INSTITUT’ DERMEDCOLLEGE OF ADVANCED AESTHETICS

Hyperpigmentation Defined

770.454.77885589 Peachtree Rd.Atlanta, GA 30341

idermedskincaretraining.com

© 2010 - 2011 Institut’ DERMed

OUR MISSION IS TO HELP YOU CREATE A UNIQUE MEDICLINICAL SPA EXPERIENCE THAT SUPPORTS WELLNESS, ENHANCES BEAUTY,

AND INCREASES INNER VITALITY.

Clinical skin care is rapidly emerging as the standard in aesthetics, thanks to baby boomers driven to achieve a more youthful and healthy appearance.Today’s licensed skin care professional must be equipped to recognize common skin conditions, develop treatment plans, and meet the growing need for skin rejuvenation. These skills are often not taught in primary aesthetic curriculums. Therefore, the marketplace relies on advanced aesthetic education to deliver the knowledge and skills necessary to perform results-oriented services.

In 1994, Lyn Ross, Master Esthetician with over 27 years of skin care experience, recognized the need for clinical skin care education supported by cosmeceutical product formulations. Lyn founded the Institut’ DERMed College of Advanced Aesthetics (IDCAA), offering post-graduate programs for licensed estheticians, cosmetologists, nurses and physicians.

We are proud to have been one of the leading pioneers in MediClinical Spa training and to have grown the Institut’ DERMed family of companies to include the IDCAA – an internationally respected advanced aesthetic education program, an extensive line of quality cosmeceutical skin care products, and MediClinical Spa Member locations.

Our goal to empower skin care specialists with knowledge and proven treatment systems is the foundation for our continued success. We are passionately committed to advancing your aesthetic skills, increasing your confidence and helping you to expand beyond your current financial potential.

IDCAA graduates see the growth in their business and are true testiments to the fact that knowledge is power.

We look forward to serving you!

Sincerely,

Lyn Ross Founder Institut’ DERMed

INSTITUT’ DERMEDCOLLEGE OF ADVANCED AESTHETICS

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Hyperpigmentation

Hyperpigmentation is the result from over proliferation of melanin within a specific area or region of the body. Melanocytes are the cells responsible in the production of melanin. Each individual is born with the same amount of melanocytes, however genetics determine how much melanin is produced in each individual.

Another name for hyperpigmentation is dyschromia which refers to the condition related to the darkening of the skin. Hyperpigmentation is a common, usually harmless condition in which patches of the skin become darker in color than the normal surrounding skin. Hyperpigmentation can affect the skin color of people of any race.

There are many different forms of hyperpigmentation. Hyperpigmentation can be induced by inflammation, hormones, drugs, and the sun. Treatments vary per condition and depth of pigmented areas. Hyperpigmentation can affect only the epidermis (superficial) or can affect the melanocytes within the dermal layer (deep).

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Freckles are small flat brown marks arising on the face and other sun exposed areas. They are most often seen in fair skinned people, especially those with red hair, but they are an inherited characteristic that sometimes affects darker skin types as well.

The medical term for this type of freckle is ephilis (plural ephilides). The melanin is diffused into the surrounding skin cells, called keratinocytes. The color of ephilides is due to localized accumulation of melanin.

Ephilides do not produce much melanin during the winter months, but produce more when exposed to the sun. Ephilides are more prominent in summer but fade considerably or disappear in winter as the keratinocytes are replaced by new cells.

As the person ages this type of freckle generally become less noticeable. Apart from sun protection, no particular treatment is necessary.

Inherited Hyperpigmentation

Freckles

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Post-inflammatory hyperpigmentation (PIH) causes skin darkening and discoloration that show up as spots or as large patches on a person’s body. This is a result of the melancoyctes going into overdrive and producing too much melanin due to a inflammatory reaction in or to an injury to the skin. If the excess melanin is produced in the upper layer of the skin (epidermis), the pigmentation color is a darker shade of brown. If the excess melanin is produced in the lower layer of the skin (the dermis), a gray blue discoloration becomes visible.

PIH can occur in all skin types but is more common in people of African, Asian and Latino and indigenous Indian background, and can affect men and women equally.

