confidential pg 1 alzheimer’s disease international toronto march 27, 2011 gillian rowe 1,2,...
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CONFIDENTIAL Pg 1
Alzheimer’s Disease InternationalToronto March 27, 2011
Gillian Rowe1,2, Angela K. Troyer1, Kelly J. Murphy1,2, Lynn Hasher2,3, & Renee Biss2
Gillian Rowe1,2, Angela K. Troyer1, Kelly J. Murphy1,2, Lynn Hasher2,3, & Renee Biss2
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Implicit Processes Enhance Cognitive Abilities in
Amnestic-Mild Cognitive Impairment
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Acknowledgements
Brian RichardsGuy Proulx
Morris Goldenberg Medical Research Endowment
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Conflict of Interest Disclosure
Gillian Rowe, Ph.DAngela Troyer, Ph.DKelly Murphy, Ph.D Lynn Hasher, Ph.D Renee Biss, M.A.
Has no real or apparent
conflicts of interest to report.
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Background and Purpose
• Pattern of impaired explicit and intact implicit memory observed in individuals with aMCI
• Can be thought of as conscious and unconscious
• Research/interventions often target impaired abilities•May be effortful and possibly distressing
• Instead, can we use implicit processes to influence explicit•Enhance explicit without effort or awareness
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• Previously shown with healthy older adults Rowe et al., 2006
• Known to be more susceptible to distraction than younger
• Evidence they pick up irrelevant information implicitly
• Use that information for later task if it becomes relevant
•Without awareness
Background and Purpose
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• People with aMCI also susceptible to distraction
• Would same effect be found?
• If so, possible opportunities for intervention in aMCI
•Everyday memory
•Autobiographical memory
•Prospective memory
Background and Purpose
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• Used adaptation of earlier work• Participants
– 22 aMCI
– 22 matched healthy controls
• Same/different judgments of consecutive stream of line drawings. Ignore letter strings
E M B L E M L O T T E R YH F X V V
L I V E R
Method
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• 10 min filler - computerized Corsi Block task
Method
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Word-Fragment Completion Task
E _ _ _ E R E R A S E R
S U _ _ L Y S U P P L Y
W I _ _ E R W I N N E R
L I _ _ R L I V E R
A _ _ I T _ O N A M B I T I O N
E _ _ _ E M E M B L E M
_ _ A M _ S T A M P
L _ T _ E _ Y L O T T E R Y
_ R _ V _ G R A V Y
Method
30 word fragments
10 words told to ignore
10 not seen earlier
10 easy fillers
Say first thing came into head
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Word-Fragment Completion Task
E _ _ _ E R E R A S E R
S U _ _ L Y S U P P L Y
W I _ _ E R W I N N E R
L I _ _ R L I V E R
A _ _ I T _ O N A M B I T I O N
E _ _ _ E M E M B L E M
_ _ A M _ S T A M P
L _ T _ E _ Y L O T T E R Y
_ R _ V _ G R A V Y
Method
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Results
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CONTROLS aMC!
% P
rim
ing
More words fragments solved for previously seen words
Significantly more for aMCI group compared to controls
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• Correlation between implicit and explicit memory (aMCI)
Results
CBT
Primin
g
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• Similar paradigm using everyday situation/materials
• Virtual shopping mall• Explicit task: list of items to buy • Test for irrelevant information
How can this be applied to everyday and autobiographical memory?
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Acknowledgements
Brian RichardsGuy Proulx
Morris Goldenberg Medical Research Endowment