Highlights of This Issue 2603

SPECIAL FEATURES

CCR Translations

2605 Insulin Receptor Activation inDeletion 11q Chronic LymphocyticLeukemiaJennifer R. BrownSee article p. 2679

CCR New Strategies

2608 New Strategies in Muscle-InvasiveBladder Cancer: On the Road toPersonalized MedicineJay B. Shah, David J. McConkey,and Colin P.N. Dinney

Molecular Pathways

2613 Aberrations of EZH2 in CancerAndrew Chase and Nicholas C.P. Cross

2619 Direct Effects of Type I Interferons onCells of the Immune SystemSandra Hervas-Stubbs, Jose Luis Perez-Gracia,Ana Rouzaut, Miguel F. Sanmamed,Agnes Le Bon, and Ignacio Melero

HUMAN CANCER BIOLOGY

2628 Unique Functional Status of NaturalKiller Cells in Metastatic Stage IVMelanoma Patients and ItsModulation by ChemotherapyGiulia Fregni, Aur�elie Perier, Gianfranco Pittari,Simon Jacobelli, Xavier Sastre, Nadine Gervois,Mathilde Allard, Nad�ege Bercovici,Marie Francoise Avril, and Anne Caignard

2638 Role and Relevance of TrkB Mutationsand Expression in Non–Small CellLung CancerTaishi Harada, Yasushi Yatabe,Masafumi Takeshita, Takaomi Koga,Tokujiro Yano, Yisong Wang,and Giuseppe Giaccone

2646 FUS-CREB3L2/L1–Positive SarcomasShow a Specific Gene ExpressionProfile with Upregulation of CD24 andFOXL1Emely M€oller, Jason L. Hornick,Linda Magnusson, Srinivas Veerla,Henryk A. Domanski, and Fredrik Mertens

2657 Genomic Loss of miR-486 RegulatesTumor Progression and the OLFM4Antiapoptotic Factor in GastricCancerHue-Kian Oh, Angie Lay-Keng Tan, Kakoli Das,Chia-Huey Ooi, Nian-Tao Deng,Iain BeeHuat Tan, Emmanuel Beillard,Julian Lee, Kalpana Ramnarayanan,Sun-Young Rha, Nallasivam Palanisamy,P. Mathijs Voorhoeve, and Patrick Tan

2668 Association of IFN-� SignalTransduction Defects with ImpairedHLA Class I Antigen Processing inMelanoma Cell LinesAnnedore Respa, Juergen Bukur, SoldanoFerrone, Graham Pawelec, Yingdong Zhao,Ena Wang, Francesco M. Marincola,and Barbara Seliger

2679 A Pathobiological Role of the InsulinReceptor in Chronic LymphocyticLeukemiaKamlai Saiya-Cork, Roxane Collins, BrianParkin, Peter Ouillette, Erlene Kuizon,Lisa Kujawski, Harry Erba, Erica Campagnaro,Kerby Shedden, Mark Kaminski,and Sami N. MalekSee commentary p. 2605

2693 Molecular Classification of GastricCancer: A New ParadigmManish A. Shah, Raya Khanin, Laura Tang,Yelena Y. Janjigian, David S. Klimstra,Hans Gerdes, and David P. Kelsen

2702 Endogenous Axon GuidingChemorepulsant Semaphorin-3FInhibits the Growth and Metastasis ofColorectal CarcinomaFeng Wu, Qi Zhou, Jing Yang, Guang-jie Duan,Juan-juan Ou, Rong Zhang, Feng Pan,Qiu-ping Peng, Hong Tan, Yi-fang Ping,You-hong Cui, Cheng Qian, Xiao-chu Yan,and Xiu-wu Bian