Injury Induced Hyperpigmentation

Post Inflammatory Hyperpigmentation

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When dark changes in your skin’s color remain after the underlying problem has gone away, you have PIH. The most common causes of PIH are injuries such as scratches, burns, cuts, or bruises. Rashes of any type can cause PIH (examples of which include eczema, psoriasis, pityriasis rosea, lichen planus, and fungal infections). Ordinary conditions such as acne or pimples are a very common cause of PIH in individuals with brown skin. PIH can also be caused by injury to the skin resulting from sunburns, surgery or cosmetic procedures such as chemical peels, dermabrasion, lasers and cryotherapy (liquid nitrogen treatments).

Alpha hydroxyl acids are a good starting point for PIH treatment. Alpha hydroxy acids help to speed up the skin’s natural exfoliation process, which can help improve the appearance of PIH. In acneic cases, it is important for the acne lesions to be treated as they occur in order to reduce the occurrence of post inflammatory hyperpigmentation. It is necessary to use a broad spectrum sunscreen daily. The sun may darken discolorations and increase fading time. Acne treatments can typically cause irritation to the skin and as a result irritated skin can lead to PIH; therefore the skin should be monitored closely to adverse reactions to product and the client should be educated properly on the usage and proper disbursement of product.

PIH Continued . . .

Post Inflammatory Hyperpigmentation

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Melasma (also known as chloasma) is a skin condition in which brown patches occur primarily on the cheekbones, forehead and upper lip. It also may develop on the nose chin, lower cheeks and sides of the neck. The dark patches usually have distinct edges. Melasma is seen most frequently in young women taking birth control pills and also occurs commonly during pregnancy. It may develop in association with menopause, hormonal imbalance, and ovarian disorders. Melasma may also be triggered by a medication called Dilantin (phenytoin). In many cases, it occurs without any of these predisposing factors and is occasionally seen in men.

The tendency to develop melasma is genetically predetermined. Persons who have inherited baseline skin color in the very light olive to very dark olive range are particularly susceptible. Melasma has been referred to as the mask of pregnancy because it often develops during pregnancy. Both ultraviolet A (UVA) and ultraviolet B (UVB are believed to contribute to the formation of melasma in predisposed persons.

Melasma

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The pigmentation of melasma may be deposited in one or more layers of the skin. The pigment may be confined to the surface layer of skin, the epidermis. Alternatively, it may be present solely in the inner layer of skin, the dermis. Generally, however, it is present to a greater or lesser degree in both outer layers of skin. The presence of pigment both within the skin’s surface layer as well as deeper within the skin has important implications for melasma treatment.

Melasma develops due to a combination of genetic, hormonal and sun related factors. The main catalyst in melasma prevention is complete sun protection including regular use of broad-spectrum sunscreens and sun protective hats and clothing as well as avoidance of sun within practical limits is necessary. The treatment of existing melasma is based upon this idea of total sun protection as well as the use of products designed to decrease pigment within the surface skin layer.

Melasma Continued . . .

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The keys to melasma prevention and treatment are sun avoidance/protection and skin lightening products. Sunscreen every morning, hydroquinone containing skin bleaches at bedtime or twice daily and vitamin A derivatives nightly as tolerated for persons with melasma. This regimen generally provides visible results within a couple months and optimal results within six months. Chemical peeling is also recommended with either glycolic or tri-chloro-acetic (TCA) acid to speed improvement of melasma. Microdermabrasion has also been found to be helpful in the treatment of melasma especially when used in conjunction with topical products.

Melasma Continued . . .

IMPORTANT NOTE:Treatment results for melasma vary greatly. This is due to the differences in where

the melasma related pigment is located within the skin. Surface pigment is

relatively easily removed by standard treatments but deeper pigment does not

respond to surface treatment. Deeper pigment (dermis) tends to slowly fade

away over months to years if there is complete and consistent sun protection.

People with primarily surface pigment (epidermis) can expect to see more rapid

and dramatic results from treatment than those with primarily deeper pigment.

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RESURFACING AND YAG LASER TREATMENTResurfacing laser treatments penetrate deep into the skin with columns of microscopic light to eliminate the cells that cause melasma. The YAG laser delivers short, intense pulses of light targeted to the melanin in the cells affected by melasma. The laser has no effect on the surrounding skin. The laser treatments are given monthly for a three to four month period, along with topical lightening treatments that are used for a few weeks prior to the laser treatments and continue after laser treatments have been completed.

