Innovation with IntegrityMALDI-TOF

Changing Microbiology

MALDI Biotyper®

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Geotrichum Fusobacterium Lodderomyces Anaerococcus Colletotrichum Edwardsiella Comamonas Pigmentiphaga Moellerella Nesterenkonia Listonella Udeniomyces Erysipelothrix Escherichia Streptomyces Bartonella Hafnia Terrimonas Pseudoxanthomonas Corynebacterium Streptococcus Aerococcus Saccharothrix Facklamia Schizosaccharomyces Tetragenococcus Lechevalieria Clavibacter Shimwellia Brachybacterium Leclercia Providencia Trabulsiella Xanthobacter Emericella Gardnerella Sporothrix Leuconostoc Pseudoclavibacter Alkalibacillus Debaryomyces Turicella Roseomonas Ruminococcus Scedosporium Dysgonomonas Staphylococcus Peptostreptococcus Paenibacillus Balneatrix Solibacillus Prototheca Cupriavidus Geobacillus Aspergillus Arthrobacter Mesorhizobium Acholeplasma Filobasidium Propioniferax Azohydromonas Chromobacterium Curtobacterium Kloeckera Austwickia Hyphomicrobium Cryptococcus Rummeliibacillus Budvicia Aquincola Enterobacter Sporobolomyces Brevundimonas Capnocytophaga Tatlockia Neisseria Salinivibrio Pullulanibacillus Arcanobacterium Tissierella Eggerthella Methanomonas Mucor Mobiluncus Caulobacter Helcococcus Psychrobacillus Campylobacter Blastomonas Wohlfahrtiimonas Thermoactinomyces Herminiimonas Tsukamurella Mycobacterium Bordetella Pichia Vibrio Iodobacter Tenacibaculum Listeria Plesiomonas Haloarcula Shewanella Paecilomyces Thauera Viridibacillus Yokenella Malassezia Novosphingobium Ornithobacterium Epidermophyton Oligella Paracoccus Aureobasidium Eubacterium Dietzia Salimicrobium Klebsiella Mycoplasma Variovorax Samsonia Schizophyllum Scopulariopsis Odoribacter Anaerotruncus Abiotrophia Burkholderia Sodalis Empedobacter Sphingopyxis Lactococcus Sphingobium Microsporum Peptoniphilus Vagococcus Beauveria Morganella Pasteurella Cedecea Bifidobacterium Micrococcus Propionimicrobium Starkeya Prevotella Histophilus Sphingomonas Acetobacter Francisella Photobacterium Propionibacterium Aneurinibacillus Arthrographis Aromatoleum Pediococcus Phoma Xenorhabdus Methylobacillus Fusarium Wolinella Bacteroides Zygosaccharomyces Cellulosimicrobium Helicobacter Rhizobium Terrabacter Ralstonia Butyricimonas Microsporum Castellaniella Borrelia Microbacterium Rheinheimera Wautersiella Saccharopolyspora Rahnella Nocardioides Gluconobacter Sphingobacterium Mannheimia Cohnella Aggregatibacter Cronobacter Lecythophora Riemerella Chaetomium Atopobium Rhizopus Acidovorax Rothia Kytococcus Chryseobacterium Alishewanella Gemella Methylobacterium Haemophilus Adlercreutzia Buttiauxella Weeksella Alloiococcus Bacillus Arxiozyma Halococcus Rhodotorula Pseudochrobactrum Leminorella Candidatus Xanthomonas Pectobacterium Brevibacterium Arthroderma Slackia Trueperella Inquilinus Brevibacillus Brachyspira Porphyromonas Aurantimonas Actinomyces Eikenella Kitasatospora Magnusiomyces Psychrobacter Acidiphilium Amycolatopsis Lactobacillus Marinibacillus Megamonas Dermatophilus Grimontia Acinetobacter Lysinibacillus Hanseniaspora Parvimonas Moesziomyces Legionella Aliivibrio Dermacoccus Exiguobacterium Virgibacillus Raoultella Gordonia Dialister Parabacteroides Cardiobacterium Stenotrophomonas Sporobolomyces Coprobacillus Sporosarcina Brenneria Rathayibacter Arsenophonus Penicillium Pseudomonas Rubrivivax Bilophila Alloscardovia Nocardia Halomonas Rhodococcus Bergeyella Malikia Actinocorallia Aeromonas Borrelia Microbacterium Rheinheimera Wautersiella Saccharopolyspora Rahnella Nocardioides Gluconobacter

Clinical Microbiology

The Market Leading Microbiology Mass Spectrometry System

Within a short period of time, the MALDI Biotyper has revolutionised the way that microbial identification is performed.

