common lab sourcesatlas.physics.arizona.edu/~shupe/physics_courses/phys... · 2012. 4. 6. ·...
TRANSCRIPT
![Page 1: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/1.jpg)
1
Common Lab Sources
![Page 2: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/2.jpg)
2
Radioactive Sources
![Page 3: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/3.jpg)
3
Radionuclides in the AZ Particle Lab
Gamma60Co @ 1uC241Am, 133Ba, 137Cs, 60Co, 88Y, 22Na, 64Mg, 203Hg, 57Co @ 10 uC
X-ray55Fe
5.90 keV (24.4%) and 6.49 keV (2.86%)
Beta90Sr/90Y @ 50 mCi, 5 mCi, 2mCi, 0.5mCi
Alpha241Am @ 5 mCi
![Page 4: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/4.jpg)
4
Radionuclides in MedicineNuclear medicine
Diagnostic Permits functional imaging (biochemistry and metabolism versus anatomical structure)>80% of all procedures use 99mTc
RadiotherapyTherapeutic
Primarily for cancer treatmentExternal beam – teletherapy using 60Co unitsInternal – brachytherapy using small, encapsulated sources
Notes90% of all radionuclide use in medicine is diagnosticUse of term “radioisotope” is commonWill there be a shortage of radionuclides in the future?
![Page 5: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/5.jpg)
5
Radionuclides in MedicineGeorge de Hevesy
Nobel in 1943 for use of isotopes as tracers for chemical processes
A failed experiment to separate Radium-D (210-lead) from lead (206-lead)The landlady’s leftovers
![Page 6: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/6.jpg)
6
Radionuclides for Diagnosis
What are the characteristics of an ideal radionuclide for diagnosis?
Half-life?Effective half-life 1/τeff = 1/τradioactivity + 1/τbiological
Type and energy of radiation?Production and expense?Purity?Target area to non-target ratio?
![Page 7: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/7.jpg)
7
Radionuclides for Diagnosis
The ideal gamma energy (for gamma camera use) is between 100 and 250 keV
![Page 8: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/8.jpg)
8
Nuclear Medicine99mTc is used in ~ 80% of diagnostic procedures
99mTc pertechnetate (TcO4-) is mixed with an
appropriate pharmaceutical (biological construct) for use for
Cardiac imaging and functionSkeletal and bone marrow imagingPulmonary perfusionLiver and spleen functionCerebral perfusionMammographyVenous thrombosisTumor location
![Page 9: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/9.jpg)
9
Technetium – 99mHalf-life t1/2=6.02 hrsDecay scheme
Which is (are) the medically useful gamma(s)?
![Page 10: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/10.jpg)
10
Technetium – 99mA closer look
There is no γ1emission, it IC’sIC competes with γ2
IC competes with γ3
X-ray and Auger electron emission can also occur
![Page 11: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/11.jpg)
11
Radionuclides for TherapyBrachytherapy
Brachys = shortBrachytherapy uses encapsulated radioactive sources to deliver a high dose to tissues near the source
Provides localized delivery of doseBut the tumor must be well localized and small
Proposed by Pierre Curie and, independently, Alexander Graham Bell shortly after the discovery of radioactivityInverse square law determines most of the dosimetric effect
![Page 12: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/12.jpg)
12
Brachytherapy
Used to treat a variety of cancers ProstateGynecologicalEyeSkin
Only ~10% of radiotherapy patients are treated via brachytherapy
![Page 13: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/13.jpg)
13
BrachytherapySources
Most of the sources used emit gammasLower gamma energies are preferred for radioprotection
![Page 14: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/14.jpg)
14
Brachytherapy
SourcesBut a few emit betas
90Sr/90Y for eye lesions90Sr/90Y , 90Y, 32P for preventing restenosis after angioplasty
In general, alphas and betas are absorbed by encapsulation to avoid tissue necrosis around the source
![Page 15: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/15.jpg)
15
Nanotargeted Radionuclides
Use monoclonal antibodies to carry a radionuclide payload
![Page 16: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/16.jpg)
16
BrachytherapySources
226Ra -> 222Rn + α -> … -> 206PbAlthough rarely used now, it’s a good reaction to know given its historical significance
![Page 17: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/17.jpg)
17
BrachytherapySources
226Ra -> 222Rn + α -> … -> 206PbWhich equilibrium is achieved (t1/2(226Ra) = 1600 years)?222Rn is a radioactive gasAbout 50 gamma energies are possible ranging from 0.184 to 2.45 MeV, though on average there are 2.2 gammas emitted for each decay The average energy (filtered by 0.5 mm of Pt) is 0.83 MeVThe exposure rate constant (assuming 0.5 mm of Pt) is Γ = 8.25 R-cm2/hr-mCi
![Page 18: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/18.jpg)
18
BrachytherapySources
More modern replacements for 226Ra are 137Cs
Familiar gamma ray spectrum with E=0.662 MeVt1/2=30 yrs and Γ=3.26 R-cm2/hr-mCi
and 192IrMore complicated gamma ray spectrum with <E> = 0.38 MeVt1/2=73.8 days and Γ=4.69 R-cm2/hr-mCi