INTENSE PULSED LIGHT TREATMENTAvoid Sun Exposure. During intense pulsed light (IPL) treatment, a hand-held laser is passed over the skin to target the melanin. IPL treatment has been shown to work best with epidermal type melasma. The light energy heats the melanin cells to destroy them. While IPL is an effective treatment for melasma, be sure to consult with your doctor to determine your type of melasma and whether IPL is right for you.

INTERESTING FACT:One day of unprotected sun exposure in a person prone to melasma can

undo months of treatment, especially in those with a tendency towards

deeper pigment.

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UVA UVB

Epidermis

Dermis

Hypodermis

Sun Induced Hyperpigmentation

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The Six Billion Year Old Star: “The Sun”

The ultraviolet rays that come from the sun are classified into different wavelengths UVA (long-wave) and UVB (short-wave). Most of us are exposed to large amounts of UVA throughout our lifetime. UVA rays account for up to 95% of the UV radiation reaching the Earth’s surface. Most ultraviolet radiation that reaches the earth is UVA with a small amount of UVB. UVB affects the outermost layer of the skin and is responsible in causing us to burn. UVA rays penetrate deeply in our skin and trigger the production of melanin – the pigment that causes our skin to tan. UVA is the dominant tanning ray. Whether tanning is done out doors or in a salon, it can cause cumulative damage over time. A tan results from injury to the skin’s DNA as a result the skin darkens in an imperfect attempt to prevent further DNA damage; which ultimately lead to cell mutations that cause skin cancer. UVA rays are also responsible for speeding up the aging process.

UVA and UVB Rays

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Tanning booths primarily emit UVA. The high-pressure sunlamps used in tanning salons emit doses of UVA as much as 12 times that of the sun. Not surprisingly, people who use tanning salons are 2.5 times more likely to develop squamous cell carcinoma, and 1.5 times more likely to develop basal cell carcinoma. According to recent research, first exposure to tanning beds in youth increases melanoma risk by 75 percent.

UVA And UVB Continued . . .

INTERESTING FACT:According to the American Association of Cancer report, the pursuit of a

bronzed body has become so popular that the indoor tanning industry

estimates that some 30 million Americans visit tanning salons each year.

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Sunscreen’s efficacy has been measured by its sun protection factor, or SPF. SPF does not reflect the amount of protection but rather, it indicates how long it will take for UVB rays to redden skin when using a sunscreen, compared to how long skin would take to redden without the product. For example, someone using a sunscreen with an SPF of 15 will take 15 times longer to redden than without the sunscreen. An SPF 15 sunscreen screens 93% of the sun’s UVB rays; SPF 30 protects against 97%; and SPF 50, 98%. There is no such thing as Complete sun protection!

A sunscreen can not prevent skin damage if it is merely used as a means of staying in the sun longer. The SPF number of a sunscreen does not realistically correspond to the amount of time you can stay out in the sun without burning because sweating, clothing rubbing against the skin and swimming will wear the sunscreen off.

Sun Protection (SPF) And UV Radiation

INTERESTING FACT:The Skin Cancer Foundation maintains that SPFs of 15 or higher are necessary

for adequate protection. (So what is the percentage of protection from a SPF

of 100?)

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There are currently 17 active ingredients approved by the FDA for use in sunscreens. These blockers fall into two categories: Inorganic and Physical. Most UV filters are organic, they form a thin protective film on the surface of the skin and absorb the UV radiation before it penetrates the skin. In contrast, the inorganic sunscreens are insoluble particles that reflect UV away from the skin. Most sunscreens contain a mixture of organic and inorganic active ingredients.

