What Is Cancer?

Cancer is actually a group of many related diseases that all have to do with cells.

Cancer cells usually group or clump together to form tumors

Cancer cells that can destroy the normal cells around the tumor and damage the body's healthy tissues

Neoplasm – new growth of tissue that serves no physiological function

Tumor – clumping of neoplasmic cells

Malignant - cancerous

Benign - noncancerous

What Causes Cancer?

Signs and Symptoms There are more than 100 different types of cancer.

Every cancer and every individual is unique.

Cancer symptoms and signs depend on the size and

location of the cancer, as well as the presence or

absence of metastasis.

Cancers are classified as either solid or li uid…

Cancer is further classified according to the tissue in

which it arises.

Symptoms and signs

Fever

Pain- off/on

Fatigue

Skin changes (redness, sores that won't

heal, jaundice, darkening)

Unintended weight loss or weight gain

More obvious signs of cancer

Lumps or tumors (mass)

Difficulty in swallowing

Changes or difficulties with bowel or bladder function

Persistent cough or hoarseness

Shortness of breath

Chest pain

Unexplained bleeding or discharge

• Squamous cell carcinoma: It is one of the main types of skin cancer. Cancers that involve the anus, cervix, head and neck, and vagina….

• Ewing sarcoma: It is a malignant small, round, blue cell tumor. The pelvis, the femur, the humorous , the ribs and clavicle….

• Multiple myeloma, also known as plasma cell myeloma: When advanced, bone pain, bleeding, frequent infections, and anemia may occur…

• Acute leukemia: Serious medical conditions, diagnosis of leukemia (myeloid,erythroid,lymphoblastic)

• Lymphoma: is a group of blood cell tumors that develop from lymphocytes, enlarged lymph nodes, fever, drenching sweats….

How Stages of Cancer Are Determined

TNM classification of a Cancer - Five stages

Stage 0: This refers to cancer that is "in situ”, This type of cancer has not spread and it is not enter into other tissues.

Stage I – Stage III: These higher stages of cancer correspond to larger tumors and/or greater extent of disease. Cancers in these stages may have spread beyond the site of origin to enter regional lymph nodes, tissues, or organs.

Stage IV: This type of cancer has spread to distant lymph nodes, tissues, or organs in the body far away from the site of origin.

Diagnosing Cancer Examination of Lymph

nodes

CBP

Mammogram

Pap Test

Tumor Marker Test

Bone Scan

MRI

Tissue Biopsy

PET-CT Scan

What Are Treatment Options?

The treatment is highly variable depending on

the type and stage of a cancer

The most common treatments are surgery,

radiation, and chemotherapy.

Targeted/biological therapies

Hematopoietic stem cell transplants

Angiogenesis inhibitors

Photodynamic therapy

What are Alkylating agents

Drugs that bind to DNA and prevent proper DNA

replication. They have chemical groups that can form permanent covalent bonds with nucleophilic substances in the DNA.

Alkylating agents are used as part of chemotherapy in different types of cancers.

• Cyclophosphamide

• Ifosfamide

• Temozolomide

Anti- Metabolites

A chemical that inhibits the use of a metabolite,

which is another chemical that is part of normal

metabolism. Such substances are often similar in

structure to the metabolite that they interfere

with, such as the anti-folates that interfere with

the use of folic acid.

• Capecitabine

• 5- Fluoro Uracil

• Methotrexate

• Gemcitabine

• Pemetrexed

Anti-Tumor Antibiotics

A variety of mechanisms, they are derived

from microorganisms, cell cycle specific drugs.

• Mitomycin

• Bleomycin

• Epirubicin

• Doxorubicin (Pegylated liposomal)

Plant Alkaloids/ Microtubule

Inhibitors

• Mitotic inhibitors

Interfere with microbuls- Taxane

Bind to tubulin- Vinca alkaloids…. • Etoposide

• Paclitaxel

• Irinotecan

• Docetaxel

• Vincristine

DNA Linking Agents

Carboplatin

Cisplatin

Oxaliplatin

Biological agents

Bis phosphonates

Hormones/other

Ayurvedic concept of Cancer

Ayurveda is supposed to add a step on to the

curative aspects of cancers.

