8/19/2019 Common Drugs & Their Antidotes

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An antidote is a substance that can counteract a form of poisoning. The termantidote is a Greek

word meaning “given against”.

This post will help you familiarize with the common antidotes that are used in the hospital setting.

The following are antidotes that should be familiarized by the nurse to respond to this emergency

situation quickly.

Agent/Drug Antidote

Acetaminophen/Tylenol/Paracetamol acetylcysteine (Mucomyst)

Antcholinesterase atrophine sulfate or pralidoxime

Anticholinergics physostigmine

Benzodiazepines flumazenilBeta blockers glucagon

Calcium channel blockers glucagon

Coumadin/Warfarin phytonadione (Vitamin K.)

Cyanide amyl nitrate, sodium nitrate, sodium thiosulfate

Cyclophosphamide mesna

Digoxin digibind

digoxine immune fab

Dopamine phentolamie (Regitine)

Extrapyramidal symptoms (EPS) diphenhydramine (Benadryl)

Ethylene glycol fomepizole

Fluorouracil leucoverin calcium

Heparin protamine sulfate

Insulin reaction glucose (Dextrose 50%)

Iron deferoxamine

Lead dimercapol, edetate calcium, disodium,

Methotrexate leucovorin calcium

Narcotics naloxone (Narcan)

Neuromuscular blockade (paralytics) anticholinesterase agents

Opioid analgesics nalmefene or naloxone

Potassium albuterol inhaler, insulin & glucose, NaHCO3, kayexalate

Tricyclic antidepressants phyostigmine or NaHCO3