How It Works

FDA-Approved Sunscreens Active Ingredient/UV Filter Name Range Covered Aminobenzoic acid (PABA) UVB Avobenzone UVA1 Cinoxate UVB Dioxybenzone UVB, UVA2 Ecamsule (Mexoryl SX) UVA2 Ensulizole (Phenylbenzimiazole Sulfonic Acid) UVB Homosalate UVB Meradimate (Menthyl Anthranilate) UVA2 Octocrylene UVB Octinoxate (Octyl Methoxycinnamate) UVB Octisalate ( Octyl Salicylate) UVB Oxybenzone UVB, UVA2 Padimate O UVB Sulisobenzone UVB, UVA2 Trolamine Salicylate UVB Titanium Dioxide UVB, UVA2 Zinc Oxide UVB,UVA2, UVA1

INTERESTING FACT:To date, no criteria exist in the U.S. for measuring and labeling the amount of

UVA defense a sunscreen provides. However, the FDA plans to introduce UVA

standards within the next few years. The FDA would assign the sunscreen a 1

to 4 star rating, with 1 star indicating the lowest and 4 the highest amount of

UVA protection.

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A solar lentigo (plural, solar lentigines), also known as a sun induced freckle or senile lentigo is a dark hyperpigmented lesion caused by natural or artificial ultraviolet light. Solar lentigines may be single or multiple. Solar Lentigines are benign, but they do indicate excessive sun exposure, a risk factor for the development of skin cancer. Solar lentigines are caused by a sudden and remarkable increase in the pigments cells, which are, located in the superficial layers of the skin. Sometimes the lesions develop into highly irregular shapes, or their color might change, or gain in thickness.

When treated, it is usually for cosmetic reasons. Cryotherapy has been successfully applied; hydroquinone (bleaching powder) preparations, retinoids, chemical peels or lasers are also found to be effective in treatment. Prevention and sustaining the cure is possible through protecting the skin against any excessive exposure with sunscreen and protective clothing. Wearing long sleeves and sun hats protect the susceptible parts of the body.

Sun Damage: Age Spots (Solar Lentigines)

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Too much sun also causes irregular coloring or pigmentation of the skin. Some areas of the skin appear darker, while others look lighter. The sun canalso cause permanent changes in small blood vessels, giving your skin a reddish appearance.

Melanin is the substance that results in the pigmentation (coloration) of skin cells. Some areas of the skin simply have less melanin than other areas. As the cells containing more melanin come in contact with prolonged periods of sunlight, they become darker. Other areas that have less melanin or that have less exposure to the sun remain lighter. Patches with the most melanin, if not exfoliated regularly can darken considerably when compared to areas with less melanin.

Sun Induced Skin Discoloration

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A Skin Scanner is used as a tool to analyze the skin beyond the “naked eye”. It uses black light that is enclosed within the skin scanner to help the esthetician or skincare specialist look beyond the surface of the skin. Above is a depiction of an illustration of sun damaged skin which is characterized by brown lesions dispersed throughout the face. The left view is what you will see through the “naked eye” and the right view is what is seen when using the black light. What you are seeing in the right view are abnormal cells that have reached the surface that were damaged from UV exposure. These cells are represented by irregular shapes and color.

Sun Damage from UV Exposure

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n Seek the shade, especially between 10 AM and 4 PM.

n Do not burn.

n Avoid tanning and UV tanning booths.

n Cover up with clothing, including a broad-brimmed hat and UV-blocking sunglasses.

n Use a sunscreen with an SPF of 15 or higher every day.

n Apply 1 ounce (2 tablespoons) of sunscreen to your entire body 30 minutes before going outside. Reapply every two hours, or immediately after swimming or excessive sweating.

n Keep newborns out of the sun. Sunscreens should be used on babies over the age of six months.

n Examine your skin head-to-toe every month.

n See your physician every year for a professional skin exam. (Skin Cancer prevention month is in May, get your free screening!)

n Get your sun in moderation; We need the sun for vitamin D!

Prevention Guidelines

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HYDROQUINONEIs a hydroxyphenolic chemical that has been the gold standard for treatment of hyperpigmentation for over 50 years. It acts by inhibiting the enzyme tyrosinase, thereby reducing the conversion of DOPA to melanin. Some of the other possible mechanisms of action are the destruction of melanocytes, degradation of melanosomes, and the inhibition of the synthesis of DNA and RNA.

Hydroquinone can be compounded into 5%-10% concentrations. The higher the concentration of hydroquinone the compound can become unstable and can be more irritating to the client. The 2% concentrations of hydroquinone available over the counter can be used without a prescription and can also achieve results but at a slower rate. Antioxidants, such as vitamin C and retinoids, as well as alpha-hydroxy acids may be used as additives to increase penetration and enhance efficacy.

