and Surgeons

Volume 8 / Issue 9September 2010North American Edition

The sudden death of a young person participating in a sports activity is a tragic and rare occurrence that nonetheless causes significant concern in both the general public and medical community. Finding strategies to prevent these catastrophes has become a prominent public health debate. A symposium on the diagnosis, therapy and prevention of sudden cardiac arrest (SCA) in children and adolescents is being planned at Disney’s Grand California Hotel and Spa in Anaheim, California for January 14-15, 2011. The symposium will address various topics of interest including causes of SCA, cardiac risk of stimulant medications used for attention deficit hyperactivity disorders, and the utility of automated external defibrillators (AED) in schools. Debates on controversial topics will include whether ECG screening should be mandatory in all school aged children, whether patients with ICD’s should be allowed to participate in competitive sports, and the utility of genetic testing for evaluation of patients at risk for SCA.

Prevalence and Rates of Sudden Cardiac Death

The United States comprises 25 million competitive athletes involved in a network of sporting activities, 10 million of whom are high school and college athletes. We do not know exactly how many athletes are dying each year as there is no national registry keeping track of these numbers. The risk for sudden cardiac

death for the young competitive-athlete population is estimated to be 2 per 100,000 persons per year1 and it is at least 2.5-fold higher than that of the age-matched non-athlete population2. The risk for sudden cardiac death grows with increasing peak intensity of exercise and increasing level of competition3,4. Maron et al. tracked sudden deaths in US athletes using a large registry over a 27-year period and reported that of the sudden deaths, 82% were with physical exertion during competition/training, and only 11% were in females5. The most common cardiovascular causes were hypertrophic cardiomyopathy (36%) and congenital coronary artery anomalies (17%).

Routine ECG Recordings in Young Athletes

The attraction of adding a rest 12-lead ECG to the screening process for young athletes is the potential to detect conditions associated with exercise-induced cardiac arrhythmias and sudden death. Abnormal ECGs are common in some conditions such as hypertrophic cardiomyopathy (in which as many as 90% of ECGs are abnormal) and in myocarditis, arrhythmogenic right ventricular dysplasia, Long- and Short-QT Syndrome, congenital atrioventricular block, Brugada Syndrome, and WPW Syndrome. Other conditions associated with sudden death during exertion such as Marfan Syndrome, coronary artery anomalies, or catecholamine- induced vent r icu lar tachycardia are usually not detected with a resting ECG.

IN THIS ISSUESudden Cardiac Arrest in Children and Adolescents: Where Do We Stand on Implementing a Screening Program with ECGs?by Anjan S. Batra, MD~Page 1

SCAI Monthly Column~Page 7

Abstracts from “Evolving Concepts in the Management of Complex Congenital Heart Disease II” - Part VI~Page 9

DEPARTMENTS

Medical News, Products and Information~Page 16

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There is an important controversy between the American and European positions on the need for routine ECG recording. The International Olympic Committee (IOC) based in Switzerland and the European Society of Cardiology (ESC) advocate routine 12-lead ECGs in addition to the history-taking and physical examination for routine screening of all young competitive athletes. The IOC-ESC consensus document published in 2005 relied heavily on the 25-year Italian experience of systematic preparticipation screening of competitive athletes6,7.

The Italian Experience

In 1982, the Italian government passed a law to stipulate that for athletes participating in organized competitive athletic events, preparticipation screening include, at a minimum, a general physical examination: 12-lead ECG, submaximal exercise test and a requirement that the screening protocol be conducted annually8. Corrado and colleagues reported the Italian experience using the screening process which included ECGs in subjects 12 to 35 years of age in 20069. The annual incidence of sudden cardiac death in athletes decreased from 3.6 deaths per 100,000 person-years in 1979 to 1981 to 0.4 deaths per 100,000 person-years in 2003 to 2004, an 89% reduction. No change occurred in the mortality rates among the unscreened nonathletic population. Of the 42,386 screened athletes, 3,914 (9%) required additional cardiovascular testing, and 879 (2%) were ultimately prohibited from athletic participation. Based on the results of this Italian study which showed a progressive reduction in mortality, the approach of universally screening all athletes with 12-lead ECGs worldwide was advocated. However, when compared to Italy, there are significant differences in implementing such a program in a country such as the United States.

Screening in the United States

In 1996, the American Heart Association (AHA) issued a scientific statement advocating universal cardiovascular preparticipation screening for high school and college athletes in an attempt to identify those at increased risk of cardiovascular events10. In the 2007 update, the 12-point recommendations (Table 1) remain unchanged and do not include universal 12-lead ECG recordings as part of every preparticipation history and physical examination, unless, of course, the athlete fails the 12-point examination11.

Concerns have been raised over the low sensitivity and cost-effectiveness of the preparticipation history and physical examination without ECGs15. Another area of concern noted in the 2007 AHA update is that more than one third of the current high school evaluations are being carried out by non-physician personnel, and the update recommended that this be corrected. The 2007 AHA update cites infrastructural factors as a major limitation to implementation of screening programs in the United States. One claim is that insufficient numbers of physicians are adequately knowledgeable in the field of adolescent electrocardiography; another is the absence of a basic infrastructure to carry out the screening of the estimated 10 million middle and high school athletes.

In the absence of a national program, a limited number of community and individual school screening initiatives in the United States have emerged. These include ECGs and/or echocardiography as part of the preparticipation evaluation, generally organized by private individuals or foundations, parent groups, hospitals or physicians, industry, or other nonprofit or volunteer groups.

Cost-Effectiveness of ECG Screening

The cost-effectiveness of using ECGs as a mass screening tool is being debated with a limited number of studies focusing on this issue. In the screening study of Nevada high school athletes, ECG screening was estimated to be more cost-effective than history and physical examination alone12. The estimated cost per year of life saved was $44,000 with ECGs versus $84 000 for history and physical examination alone13. These figures include the cost of the additional testing of the 10% of athletes (582 of 5,615) who underwent echocardiogram or other testing to further investigate abnormalities in history, physical examination, or ECG. Wheeler et al. recently evaluated the cost-effectiveness of ECG plus cardiovascular-focused history and physical examination compared with cardiovascular-focused history and physical examination alone for preparticipation screening and concluded that addition of ECG to preparticipation screening saves 2.06 life-years per 1000 athletes at an incremental total cost of $89 per athlete and yielded a cost-effectiveness ratio of $42,900 per life-year saved compared with cardiovascular-focused history and physical examination alone13. A recent study from Massachusetts showed that adding ECG to medical history and physical examination improves the overall sensitivity of preparticipation

CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010 3

Working Together to Develop a Better Tomorrow

Table 111

The 12-Element AHA Recommendations for Preparticipation Cardiovascular Screening of Competitive Athletes

Medical history*Personal history1. Exertional chest pain/discomfort2. Unexplained syncope/near syncope †3. Excessive exertional and unexplained dyspnea/fatigue

associated with exercise4. Prior recognition of a heart murmur5. Elevated systemic blood pressure

Family history6. Premature death (sudden and unexpected or otherwise) before

50 years of age resulting from heart disease in 1 relative7. Disability from heart disease in a close relative < 50 years of age8. Specific knowledge of certain cardiac conditions in family

members: hypertrophic or dilated cardiomyopathy, Long-QT Syndrome or other ion channelopathies, Marfan Syndrome, or clinically important arrhythmias.

Physical examination9. Heart murmur ‡10. Femoral pulses to exclude aortic coarctation11. Physical stigmata of Marfan Syndrome12. Brachial artery blood pressure (sitting position) §

* Parental verification is recommended for high school and middle school athletes.† Judged not to be neurocardiogenic (vasovagal); of particular concern when related to exertion.‡ Auscultation should be performed in both supine and standing positions (or with Valsalva maneuver), specifically to identify murmurs of dynamic left ventricular outflow tract obstruction.§ Preferably taken in both arms.

cardiovascular screening in athletes (45% to 90%). However, this strategy was associated with an increased rate of false-positive results 16.9% (vs. 5.5% for screening with history and examination only)14. Wilson et al. pointed out the limitation of personal symptom and family history questionnaires and physical examination when screening for diseases with the potential to cause sudden cardiac death in a study in which none of the participants diagnosed with a disease associated with sudden cardiac death were symptomatic or had a family history of note15.

Medical-Legal Concerns

Three general areas of medical-legal impact relate to ECG screening for adolescents, especially for young athletes: potential legal conflict on the question of the right to participate if the abnormality is identified or, conversely, the right to refuse ECG screening and still be allowed to participate, and the medical malpractice implications of ECG interpretations that fail to identify a condition that is present. In regard to the participation issue, case law preserves the right of an institution to prohibit participation on the basis of the presence of a medical condition interpreted to constitute a risk to the athlete. In Knapp v Northwestern University, an appellate court ruled that college athletes can be medically disqualified from sports and supported the use of national association medical guidelines by team physicians in formulating eligibility/disqualification decisions16.