The speed, accuracy, ease of use and cost efficiency of the MALDI Biotyper is proven in hundreds of peer-reviewed publications. The MALDI Biotyper is acknowledged all over the world as the state-of-the-art system solution for the identification of microorganisms.

Identifying microorganisms by their molecular fingerprint

The MALDI Biotyper identifies micro-organisms using MALDI-TOF (Matrix Assisted Laser Desorption Ionization-Time of Flight) Mass Spectrometry to determine the unique molecular fingerprint of an organism.

The characteristic spectrum pattern of this molecular fingerprint is used to reliably and accurately identify a particular microorganism by matching thousands of reference spectra of microorganism strains.

But there‘s more. The outstanding capabilities of the system go well beyond microbial identification and Bruker is working on continuous innovation bringing MALDI Biotyper into new fields of application such as functional resistance testing.

Staphylococcus aureus Mass Spectrum Profile

Additional workflows are available for blood culture processing as well as the processing of other traditionally difficult to analyze groups of organisms including fungi and mycobacteria.

The open microbiology concept

Software modules like the Compass Translator allow for smooth integration with existing laboratory informatics.MALDI Biotyper results are converted into a format that a LIS or an AST System can easily understand.

There is nothing easier

The MALDI Biotyper workflow has been designed to be as robust and easy to perform as possible. Only a few simple steps are required to generate high quality microorganism identifications. No experience with mass spectrometry is required. Our dedicated MBT Compass microbiology software automates the process of acquiring the mass spectrum and spectra-matching, providing high fidelity identification results.

Straight Forward to Result

Clear identification results display at species level

Staphylococcus aureus Mass Spectrum Profile

Convenient user interface for easy set-up of working lists

More Than a Comprehensive Library

Every Microorganism could be of Clinical Relevance

What Will You Identify?

Spectra are determined from clinical iso-lates from collaborating partners, round robin strains and strains from isolates from accredited ISO 9001:2008 certified strain collections.

Up-to-date and traceable

The integrated library of the MBT Compass Software comprises spectra of thousands of strains. The library is continuously maintained and updated according to strict quality controlled procedures.

Wohlfahrtiimonas chitiniclastica

Intensity

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The Best Technology from the Experts in Mass Spectrometry

As leader in MALDI-TOF technology is it of great importance to us to design robust, compact, high performance plat-forms intended for extensive and routine usage in the microbiology laboratory.The core of the MALDI Biotyper system is the cutting-edge microflex LT MALDI-TOF mass spectrometer.

A space saving system

A true bench-top solution with less than 1 meter of counter space offers flexibility in meeting laboratory needs. Requires only a 110/220 V electrical outlet with very minimal heat output.

Resolution meets sensitivity

Resolution and sensitivity of the spec-trometer are tailored to the needs of microbiologists. For optimal results with-out the need for unnecessarily long and bulky instrument flight tubes.

Accelerated data acquisition

With Smart Spectra Acquisition data generation is accelerated by minimizing the number of laser shots per sample needed to generate a signal. At approxi-mately 200 identifications per hour, the system offers the highest throughput for MALDI-TOF microbiology testing.

Highly reproducible results – day to day

The quick and simple performance check performed before each run provides the highest standard of reproducibility.

Continuous operation

Routine maintenance such as cleaning is reduced to a minimum and can be easily performed by the user.

MALDI Biotyper System Overview

Microbial Identification Applications

Gram +/- Bacteria, Fungi

System Compounds

Instrument: microflex LT/SH Mass Spectrometer Computer: MALDI Biotyper data-

system running under Windows 7 Software: MALDI Biotyper Compass

Software according to the European Union IVD Directive 98/79/EC

Dimensions & Operating Parameters

LxWxH: 510 x 680 x 1093mm [20.1” x 26.8” x 43”]Weight: 84kg (185 lb) net weight Noise: <30 dB under normal operating conditions Temp Range: 10-30ºC (50-86ºF) Operating Humidity: 15-85% non-condensing @ 30ºC

Consumables and Ancilliaries

HCCA IVD Bacterial Test IVD Reusable polished stainless steel targets:

48 & 96 position with barcode Disposable 48 position biotarget with

individual barcode

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Bruker Daltonik GmbH

Bremen · GermanyPhone +49 (0)421-2205-0 Fax +49 (0)421-2205-103 detection@bruker.com

www.bruker.com

The Best Technology from the Experts in Mass Spectrometry

MALDI Biotyper® is a registered trademark of Bruker Daltonik GmbH in the European Union and USA