Prolonged use of hydroquinone has been associated with the development of exogenous ochronosis (a persistent blue-black pigmentation). Other adverse reactions include: irritant and allergic contact dermatitis, and nail discoloration. Postinflammatory hyperpigmentation may occur from the contact dermatitis. Hypopigmentation of the normal skin surrounding the treated areas may also occur. These usually resolve with the discontinuation of the hydroquinone treatment.

Precautions: Do not use benzoyl peroxide, hydrogen peroxide, or other peroxide products when using hydroquinone. A temporary dark staining of the skin may occur. If accidentally used together, wash the skin with soap and water to remove the staining.

Hydroquinone creams may contain sodium metabisulphite that may cause serious allergic reactions (including anaphylaxis) in certain susceptible people.

Hydroquinone should not be used in pregnancy or when breastfeeding.

4% Hydroquinone Products:

* Alustra™ * Solaquin Forte® * Claripel™ * Tri-Luma® * Epiquin Micro * Glyquin® * Eldoquin Forte™ * Lustra® * Eldopaque Forte™ * Lustra-AF™ * Glyquin XM™

Alternative Medicinal Treatment Ingredients

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Kojic AcidKojic acid is derived from Koji (a Japanese mushroom). Kojic acid lightens the skin by inhibiting the production of an enzyme in the skin called tyrosinase which in turn reduces the amount of melanin produced. Kojic acid is one of the most popular natural ingredients found in skin lightening products.

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MulberryThis skin lightening ingredient is extracted from the roots of the paper mulberry plant. Mulberry is said to be more effective than hydroquinone and kojic acid in the sense that significantly lower concentrations are needed to have the same effect as higher concentrations of kojic acid and hydroquinone.

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Alpha ArbutinAlpha arbutin has a stronger effect than beta-arbutin and is also commonly found in skin lightening products as a safer alternative to hydroquinone.

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Beta Arbutin (Bearberry Extract)Beta arbutin (commonly known as just arbutin) is derived from the leaves of bearberry, cranberry and blueberry plants. It works in a similar way to kojic acid, in that it inhibits the production of tyrosinase to restrict the amount of pigment produced. Although naturally derived, it can cause skin irritation in some people with sensitive skin.

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L-ArbutinA natural form of hydroquinone derived from Bearberry Extract also known as uva-ursi resembles the amino acid tyrosinase enzyme to inhibit the production of melanin.

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GlutathioneGlutathione is a powerful antioxidant that has several health benefits including boosting the immune system and cleansing the liver. The only known side effect of glutathione is skin whitening. All these health benefits plus a smooth, glowing, lighter skin tone - amazing! Glutathione is commonly found in skin lightening pills but can also be used topically when found in skin lightening soaps.

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Licorice RootThe main active ingredient found in licorice extract for skin bleaching is glabridin. Glabridin inhibits pigmentation by preventing tyrosinase activation. It is nontoxic to melanocytes, preventing permanent discoloration nor is it toxic to surrounding keratinocytes. In fact, licorice extract has long been purported to have anti-inflammatory properties.

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PapayaThe papain enzyme found in papaya works to gently exfoliate dead skin cells and reveal new, brighter skin cells beneath. Orange and green papaya are both effective but green papaya contains more of the papain enzyme. This ingredient is most often found in soaps but sometimes in skin lightening creams too.

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Vitamin A (Retinol)Vitamin A Acid, also known as retinol or tretinoin increases the rate at which skin cells are renewed. Increased skin cell turnover means that the brighter, fresh skin underneath can be revealed.

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Vitamin B3 (Niacinamide)Niacinamide, also known as Vitamin B3 has antioxidant and anti-inflammatory properties. It is an effective topical skin lightener and works by inhibiting melanin production in the skin. Vitamin B3 is found in some skin whitening products and sun screens but it is also possible to buy Niacinamide capsules where the contents can be applied directly to the skin.

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Vitamin CAt concentrations of about 10%, Vitamin C works to suppress the production of pigment in the skin. Magnesium Ascorbyl Phosphate is a derivative of Vitamin C and this is the form of the ingredient that is commonly found in skin whitening products. Vitamin C can also protect the skin from ultraviolet rays.