Orange County Experience

Orange County has a population of 3 million, making it the sixth most populous county in the United States. There are 504,072 students in Orange County public schools and 58,008 students in Orange County private schools. High school students comprise approximately a third of this population. Orange County has the largest number of per capita NCAA and Olympic athletes of any county in the United States. The precise incidence of life threatening events in this population is unknown. However, within the last year, there have been three deaths of high school athletes reported by the media. In addition there were other cases of life threatening events that were not reported by the media because they went on to succumb to irreversible neurological injury or completely recover.

The Life Threatening Events Associated with Pediatric Sports (LEAPS) initiative emerged in Orange County 3 years ago. This included an annual symposium with local and national experts in the area geared towards school educators, nurses, parents and physicians in the community. There were approximately 150 participants in each of the previous 2 symposiums. Task forces were created for screening strategies including ECGs, implementation of an

4 CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010

“As a direct result of the LEAPS initiative, a screening program which includes ECGs was implemented in collaboration with the Orange County department of education, local hospitals, and physician and staff volunteers.”

THE UNIVERSITY OF CHICAGODEPARTMENT OF PEDIATRICS

SECTION OF PEDIATRIC CARDIOLOGY

The Department of Pediatrics at the University of Chicago is expanding its section of Pediatric Cardiology. We are currently recruiting a BC/BE senior-level pediatric cardiologist as our director of the pediatr ic echocardiography laboratory. Experience in fetal echocardiography is highly preferred. Join us in our comprehensive efforts to expand our care of patients with congenital heart defects.

The successful candidate will have an M.D., or M.D./ Ph.D., and hold or be eligible for licensure in Illinois and Indiana. Candidates should be able to demonstrate excellent teaching skills. Academic appointment and salary will be commensurate with experience. Research opportunities are available for appropriately qualified candidates. The section has research opportunities in the field of interventional biodegradable stent development and cardiac morphogenesis as well as various clinical aspects of congenital heart disease.

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AED program in the schools, improved CPR training within schools, and an incident review team to provide feedback to the school and community after any incident involving a sudden death in a school setting. Each task force is comprised of school educators, coaches, nurses, parents, and physicians.

As a direct result of the LEAPS initiative, a screening program which includes ECGs was implemented in collaboration with the Orange County Department of Education, local hospitals, and physician and staff volunteers. Various independent organizations within Orange County that had already been doing screening for cardiac causes of sudden death (some for many years) joined forces to make this a success. A formal research protocol was set-up to also evaluate the true and false positives, and hence, the efficacy of implementing such a program. Additionally, AED programs were set-up in various school districts. A core incident review team was formed which provided feedback to the schools after incidents involving a life threatening event or sudden death. This included a record review and information gathering including a visit to the site of the incident, and interviewing people who observed the incident within 72 hours. A report was given to the Orange County Department of Education superintendent regarding the incident and whether there were systemic problems needing to be addressed.

The 3rd annual LEAPS symposium will be held this year on January 13th at the same venue as the Sudden Cardiac Arrest in Children and Adolescents. This symposium will involve discussion and implementation of programs for prevention of sudden cardiac death that have been implemented in Orange County and be geared specifically for the families, school educators, coaches and nurses.

Conclusion

The efficacy of including ECGs for routine screening remains a highly debated controversial topic. Although the 2007 AHA screening recommendations do not endorse mandated national ECG screening for all competitive athletes, in no way do the recommendations discourage individual initiatives which offer ECG screening such as the LEAPS initiative in Orange County, California. More research is needed to evaluate the efficacy of a screening program that includes the ECG. We do not know how many athletes are dying each year. This highlights the need for a national registry that could be used to refine incidence estimates. We are hopeful that the Symposium on Sudden Cardiac Arrest in January, 2011 will help us shed more light on some of these issues and also lead to the initiation of multicenter studies to further answer these questions.

Registration information for the Symposium on Sudden Cardiac Arrest in Children and

A d o l e s c e n t s c a n b e f o u n d a t www.choc.org/conference or by calling 1-800-329-2900.

References

1. Maron BJ. Hypertrophic cardiomyopathy and other causes of sudden cardiac death in young competitive athletes, with considerations for preparticipation screening and criteria for disqualification. Cardiol Clin. 2007;25:399-414.

2. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol. 2003;42:1959-63.

3. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol. 2003;42:1959-63.

4. Mark Thompson PD, Franklin BA, Balady GJ, Blair SN, Corrado D, Estes NA 3rd, et al; American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism and the Council on Clinical Cardiology. Circulation. 2007;115:2358-68.

5. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980-2006. Circulation. 2009 Mar 3;119:1085-92.

6. Corrado D, Pelliccia A, Bjørnstad HH, et al. Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol. Consensus Statement of the Study Group of Sport Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur Heart J. 2005;26:516-24.

7. International Olympic Committee Medical Commission. Sudden cardiovascular death in sport. Lausanne recommendations: preparticipation cardiovascular screening. Vol. 2008. Lausanne: International Olympic Committee Medical Commission; 2004.

8. Corrado D, Basso C, Schiavon M, Pelliccia A, Thiene G. Pre-participation screening of young competitive athletes for prevention of sudden cardiac death. J Am Coll Cardiol. 2008;52:1981-9.

9. Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G. Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. JAMA. 2006;296:1593-601.

10. Maron BJ, Thompson PD, Puffer JC, McGrew CA, Strong WB, Douglas PS, Clark LT, Mitten MJ, Crawford MH, Atkins

D L , D r i s c o l l D J , E p s t e i n A E . Cardiovascular preparticipation screening of competitive athletes: a statement for Health Professionals from the Sudden Death Committee (Clinical Cardiology) and Congenital Cardiac Defects Committee (Cardiovascular Disease in the Young), American Heart Association. Circulation. 1996; 94: 850–856.

CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010 5

TWO Non-Invasive Pediatric Cardiologists Maryland and Virginia

The Children’s Heart Institute is recruiting two full time non-invasive pediatric cardiologists to join a staff of seven Cardiologists. The successful candidates must be board certified in pediatrics and BE/BC in Pediatric Cardiology, and must have outstanding personal, clinical and ECHO skills.

The Children’s Heart Institute provides comprehensive pediatric cardiology services that span the entire Pediatric c a r d i o l o g y f i e l d ; i n c l u d i n g electrophysiology, fetal cardiology, interventional cardiology, and world renowned Dysautonomia clinic. We enjoy a multi state expanding referral base. Our supportive cardiovascular programs perform state of the art procedures including the Hybrid and stage 1 Norwood.

Both locations are in close proximity to the Washington DC Major metropolitan areas, with abundant outdoor activities as well as the advantages of major metro cities. The area offers a wide variety of activities to enjoy, including fine dining, shopping, biking, hiking, boating, river rafting, theater, and many historical and cultural sites. We are close to historic Annapolis, the inner harbor, the Chesapeake Bay, and many communities with outstanding public and private schools. Maryland and Virginia beaches, the Catoctin and Appalachian Blue Ridge Mountains and the Potomac River attraction are within driving distance.

J1 Eligible.

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Hasan Abdallah, MD, FAAP, FACC, FASCIMedical DirectorEmail: abda l l ah@ch iva .us Phone: 703-481-5801 (O)703-628-1114 (C)

11. Maron BJ, Thompson PD, Ackerman MJ, e t a l . R e c o m m e n d a t i o n s a n d considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 update: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation. 2007;115:1643-455.

12. Fuller CM. Cost effectiveness analysis of screening of high school athletes for risk of sudden cardiac death. Med Sci Sports Exerc. 2000;32:887-90.

13. Mark Wheeler MT, Heidenreich PA, Froelicher VF, Hlatky MA, Ashley EA. Cost-effectiveness of preparticipation screening for prevention of sudden cardiac death in young athletes. Ann Intern Med. 2010;152:276-86.

14. Baggish AL, Hutter AM Jr, Wang F, Yared K, et al. Cardiovascular screening in college athletes with and without electrocardiography: A cross-sectional study. Ann Intern Med. 2010;152:269-75.

15. Wilson MG, Basavarajaiah S, Whyte GP, Cox S, Loosemore M, Sharma S. Efficacy of personal symptom and family history questionnaires when screening for inherited cardiac pathologies: the role of electrocardiography. Br J Sports Med 2008;42:207-211.

16. Paterick TE, Paterick TJ, Fletcher GF, Maron BJ. Medical and legal issues in the cardiovascular evaluation of competitive athletes. JAMA. 2005;294:3011-8.

