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Contents

WHO Classification 6

1 Astrocytic tumours 9Diffusely infiltrating astrocytomas 10

Diffuse astrocytoma 22Anaplastic astrocytoma 27

Glioblastoma 29

Giant cell glioblastoma 40

Gliosarcoma 42

Pilocytic astrocytoma 45

Pleomorphic xanthoastrocytoma 52

2 Oligodendroglial tumoursand mixed gliomas 55Oligodendroglioma 56

Anaplastic oligodendroglioma 62

Oligoastrocytoma 65

Anaplastic oligoastrocytoma 68

Other mixed gliomas 69

3 Ependymal tumours 71Ependymoma 72

Anaplastic ependymoma 76

Myxopapillary ependymoma 78

Subependymoma 80

4 Choroid plexus tumours 83

5 Neuroepithelial tumours ofuncertain origin 87Astroblastoma 88

Chordoid glioma of the third ventricle 90Gliomatosis cerebri 92

6 Neuronal and mixed neuronal-glialtumours 95Ganglioglioma and gangliocytoma 96

Desmoplastic infantile astrocytoma and

ganglioglioma 99

Dysembryoplastic neuroepithelial tumour 103

Central neurocytoma 107

Cerebellar liponeurocytoma 110

Paraganglioma 112

7 Pineal parenchymal tumours 115Pineoblastoma 116Pineocytoma 118

Pineal parenchymal tumour of

intermediate differentiation 121

8 Embryonal tumours 123Medulloepithelioma 124

Ependymoblastoma 127

Medulloblastoma 129

Medullomyoblastoma 138

Melanotic medulloblastoma 140

Supratentorial primitive neuroectodermal

tumour (PNET) 141

Atypical teratoid/rhabdoid tumour 145

9 Peripheral neuroblastic tumours 149Olfactory neuroblastoma 150

Neuroblastic tumours of adrenal gland

and sympathetic nervous system 153

10 Tumours of cranial andperipheral nerves 163Schwannoma 164

Neurofibroma 167

Perineurioma 169

Malignant peripheral nerve

sheath tumour (MPNST) 172

11 Meningeal tumours 175Meningiomas 176

Mesenchymal, non-meningothelial tumours 185

Haemangiopericytoma 190

Melanocytic lesions 193

12 Tumours of the haemopoietic system 197Malignant lymphomas 198

Histiocytic tumours 204

13 Germ cell tumours 207

14 Familial tumour syndromes 215

Neurofibromatosis type 1 216Neurofibromatosis type 2 219

Von Hippel-Lindau disease and

capillary haemangioblastoma 223

Tuberous sclerosis complex and

subependymal giant cell astrocytoma 227

Li-Fraumeni syndrome and

TP53germline mutations 231

Cowden disease and dysplastic

gangliocytoma of the cerebellum/

Lhermitte-Duclos disease 235

Turcot syndrome 238

Naevoid basal cell carcinoma syndrome 240

15 Tumours of the sellar region 243Craniopharyngioma 244

Granular cell tumour of the neurohypophysis 247

16 Metastatic tumours of the CNS 249

Contributors 255Source of charts and photographs 263References 267Subject index 309

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