ClinicalCancer

ResearchThe Journal of Clinical and Translational ResearchContents

May 1, 2011 � Volume 17 � Number 9

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2712 miR-34a Induces the Downregulationof Both E2F1 and B-Myb Oncogenes inLeukemic CellsGiorgio Zauli, Rebecca Voltan,Maria Grazia di Iasio, Raffaella Bosco,Elisabetta Melloni, Maria Elena Sana,and Paola Secchiero

CANCER THERAPY: PRECLINICAL

2725 MicroRNA-125a-5p Is an IndependentPrognostic Factor in Gastric Cancerand Inhibits the Proliferation ofHuman Gastric Cancer Cells inCombination with TrastuzumabNaohiro Nishida, Koshi Mimori, Muller Fabbri,Takehiko Yokobori, Tomoya Sudo,Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii,Yuichiro Doki, and Masaki Mori

2734 Nonproteasomal Targets of theProteasome Inhibitors Bortezomiband Carfilzomib: a Link to ClinicalAdverse EventsShirin Arastu-Kapur, Janet L. Anderl,Marianne Kraus, Francesco Parlati,Kevin D. Shenk, Susan J. Lee, TonyMuchamuel,Mark K. Bennett, Christoph Driessen,Andrew J. Ball, and Christopher J. Kirk

2744 Synergistic Effect between Erlotiniband MEK Inhibitors in KRAS Wild-Type Human Pancreatic Cancer CellsCaroline H. Diep, Ruben M. Munoz,Ashish Choudhary, Daniel D. Von Hoff, andHaiyong Han

2757 IL-4R Drives Dedifferentiation,Mitogenesis, and Metastasis inRhabdomyosarcomaTohru Hosoyama, Mohammed Imran Aslam,Jinu Abraham, Suresh I. Prajapati,Koichi Nishijo, Joel E. Michalek,Lee Ann Zarzabal, Laura D. Nelon,Denis C. Guttridge, Brian P. Rubin,and Charles Keller

2767 Internalization of Oncolytic Reovirusby Human Dendritic Cell CarriersProtects the Virus fromNeutralizationElizabeth J. Ilett, Montserrat B�arcena,Fiona Errington-Mais, Stephen Griffin,Kevin J. Harrington, Hardev S. Pandha,Matthew Coffey, Peter J. Selby,Ronald W.A.L. Limpens, Mieke Mommaas,Rob C. Hoeben, Richard G. Vile,and Alan A. Melcher

2777 Genz-644282, a NovelNon-Camptothecin Topoisomerase IInhibitor for Cancer TreatmentLeslie S. Kurtzberg, Stephanie Roth,Roy Krumbholz, Jennifer Crawford,Christy Bormann, Sarah Dunham, Min Yao,Cecile Rouleau, Rebecca G. Bagley, Xian-Jie Yu,Fei Wang, Steven M. Schmid,Edmond J. LaVoie, and Beverly A. Teicher

2788 In vivo Evaluation of MucoadhesiveNanoparticulate Docetaxel forIntravesical Treatment of Non–Muscle-Invasive Bladder CancerClement Mugabe, Yoshiyuki Matsui, Alan I. So,Martin E. Gleave, Jennifer H. E. Baker,Andrew I. Minchinton, Irina Manisali,Richard Liggins, Donald E. Brooks,and Helen M. Burt

2799 MK-1775, a Potent Wee1 Inhibitor,Synergizes with Gemcitabine toAchieve Tumor Regressions,Selectively in p53-DeficientPancreatic Cancer XenograftsN.V. Rajeshkumar, Elizabeth De Oliveira,Niki Ottenhof, James Watters, David Brooks,Tim Demuth, Stuart D. Shumway,Shinji Mizuarai, Hiroshi Hirai, Anirban Maitra,and Manuel Hidalgo

2807 Enhanced Safety Profiles of theTelomerase-Specific Replication-Competent Adenovirus byIncorporation of Normal Cell-Specific microRNA-TargetedSequencesKumiko Sugio, Fuminori Sakurai,Kazufumi Katayama, Katsuhisa Tashiro,Hayato Matsui, Kenji Kawabata,Atsushi Kawase, Masahiro Iwaki,Takao Hayakawa, Toshiyoshi Fujiwara,and Hiroyuki Mizuguchi