CCT

Anjan S. Batra, MDDirector of ElectrophysiologyChildren's Hospital of Orange CountyAssociate Professor of Clinical PediatricsUniversity of CaliforniaIrvine, CA USA Phone: (714) 221-5500

abatra@uci.edu

PROGRAM MANAGER - CARDIAC CATHETERIZATION & ELECTROPHYSIOLOGY SERVICES

ACUTE CARE PRACTITIONER - CARDIOTHORACIC ICU

The Heart Center at Nationwide Children’s Hospital, in Columbus Ohio, has earned an international reputation for innovation and forward-thinking. From the creation of the world’s first Hybrid Cardiac Catheterization Suites and the first Hybrid Congenital Cardiac Operating room in the nation to the development of a comprehensive adolescent and adult congenital heart disease program, The Heart Center team is constantly looking to improve care options. Nationally ranked as one of America’s best for Heart and Heart Surgery by U.S.News and World Report and in the top three for Cardiology/Cardiothoracic Surgery by Parent’s Magazine, you can be assured that you will have access to the expertise and resources to handle any level of care necessary.

We are currently seeking qualified candidates for the positions referenced above. The Program Manager will manage day-to-day operations of the department. Will direct a team of professional and support staff to ensure assessment, planning, provision and evaluation of patient care. Leadership for complex programs by communicating goals and strategies, providing direction and priorities and providing enthusiasm and support is required as well. The Program Manager will have daily interaction with constituents (physicians, patients, families, and staff) to ensure goal alignment, strategic and tactical direction.

With the opening of our new patient tower in 2012 our CTICU will expand with additional beds. We are seeking an experienced Acute Care Practitioner to manage and coordinate care for cardiothoracic patients and post-operative cardiothoracic patients throughout the continuum. The Practitioner will assist the attending physician of the cardiology service and the surgical team in the care of Heart Center patients in the Cardiothoracic Intensive Care Unit. The Practitioner is responsible for coordinating admissions, transfers, and discharge of patients. In addition, will participate in rounds and be the primary contact for the cardiology consult service, with the attending physician’s involvement.

With experts in all areas of surgical and medical subspecialties, The Heart Center comprehensive team of cardiologists, surgeons, intensivists, nurses and technicians have available resources, including an accredited echocardiography laboratory by the Intersocietal Commission for the Accreditation of Echocardiography Laboratories (ICAEL), to provide state-of-the-art diagnostic imaging, diagnosis, intervention, surgery and support for the patient and patient’s family. With extensive programs and services ranging from interventional cardiology and ablative therapies in electrophysiology to a comprehensive heart and heart/lung transplant program, The Heart Center team is compassionate and dedicated to providing innovation and the highest level of care possible to patients from Columbus to Australia.

Recognition and dedication to the advancements of congenital heart disease and patient care is demonstrated by receiving a Center of Excellence designation by Optum Health for Congenital Heart Disease. Nationwide Children's Hospital is among one of the first children’s hospitals in the nation to utilize 3D Video Assisted Thorascopy to help expand the use of minimally invasive techniques to the treatment of our patients by The Center for Cardiovascular and Pulmonary Research ranking in the top ten for National Institutes of Health funding.

To learn more about Nationwide Children's Hospital, The Heart Center and to apply on-line, please visit our web site at www.nationwidechildrens.org. You may also reply in confidence by submitting your resume to Kathleen.Hunt@nationwidechildrens.org. Relocation assistance will be provided. To learn more about Columbus Ohio please visit www.experiencecolumbus.com.

Is There a Need for a North American Pediatric Cardiology Organization?

Read the article by the same name in the July issue of Congenital Cardiology Today (page 10) by Drs. Robert Campbell and Robert Shaddy.

Please complete this survey and share your views: w w w. s u r v e y m o n k e y. c o m / s / K F 8 N Q Z 8

6 CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010

It’s not too late to make plans to join the wor ld o f congen i ta l and s t ruc tura l interventional cardiology as it gathers at SCAI’s Global Interventional Summit (GIS) on October 22-24, 2010. Taking place in Istanbul, Turkey, nearly three dozen regional and national cardiology societies from Latin America, Asia, Africa, Europe, and the Middle East are cosponsoring this program.

I will be co-chairing the GIS along with SCAI Past President Ted Feldman, MD, FSCAI, of NorthShore University Health System in Chicago; Turkish Society of Cardiology President Oktay Ergene, MD, FSCAI, of Izmir Ataturk Education and Research Hospital; and Levent Saltik, MD, FSCAI, of Istanbul University Cerrahpasa Medical School.

The first of its kind, the Summit is the result of collaboration between SCAI and the Turkish Society of Cardiology; it will be held Oct. 22–24, 2010, in Istanbul. Symbolized by the host city, which straddles Europe and Asia, the event’s goal is to improve patient care worldwide by bridging the gaps that often limit the dissemination of state-of-the-art knowledge in cardiovascular care.

In line with this goal, the idea is to bring this SCAI meeting to structural and congenital interventional specialists practicing outside the United States in order to enhance collaboration between physicians inside and out the US. We’ll be sharing our knowledge and experiences with each other.

The Turkish Society of Cardiology will host the GIS, which will be held in conjunction with its own National Congress. In addition to allowing the two groups to share meeting infrastructure and save costs, scheduling the two events at the same time and place will allow participants in the Turkish Society’s meeting to attend the Summit as well and further the goal of collaboration.

The three-day GIS will cover the latest advances in interventional therapies for coronary, peripheral, congenital and

structural heart disease. The program is divided into three tracks: sessions for adult cardiologists, sessions aimed at pediatric/congenital heart disease cardiologists, and sessions that will appeal to both groups.

Featuring an international faculty, the extensive program will feature lectures, case presentations, and collaborative question-and-answer sessions on both basic and cutting-edge topics. In addition, the event will feature live cases transmitted from hospitals in Istanbul, with host operators and guest operators from the various cardiology societies.

The meeting will appeal to a broad spectrum of physicians, whether they’re intervent ional cardiologists, cardiac surgeons, echocardiographers, or even general internists who want to get the latest information on the technologies that are available for patients. The program will also be a learning experience for the whole cardiac catheterization care team, including technologists, nurses, and interventional radiologists.

Of course, you’ll also want to leave some time to explore Istanbul. Visitors who might have a hard time getting a visa to the US should have no problems visiting Turkey,

and Istanbul is a city rich with history. Everyone should experience it!

More information on SCAI’s Global Interventional Summit, including registration is online at www.SCAI.org/GIS.

CCT

SCAI View - A Monthly Column from The Society for Cardiac Angiography and Interventions

Ziyad M. Hijazi, MD, MPH, FSCAIDirector, Rush Center for Congenital and Structural Heart Disease at Rush University Medical Center1653 W. Congress ParkwayKellogg Building7th Floor, Suite 708Chicago, IL 60612 USA

By Ziyad M. Hijazi, MD, MPH, FSCAI

CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010 7

“The meeting will appeal to a broad spectrum of physicians, whether they’re interventional cardiologists, cardiac surgeons, echocardiographers, or even general internists who want to get the latest information on the technologies that are available for patients. The program will also be a learning experience for the whole cardiac catheterization care team, including technologists, nurses, and interventional radiologists.”

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Objective:

To provide background and current information on recommendations regarding surveillance of patients with ADHD and potential cardiac effects in patients with and without congenital heart disease.

Abstract:

Attention Deficit, Hyperactivity Disorder (ADHD), the most common neurobehavioral disorder of childhood, is characterized by developmentally inappropriate levels of hyperactivity, inattention and impulsivity. Prevalence rates of 4% to 16% have been reported in community-based samples of school-aged children in the United States1. The diagnosis of ADHD is based on criteria delineated in The Diagnostic and Statistical Manual of Mental Disorders-4th Edition (DSM-IV, American Psychiatric Association, 1994) and requires at least 6 symptoms of inattention and/or 6 symptoms of hyperactive-impulsive behaviors causing impairment in functioning in at least two settings (home, school, social).

Etiology and Risk Factors: Investigations into the etiology of ADHD have focused on: 1) the central nervous system involvement; 2) the genetics of the disorder; 3) and the environmental risk factors2. Family studies report a higher incidence of ADHD among first-degree family members of ADHD patients. Environmental factors that have been most consistently associated with ADHD include maternal smoking during pregnancy, emotional distress or family adversity during pregnancy and early in life, and birth weight under 1500 grams3.

ADHD in Children with Heart Disease: ADHD may be more prevalent in children with heart disease than in the general pediatric population. Shillingford reported abnormal attention

scores in 45% of children and abnormal hyperactivity scores in 39% of children with heart disease4. Congenital cardiovascular anomalies are present in 76% of children with velocardiofacial syndrome/DiGeorge syndrome, caused by 22q11 microdeletion5. ADHD affects 35-55% of these children6.

Impact and Sequellae of ADHD and Risks of Not Treating: ADHD and its associated conditions have a profound impact on individuals, families, and society.7 Children with ADHD a re a t h i gh r i s k f o r i n j u r i e s , a cadem i c underachievement, and social difficulties such as peer rejection. These difficulties often persist into adulthood. Individuals with ADHD attain lower occupational status than peers, and are at increased risk for developing problems with substance use and antisocial behavior.