![Page 19: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/19.jpg)
19
Brachytherapy
Methods of deliveryLDR (0.4-2 Gy/hr) versus HDR (> 12 Gy/hr)Temporary versus permanentIntracavity versus interstitial
Also surface, intraluminal, intravascular, intraoperative
Seeds, needles, tubes, pellets, wire
![Page 20: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/20.jpg)
20
Brachytherapy
![Page 21: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/21.jpg)
21
Radionuclide Production
How are radionuclides made?Primary sources
Nuclear reactors235U fission produced Neutron activatedBoth produce neutron rich radionuclides
CyclotronsUses charged particle beams (p, d, t, α)Produces proton rich radionuclides
Secondary sourceRadionuclide generators
![Page 22: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/22.jpg)
22
Nuclear Fission
Fission of 236U* yields two fission nuclei plus several fast neutrons
![Page 23: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/23.jpg)
23
Nuclear Reactors
Nuclear reactor schematic
![Page 24: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/24.jpg)
24
Fission ProductionNuclei such as 99Mo, 131I, and 133 Xe are produced in the fission products using an enriched 235U target (HEU – 90%)Complex chemical processing (digestion or dissolution) and purification separates the 99Mo from chemically similar elements and radiocontaminents
The result is a high specific activity (Bq/kg), carrier free nuclide
This means there is no stable isotope of the element of interestSome negatives are the potential proliferation of HEU targets and radioactive waste
![Page 25: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/25.jpg)
25
Neutron ActivationAn alternative use of reactors is to produce radionuclides via neutron activation
Two drawbacks of this method areSmall activation fractionChemically similar carrier that cannot be separated
( )( ) ( )( ) IXenXe
PnPMonMo
XnX AX
AX
12553
12554
12454
3215
3115
9942
9842
1
,
, ,,
,
→
+
γ
γγ
γ
![Page 26: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/26.jpg)
26
Cyclotrons
We will cover accelerator physics later in the course
![Page 27: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/27.jpg)
27
Cyclotron ProductionCyclotron energies can be a few MeV to a few GeV
Laboratory/university or hospital basedBeam currents of 40-60 uAProduces Ci-level radioisotopes
FnpO
OnpN
NpO
CpN
189
188
158
157
137
168
116
147
),(
),(
),(
),(
α
α
Siemens Eclipse
![Page 28: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/28.jpg)
28
Cyclotron ProductionThe reactions shown on the previous page
Are proton rich -> decay by e+ emission or EC18F is the most common radionuclide in PET oncology
Are important elements of all biological processes hence make excellent tracers
18F is used to label FDG (18F-fluorodeoxyglucose)Useful because malignant tumors show a high uptake of FDG because of their high glucose consumption compared with normal cells
Have short lifetimes (O(minutes))Except t1/2 for 18F = 110 minutes
![Page 29: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/29.jpg)
29
Cyclotron Production18F in PET/CT
![Page 30: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/30.jpg)
30
Cyclotron Production
Alzheimer’s diagnosis
![Page 31: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/31.jpg)
31
Radionuclide GeneratorsGenerates a radionuclide by exploiting transient equilibrium
Most important application are moly generators 99Mo (67 hours) decaying to 99mTc (6 hours)
Sodium pertechnetate (NaTcO4) results which can then be combined with an appropriate pharmaceuticalDeveloped at BNL, a particle and nuclear physics labOther generators also exist (69Ge to 68Ga, 82Sr to 82Rb, …)
![Page 32: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/32.jpg)
32
Radionuclide GeneratorsProcedure
A glass column is filled with aluminum oxide that serves as an adsorbentAmmonia molybdenate attaches to the surface of the resinA sterile saline (the eluant) solution is drawn through the columnThe chloride ions exchange with the TcO4
- but not the MoO4-
The elute is thus Na+TcO4- (sodium
pertechnetate)
![Page 33: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/33.jpg)
33
Radionuclide Generators
Technetium cow
![Page 34: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/34.jpg)
34
Radionuclide Generators
Generator schematic
![Page 35: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/35.jpg)
35
Radionuclide Generators
Generally shipped weekly and milked daily
![Page 36: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/36.jpg)
36
Gamma CameraThese images are made using gamma cameras
We will cover the details of these (and similar detectors) in upcoming lectures
![Page 37: Common Lab Sourcesatlas.physics.arizona.edu/~shupe/Physics_Courses/Phys... · 2012. 4. 6. · Alexander Graham Bell shortly after the discovery of radioactivity ... The exposure rate](https://reader033.vdocuments.site/reader033/viewer/2022060604/6059149f2a7e425bb1457748/html5/thumbnails/37.jpg)
37
Gamma CameraA schematic of a standard gamma camera