Arbuda and Granthi mentioned in Sushruta

samhita.

Several studies have been conducted on herbs

under a multitude of ethno botanical grounds.

Rasa sastra drugs are proved anti cancer activity,

due to heavy metal toxicity, lack of knowledge

doctors panic to use this nectar medicine.

Fundamental classification of Cancer

in Ayurveda

Vataja

Pittaja

Kaphaja

Raktaja

Mamsaja

Medoja

Pathogenesis of tumours

Sanchaya: Early stages of localized neoplastic

changes.

Prakopa: Transformation of primary growths into metastatic tumours.

Prasara: Metastasis.

Sthana samsraya: Complete metastasis and secondary growth.

Vyakti: Clinical signs and symptoms are expressed.

Bheda: The stage where differentiation of growth occurs on the basis of histopathology.

Treatment modalities

• Sodhana chikitsa

• Shamana chikitsa

• Rasayana chikitsa

• Dhatwagni chikitsa

• Vyadhipratyanika chikitsa

• Lakshanika chikitsa

Classical drugs list in Ayurveda

• Fresh herbal decoction is very powerful for

various types of cancers.

• Plant extracts and their bio-active compounds

present in them which are responsible for anti

cancer activity.

• The phyto/chemical exploration of herbo-

minerals can contribute to the discovery of

new anti-cancer drugs.

Role of Ayurvedic Physicians

• Ayurveda practitioners and researchers in medical sciences can help to improve this medicine by increasing their involvement and contribution

• Standardization and quality production of herbo- mineral products may allow us to develop low cost therapies

• Observation in modern eye with Ayurvedic approach…

Ayurvedic Cancer Treatment

Use medicine to weaken and destroy cancer cells in the body, including cells at the original cancer site and any cancer cells that may have spread to another part of the body,

1. Rasayana drugs herbo- i erals…. 2. Swarna bhasma preparatio s….. 3. Heeraka bhasma preparatio s….. 4. Panchakarma therapies…. 5. Stress a age e t….. 6. Healthy lifestyle……….

Crude drugs as anticancer age ts…

• Crude drugs are believed to have nutriceutical effects upon cancer patients

• Crude drug targets in cancer therapy and chemoprevention.

• Known environmental factors associated with cancer are: diet, lifestyle, and environmental toxins.

• Turmeric is fat-soluble When combined with healthy fats, including coconut, ghee or olive oil,

• Curcumin is directly absorbed into the bloodstream through the ly phatic …

Crude drugs as anticancer agents

• Gold complexes as prospective metal-based anticancer drugs

• Medical and therapeutic value of gold has been recognized thousands of years ago, but its rational use in medicine has not begun until the early 1920s

• Cisplatin is one of the first metal-containing compounds with anti-cancer activity discovered in the 1960s.

Crude drugs as anticancer agents

Crude drugs as anticancer agents • British researchers now say that silver compounds are as

effective at killing certain cancer cells as a leading

chemotherapy drug, but with potentially far fewer of side-

effects.

• They compared silver to Cisplatin, currently used to treat a

wide variety of cancers, but known to have harsh side effects

including nausea, vomiting and even kidney da age…….

• Silver is used already in everyday products such as deodorant

with no known side-effects, and could make for a potentially

cheaper alternative to platinum-based Cisplatin.

Could You Benefit From Ayurvedic

Treatment For Cancer?

Ayurveda

acknowledges that cancer cells are always present in the body,

but when the body is in a state of Dosha balance this is not a problem.