Mechanisms and Efficacy of Pharmacotherapy: Stimulant medications are known to increase heart rate and blood pressure in children, but this has not been shown to be clinically significant. Medications approved by the FDA for the management of ADHD include immediate-release and long-acting methylphenidate, amphetamine preparations, and atomoxetine. The stimulant medications, methylphenidate and amphetamine compounds release and/or inhibit reuptake of catecholamines (e.g. dopamine and norepinephrine), increasing the level of these neurotransmitters at the synapse while atomoxetine is predominantly a selective norepinephrine reuptake inhibitor8. The efficacy of these medications been widely studied with response rates over 70%9,10. Side Effects: The common side effects of stimulant medications include decreased appetite, insomnia, emotional lability, stomach aches and headaches and these appear to be similar during short-term treatment (approximately 4 weeks) and long term maintenance. Data from multi-site clinical trials of both amphetamine and methylphenidate-based stimulants indicate that these medications are generally safe for children with ADHD7. On average there is an increase in heart rate of approximately 1 to 2 beats per minute and an increase in systolic and diastolic blood pressure of 3 to 4 mm Hg11. In general, these cardiac side effects have been thought to be clinically insignificant for most children with ADHD, but there has been some concern that stimulant drugs could cause hypertension, tachycardia or arrhythmias that would be deleterious in children with CHD12. Reports of sudden deaths directly related to methylphenidate as the sole agent are rare, but there are reports of ventricular arrhythmias and suppression of cardiac function with methylphenidate abuse13. Amphetamines have been associated with tachyarrhythmias and sudden death. Short-term studies of atomoxetine found a small but statistically significant increase in mean systolic blood pressure in adults and a marginal increase in diastolic blood pressure in adults and children which decreased upon discontinuation14.

Safety of Stimulant Drugs: Sudden cardiac death has been reported to the FDA in children and adolescents taking stimulant medications although no studies have proven a

Abstracts from “Evolving Concepts in the Management of Complex Congenital Heart Disease II” - Part VI

“Abstracts from ‘Evolving Concepts in the Management of Complex Congenital Heart Disease II’ - Part VI” includes the following topics and presenters:

• DHD in Patients With and Without CHD, Use of Stimulant Medication by Victoria L. Vetter, MD, MPH

• Establishing an ACHD Program by Gary Webb, MD• Patient-related, Procedure-Related and ICU-Related Factors

Impacting Long-Term Quality of Life by Gil Wernovsky, MD

This is the final in the series.

Abstract Title: DHD in Patients With and Without CHD, Use of Stimulant MedicationPresenter: Victoria L. Vetter, MD, MPHDivision of Cardiology The Children’s Hospital of Philadelphia, Philadelphia, PAUSA

8 CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010

causal association. Many of these children were found after death to have conditions known to be associated with sudden cardiac arrest/death. Even though a causal effect has not been proven, it is biologically plausible that stimulant medications could trigger a life-threatening event in a susceptible individual15. By 2005, a number of cases of sudden cardiac death (SCD) that had been reported to the FDA’s Adverse Event Reporting System (AERS) came to public attention. Between 1992 and 2005, 20 cases of SCD during treatment with amphetamine were reported: 14 in children and 6 in adults. Six of the 14 children had structural heart abnormalities or predisposing factors suggesting a SCD. Similarly, during the time period, 18 cases of SCD during methylphenidate treatment were reported, 14 in children, 6 of whom had structural cardiac defects. Reports of SCD in children treated with atomoxetine have been reported, as well. AERS is a voluntary reporting system so attempts to calculate SCD incidence rates from these data as a numerator and using the total number of children treated with stimulant medications as a denominator is totally inaccurate. Even in these reported cases, validated data are severely limited. However, these data may indicate a signal that there is an association, not causation, between ADHD medications and SCD in susceptible individuals. In February of 2005, Health Canada, the Canadian drug regulatory agency, suspended the sale of Adderall XR in the Canadian market based on the FDA AERS reports, but subsequently reinstated the drug once the labeling was changed to indicate possible cardiac risks. Despite the lack of data to support limiting the use of the stimulant medications in children with heart disease, in 2007, the FDA added a warning to the Adderall labeling that it generally should not be used in children or adults with structural cardiac abnormalities. Additionally, a boxed warning states, Misuse of amphetamine may cause sudden death and serious cardiovascular events.

Since February 2007, the FDA has required all manufacturers of drug products approved for ADHD treatment to develop Medication Guidelines to alert patients to possible cardiovascular risks. These Medication Guidelines mention the risk of sudden death in patients who have heart problems or heart defects and indicate “they either should not be taken or may not be right for you or your child” if you have a variety of cardiovascular conditions. Many of the drug monographs state that the “stimulant products generally should not be used in children or adolescents with known serious structural cardiac abnormalities, cardiomyopathy, heart rhythm abnormalities, or other serious cardiac problems…” The user is advised inform their doctor if they have a heart condition.

AHA Scientific Statement 2008: Cardiovascular Monitoring of Children and Adolescents with Heart Disease Receiving Medications for ADHD: 16 This statement was felt to be necessary related to concerns over potential cardiovascular effects of psychotropic drugs including stimulants used to treat ADHD, given that each stimulant medication was being dispensed (and still is) with a warning to “not use” if a cardiac condition is present. Those who practice pediatric cardiology know that less than half of the cases that can cause SCD are diagnosed on routine evaluation. Conditions that are associated with sudden cardiac arrest/death in children are often subtle without symptoms or a family history, and may not be diagnosed at the time that an ADHD drug is being considered. These include hypertrophic cardiomyopathy (HCM) and other cardiomyopathies, electrical cardiac conditions including Long QT Syndrome (LQTS) and other primary ventricular arrhythmias, Wolff-Parkinson-White Syndrome, structural abnormalities such as anomalous origin of the coronary arteries, and congenital heart defects, either before or after surgical repairs. For over a decade the AHA has

For more information orto apply for this position,please contact:Robert Mangano, MD, c/oKathy Kardisco, Departmentof Professional Staffing,at 1-800-845-7112,email:kkardisco@geisinger.edu

This position involves working within a largemultidisciplinary group, providing inpatient carein our children’s hospital and outpatient carelocally and at outreach locations. It providesopportunities to practice state-of-the-artmedicine, teach students and residents, benefitfrom a fully digital echo system, and work withothers providing comprehensive advanced cardiaccare. Research opportunities are available.

Janet Weis Children’s Hospital is a dedicatedchildren’s hospital within a hospital, with anICAEL-certified Echocardiography laboratory, an

advanced cardiac imaging center, an InterventionalCardiac Catheterization program, ECMO, a 12-bedPICU and a 38-bed Level III NICU, with all sub-specialties well represented.

Geisinger Health System serves nearly 3 millionpeople in Northeastern and Central Pennsylvaniaand is nationally recognized for innovativepractices and quality care. A mature electronichealth record connects a comprehensive networkof 2 hospitals, 38 community practice sites andmore than 700 Geisinger primary and specialtycare physicians.

P E D I A T R I C C A R D I O L O G Y

Learn more at Join-Geisinger.org/150/PedCard

Geisinger Health System is seeking a BC/BE Pediatric Cardiologist to join its

collaborative team of 4 Pediatric Cardiologists and 1 Pediatric Cardiovascular

Surgeon at Geisinger’s Janet Weis Children’s Hospital, an exceptional tertiary

referral center, located on the campus of Geisinger Medical Center in Danville, PA.

CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010 9

recommended use of a detailed history and physical exam with 12 elements in an attempt to identify youth at risk of SCD prior to athletic participation. To date, there is no evidence to indicate the efficacy of this method. On the other hand, the Italians have added an ECG to the history and physical evaluation of their athletes and have decreased SCD by 89% over 25 years17. The AHA statement was the consensus of the authors on the best methods currently available to identify at risk children prior to giving them medication and to monitor them safely if medication is needed to treat their ADHD. Its intent was to provide the practitioner with tools to answer questions in patients who have ADHD, such as how to know if the child has a heart condition; what to do if you know the child has a heart condition; and what to do if the child has a heart condition known to be associated with sudden cardiac death. The AHA Scientific Statement in 2008 stated that it is reasonable to consider adding an ECG…to the history and physical examination in the cardiovascular evaluation of children who need to receive treatment with drugs for ADHD.

The AHA Statement did not require an ECG, but suggested it be considered to aid in the identification of cardiac conditions associated with SCD, especially if history and physical imply that such a condition might be present. Further, the statement never indicated that the risk/benefit ratio of ADHD medications was negative or had changed, but that physicians should be aware of potential adverse events in susceptible individuals and appropriately diagnose and treat those individuals, even allowing them to be treated with stimulant medications under proper monitoring. The Statement indicated that “It is reasonable to use stimulants with caution in patients with known congenital heart disease and/or arrhythmias, if these patients are stable and under the care of a pediatric cardiologist.” The benefits of ADHD medications were emphasized. What is commonly dismissed is that the potential risk (of death) is not a reversible event, and thus may indicate a need for higher vigilance than would be needed for another less severe side effect of the medications. The Statement further indicated that “Future studies are needed to assess the true risk of Sudden Cardiac Arrest in association with stimulant drugs in children and adolescents with and without heart disease including studies on the efficacy of ECG screening in children.”

