colitis indeterminate najib haboubi professor of health sciences, liver and gastrointestinal...
TRANSCRIPT
![Page 1: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/1.jpg)
Colitis IndeterminateColitis IndeterminateNajib HaboubiNajib Haboubi
Professor of Health Sciences, Liver and Professor of Health Sciences, Liver and Gastrointestinal PathologyGastrointestinal Pathology
Head of Surgical pathologyHead of Surgical pathologyTrafford Healthcare Centre.Trafford Healthcare Centre.
UKUK
![Page 2: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/2.jpg)
Overlap in the spectrum of Overlap in the spectrum of non-specific IBD ;non-specific IBD ;
colitis indeterminate (CI)colitis indeterminate (CI)
Ashley PriceAshley Price
J.Clin Path 1978J.Clin Path 1978
![Page 3: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/3.jpg)
Material & MethodsMaterial & Methods330 consecutive cases of 330 consecutive cases of
colectomy or proctocolectomycolectomy or proctocolectomy for UC or CD between for UC or CD between 1960-1973.1960-1973.
30 cases of IBD which could 30 cases of IBD which could not be categorised further and not be categorised further and therefore classified as C1therefore classified as C1
![Page 4: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/4.jpg)
27 out of 30 cases (90%) 27 out of 30 cases (90%)
Were presented as Were presented as acute acute severesevere disease in comparison disease in comparison to (30%) in UC and CD in to (30%) in UC and CD in the same hospital for the the same hospital for the same period.same period.
![Page 5: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/5.jpg)
Indeterminate Colitis in the Indeterminate Colitis in the Spectrum of Inflammatory Spectrum of Inflammatory
Bowel DiseaseBowel Disease
Ken Lee, Alan Medline & Stanley ShockeyKen Lee, Alan Medline & Stanley Shockey
Arch. Path & Lab Med, 1979Arch. Path & Lab Med, 1979
Confirm Price’s observation.Confirm Price’s observation.
![Page 6: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/6.jpg)
ClassicallyClassically CI CI
5-15% of colonic 5-15% of colonic resectates resectates in in IBD.IBD. Mostly seen in the Mostly seen in the severe activesevere active
phase.phase. There is There is histological overlap between histological overlap between
UC and CDUC and CD..
![Page 7: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/7.jpg)
CI CI Not a specific Not a specific pathological entitypathological entity
A condition that ‘awaits final A condition that ‘awaits final diagnosis’ which we may never diagnosis’ which we may never arrive to.arrive to.
Has no specific distinguishing Has no specific distinguishing pathological feature.pathological feature.
![Page 8: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/8.jpg)
Dilated segment (transverse), Dilated segment (transverse), relative rectal sparing, thin wall, relative rectal sparing, thin wall,
severe mucosal ulceration severe mucosal ulceration
![Page 9: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/9.jpg)
HistologyHistology
Severe inflammation.Severe inflammation. In most the process In most the process
is continuous and is continuous and diffuse.diffuse.
Islands of relatively Islands of relatively intact mucosa.intact mucosa.
![Page 10: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/10.jpg)
CI is has no diagnostic CI is has no diagnostic histological featureshistological features
Knife like Knife like ‘stab’ or V ‘stab’ or V types fissures types fissures that may extend that may extend to superficial to superficial muscularis. muscularis.
MyocytolysisMyocytolysis. .
![Page 11: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/11.jpg)
ProblemsProblems Terminology.Terminology. DiagnosisDiagnosis Definitions.Definitions. OutcomeOutcome..
![Page 12: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/12.jpg)
Indeterminate Colitis Indeterminate Colitis
Colitis IndeterminateColitis Indeterminate Fulminant ColitisFulminant Colitis Toxic Mega colonToxic Mega colon Disintegrative ColitisDisintegrative Colitis Acute Severe ColitisAcute Severe Colitis
![Page 13: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/13.jpg)
ProblemsProblems TerminologyTerminology.. DiagnosisDiagnosis Definitions.Definitions. OutcomeOutcome..
![Page 14: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/14.jpg)
Shared features of CD and ICShared features of CD and IC
CDCD Rectal sparing Rectal sparing Deep FissuresDeep Fissures True True
Transmural Transmural inflammationinflammation
ICIC Rectal sparingRectal sparing.. Superficial FissuresSuperficial Fissures False Transmural False Transmural
Inflammation (in Inflammation (in areas of ulcerationareas of ulceration).).
