© 2 0 1 6 S K I N C E U T I C A L S A L L R I G H T S R E S E R V E D • W W W. S K I N C E U T I C A L S . C O M • 8 0 0 . 8 1 1 . 1 6 6 0

S 2 3 7 6 1 0 0

REFILLEDANTI -AGING TREATMENT TO REF ILL CELLULAR L IP IDS AND NOURISH SK IN

TRIPLE LIPID RESTORE 2:4:2

MAXIMIZED CONCENTRATION

2% CERAMIDES4% NATURAL CHOLESTEROL2% FATTY ACIDS

FULLNESS RESTORED

TEXTURE RESURFACED

RADIANCEREDISCOVERED

COMPREHENSIVE REGIMEN FOR ANTI-AGING CORRECTION AND NOURISHMENT

TRIPLE LIPID RESTORE 2:4:2

Anti-aging treatment to refill cellular lipids and nourish skin

AM + PM

PHYSICAL FUSION UV DEFENSE SPF 50 Provides broad spectrum protection and enhances natural skin tone to boost the appearance of radiance

AM

C E FERULIC®

Daytime antioxidant serum delivers advanced environmental protection, while reducing the appearance of fine lines and wrinkles

AM

LOSS OF FACIAL FULLNESS

ROUGHNESS UNCOMFORTABLETIGHTNESS

DULLNESS

Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin, present in the form of ceramides, cholesterol, and fatty acids. This lipid loss compromises skin’s natural protective barrier, resulting in signs of accelerated aging as skin loses its ability to effectively self-repair.

LIPID DEPLETION ULTIMATELY LEADS TO THE

APPEARANCE OF ACCELERATED AGING

SIGNS OF ACCELERATED AGING DUE TO LIPID DEPLETION

Protocol: A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30.Inclusion Criteria: Females ages 55-75 with moderate fine lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

BEFORE

AFTER

8 WEEKS

Above-average results shown for skin evenness and overall radiance. Average results shown for other criteria.

CLINICAL RESULTS

VISIBLE RESULTSIMPROVEMENT IN SKIN EVENNESS AND OVERALL RADIANCE

TRIPLE LIPID RESTORE 2:4:2ANTI-AGING TREATMENT TO REFILL CELLULAR LIPIDS AND NOURISH SKIN

2% : 4% : 2%PURE

CERAMIDESNATURAL

CHOLESTEROLFATTY ACIDS

MAXIMIZED CONCENTRATION OF LIPIDS

Triple Lipid Restore 2:4:2 is formulated in a

cholesterol-dominant ratio with a maximized

concentration of reparative lipids: 2% pure

ceramides, 4% natural cholesterol, and 2% fatty

acids. This unique formulation works to restore

skin’s external barrier, support natural self-repair,

and nourish skin to improve signs of aging.

CORRECT NOURISH

ACTIONS IN SKIN

+30%

+39% improvement in hydration at 24 hours

Protocol: Lipidomics analysis on 28 females ages 55-75. Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2.

Protocol: Corneometer and TEWL measurements on 25 females ages 55-75. TEWL measurement statistically significant at 1 hour.

Protocol: Corneocyte double staining on 26 females ages 55-75. Corneocytes were isolated by tape stripping and stained with nile red and involucrin antibody. Staining intensity was measured microscopically.

+66%IMPROVEMENT IN SMOOTHNESS

+26%IMPROVEMENT IN

RADIANCE

+35%IMPROVEMENT

IN LAXITY

CHOLESTEROL is a

naturally-occurring lipid

+57% increase in ceramides

+50% increase in cholesterol

+12% increase in fatty acids

1 REFILLS ESSENTIAL SKIN LIPIDS

RESTORES EXTERNAL BARRIER2

2x improvement in barrier quality (represented by ratio of mature corneocytes)

SUPPORTS NATURAL REPAIR3

BEFORE

8 WEEKS

GREEN: IMMATURE CORNEOCYTE

RED: MATURE CORNEOCYTE

immediate improvement in barrier recovery