Response to AHA Scientific Statement: The AHA Scientific Statement was met with an unexpected furor. Basically, the recommendations were misunderstood and viewed through the lens of the media rather than the document itself. A revision was published on line to clarify the intent and substance of the document. The American Academy of Pediatrics and American Academy of Child and Adolescent Psychiatry do not recommend an ECG. A recent Canadian consensus statement recommends use of a focused history and physical with additional tests such as an ECG only if cardiac disease is suspected18.

Division of Pediatric CardiologySaint Louis University School of Medicine

Cardinal Glennon Children’s Medical Center

Saint Louis University, a Catholic, Jesuit institution dedicated to student learning, research, health care, and service is seeking an additional pediatric cardiologist to join an established group within the Division of Cardiology and the Department of Pediatrics at Cardinal Glennon Children’s Medical Center. Applicants will be considered at the Assistant/Associate Professor rank, and must be board certified/eligible in Pediatric Cardiology. General responsibilities will include clinical care, teaching, and research.

Interventional Cardiologist

We are seeking a second invasive cardiologist to assist our current faculty with the growing number of cardiac catheterizations and interventional cases. A complete spectrum of pediatric interventional procedures is currently being performed. An interest in clinical research is encouraged. Academic rank will be commensurate with qualifications and experience.

The cardiology division is in a period of significant expansion, with the opening of the Dorothy and Larry Dallas Heart Center within Cardinal Glennon Children’s Medical Center in January, 2009. An active congenital heart surgery program exists, and the hospital houses state-of-the-art operating rooms and a new 60-bed neonatal intensive care unit. Construction of a new hybrid cardiac catheterization lab/operating suite is scheduled to begin in 2010. The Doisy Research Center, a new 10-story tower housing the Health Sciences Center Research laboratories, was opened in 2007.

Interested candidates must submit a cover letter, application, and current CV to http://jobs.slu.edu. Other correspondence regarding this position can be sent to:

Kenneth O. Schowengerdt, MD, Wieck-Sullivan Professor and Director of Pediatric Cardiology,

Saint Louis University School of Medicine, 1465 South Grand Blvd,

St. Louis, MO 63104. Telephone: (314)-577-5633

Fax: (314)-268-4035email schowko@slu.edu

Saint Louis University is an Affirmative Action, Equal Opportunity Employer, and encourages nominations of and applications from women

and minorities.

10 CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010

Ongoing and Recent Research Studies on ADHD Medications: Long-term safety trials and targeted CV risk studies have been recommended as a potential option to better understand the cardiovascular risks for all drug products approved for ADHD and several are in progress. Stimulant use is associated with a 20% increase in the hazard for emergency department visits when compared with non use19,20. A survey of Canadian physicians regarding the Health Canada advisory showed that non-cardiologists had changed their practices and were more aware of potential risks and the need to provide some type of cardiovascular assessment in ADHD patients21. A case control study in 2009 indicated that there was an association of sudden death in children on stimulant medications with an odds ratio of 7.422. A recent analysis of 1470 ECGs obtained in children with ADHD showed a low positive predictive value of 4.2%, but identified cardiac disease in 5 subjects at a cost of $58/child and $17,162 to identify a true-positive result23. Several large secondary database analysis studies are ongoing. Scientific studies will determine if there are risks of ADHD medications and if so, whether those at risk need to be identified prior to taking the medication. The best methods of identification (history, physical and/or ECG, ECHO, or genetic testing) will be determined over time and applied to the appropriate populations. Once evidence is available, the best treatment of our children can be achieved.

Reference List

1. Barbaresi WJ, Katusic SK, Colligan RC et al. How common is attention-deficit/hyperactivity disorder? Incidence in a population-based birth cohort in Rochester, Minn. Arch Pediatr Adolesc Med 2002 March;156(3):217-24.

2. Faraone SV, Perlis RH, Doyle AE et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 2005;57(11):1313-23.

3. Linnet KM, Dalsgaard S, Obel C et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry 2003 June;160(6):1028-40.

4. Shillingford AJ, Glanzman MM, Ittenbach RF, Clancy RR, Gaynor JW, Wernovsky G. Inattention, hyperactivity, and school performance in a population of school-age children with complex congenital heart disease. Pediatrics 2008 April;121(4):e759-e767.

5. Shprintzen RJ. Velo-cardio-facial syndrome: a distinctive behavioral phenotype. Ment Retard Dev Disabil Res Rev 2000;6(2):142-7.

6. Gothelf D, Gruber R, Presburger G et al. Methylphenidate treatment for attention-deficit/hyperactivity disorder in children and adolescents with velocardiofacial syndrome: an open-label study. J Clin Psychiatry 2003 October;64(10):1163-9.

7. Wilens TE, Prince JB, Spencer TJ, Biederman J. Stimulants and sudden death: what is a physician to do? Pediatrics 2006 September;118(3):1215-9.

8. Solanto MV. Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav Brain Res 1998 July;94(1):127-52.

9. Greenhill LL, Swanson JM, Vitiello B et al. Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial. J Am Acad Child Adolesc Psychiatry 2001 February;40(2):180-7.

10. Jensen PS, Hinshaw SP, Swanson JM et al. Findings from the NIMH Multimodal Treatment Study of ADHD (MTA):

Designed for physicians, nurses and other healthcare professionals, this conference will present the current state of the art on topics related to the diagnosis, therapy and prevention of cardiac arrest in young people.

Topics will include:

AMA PRA Category 1 CreditTM for CME will be offered

To register or more information visit www.choc.org/cardiacconference or call (800) 329-2900

• Clinical syndromes associated with risk of sudden death

• Use of automated external and implantable defibrillators in the young

• Arrhythmias in the young• Screening, with an emphasis on defining

levels of evidence and areas of controversy in management decisions

Presents

Sudden Cardiac Arrest in Children and Adolescents: Diagnosis, Therapy and Prevention

January 14 - 15, 2011 Disneyʼs Grand Californian Hotel® & Spa

1600 South Disneyland Drive, Anaheim, CA 92802

CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010 11

implications and applications for primary care providers. J Dev Behav Pediatr 2001 February;22(1):60-73.

11. Findling RL, Short EJ, Manos MJ. Short-term cardiovascular effects of methylphenidate and adderall. J Am Acad Child Adolesc Psychiatry 2001 May;40(5):525-9.

12. Ballard JE, Boileau RA, Sleator EK, Massey BH, Sprague RL. Cardiovascular responses of hyperactive children to methylphenidate. JAMA 1976 December 20;236(25):2870-4.

13. Lucas PB, Gardner DL, Wolkowitz OM, Tucker EE, Cowdry RW. Methylphenidate-induced cardiac arrhythmias. N Engl J Med 1986 December 4;315(23):1485.

14. Kratochvil CJ, Heiligenstein JH, Dittmann R et al. Atomoxetine and methylphenidate treatment in children with ADHD: a prospective, randomized, open-label trial. J Am Acad Child Adolesc Psychiatry 2002 July;41(7):776-84.

15. Vitiello B. Understanding the risk of using medications for attention deficit hyperactivity disorder with respect to physical growth and cardiovascular function. Child Adolesc Psychiatr Clin N Am 2008 April;17(2):459-74, xi.

16. Vetter VL, Elia J, Erickson C et al. Cardiovascular monitoring of children and adolescents with heart disease receiving medications for attention deficit/hyperactivity disorder [corrected]: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young Congenital Cardiac Defects Committee and the Council on Cardiovascular Nursing. Circulation 2008 May 6;117(18):2407-23.

17. Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G. Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. JAMA 2006 October 4;296(13):1593-601.

18. Hamilton R, Gray C, Belanger SA et al. Cardiac risk assessment before the use of stimulant medications in children and youth: A joint position statement by the Canadian Paediatric Society, the Canadian Cardiovascular Society and the Canadian Academy of Child and Adolescent Psychiatry. J Can Acad Child Adolesc Psychiatry 2009 November;18(4):349-55.

19. Winterstein AG, Gerhard T, Shuster J, Johnson M, Zito JM, Saidi A. Cardiac safety of central nervous system stimulants in children and adolescents with attention-deficit/hyperactivity disorder. Pediatrics 2007 December;120(6):e1494-e1501.

20. Winterstein AG, Gerhard T, Shuster J, Saidi A. Cardiac safety of methylphenidate versus amphetamine salts in the treatment of ADHD. Pediatrics 2009 July;124(1):e75-e80.

21. Conway J, Wong KK, O'Connell C, Warren AE. Cardiovascular risk screening before starting stimulant medications and prescribing practices of canadian physicians: impact of the Health Canada advisory. Pediatrics 2008 October;122(4):e828-e834.