Dosha imbalance basic stages:

Accumulation − here o e or more of the Doshas has increased

Aggravation − as le els i crease for one Dosha, this causes the

remaining Doshas to become

imbalanced

Overflow − the accu ulated Dosha spreads into the body

carrying Aama, or toxic waste

products

Localization − the Dosha settles at a weak site in the body

Manifestation − i.e. symptoms

Disease − such as a particular

kind of cancer

Crude drugs as anticancer agents

Turmeric

Guduchi

Ginger/Sunthi

Tulasi

Neem

Garlic

Ashwagandha

Bhallataka

Saffron

Gomutra: Cow’s u i e

Today many Cancer , Skin

diseases and AIDS patients

are taking cow urine therapy.

Cow urine & Panchgavya is

great elixir, proper diet,

pleasing to heart, giver of

mental and physical strength,

enhances longevity. It

balances bile, mucous and

tridosha. Remover of heart

diseases and effect of poison.

Ayurvedic Drugs for symptomatic

t eat e t…. All Guggulu Combinations are useful in pain

relief and reducing size of tumors

Vyadhiharan ras, G.Rasayan : for all infective conditions

Bilva, Kutaja,Chardiripu,Karpura ras : for loose motions and vomiting

Sukthi, sanka bhasma, kuberaksha,chitraka: for pain abdomen

Arogyavardini vati, Rasa Sindura: very effective solution for almost all types of diseases.

Ayurvedic Drugs for symptomatic

t eat e t…. • Khadiradi Vati, Rasamanikyam- mouth ulcer & throat

infection

• Mukta Pishti, Pravala, Abhrak, Emerald bhasma -heart , Lung diseases, nutritional deficiencies in the brain ..

• Panchanimba Churna, PTGG -All severe skin disorders ,

• Kushmanda Avaleha - Digestive Stimulant, blood vomiting

• Vatkulantak ras - Epilepsy, Brain cell stimulation, Tumors

• Mrityunjaya Ras, Malla Sindur – fever, pneumonia, Fungal

infections, diseases due to bacteria, irus…

• Tribhuvan kirthi ras – in all chronic fevers

• Makardhwaj: Cellular protection, Rasayan, Balance -Vata,

Pitta and Kapha.

Ayurvedic Drugs for symptomatic

treatment

Hirak Bhasma

Vaikranta Bhasma

Seethamsu ras

Pradarantak ras

Gomutra Silajit

Varunadi kasayam

* Bhunaga tailam

* Jathiphaladi churnam

* Vranasodana tailam

Subhra bhasma, Raktabandini, Vasa : in bleeding

Ahiphena, Banga : Severe pains & in Bone pai …..

Module 1

ARBUDA / eoplas …. Kanchanara ghanam 50 Gms

Pravala bhasma 30 Gms

Swarna makshika bhasma 20 Gms

Abhraka bhasma (100 puta) 4 Gms

Rasa karpuram 5 Gms

Swarna Bhasma 1.5 Gms

Hiraka bhasma 1 Gm

combine above all and dose 2gms T.I.D

Tab. Seethamsu ras 2 B.I.D

Tab. Ballataka Vati 2 B.I.D

Tab. Varunadi Kasayam 1 B.I.D

Tab. Vatkulantak ras 2 B.I.D

Module 2

• ACUTE LEUKEMIAS (myeloid, erythroid,lymphoblastic) • Laksha churnam 50 Gms

• Vasa ghana churnam 50 Gms

• Subhra bhasma 30 Gms

• Swarna makshika bhasma 20 Gms

• Raktabandini 10 Gms

• Rasa sinduram 5 Gms

• Abhrak bhasma(100 puta) 4 Gms

• Vaikranta bhasma 2 Gms

• Swarna Bhasma 1.5 Gms

combine above all and dose 2gms T.I.D

Tab. Pradarantaka ras 2 B.I.D

Tab. Bhallataka vati 1 B.I.D

Tab. Seethamsu ras 2 B.I.D

Conclusion

• Excess intake of vitamins may cause CANCER

• Focus on fruits and vegetables

• Moderate Your Meat Portions, limiting

alcohol, avoid tobacco

• Keep a Healthy Weight

• Consume Less Salt

• in early stage of Cancer Ayurvedic treatments

are useful