WELCOME

To my Presentation

Presentation Topic

Compartmental Analysis

NameBisshojit Biswas Student of pharmacy, Final

year.

Pharmacokinetic Model

A Pharmacokinetic model may be defined as complex biological

system which describes the-

Movement of drugs

Absorption of drugs

Distribution of drugs

Elimination of drugs from one or more compartments

Fate Of Drug In The BodyADME:-

Oral Administrati

on

GI Tract

Exec

ratio

n

IntravenousInjection

Circulatory system

Intramuscular injection

Subcutaneous injection

Tissues Metabolic Sites

Pharmacokinet ic Model ing

A Model is a hypothesis using mathematical terms to describe

quantitative relationships

Modeling Requires: Thorough knowledge of anatomy and physiology

Understanding the concepts and limitations of mathematical models

Assumptions are made for simplicity.

Classif ication Of Pharmacokinetic Model

Pharmacokinetic Model

Compartmental Model

Mammillary Model Catenary Model

Physiologic Model

Classif ication of Mammilary Model

Mammilary model

One compartment open model

Two compartment model

Three compartment model

Compartment Model

Describes the pharmacokinetics of drug disposition by grouping body

tissues that are kinetically indistinguishable & describes the transfer of drug

between body tissues in terms of rate constants.

The model is an open system since drug is eliminated from the system.

The amount of drug in the body is the sum of drug present in the

compartments.

Compartmental Model

Extrapolation from animal data is not possible because the

volume is not a true volume but is a mathematical concept.

Parameters are kinetically determined from the data.

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