THE UNIVERSITY OF CHICAGODEPARTMENT OF PEDIATRICS

SECTION OF PEDIATRIC CARDIOLOGY

The Department of Pediatrics at the University of Chicago is expanding its section of Pediatric Cardiology. We are currently recruiting a general pediatric cardiologist with an interest in cardiac imaging including fetal echocardiography. The successful candidate will also be an integral part of the Section's collaboration with the Northshore University Health System located in the northern suburbs of Chicago. Join us in our comprehensive efforts to expand our care of patients with congenital heart defects.

The successful candidate will have an M.D., or M.D./ Ph.D., and hold or be eligible for medical licensure in Illinois and Indiana. Candidates should be able to demonstrate excellent teaching skills. Academic appointment and salary will be commensurate with experience. Research opportunities are available for appropriately qualified candidates. The section has research opportunities in the field of interventional biodegradable stent development and cardiac morphogenesis as well as various clinical aspects of congenital heart disease.

This position will have responsibility for teaching students, residents and fellows. Outpatient and inpatient venues are included.

Qualified candidates should submit a curriculum vitae, letter of interest and names of three references to our academic website: http://academiccareers.uchicago.edu/applicants/Central?quickFind=51141

The University of Chicago is an Affirmative Action / Equal Opportunity Employer

Master Class in Congenital Cardiac MorphologyOctober 6-8, 2010

Childrenʼs Hospital of Pittsburgh of UPMCJohn G. Rangos Sr. Conference Center, Pittsburgh, PA USA

www.chp.edu/masterclass

12 CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010

22. Gould MS, Walsh BT, Munfakh JL et al. Sudden death and use of stimulant medications in youths. Am J Psychiatry 2009 September;166(9):992-1001.

23. Mahle WT, Hebson C, Strieper MJ. Electrocardiographic screening in children with attention-deficit hyperactivity disorder. Am J Cardiol 2009 November 1;104(9):1296-9.

CCT

Abstract:

Commit yourself to excellent patient care. This will reduce the number of times you do things you shouldn’t because of pride or self-interest.

Know where your patients will be coming from, and know how many to expect.

In order to build a large program, I believe you need 250-500 new referrals annually.• To develop and maintain team skills.• To drive adequate volumes to support your business plan.• To train fellows and staff.

Try to ensure patients are not lost to care in your region. Work with pediatric cardiologists to have an orderly transfer of care.Make sure you have strong basic skills and services:• ACHD cardiology.• ACHD echocardiography and sonography.

Have a clear business plan, and make it as easy as possible to succeed.

Locate your program in a supportive environment.A supportive institution/group, with a long-term commitment.Supportive colleagues, especially from pediatric cardiology.

Decide where you will deliver outpatient ACHD care.Decide where you will deliver inpatient ACHD care.

Be clear on what services you will be able to provide locally.

Identify your consulting team members, and understand their abilities and limitations.

Develop and improve your consulting team in a realistic and constructive way.

Be clear on what services you will need to refer out, and make clear and appropriate arrangements. These service arrangements may change with time.

Be available to referring providers and patients.

Provide care 24/7.

Be generous sharing information (e.g. offer patients copies of their letters).

Educate your patients and families:• That and why they need special care;• That and why they need lifelong surveillance.• Where and how to find the skilled care they need.

CCT

Objectives:

1. Understand the neurodevelopmental ‘phenotype’ of the school-age child with CHD.

2. Describe the multiple mechanisms implicated in adverse neurodevelopmental outcomes.

3. List important elements in a targeted follow-up program.

Abstract:

Advances in prenatal detection, perioperative management and cardiothoracic surgical techniques have contributed to a significant increase in the number of children with complex congenital cardiac disease entering preschool and beyond. As initial survival has increased, and indeed is now expected for most forms of congenital cardiac disease, greater attention has been directed toward understanding the longer-term neurodevelopmental and functional outcomes of this growing patient population.

Studies have shown that children with complex CHD requiring surgery in early infancy have an increased incidence of fine and gross motor delays, academic and behavioral difficulties, and inattention/hyperactivity; they are also more likely to have executive planning deficits, delays in expressive language, and lower than expected scores on standardized intelligence quotient (IQ) tests. The figure above demonstrates the multiple factors that may impact upon mid-term neurological outcomes, including both modifiable and non-modifiable risk factors.

There has been great interest of late in focusing on the operating room as the most likely source of central nervous system injury that is modifiable, including the conduct of cardiopulmonary bypass in general and the use of deep hypothermic circulatory arrest in particular. All too often, well-meaning clinicians have made major changes in clinical practice – such as the widespread use of continuous cerebral perfusion during neonatal arch reconstruction - without adequate clinical trials or registry data to suggest improvement with the alternative strategies. Inadequate

Abstract Title: Patient-related, Procedure-Related and ICU-Related Factors Impacting Long-Term Quality of LifePresenter: Gil Wernovsky, MDAssociate Chief, Division of Cardiology; Directory of Program Development, The Cardiac Center, Children’s Hospital of Philadelphia, Philadelphia, PA USA

Abstract Title: Establishing an ACHD ProgramPresenter: Gary Webb, MDDirector, Philadelphia Adult Congenital Heart Center, Philadelphia, PA USA

CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010 13

attention has been paid to the potential morbidities in the intensive care unit, both preoperatively and postoperatively, which may be modifiable and have a significant impact on longer term function. Well designed trials, including tracker trials and randomized clinical trials, as well as registry data which includes systematic long-term cardiac and neurodevelopmental follow-up, is a paradigm shift which

should be adopted and endorsed by national and international societies.

During follow-up visits, the cardiologist and primary caregiver should inquire about school performance, behavior and other developmental issues, and partner with the child’s primary care provider and necessary consultants and therapists to formulate a plan for evaluation and management of possible behavior and academic difficulties. Parents should be made aware of the potential for academic and behavioral difficulties early in the follow-up process.

References:

1. Gaynor JW, Nord AS, Wernovsky G, et al. Apolipoprotein E genotype modifies the risk of behavior problems after infant cardiac surgery. Pediatrics. 2009;124:241-50.

2. Licht DJ, Shera DM, Clancy RR, Wernovsky G, et al. Brain maturation is delayed in infants with complex congenital heart defects. J Thorac Cardiovasc Surg. 2009;137:529-36

3. Joynt CA, Robertson CM, Cheung PY, et al, Two-year neurodevelopmental outcomes of infants undergoing neonatal cardiac surgery for interrupted aortic arch: a descriptive analysis. J Thorac Cardiovasc Surg. 2009;138:924-32.

4. Samanta B, Bird GL, Kuijpers M, et al. Prediction of periventricular leukomalacia. Part II: Selection of hemodynamic features using computational intelligence. Artif Intell Med. 2009;46:217-31.

5. Neufeld RE, Clark BG, Robertson CM, et al. Five-year neurocognitive and health outcomes after the neonatal arterial switch operation. J Thorac Cardiovasc Surg. 2008;136:1413-21.

6. Hövels-Gürich HH, Bauer SB, Schnitker R, et al. Long-term outcome of speech and language in children after corrective surgery for cyanotic or acyanotic cardiac defects in infancy. Eur J Paediatr Neurol 2008;12:378-86.

7. Atallah J, Dinu IA, Joffe AR, et al. Two-year survival and mental and psychomotor outcomes after the Norwood procedure: an analysis of the modified Blalock-Taussig shunt and right ventricle-to-pulmonary artery shunt surgical eras. Circulation. 2008;118:1410-8.

8. Shillingford AJ, Glanzman MM, Ittenbach RF et al. Inattention, hyperactivity, and school performance in a population of school-age children with complex congenital heart disease. Pediatrics. 2008;121: e759-67.

14 CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010

PediatricCardiology Faculty PositionThe Division of Pediatric Cardiology at Loyola University Chicago (LUC) Stritch School of Medicine’s Department of Pediatrics is seeking a pediatric cardiologist to join its growing practice. The position requires excellent clinical skills in general pediatric cardiology. The ideal candidate should be BE/BC in pediatric cardiology with demonstrated expertise in multimodality noninvasive imaging of congenital and structural heart disease. Candidates should have excellent judgment, good work ethic, and interact well with peers, other medical and support personnel, and community physicians. Faculty also have important roles in student and resident education and have the opportunity to conduct research.

Based in the western suburbs of Chicago, Loyola University Health System (LUHS) is a quaternary care system with a 61-acre main medical center campus and 14 off-site facilities in Cook, Will and DuPage counties and the Gottlieb Memorial Hospital campus in Melrose Park. On the medical center campus is Loyola University Hospital, a 570-bed licensed facility; it houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald ® Children’s Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine, and Loyola Oral Health Center as well as the LUC Stritch School of Medicine, LUC Niehoff School of Nursing and a fitness center. LUHS is a nationally recognized leader in providing specialty and primary health-care services as well as in conducting groundbreaking research in treatment of heart disease, cancer, organ transplantation and neurological disorders.

