cognitive challenge summary analysis of phase ii data –240 sessions analyzed using bputil...
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Cognitive Challenge Summary
• Analysis of Phase II data– 240 sessions analyzed using BPutil pipeline,
BIRN QA and Eventstats– ROI analysis of MFG, IPL, and STG– Comparison of FIPS and BPutil for Iowa data
• New task development– Emotional oddball (event-related)– Emotional executive (blocked)– Movie clips
Constant Fixation
15s
………
.5s 6-15 s 6-15 s
1000Hz 1200Hz
Slice Depth: Z=-11ControlsPatients
Controls:N=41, p<1x10-10
Patients:N=44, p<1x10-5
Vis
it 1
Vis
it 2
MFG, Right Hemisphere, Visit 1
MFG, Right Hemisphere, Visit 2
Voxel Counts by Visit and ROI
Time-Course by Visit and Diagnosis in MFG
Auditory Oddball
Auditory Oddball Summary
• Robust activations of dlPFC, IPL, STG, insula, cingulate, thalamus, and motor cortex– In all locations, controls > patients
• Strong visual cortex activation suggests that infrequent tones evoke an orienting response– Brainstem activation is also suggestive, but
less visible in count conditions
Learn
Probes (14 Total)
0 2 1 3 8 9 7 2 4 . . .7 * 5 * 4 4 6 5 1 . . .* * 9 * * 3 9 2 8 . . .
Prompt
Learn
Learn
…
Encoding
…
4s-20sFixation
0s 8s6s4s2s 10s … … 46s
4s-20sFixation
5 items
3 items
1 item
IPS SIRP
MFG SIRP
Preliminary SIRP Summary
• Strong co-activation of regions also activated by Auditory Oddball (except STG)
• At low and medium load, patients > controls during probe intervals
• At high load, patients ~= controls
MFG
IFG
STG
IPS Encode
IPS Probe
MFG Encode
MFG Probe
Cognitive Challenge Summary
New task development– Emotional oddball (event-related)– Emotional executive (blocked)– Movie clips
Dorsal executive control system
LC Amyg
Th BGVTA
Raphe vmPFC
dlPFC
Amyg
IPS
vlPFC
OFC
Ventral affective processing system
TargetsStandard NovelsNeutral Emotional
84% 8% 4% 4%
Emotional Distracter Task
Yamasaki, LaBar, McCarthy, PNAS, 2002
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Emotional Distracter Task
Sad Stimulus Distracter Task
Wang, LaBar, McCarthy, Biol Psychiat, in press
Emotional Distracter
Emotional Distractor TaskMiddle Frontal Gyrus (anterior)
-0.10%
-0.05%
0.00%
0.05%
0.10%
0.15%
-3 0 3 6 9 12 15
Emotional novel
Neutral novel
Target
-0.10%
-0.05%
0.00%
0.05%
0.10%
0.15%
0.20%
0.25%
0.30%
-3 0 3 6 9 12 15
Emotional novel
Neutral novel
Target
Emotional Distractor TaskAmygdala
Emotional Distracter
Anterior MFG
Posterior IFG
-0.10%
-0.05%
0.00%
0.05%
0.10%
0.15%
-3 0 3 6 9 12 15
Emotional novel
Neutral novel
Target
-0.10%
-0.05%
0.00%
0.05%
0.10%
0.15%
0.20%
-3 0 3 6 9 12 15
Emotional novel
Neutral novel
Target
Emotional Distracter Task
Phase I (15s) Phase II (14s)
Memoranda Probe
3.5s 1.5s
Novel stimuli (6s)
+ ++
Emotional Distracters and Working Memory
Dolcos and McCarthy, J Neurosci, 2006
Increased distractibility to emotional distracters linked to differential patterns of activity in the dorsal executive vs. ventral affective neural systems.