![Page 15: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/15.jpg)
Rectal sparing in Rectal sparing in genuine UCgenuine UC
After topical or systemic After topical or systemic treatment.treatment.
Children at initial presentation.Children at initial presentation.
![Page 16: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/16.jpg)
ProblemsProblems TerminologyTerminology.. DiagnosisDiagnosis DefinitionsDefinitions.. OutcomeOutcome..
![Page 17: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/17.jpg)
Definition 1 (Price 1978)Definition 1 (Price 1978)
AcuteAcute clinical situation. clinical situation. Overlap of histological features of Overlap of histological features of
CD and UCCD and UC . . Surgical Resectates.Surgical Resectates.
![Page 18: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/18.jpg)
Definition 2 St. Marks 1991Definition 2 St. Marks 1991 Cleveland Clinic 1992 Cleveland Clinic 1992
Typically fulminant.Typically fulminant. Resectates. Resectates. Overlapping features.Overlapping features. Further sub classify into Further sub classify into
CI probably UCCI probably UC
CI probably CD CI probably CD
CI ‘unspecified’CI ‘unspecified’
![Page 19: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/19.jpg)
Definition 3 (Kangas 1994)Definition 3 (Kangas 1994)
Patients who had the Patients who had the clinical and clinical and macroscopical features of either CD or UC macroscopical features of either CD or UC both pre and intra operativelyboth pre and intra operatively
AND AND The histology remained indertermined.The histology remained indertermined. They included cases in which the They included cases in which the
diagnosis was based on mucosal biopsiesdiagnosis was based on mucosal biopsies. .
![Page 20: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/20.jpg)
RecommendationRecommendation Mucosal biopsies Mucosal biopsies
CIBD with no distinguishing CIBD with no distinguishing histological features.histological features.
IBD unclassified.IBD unclassified.
![Page 21: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/21.jpg)
Definition 4 (Mayo Clinic 1995)Definition 4 (Mayo Clinic 1995)
Unequivocal diagnosis of chronic Unequivocal diagnosis of chronic UC preoperativelyUC preoperatively but but
inconclusiveinconclusive histology on examiation of histology on examiation of the pathologic specimens the pathologic specimens intra operativelyintra operatively..
![Page 22: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/22.jpg)
Definition 5 (Price 2 1996)Definition 5 (Price 2 1996)
‘‘The inability to make a confident The inability to make a confident diagnosis of the pattern of colitis despite diagnosis of the pattern of colitis despite an adequate surgical resectates or an adequate surgical resectates or adequate mucosal biopsies from the adequate mucosal biopsies from the colon and rectum’colon and rectum’
Resectates and mucosal biopsiesResectates and mucosal biopsies
Not necessarily a surgical acute condition.Not necessarily a surgical acute condition.
Not necessarily cases of IBD.Not necessarily cases of IBD.
![Page 23: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/23.jpg)
Definition 6 Indeterminate colitis,Definition 6 Indeterminate colitis, Montreal Working Party 2005Montreal Working Party 2005
Returned to original definition by PriceReturned to original definition by Price
‘‘should be reserved only for those cases should be reserved only for those cases where colectomy has been performed and where colectomy has been performed and pathologists are unable to make a definitive pathologists are unable to make a definitive diagnosis of either Crohn’s disease or diagnosis of either Crohn’s disease or ulcerative colitis after full examination’ulcerative colitis after full examination’
Satangi J, Silverberg MS, Vermeire S and J-F Colombel. The Montreal classification Satangi J, Silverberg MS, Vermeire S and J-F Colombel. The Montreal classification of inflammatory bowel disease: controversies, consensus and implications. of inflammatory bowel disease: controversies, consensus and implications.
Gut 2006;55:749-753Gut 2006;55:749-753..
![Page 24: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/24.jpg)
ProblemsProblems TerminologyTerminology.. Diagnosis.Diagnosis. Definitions.Definitions. OutcomeOutcome..
![Page 25: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/25.jpg)
Natural History, Variable. Natural History, Variable.
87% will end up with either CD or UC 87% will end up with either CD or UC (Swan et al) after time and careful review.(Swan et al) after time and careful review.