Loyola’s Ronald McDonald Children’s Hospital, located in Loyola University Hospital, is a “hospital-within-a-hospital” and is comprised of 36 general inpatient, 20 newborn nursery, 14 pediatric intensive care, and 50 neonatal intensive care beds. The hospital is staffed by a full complement of pediatric subspecialty services and a 46-member residency program.

Please send a letter of interest and CV to: Joel Hardin, MD, Division Director of Pediatric Cardiology, Jhardin@lumc.edu, or Holly Nandan, Director of Faculty Recruitment, hnandan@lumc.edu.

www.LoyolaMedicine.org

www.stritch.luc.edu

The Loyola University Health System is an affirmative action/equal opportunity educator and employer. The University undertakes affirmative action to assure equal employment opportunity for underrepresented minorities, women, and persons with disabilities.

Working Together to Develop a Better Tomorrow

9. Zeltser I, Jarvik GP, Bernbaum J, Wernovsky G, et al. Genetic factors are important determinants of neurodevelopmental outcome after repair of tetralogy of Fallot. J Thorac Cardiovasc Surg. 2008;135:91-7.

10. Hövels-Gürich HH, Konrad K, Skorzenski D, et al. Attentional dysfunction in children after corrective cardiac surgery in infancy. Ann Thorac Surg 2007;83:1425-30.

11. Ballweg JA, Wernovsky G, Ittenbach RF et al. Hyperglycemia after infant cardiac surgery does not adversely impact neurodevelopmental outcome. Ann Thorac Surg. 2007 Dec;84:2052-8.

12. Gaynor JW, Wernovsky G, Jarvik GP, et al. Patient characterist ics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery. J Thorac Cardiovasc Surg. 2007;133:1344-53.

13. Atallah J, Joffe AR, Robertson CM et al. Two-year general and neurodevelopmental outcome after neonatal complex cardiac surgery in patients with deletion 22q11.2: a comparative study. J Thorac Cardiovasc Surg 2007;134:772-9.

14. Shillingford AJ, Ittenbach RF, Marino BS, et al. Aortic morphometry and microcephaly in hypoplastic left heart syndrome. Cardiol Young. 2007;17:189-95.

15. Mahle WT, Visconti KJ, Freier MC, et al. Relationship of surgical approach to neurodevelopmental outcomes in hypop las t i c l e f t hea r t syndrome. Ped ia t r i c s 2006;117:e90-7.

16. Kaltman JR, Jarvik GP, Bernbaum J, Wernovsky G, et al. Neurodevelopmental outcome after early repair of a ventricular septal defect with or without aortic arch obstruction. J Thorac Cardiovasc Surg. 2006;131:792-8.

17. Wernovsky G. Current insights regarding neurological and developmental abnormalities in children and young adults with complex congenital cardiac disease. Cardiol Young. 2006;16 Suppl 1:92-104.

18. Licht DJ, Wang J, Silvestre DW, et al. Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects. J Thorac Cardiovasc Surg 2004;128:841-9.

19. Wypij D, Newburger JW, Rappaport LA et al. The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg 2003;126:1397-403.

20. Be l l i nge r DC , Wyp i j D , duP l e s s i s A J e t a l . Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg. 2003;126:1385-96.

21. Newburger JW, Wypij D, Bellinger DC, et al. Length of stay after infant heart surgery is related to cognitive outcome at age 8 years. J Pediatr 2003;143:67-73.

CCT

Rush University Medical Center, Chicago - Pediatric Electrophysiologist

The Department of Pediatrics, the Electrophysiology and Pacemaker Service, and the Center for Congenital and Structural Heart Disease at Rush University Medical Center, located in downtown Chicago, seek an electrophysiologist.

We are in quest of a cardiologist with fellowship training in pediatric and congenital/structural electrophysiology. Candidates should have expertise in invasive/non-invasive electrophysiology and skills and expertise in diagnosis and management of complex arrhythmias. Willingness to perform routine adult EP procedures is highly desirable. A conjoint appointment in the Department of Internal Medicine will be considered based on candidate qualifications and interest level.

This recruitment is part of a key strategic growth initiative in a multidisciplinary advanced congenital/structural cardiology program. Candidates are eligible for faculty appointment at the Assistant or Associate Professor level.

Please contact:Courtney KammerDirector, Faculty RecruitmentRush University Medical Center312-942-7376Courtney_Kammer@rush.edu

Rush is an Equal Opportunity Employer.

CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010 15

Pediatric CardiologistThe Division of Pediatric Cardiology at the University Of Utah School Of Medicine is recruiting a pediatric cardiologist with a major interest in Adult Congenital Heart Disease. The candidate should have a strong clinical background in all areas of pediatric cardiology with expertise in caring for adults with congenital heart disease. The candidate will be joining a 24-member division of Pediatric Cardiology including one pediatric cardiologist currently running the Adult Congenital Heart Disease Program. The Division has a very active clinical program, currently seeing a large volume of adults with congenital heart disease. The Division also has a very active clinical research program and is one of the participating centers in the Pediatric Heart Disease Clinical Research Network funded by the NIH. There will be protected time for clinical research with mentoring available within the Division for clinical research studies.

The successful candidate will receive a faculty appointment at the University of Utah. The Pediatric Cardiology Division is based at Primary Children’s Medical Center, a tertiary referral center for a three-state area located on the hills overlooking Salt Lake City. Adults with congenital heart disease are seen at the children’s hospital and at nearby ‘adult’ hospitals. The area offers an excellent quality of life with immense cultural and recreational opportunities close and available.

The University of Utah is an Affirmative Action/Equal Opportunity employer and does not discriminate based upon race, national origin, color, religion, sex, age, sexual orientation, gender identity/expression, disability, or status as a Protected Veteran. Upon request, reasonable accommodations in the application process will be provided to individuals with disabilities. To inquire about the University’s nondiscrimination policy or to request disability accommodation, please contact: Director, Office of Equal Opportunity and Affirmative Action, 201 S. Presidents Circle, Room 135, (801) 581-8365.

Interested individuals should send or email a cover letter and curriculum vitae to: Lloyd Y. Tani, M.D.Chief, Division of Pediatric CardiologyUniversity of Utah School of Medicine100 N. Mario Capecchi DriveSalt Lake City, UT 84113Email: lloyd.tani@imail.org

Risks, Benefits of Heart Valve Replacement Technique Not Fully Understood

Newswise — A newer, less invasive method of heart valve replacement shows promise and may be appropriate for patients who cannot tolerate traditional open heart surgery, but research is needed to understand its potential risks and benefits, according to a new study funded by HHS’ Agency for Healthcare Research and Quality (AHRQ).

The report finds that percutaneous heart valve replacement, a procedure in which a replacement valve is implanted through a catheter rather than by open-heart surgery, is a realistic option for some patients with heart valve disease, especially older or sicker patients. The report found that percutaneous heart valve replacement may be a safe and effective alternative to open heart surgery, especially in the short term, for those patients. However, information is lacking on the potential long-term benefits and risks of this procedure, particularly compared with open heart valve replacement surgery. The report did not conclude that any of the seven valves studied is safer or more effective than another.

The report was produced by the Duke Evidence-based Practice Center for AHRQ, a leading federal agency conducting comparative effectiveness research. Results of the report were published online today in Annals of Internal Medicine. Heart valve disease—a narrowing of the heart valve—is blamed for approximately 20,000 deaths a year.

“As the US population ages, the number of patients with heart valve disease will increase, so more Americans will need options for safe, effective heart valve replacement,” said AHRQ Director Carolyn M. Clancy, MD. “This report identifies what is known about this emerging procedure and where the research is lacking to give patients more options about their treatment.”

Conventional heart valve replacement is a well-established procedure, with approximately 95,000 open heart surgeries performed per year for patients with severe narrowing of the heart valve. However, as many as one-third of patients with severe heart valve disease are considered too high risk for open heart surgery, in which patients typically are under general anesthesia for 3 to 6 hours, are hospitalized for 5 to 6 days, and require recovery time of 12 weeks. These patients would likely benefit from a less invasive option.

The report found that percutaneous heart valve replacement is a good option for patients at high risk for traditional surgery because of advanced age or illness. Approximately 92% of patients who received a percutaneous valve survived the procedure; of those, 86% survived for at least 30 days, the report found.

Catheter-based valve implantation was first reported in 2002. Just one device, the Medtronic Melody Transcatheter Pulmonary Valve

16 CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010

Medical News, Products and Information

For information on PFO detection go to: www.spencertechnologies.com

and Ensemble Delivery System, currently has approval from the US Food and Drug Administration. This device was approved in January 2010 under the Humanitarian D e v i c e E x e m p t i o n p r o g r a m . Percutaneous heart valve replacement surgery has been available in Europe for nearly 2 years.