2819 Epigenetic Modulation Enhances theTherapeutic Effect of Anti–IL-13R�2Antibody in Human MesotheliomaXenograftsMakoto Takenouchi, Sachie Hirai,Naoya Sakuragi, Hideo Yagita,Hirofumi Hamada, and Kazunori Kato

2830 PRIMA-1Met/APR-246 InducesApoptosis and Tumor Growth Delayin Small Cell Lung Cancer ExpressingMutant p53Roza Zandi, Galina Selivanova,Camilla Laulund Christensen,Thomas Alexander Gerds,Berthe Marie Willumsen,and Hans Skovgaard Poulsen

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2842 Prevention of Radiation-InducedSalivary Hypofunction FollowinghKGF Gene Delivery to MurineSubmandibular GlandsChangyu Zheng, Ana P. Cotrim,Anne Rowzee, William Swaim,Anastasia Sowers, James B. Mitchell,and Bruce J. Baum

2852 Combination of Farnesyltransferaseand Akt Inhibitors Is Synergistic inBreast Cancer Cells and CausesSignificant Breast Tumor Regressionin ErbB2 Transgenic MiceMaria E. Balasis, Kara D. Forinash,Y. Ann Chen, William J. Fulp,Domenico Coppola, Andrew D. Hamilton,Jin Q. Cheng, and Saïd M. Sebti

2863 Effects of mTOR Inhibitor Everolimus(RAD001) on Bladder Cancer CellsEdmund Chiong, I-Ling Lee, Ali Dadbin,Anita L. Sabichi, Loleta Harris, Diana Urbauer,David J. McConkey, Rian J. Dickstein,Tiewei Cheng, and H. Barton Grossman

2874 Ribavirin Treatment Effects onBreast Cancers OverexpressingeIF4E, a Biomarker with PrognosticSpecificity for Luminal B-Type BreastCancerFilippa Pettersson, Christina Yau,Monica C. Dobocan,Biljana Culjkovic-Kraljacic, H�el�ene Retrouvay,Rachel Puckett, Ludmila M. Flores, Ian E. Krop,Caroline Rousseau, Eftihia Cocolakis,Katherine L. B. Borden, Christopher C. Benz,and Wilson H. Miller, Jr.

IMAGING, DIAGNOSIS, PROGNOSIS

2885 The Viral Load of Epstein–Barr Virus(EBV) DNA in Peripheral BloodPredicts for Biological and ClinicalCharacteristics in HodgkinLymphomaStefan Hohaus, Rosaria Santangelo,Manuela Giachelia, Barbara Vannata,Giuseppina Massini, Annarosa Cuccaro,Maurizio Martini, Valeriana Cesarini,Tonia Cenci, Francesco D’Alo,Maria Teresa Voso, Giovanni Fadda,Giuseppe Leone, and Luigi M. Larocca

2893 Expression of nm23-H1 Is Associatedwith Poor Prognosis in PeripheralT-Cell Lymphoma, Not OtherwiseSpecifiedNozomi Niitsu, Hirokazu Nakamine, andMasataka Okamoto

2900 Excellent Prognosis in a Subset ofPatients with Ewing SarcomaIdentified at Diagnosis by CD56 UsingFlow CytometryShifra Ash, Drorit Luria, Ian J. Cohen,Yacov Goshen, Helen Toledano,Josephine Issakov, Isaac Yaniv,and Smadar Avigad

2908 Digital Transcript Profile Analysiswith aRNA-LongSAGE ValidatesFERMT1 As a Potential NovelPrognostic Marker for Colon CancerJunwei Fan, Dongwang Yan, Mujian Teng,Huamei Tang, Chongzhi Zhou,Xiaoliang Wang, Dawei Li, Guoqiang Qiu,and Zhihai Peng