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Glycolic AcidAlpha Hydroxy Acid (AHA) derived from sugarcane increases desquamation to lighten the skins surface.

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Salicylic AcidIntensively exfoliates superficial skin cell layers to accelerate the removal of hyper-pigmented brown and red skin discoloration.

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Gallic AcidA plant phenolic compound abundant in pomegranate, strawberry, rhubarb, soybeans, tea leaves, grapes and oak bark, these phenols are known as powerful antioxidants, anti-inflammatory and tyrosinase inhibitors.

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Gluconic AcidA polyhydroxy acid that occurs naturally in fruit, honey, kombucha tea and wine. Known as a gluconolactone used as a tyrosinase inhibitor and UV protector to prevent against photo-aging.

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Azelaic AcidAzelaic acid is an antibacterial and anti-proliferative agent that has anti- inflammation properties. It is commonly used for the treatment of different skin conditions, including acne and rosacea. It does this by facilitating skin renewal, which results in a decrease in blemishes and blackhead development. It also acts to destroy the bacteria before it causes an acne or rosacea outbreak. It has also been used to treat melasma, lentigo maligna and other disorders of hyperpigmention. Its mechanism of action is to inhibit DNA synthesis and mitochondrial enzymes, thereby inducing direct cytotoxic effects toward the melanocyte.

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Vitamin KIts topical application provides protection from UV rays and heals discoloration associated with bruising.

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Mitracarpus Scaber ExtractMitracarpus scaber extract is a botanically derived lightening agent from the leaves of this tropical plant. Like hydroquinone, it prevents the actions of tyrosinase circumventing melanin formation. The active ingredient found in Mitracarpus scaber extract is harounoside, a derivative of hydroquinone. While chemically related to it, Mitracarpus Scaber Extract is less irritating but considered more effective in skin lightening.

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Beta CaroteneThis photoprotection constituent of carrot oil reduces pigment formation by blocking tyrosinase receptors on the melanocyte. In doing so, the enzyme tyrosinase can’t “turn on” the melanocyte to produce melanin.

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SutilainsA member of the keratase family which includes agents like papain, sutilains dissolve the intercellular cement, effectively dissolving the bonds which hold the cells together and easing the desquamation process. Sutilains also improve penetration of ingredients meant to reduce melanin production.

INTERESTING FACT:These ingredients are not usually intended to work in isolation. An effective skin

lightening treatment combines several of these ingredients as they tend to work

well together to produce the desired results.

Introducing:

CHROMABRIGHT™

A CUTTING-EDGE MOLECULE FOR A RADIANT SKIN TONEand a new active for safe skin brightening

Research provided by:

Exclusive N.A. DistributorCENTERCHEM, INC, NORWALK, CT

CHROMABRIGHT™, a new patented molecule for skin brightening:

n Inhibits human tyrosinase activity in vitron Higher melanogenesis inhibition than Arbutin, MAP and Kojic Acidn Same depigmenting activity than Hydroquinone without cytotoxicityn Proven in vivo brightening efficacyn High stability in formulationsn High solubility in oilsn Impeccable safety profile

n Unlike other depigmenting agents that can cause photo irritation, preventing UV- induced skin damage, CHROMABRIGHT™ has a photoprotective effect.

CHROMABRIGHT™ EFFICACYIN VITRO:

n Inhibition of mushroom tyrosinase activityn Inhibition of endogenous human tyrosinase activityn Depigmenting effect on human melanocytesn Melanogenesis inhibition on human epidermal melanocytesn Photoprotective effect on human epidermal keratinocytes

IN VIVO:

n Skin brightening effect on human volunteers n 20 Asian female volunteers aged 18 to 46 used a cream containing 0.1% CHROMABRIGHT™ twice daily during 60 days n The volunteers applied a placebo cream on one side of the face and the cream containing CHROMABRIGHT™ on the other side n The brightening effect was instrumentally evaluated by means of a Chromameter CR-300 n Measurements were taken before application, after 30 days and after 60 days of treatment

n Two parameters were used to evaluate the in vivo effects of CHROMABRIGHT™ on the colour of the skin: n L* (Luminance): represents the relative brightness from total darkness (L*=0) to absolute white (L*=100) n ITAº (Individual Typological Angle): categorizes skin colour, and is obtained combining L* and b*(yellow-blue colour axis) n The brighter is the skin, the higher are the L* and ITAº parameters

n After 30 and 60 days of treatment, a statistically significant increase2 in the L* and the ITAº was observed with the cream containing CHROMABRIGHT™

n The brightening effect of CHROMABRIGHT™ was significantly superior to that of the placebo cream