Most polarise into UC. Meucci et al Most polarise into UC. Meucci et al 80% UC.80% UC.
10-40% CD.10-40% CD. Still there is a group of patients who after Still there is a group of patients who after
long term follow up the pathologist and long term follow up the pathologist and the clinician can not put it into either the clinician can not put it into either CD or UC.CD or UC.
![Page 26: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/26.jpg)
Natural History of Natural History of Indeterminate ColitisIndeterminate Colitis
Wells, McMillen, Price, Ritchie & Nicholls.Wells, McMillen, Price, Ritchie & Nicholls.
Br. J. Surgery 1991.Br. J. Surgery 1991.
![Page 27: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/27.jpg)
After mean follow up of 108 months After mean follow up of 108 months and review of histological and review of histological
radiological and clinical dataradiological and clinical data
Group 1Group 1 1919 Probable CD -Probable CD - UC (1)UC (1)
Group 2Group 2 1111 Probable UC - Probable UC - No changeNo change
Group 3Group 3 1616 Indeterminate - Indeterminate - UC (3) UC (3) CD CD
(1)(1)
![Page 28: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/28.jpg)
ConclusionConclusion
Patients continuing with a Patients continuing with a diagnosis of IC are unlikely diagnosis of IC are unlikely to show features of CD on to show features of CD on long term follow-up.long term follow-up.
![Page 29: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/29.jpg)
Current Research and Current Research and Development Development
Serology: ASCA/ANCASerology: ASCA/ANCA Genetics.Genetics. Gastric biopsies.Gastric biopsies. RANTESRANTES
![Page 30: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/30.jpg)
Ansari et al J Clin Path Ansari et al J Clin Path 2006 Bahrain2006 Bahrain
Comparison of RANTES expression in Comparison of RANTES expression in CD and UC: an aid in the differential CD and UC: an aid in the differential diagnosis.diagnosis.
Mucosal biopsies from patients with Mucosal biopsies from patients with UC have a significantly more staining UC have a significantly more staining of lymphocytes and histiocytes in of lymphocytes and histiocytes in UC than CD.UC than CD.
![Page 31: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/31.jpg)
Outcome after IAP ; Varies Outcome after IAP ; Varies
UC like (UC like (St MarksSt Marks) ) CD like CD like ( Kangas et al 1994)( Kangas et al 1994)
BetweenBetween ( Yu et al Mayo 2000)( Yu et al Mayo 2000)
![Page 32: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/32.jpg)
Indeterminate Colitis – Pouch SurgeryIndeterminate Colitis – Pouch Surgery
Yu et al 2000 Mayo ClinicYu et al 2000 Mayo Clinic82 IC patients82 IC patientsPouch failure 27% IC vs. 11% UCPouch failure 27% IC vs. 11% UCPelvic sepsis 13% IC vs. 7% UCPelvic sepsis 13% IC vs. 7% UCPouch Fistula 31% IC vs. 9% UCPouch Fistula 31% IC vs. 9% UC15% of IC evolved into CD.15% of IC evolved into CD.Removal of converted cases = outcome Removal of converted cases = outcome
identical between IC and UCidentical between IC and UC
![Page 33: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/33.jpg)
SUMMARYSUMMARY CI constitutes a small but important subgroup of CI constitutes a small but important subgroup of
IBDIBD Mostly in fulminant state.Mostly in fulminant state. Most patients will polarize to either CD or UC Most patients will polarize to either CD or UC
after:after:1.1. Good clinico-pathological correlation Good clinico-pathological correlation ANDAND2.2. Long term follow-up.Long term follow-up.
Standardisation of definition is important for Standardisation of definition is important for meaningful comparison between various studies meaningful comparison between various studies and treatment options.and treatment options.
