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Vol - 1 Issue - 1 April - June 2016
Editorial
Teratogenic Drugs in Pregnancy and
Lactation (Raipuar leh nau hnutetui pe
lai tana damdawi hlauhawmte)
Common drugs use and counseling
tips for Pharmacists.
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Common Drugs Use and Counseling Tips for Pharmacists.
Vol - 1 Issue - 1 April - June 2016
Generic Trade names Therapeutic use Classification Counseling tips
Ciprofloxacin
Ciplox, Cifran OD, Ciprodac, Wyserin, etc.
Anti-infective Fluoroquinolone antibiotic
Finish course as prescribed. Moni-tor glucose. Do not take within 2 hours of consuming foods or other products containing di- or trivalent cations (ex. milk, calcium antacids, multivitamins and supplements). May cause sun sensitivity and CNS side- effects. FDA requires assess-ment of risk of QTc prolongation. Black box warning for tendonitis/tendon rupture. Available orally and in ophthalmic and otic suspen-sions.
Metronidazole Metrogyl, Flagyl, Aristogyl, etc.
Anti-infective Antibacterial, Antiprotozoal
Finish course as prescribed. Avoid alcohol during therapy and for 2 days after. May discolor urine red-dish-brown.
Azithromycin
Azithral, Azibac, Azowok, Azyxin, Rulide AZ, etc
Anti-infective Macrolide antibiotic
Finish course as prescribed. No CYP 3A4 inhibition. QT prolonga-tion possible. Opthalmic solution, Azasite, is refrigerated.
Amoxicillin + Clavulanate
Inclav, Amoxiclav, Augmentin, Clavam, etc
Anti-infective Penicillin antibiotic
Finish course as prescribed. May
cause GI upset; take with food.
More likely to have diarrhea be-
cause of clavulanate- maintain hy-
dration. Clavulanic acid doses vary
among formulations; double-check
if using alternate formulation to
achieve prescribed dose (ex.
400mg-57mg/5ml suspension can-
not be substituted for 600mg-
42.9mg/5ml suspension). Shake
susp well and keep refrigerated,
note exp. date after reconstitution.
8th Sem. B.Pharm. students, RIPANS giving
counselling to ambulatory and inpatients at Aizawl Hospital Acyclovir
Herperax, Acivir, Cyclovir, Docvir DT, Herpex
Anti-infective
Antiviral against HSV
Available topically and orally. Avoid intercourse during herpes outbreaks. Dose and duration de-pends on indication. CNS side- ef-fects especially in elderly and renal impairment. Interacts with herpes zoster vaccine. Stay well hydrated.
Vol - 1 Issue - 1 April - June 2016 Vol - 1 Issue - 1 April - June 2016
Editorial
From the Editor in Chief Dr. Chawngthanliana. Director, RIPANS.
It gives me immense pleasure to introduce the first edition of Drug Information Bulletin by the Dept. of Phar-macy, RIPANS. I hope this bulletin will benefit all the readers. Pregnant and lactating mothers should be very cautious on taking drugs. Although the drugs may have cured the mother, the same drug can cause different health problems and/or even physical/mental abnormali-ties to the fetus or the lactating baby, the article in this bulletin examines the drugs use in pregnancy and lacta-tion, I hope it will be a good information to the readers.
Drug Information Bulletin vawikhatna Dept. of Pharma-
cy, RIPANS in kan tichhuak thei hi a lawmawm ka ti hle mai. A
chhiartu zawng zawngten he bulletin hi an hlawkpui ngei ka beisei.
Nu naupai lai leh nau hnute pe laite tan bik hian
damdawi ei fimkhur a ngai hle mai. Damdawi eitute kha lo dam
pawh ni se, a taksa chhunga naute insiam mek emaw, a naute
chawm lai mekah harsatna leh piansualna a thlen hlauh thei thung a
ni tih hre rengin he bulletin a article hi ngun takin chhiar theuh ila,
kan hlawkpui ngei ka beisei.
From the Editor’s desk Dr. H. Lalhlenmawia. Head, Dept. of Pharmacy, RIPANS.