The report identified 62 published studies representing a total of 856 patients, as wel l as addi t ional s tudies not yet published. However, researchers were unable to make direct comparisons between percutaneous va lves and traditional surgical replacement because of differences between patient groups receiving the treatments. Clinical trials that may allow direct comparisons are currently underway in the US.

Percutaneous Heart Valve Replacement is the newest technical brief from AHRQ’s Effective Health Care Program. Technical briefs are rapid-turnaround reports that s u m m a r i z e k e y i s s u e s r e g a r d i n g emerging treatments, highlighting where more research is needed, and where research may be sufficient to warrant a full systematic comparative effectiveness rev iew. The Effect ive Heal th Care Program represents a leading federal effort to compare alternative treatments for health conditions and make the findings public to help doctors, nurses, pharmacists and others work together with patients to choose the most effective treatments.

In conjunction with the new report, AHRQ will soon publish plain-language summary guides about heart surgery for patients, clinicians and policymakers. Summary guides on numerous clinical topics and other information and background on the Effective Health Care Program can be found at www.effectivehealthcare.ahrq.gov.

Image-Processing Algorithm Reduces CT Radiation Dose By As Much As 95%

Perfusion CT scanning, an emerging imaging technology, got a bad rap last year when a machine set to incorrect radiation levels overdosed hundreds of people in Los Angeles. In the wake of this incident, researchers at the Mayo Clinic,

excited by the technology's promise for diagnosing stroke, cancer, and possibly heart disease, have developed a way to reduce the amount of radiation involved in the procedure -- which, when done properly, already involves very little risk.

"At the correct dose, there should be no injury," said Cynthia McCollough. "We believe in the clinical value of perfusion CT, so we're trying to lower the dose and reduce the stigma."

McCollough and her colleagues created a new image-processing algorithm that can give radiologists all of the information they need using as up to 20 times less radiation, depending on the diagnostic application. The research was presented at the 52nd Annual Meeting of the American Association of Physicists in Medicine (AAPM) in Philadelphia, PA.

A typical CT perfusion procedure lasts about half a minute and scans the same tissue many times, each scan at a low dose. These scans both reveal the internal anatomy of the patient and show how levels of a contrast agent, such as iodine injected into the bloodstream, c h a n g e o f o v e r t i m e . C h a n g i n g concentrations of iodine can be used to calculate blood volume and flow in order to detect injuries to blood vessels or tumor responses to treatment.

The new adaptive algorithm compares these 20-30 scans and can differentiate between anatomical regions that do not change from moment to moment and those regions that carry the contrast agent --effectively reducing image noise while preserving iodine signal. The quality of each scan improves through non-linear comparisons with scans acquired earlier and later in the exam.

"When we use very low doses, the noise gets so high that it's hard to tell what you are seeing," said Juan Carlos Ramirez Giraldo. "With this algorithm, we're trying to maintain both the image quality, so that a doctor can recognize the anatomic structures, and the functional information, which is conveyed by analyzing the flow of the contrast agent over the many low dose scans."

Pediatric Cardiac Intensivist

The Division of Pediatric Cardiology at the University of Miami Miller School of Medicine is seeking an additional Pediatric Cardiologist with a focused interest and experience in pediatric cardiac critical care.

Candidate must have an M.D. degree, be board certifi ed/eligible in pediatric cardiology and to have/obtain a Florida medical license. The position is at the level of Assistant or Associate Professor of Clinical Pediatrics. The full-time faculty member will serve as attending physician on our multi-disciplinary cardiac critical care service which consists of cardiologists, intensivists and nurse practitioners. Care is provided in a state of the art 30-bed ICU with an adjoining pediatric catheterization lab and 2 pediatric cardiac operating rooms. Service time will be on the cardiac critical care service, with ample opportunity for participation in outpatient cardiology clinics or other aspects of pediatric cardiology practice as tailored to individual experience and interest. Our program cares for the full spectrum of pediatric heart disease, which includes a long standing cardiac transplantation service with state of the art ECMO and VAD availability.

Teaching is central to this appointment where the as the candidate will educate pediatric cardiology and critical care fellows, pediatric residents, and nursing staff.

Progress within this position will entail the development of skills in one or more of the following areas: (1) clinical education, (2) clinical research, and (3) basic science research. Suffi cient time and support to successfully develop these skills in the chosen areas will be provided by the appropriate senior division staff. Opportunities are available for participation in administrative activities within the Holtz Children’s Hospital at the Jackson Memorial Medical Center and/or Department of Pediatrics as assigned by the Chair of Pediatrics or designee.

Interested personnel should contact William G. Harmon, M.D., Chief of the Division of Pediatric Cardiology (305) 585-6683; wharmon@med.miami.edu

The University of Miami Miller School of Medicine is an equal opportunity/affi rmative action employer. Women, minorities, veterans, and disabled persons are encouraged to apply.

CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010 17

2011

15th Annual Update on Pediatric and Congenital Cardiovascular DiseaseFebruary 2 – 6, 2011 • Scottsdale, Arizona • www.chop.edu/cardiology

At the AAPM meeting, the researchers will present animal data showing the effectiveness of the technique. They have also begun to process data from clinical brain perfusion CT exams in patients.

"We're up to 15 or 20 cases that we've shown to the docs, and they're all giving us the thumbs up," said McCollough.

The presentation "20-Fold Dose Reduction Using a Gradient Adaptive Bilateral Filter: Demonstration Using in Vivo Animal Perfusion CT" by J Ramirez Giraldo et al. was presented in July 20 in the Philadelphia Convention Center.

ABSTRACT: aapm.org/meetings/amos2/pdf/49-12884-22113-304.pdf

18 CONGENITAL CARDIOLOGY TODAY www.CongenitalCardiologyToday.com September 2010

Medical Director of Cardiothoracic ICU The Heart Center at Nationwide Children's Hospital, pediatric teaching facility for the Ohio State University in Columbus Ohio, is recruiting for a Medical Director of the Cardiothoracic Intensive Care Unit (CTICU). Candidates must embrace a culture of quality of care and patient safety and should be prepared to lead administratively, clinically, and academically a group of 8 cardiac intensivists (training in Cardiology/ICU, CCM, Anesthesiology), 7 dedicated nurse practitioners and support team committed to the CTICU. The current 10+ bed independently-managed CTICU will expand to a 20 bed unit in 2012 when we move into our new children's hospital. Current annual clinical metrics include: 450 cardiac/thoracic surgeries, 600 catheterizations, 10,000 cardiology outpatient visits. We have an active hybrid palliation of single ventricle program, heart/heart-lung/lung transplantation programs, blood conservation strategies and manage a large number of adult patients with an on-campus adult CHD program as examples of our clinical innovations. We have a pediatric and pediatric/adult combined cardiology fellowship program. We participate in numerous multicenter clinical trials and quality initiatives. We are directly linked to our Center for Cardiovascular and Pulmonary Research which has recently been award a NIH T-32 training grant.

Interested candidates are encouraged submit their curriculum vitae to: Timothy F. Feltes, MD

Nationwide Children’s Hospital700 Children’s Drive ED 617

Columbus, Ohio 43205 or email: timothy.feltes@nationwidechildrens.org

The Ohio State University is an Equal Opportunity, Affirmative Action Employer. Women, minorities, veterans, and Individuals with disabilities are encouraged to apply.

OCTOBER 11-15, 2010 ● CHICAGO

A BOARD REVIEW COURSE PRESENTED BYAmerican Academy of Pediatrics Section on Cardiology & Cardiac Surgery

― in collaboration with ―Society of Pediatric Cardiology Training Program Directors

Discounts for early registration and AAP section members available.

http://aap.org/sections/cardiology/pediatric_cardiology

CONGENITAL CARDIOLOGY TODAY

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Editorial Board: Teiji Akagi, MD; Zohair Al Halees, MD; Mazeni Alwi, MD; Felix Berger, MD; Fadi Bitar, MD; Jacek Bialkowski, MD; Philipp Bonhoeffer, MD; Mario Carminati, MD; Anthony C. Chang, MD, MBA; John P. Cheatham, MD; Bharat Dalvi, MD, MBBS, DM; Horacio Faella, MD; Yun-Ching Fu, MD; Felipe Heusser, MD; Ziyad M. Hijazi, MD, MPH; Ralf Holzer, MD; Marshall Jacobs, MD; R. Krishna Kumar, MD, DM, MBBS; Gerald Ross Marx, MD; Tarek S. Momenah, MBBS, DCH; Toshio Nakanishi, MD, PhD; Carlos A. C. Pedra, MD; Daniel Penny, MD; James C. Perry, MD; P. Syamasundar Rao, MD; Shakeel A. Qureshi, MD; Andrew Redington, MD; Carlos E. Ruiz, MD, PhD; Girish S. Shirali, MD; Horst Sievert, MD; Hideshi Tomita, MD; Gil Wernovsky, MD; Zhuoming Xu, MD, PhD; William C. L. Yip, MD; Carlos Zabal, MD

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