cognitive impairment in patients with anxiety, depression and bipolar disorder
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ABOUT THE AUTHOR
John Harrison is a consultant in occupational medicine
and clinical director for organizational health and wellbe-
ing in Imperial College Healthcare NHS Trust, in London.
He was Senior Lecturer in occupational medicine at the
University of Newcastle upon Tyne and was appointed
Professor (Associate) in Clinical Organizational Develop-
ment at the Business School of Brunel University in
November 2005. He was Academic Dean of the Faculty of
Occupational Medicine (1999–2007) and led the develop-
ment of a new national training curriculum for occupa-
tional medicine. He is immediate past-chairman of
EASOM (European Association of Schools of Occupational
Medicine). He is the UK national secretary and a board
member of the International Commission for Occupa-
tional Health (ICOH).
CORRESPONDENCE ADDRESS
Prof. John Harrison, Imperial College Healthcare NHS
Trust / Brunel University, Du Cane Road, London W12
0HS, United Kingdom.
Email: [email protected].
444 TBV 16 / no. 10 / December 2008
Cognitive impairment in patients with anxiety, depression
and bipolar disorder
Patients with anxiety, depression, and bipolardisorder are known to be impaired relative tohealthy controls on neurocognitive tests, but thedegree of impairment may be obscured if thedata are analyzed in terms of group means.Patients and controls were administered a com-prehensive neurocognitive assessment thatmeasured performance in memory, psychomotorspeed, reaction time, attention, and cognitiveflexibility. There were small differences between patientsand controls, but comparisons of results in termsof the frequency with which patients and con-trols fell below certain cutoff scores amplified
the importance of these differences. Only 4% of controls fell below a standard scoreof 70 (two standard deviations below the mean)on two or more cognitive domains, but 19% ofanxiety patients, 21% of depressed patients, and30% of bipolar patients fell below the standardscore. Substantial numbers of patients with anxiety,depression, and bipolar disorder are cognitivelyimpaired. A score that is two standard deviationsbelow the mean is usually clinically important,and two domain scores in that range is cause forserious concern. Source: The Journal of Clinical Psychiatry, July 2008
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