Every woman in the general population has
a 3–5% risk of having a child with a birth
defect or mental retardation. Two im-
portant factors to consider when assessing
the teratogenic potential of a medication
are the stage of pregnancy at which the
exposure occurred and the amount of medi-
cation taken. If a pregnant or breast feed-
ing patient who is currently taking, or con-
sidering taking a medication, the patient
needs to know about potential adverse
effects the medication could have on her
fetus or infant. The USFDA pregnancy
safety category (A,B,C,D & X) of the pre-
scribed or OTC drugs should always be
kept in mind when taking medications dur-
ing pregnancy. Children are the blessing
from above, maintaining their health and
welfare is the responsibility of every par-
ents from the time the baby in in the moth-
er’s womb. Prevention as far as we can is
always the better cure every now and then.
Raipuar reng reng hian za-ah 3-5%
thleng hian pianphung leh rilru lama ru-
albanlo fa hrin theihna chance an nei a.
Naute tana pawi thei damdawi
(teratogenic) raipuarin a ei hian a naupai
rei tawh dan a zirte leh damdawi a ei zat
a zirin a hlauhawm dan a inanglo thei a
ni. Raipuar leh nau hnutetui pe laiin
damdawi a ei a ni emaw ei a tum anih
reng rengin naute a damdawi nghawng
thalo awm theite a hre tur a ni a. Rai lai
chuan USFDA ten raipuarte tana
damdawi him leh himloh dan zirin an
thenhranna (category A,B,C,D &X) uluk
taka zirchiangin damdawi reng reng kan
ei thin tur a ni. Naupangte hi chunglam
malsawmna, kan rohlute an ni a, nu pum
chhunga an awm lai atangin nun hlim leh
hrisel tak an neih theihna tur a tan lak hi
nu leh pa zawng zawng mawhphurhna a
ni. Kan theihna ang chin chinah kan lo
inven hi tihdam aiin a tha a, a la tha zawk
reng zel dawn bawk a ni.
For any query on drugs, (Damdawi chungchangah zawhna I neih chuan):
Mail to- Drug Information Centre The Department of Pharma-cy, RIPANS. Zemabawk, Aizawl. Pin 796017
Email: [email protected]
Facebook page: DRUG INFORMATION CENTRE,RIPANS. SMS: 8730955168 Please log in to the website: www.ripans.in
Dr. H. Lalhlenmawia
Executive editor Drug Information Bulletin
Teratogenic Drugs in Pregnancy and Lactation
(Raipuar leh nau hnutetui pe lai tana damdawi hlauhawmte) Dr. C. Zothanmawia*
Nu naupai lai leh nau hnutetui pe lai tan hian ei leh inah fimkhur a ngai em em a, a bikin damdawi hman ngat phei chu fim-
khur a ngai lehzual a ni. Kum 1960-1962 bawr vel khan naupai tan tirh a luhai leh luakchhuak tihrehna atana tha tak (a hunlai a ‘wonder
drugs’ an tih hial) Thalidomide hman a ni a. Nu harsatna chu chhawk tha hle mahse, he damdawi hmang thin nu chuan a fa paiah harsat-
na a thlen ta hlauh thung a, naupang sing chuang chuan kut leh ke a rualbanlohna chikhat ‘phocomelia’ an neih phah a ni. Hetiang nau-
sen a nghawng thalo nei thei hi ‘teratogens’ tih a ni a, tunah hian khawvela drug regulatory authority lian ber leh ramdangte pawhin an
entawn ber US Food & Drugs Administration (USFDA) chuan damdawi reng reng hi raipuar tana hman a him dan a zirin class hrang
hrangah a then vek a. Raipuarin damdawi leh pawn lam thil reng reng a ei zawng zawng deuhthaw hian raipuar leh a pumchhung a naute
daidantu (mother fetal placental barrier) a kaltlang theih avangin fimkhur a ngai em em a ni. Damdawi leh natna, nausen leh nu pum
chhunga awm naute insiam mekte a nghawng thalo nei thei thenkhat lo tarlang ila.
