combining dna evidence for greater match information american academy of forensic sciences february,...
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![Page 1: Combining DNA Evidence for Greater Match Information American Academy of Forensic Sciences February, 2012 Atlanta, GA Mark W Perlin, PhD, MD, PhD Cybergenetics,](https://reader035.vdocuments.site/reader035/viewer/2022070305/5513f17855034679748b5c1a/html5/thumbnails/1.jpg)
Combining DNA Evidence for Greater Match Information
American Academy of Forensic SciencesAmerican Academy of Forensic SciencesFebruary, 2012February, 2012
Atlanta, GAAtlanta, GA
Mark W Perlin, PhD, MD, PhDMark W Perlin, PhD, MD, PhDCybergenetics, Pittsburgh, PACybergenetics, Pittsburgh, PA
Cybergenetics © 2003-2012Cybergenetics © 2003-2012
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Two DNA Mixture SamplesCSF locus in PowerPlex 16 kit
Sample 1
Sample 2
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DNA Mixture SeparationDetermine mixture weights of each sample
10% contributor
50% contributor
Sample 1
Sample 2
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Joint Likelihood FunctionJointly explain data of multiple experiments
90%:10%
50%:50%
Sample 1
Sample 2One contributor
genotype10, 11
Another contributorgenotype
12, 12
MW Perlin, MM Legler, CE Spencer, JL Smith, WP Allan, JL Belrose, BW Duceman. Validating TrueAllele® DNA mixture interpretation. Journal of Forensic Sciences, 2011.
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Probabilistic GenotypeThoroughly examine all genotype explanations of the data,
assessing the likelihood of each one
Sample 1
Sample 2
Samples 1 & 2
objective
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DNAMatch
Information
Sample 1 - 109.9
Sample 2 - 109.0
Samples 1 & 2
1018.9
1 10 100
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Massereene Barracks Attack
PatrickAzimkar
MarkQuinsey
Real Irish Republican Army claimed responsibility
Homicide victims
March 7, 2009 in Antrim, Northern Ireland
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Abandoned Burned Car
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Touch DNA Evidence
passenger sidesafety belt buckle
cell phone incenter console
match stickat side of road
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Data Ambiguity
DNAmixture
low DNAquantity
alleledrop out
D21 D18D8
vWAD3 D18 D2
FGATH01D18no DNAvisible
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Much Data,Little Consensus
No Match Statistic
a b c
0 2 1
BrianShivers
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Joint Likelihood Function
TH01 locus3 amplifications
a
b
c
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Combining DNA Evidence
a
b
c
a
b
c
a b
a
c
singles pairs all threedata
10 20 30
b
c a b c
1.1 million
6.04
STR tests
40,000
4.60
26,000
4.42
560
2.75
25
1.40
27
1.43
6
0.75
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Computer's Match Statistics
5.91 trillion
6.01 billion
1.1 million
ColinDuffy
BrianShivers
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Admissibility Ruling
I am satisfied that the stage has now been reached in the case of this system where it can be regarded as being reliable and accepted, and I am satisfied that Dr Perlin has given his evidence in a credible and reliable fashion. In the light of these conclusions I can see no basis on which I could properly exercise my discretion … to exclude this evidence, and I therefore admit it in evidence.
December 1, 2011The Honorable Mr. Justice Hart
18 page ruling on TrueAllele, concluding:
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E Pluribus Unum
www.cybgen.com/information
Out of many experiments, one informative solution