![Page 34: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/34.jpg)
ACGBIACGBI
Glasgow 2-5Glasgow 2-5thth July July
![Page 35: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/35.jpg)
ESCP Annual General MeetingESCP Annual General MeetingMalta September 26-29Malta September 26-29
Pre-meeting coursePre-meeting course
Core Subject UpdateCore Subject UpdateWednesday 26 September 14:00 – 17:00Wednesday 26 September 14:00 – 17:00
![Page 36: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/36.jpg)
ESCP Annual General MeetingESCP Annual General MeetingMalta September 26-29Malta September 26-29
SymposiaSymposiaImaging in Colorectal CancerImaging in Colorectal Cancer
Pelvic Floor DisordersPelvic Floor DisordersLaparoscopyLaparoscopy
Pouches in Ulcerative ColitisPouches in Ulcerative Colitis
DebatesDebatesHaemorrhoidectomyHaemorrhoidectomy
Rectal ProlapseRectal ProlapseLaparoscopyLaparoscopy
![Page 37: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/37.jpg)
ESCP Annual General MeetingESCP Annual General MeetingMalta September 26-29Malta September 26-29
Keynote LecturesKeynote LecturesManagement of Large WoundsManagement of Large Wounds
LaparoscopyLaparoscopyUpdate on Familial Adenomatous PolyposisUpdate on Familial Adenomatous Polyposis
Sacral Nerve Stimulation for Fecal IncontinenceSacral Nerve Stimulation for Fecal IncontinenceInterpretation of Endpoints in Cancer TrialsInterpretation of Endpoints in Cancer Trials
Management of the Advanced Pelvic MalignancyManagement of the Advanced Pelvic Malignancy
Consultants’ CornerConsultants’ Corner
Free Paper and Oral Poster PresentationsFree Paper and Oral Poster Presentations
Six Best PapersSix Best Papers
![Page 38: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/38.jpg)
Abstract deadline date Abstract deadline date SundaySunday 20 20 May 2007 May 2007
Submissions open at Submissions open at www.escp.eu.comwww.escp.eu.com
Future ESCP Scientific MeetingsFuture ESCP Scientific Meetings 2008: 24 – 27 September: 2008: 24 – 27 September: Nantes, FranceNantes, France2009: 23 – 26 September 2009: 23 – 26 September 2010: 22 – 25 September2010: 22 – 25 September
![Page 39: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/39.jpg)
![Page 40: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/40.jpg)
Is ‘Indeterminate Colitis’ Is ‘Indeterminate Colitis’ Crohn’s Disease in Long-Term Crohn’s Disease in Long-Term
Follow-Up?Follow-Up?
Kangas, Matikainen & Matila.Kangas, Matikainen & Matila.
Int. Surg. 1994.Int. Surg. 1994.
Tampere, Finland.Tampere, Finland.
![Page 41: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/41.jpg)
ConclusionConclusion
Cases labelled for IC show Cases labelled for IC show tendency to develop CD after tendency to develop CD after a long follow-up.a long follow-up.
![Page 42: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/42.jpg)
Fulminant Colitis in IBDFulminant Colitis in IBDDetailed Pathologic and Clinical Detailed Pathologic and Clinical
AnalysisAnalysis
Swan, Geogehan, O’Donoghue, Hyland Swan, Geogehan, O’Donoghue, Hyland and Sheahanand Sheahan
Dis Col and Rectum 1998Dis Col and Rectum 1998
![Page 43: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/43.jpg)
67 FC of IBD67 FC of IBD
DiseaseDisease Original DxOriginal Dx After Path After Path reviewreview
CP CP correlationcorrelation
UCUC 4040 4545 4545
CDCD 1616 1313 1616
ICIC 1111 99 66
![Page 44: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/44.jpg)
Can the pathologist come off the Can the pathologist come off the fence?fence?
Yes , after a long follow Yes , after a long follow up .up .
![Page 45: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/45.jpg)
![Page 46: Colitis Indeterminate Najib Haboubi Professor of Health Sciences, Liver and Gastrointestinal Pathology Head of Surgical pathology Trafford Healthcare Centre](https://reader035.vdocuments.site/reader035/viewer/2022062421/56649f565503460f94c7ae79/html5/thumbnails/46.jpg)
Definition 6 Montreal Definition 6 Montreal Classification 2005Classification 2005
Satangi J et al The Montreal classification of inflammatory bowel disease: Satangi J et al The Montreal classification of inflammatory bowel disease: controversies, consensus and implications. Gut 2006;55:749-753.controversies, consensus and implications. Gut 2006;55:749-753.
Back to original Price 1978 classification.Back to original Price 1978 classification. Acute phaseAcute phase ResectateResectate IBD but cannot be further categorised IBD but cannot be further categorised
histologicallyhistologically