MR
sig
nal c
hang
e (
%)
-0.2
-0.1
0.1
0.3 dlPFC
MR
sig
nal c
hang
e (
%)
-0.2
-0.1
0.1
0.3
0.4
AMY
0.5
0.6
0.7
0.8
Cor
rect
ed R
ecog
nitio
n S
core
s
Scrambled Scene DistractersNeutral Scene DistractersEmotional Scene Distracters
Amygdala activity to emotional distracters
5.5 6.75 8-0.1
0.05
0.2
0.35
-2 2 6 10 14 18 22 26
time (sec)
Scrambled Neutral Emotional
MR
sig
na
l ch
an
ge
(%
)
-0.2
-0.1
0.1
0.3
0.4
0.6
-2 2 6 10 14 18 22 26
-0.2
-0.1
0.1
0.3
0.4
0.6
-2 2 6 10 14 18 22 26
-0.2
-0.1
0.1
0.3
0.4
0.6
-2 2 6 10 14 18 22 26
-0.2
-0.1
0.1
0.3
0.4
0.6
-2 2 6 10 14 18 22 26
-0.1
0.1
0.3
0.5
0.7
-2 2 6 10 14 18 22 26
-0.1
0.1
0.3
0.5
0.7
-2 2 6 10 14 18 22 26
-0.1
0.1
0.3
0.5
0.7
-2 2 6 10 14 18 22 26
-0.1
0.1
0.3
0.5
0.7
-2 2 6 10 14 18 22 26
-0.6
-0.4
-0.2
0.1
0.3
-2 2 6 10 14 18 22 26
-0.6
-0.4
-0.2
0.1
0.3
-2 2 6 10 14 18 22 26
-0.6
-0.4
-0.2
0.1
0.3
-2 2 6 10 14 18 22 26
-0.6
-0.4
-0.2
0.1
0.3
-2 2 6 10 14 18 22 26
-0.2
0.2
0.6
0.9
1.3
-2 2 6 10 14 18 22 26
-0.2
0.2
0.6
0.9
1.3
-2 2 6 10 14 18 22 26
-0.2
0.2
0.6
0.9
1.3
-2 2 6 10 14 18 22 26
-0.2
0.2
0.6
0.9
1.3
-2 2 6 10 14 18 22 26
Negative DistracterMeaningless Distracter Neutral Distracter
Emotional Oddball
• Ayse Belger’s group collected data
• 10 CONTROLS, 11 SCZ PATIENTS
MFGCONTROLS SCZ PATIENTS
CONTROLS SCZ PATIENTSIfg/BA 47
CONTROLS SCZ PATIENTSOF
CONTROLS SCZ PATIENTSFFG
CONTROLS SCZ PATIENTSPosterior Parietal
CONTROLS SCZ PATIENTSAMYGDALA
0s 10s 30s20s 40s 60s50s 80s70s
Neutral BlockExecutive Block
Fixation
Emotional Block
…
Emotional Executive Task, Block-Design
……
……
Scrambled Images
…… ……
MFG
IFG
vmPFC
Blocked Emotional Executive
Left MFG
-0.15
-0.10
-0.05
0.00
0.05
0.10
0.15
0.20
0.25
-4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24
Emotional
Neutral
Target
left MFG
Left IFG
-0.10
-0.05
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
-4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24
Emotional
Neutral
Target
right IFG
Inferior Frontal Gyri
vmPFC
vmPFC
-0.20
-0.15
-0.10
-0.05
0.00
0.05
0.10
0.15
0.20
0.25
-4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24
Emotional
Neutral
Target
vmPFC
Inferior Parietal Lobule and VOTC
Left Parietal
-0.10
-0.05
0.00
0.05
0.10
0.15
0.20
-4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24
Emotional
Neutral
Target
left Parietal
Left VOTC
-0.20
-0.10
0.00
0.10
0.20
0.30
0.40
0.50
-4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24
Emotional
Neutral
Target
left VOTC
CONTROLS SCZ PATIENTSINSULA
CONTROLS SCZ PATIENTSACG
CONTROLS SCZ PATIENTSThalamus
CONTROLS SCZ PATIENTSCaudate