Natna (Teratogenic infections)
Damdawi leh Chemical naute tana pawithlen thei (Known Teratogenic)
Damdawi dang fimkhur ngaihnate (Possible teratogenics)
Cytomegalovirus
Herpes simplex virus I & II
Parvovirus
B-19 (Erythema infectiosum)
Rubella virus
Syphilis (VD/Dadu natna)
Toxoplasmosis
Varicella virus
Venezuelan equine
Encephalitis virus
Busulfan - Bucelon, Mylefan Cigarette Smoking (meizial zuk) Warfarin leh amah ang chi damdawi-Sofarin, Warf, Uniwarfin Cyclophosphamide - Cyclocel, Celomide. Diethylstilbestrol - DES, Stilphostrol. Fluconazol - Nuforce, Rocin, Flunova. Aminopterin - Cancer damdawi Iodides - Potassium Iodide, Sodium Iodide. Isotretinoin - Acnestar, Acotret, Isotane. Methimazole - Methimez, Metnimez. Methotrexate - Methorex, Biotrexate. Ulipristal – Ella. Triazolam - Halcoin, Hypam, Trilam. Simvastatin - Simlo, Starstat, Vastatin, Zosta. Rosuvastatin - Rosulip, Rostar, Razel. Pracastin - Pravator, Prastatin Tazarotene– Tazret, Latez. Misoprostol - Misolup, Mesopil, Mizolast. Penicillamine- Artamin, Cilamin, Penicitin. Phenytoin - Eptoin, Dilantin, Fentoin-ER. Tetracyclines-Achromycin, Lupitterra. Thalidomide- Oncothal, Thycad, Thaloda. Raloxifene-Fiona,Ralofen,Bonmax,Ralosto Trimethadione-Troxidone,Tridione. Valproic acid-Encorate,Apilex,Epival. Stanozolol-Menabol,Neurabol Cap,Tanzol. Flurazepam-Nindral,Fluraz. Clomifene-Fertomid,Folistim,Fertex. Cocaine Acitretin-Acitrin,Zoratame,Acrotac. Ambrisentan-Ambrican,Endobloc, Anastrozole-Anaday,Anabrez,Armotraz. ACE inhibitors (Thisen sang damdawi)- Rami-pril-Cardiopril, Ramil, Corpril. Captopril-Aceten, Capotril. Enalapril-Enam, Hytrol, Lupinace. Lisinopril-Lipril. Androgenic hormones- (Steroids) Nisdrol, Cadec, Cernos, Decasun, Idec,.
Carbamazepine-Antilep,Carmaz, Colchicine-Zycolchin,Goutnil Disulfiram-Esperal, Ulfiram Ergotamine-Vasograin,Migranil Glucocorticoids-Prednisolone-Wysolone,Kidpred; Dexamethasone-Dexona,Wymesone.Hydrocortisone. Lead Primidone-Mysoline. Quinine (suicidal doses) Streptomycin Vitamin A (dose sang tak a eiin) Zidovudine (HIV damdawi) Zinc deficiency (Zinc tlakchhamna)
Radiations (In Hem) USFDA Pregnancy Category
Atomic weapons
Radioiodine
Therapeutic radiation
Cancer enkawlna atana inhem.
Category A: Zirchianna hrang hrang atangin raipuar leh naute tan a him tawka ngaih a ni. Category B: Mihring a zirchianna awmlo mahse ramsa a zirchiannaah chuan nausen tana hlauhawmna hmuh a ni hran lo. Category C: Ramsa a zirchiannaah chuan naute tan nghawng thalo a nei thei tih hmuhchhuah a ni, mihringah zirchianna a awm lo. Nu in a thatpui dawn chuan fim-khur tak a hman tur a ni. Category D: Nauteah nghawng thalo tak a nei theih avangin a tul tawp khawkah chi-ah hman tur a ni. Category X: Nauteah pianphung ru-albanlohna leh nghawng thalo dang a nei thei a, nu nunna in a tuar dawn a nihloh chuan hmanloh hram tur a ni.
*Guest faculty, Dept. of Pharmacy, RIPANS