For more information, call 770.454.7788 or email akim@idermed.com

% of Pigment Reduction

Primary human melanocytes (HEMn-DP) cell cultures were used to compare the skin lightening performance of Hydroquinone, Arbutin, Magnesium Ascorbyl Phosphate (MAP) and Kojic Acid to that of CHROMABRIGHT™ at the same concentration (10μM) for a period of 20 days. As the graph above demonstrates, CHROMABRIGHT™

exhibited a better depigmenting effect than MAP, Kojic Acid and Arbutin, and a had similar efficacy to Hydroquonone.

CHROM

ABRIG

HT™

Hydro

quino

ne

Kojic

Aci

d

Arbut

in

MAP

100

80

40

60

20

0

Chemist’s Clinical Ingredient Research

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Brightening CleanserStart your treatment with this rich, foaming gel cleanser that prepares your skin for treatment by gently removing impurities and revitalizing dull skin for a fresh, luminous complexion.

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Brightening TonerBalance your skin with this pH balancing toner that lightens your skin for a vibrant, more even complexion.

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Vital C SerumTransform your skin’s future with this powerful lightening treatment that stimulates the skin’s immune cells to prevent abnormal melanin production.

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Vital C ComplexTransform your skin’s future with this powerful lightening treatment that targets visible discolorations, and loss of elasticity in photo-aged skin.

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Institut’ DERMed Brightening Products

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Chromabright SerumEven your skin tone with this revolutionary hydroquinone-free serum formulated with Chromabright and Glycolic Acid fades dark brown discoloration and renews the skin’s surface for a radiant, luminous complexion.

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Intensive Brightening SerumTarget stubborn hyperpigmentation with this fast-acting treatment that helps accelerate the exfoliation of dark spots while suppressing melanin production for a more even skin tone.

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Brightening Moisturizer SPF15/28Defend your skin from the sun’s harmful UV rays with this hydrator that provides broad spectrum UVA and UVB protection to prevent discoloration and premature aging for a healthy, vibrant complexion.

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Brightening Eye CreamRedefine your eye area with this luxurious treatment that is formulated with a unique blend of botanical extracts and Lactic Acid to lighten dark circles and smooth the eye contour.

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Brightening PeelExtend professional results at home with this intensive peeling mask that dramatically lightens your skin. Clinically proven active ingredients remove dark, pigmented, dead skin cells to reveal radiant luminous skin.

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Brightening Infusion TreatmentLighten and brighten your skin tone with this potent Arbuten,Kojic and Ascorbic Acid treatment that supresses melanin and slows teh production of pigment to correct and prevent abnormal skin discoloration.

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C+ Peel with ActivatorThis potent proteolytic and keratolytic exfoliator combines both Acids and Enzymes to accelerate the exfoliation of abnormal discolored cells to lighten and brighten photo-damaged skin.

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Ruby PeelThis potent peel blend decongests and clears your skin. It works br removing the top layer of damaged skin cells for fresher, lighter and brighter skin.

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G3 PeelThis gentle Glycolic, Gluconic and Gallic Acid peel formulation is an excellent skin lightening peel. It works by exfoliating environmentally damaged skin cells to lighten, brighten and even the skin tone for a youthful complexion.

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Modified JessnerThis intensive Resorcinol, Lactic and Salicylic Acid peel blend revitalizes your skin. It works by removing layers of skin cells to reveal new healthy cells while re-organizing collagen and elastin networks for a tighter, lighter, younger appearance.

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Non-Resorcinol JessnerThis intensive Lactic, Glycolic and Salicylic Acid peel blend restores your skin. It works by combining three unique peeling solutions for increased penetration to reduce oil and heal acne breakouts for a clean, fresh, clear complexion.

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