2919 The Histone Methyltransferase andPutative Oncoprotein MMSET IsOverexpressed in a Large Variety ofHuman TumorsHeidi Rye Hudlebusch, Eric Santoni-Rugiu,Ronald Simon, Elisabeth Ralfkiær,Henrik Holm Rossing, Jens Vilstrup Johansen,Mette Jørgensen, Guido Sauter,and Kristian Helin

2934 Prediction of PostoperativeRecurrence-Free Survival inNon–Small Cell Lung Cancer by Usingan Internationally Validated GeneExpression ModelRanjana Mitra, Jinseon Lee, Jisuk Jo,Monica Milani, Jeanette N. McClintick,Howard J. Edenberg, Kenneth A. Kesler,Karen M. Rieger, Sunil Badve,Oscar W. Cummings, Ahmed Mohiuddin,Dafydd G. Thomas, Xianghua Luo,Beth E. Juliar, Lang Li, Clementina Mesaros,Ian A. Blair, Anjaiah Srirangam,Robert A. Kratzke, Clement J. McDonald,Jhingook Kim, and David A. Potter

2947 Comparative Prognostic Value ofEpidermal Growth FactorQuantitative Protein ExpressionCompared with FISH for Head andNeck Squamous Cell CarcinomaEirini Pectasides, Theodore Rampias,Panteleimon Kountourakis, Clarence Sasaki,Diane Kowalski, George Fountzilas,Thomas Zaramboukas, David Rimm,Barbara Burtness, and Amanda Psyrri

2955 Global Gene Expression Profiling andValidation in Esophageal SquamousCell Carcinoma and its Associationwith Clinical PhenotypesHua Su, Nan Hu, Howard H. Yang,Chaoyu Wang, Mikiko Takikita,Quan-Hong Wang, Carol Giffen,Robert Clifford, Stephen M. Hewitt,Jian-Zhong Shou, Alisa M. Goldstein,Maxwell P. Lee, and Philip R. Taylor

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2967 Persistence of Disseminated TumorCells in the Bone Marrow of BreastCancer Patients Predicts IncreasedRisk for Relapse—A European PooledAnalysisWolfgang Janni, Florian D. Vogl,Gro Wiedswang, Marit Synnestvedt,Tanja Fehm, Julia J€uckstock, Elin Borgen,Brigitte Rack, Stephan Braun, Harald Sommer,Erich Solomayer, Klaus Pantel, Jahn Nesland,Klaus Friese, and Bjørn Naume

CANCER THERAPY: CLINICAL

2977 Phase II Study of Dasatinib inRelapsed or Refractory ChronicLymphocytic LeukemiaPhilip C. Amrein, Eyal C. Attar, Tak Takvorian,Ephraim P. Hochberg, Karen K. Ballen,Kathleen M. Leahy, David C. Fisher,Ann S. LaCasce, Eric D. Jacobsen,Philippe Armand, Robert P. Hasserjian,Lillian Werner, Donna Neuberg,and Jennifer R. Brown

2987 Intra–Lymph Node Prime-BoostVaccination against Melan A andTyrosinase for the Treatment ofMetastatic Melanoma: Results of aPhase 1 Clinical TrialAntoni Ribas, Jeffrey S. Weber,Bartosz Chmielowski, Begonya Comin-Anduix,David Lu, Michael Douek, Nagesh Ragavendra,Steve Raman, Elizabeth Seja, Darlene Rosario,Sabrina Miles, David C. Diamond, Zhiyong Qiu,Mihail Obrocea, and Adrian Bot

2997 Phase 1 Study of the Safety,Tolerability, and Pharmacokineticsof TH-302, a Hypoxia-ActivatedProdrug, in Patients with AdvancedSolid MalignanciesGlen J. Weiss, Jeffrey R. Infante,E. Gabriela Chiorean, Mitesh J. Borad,Johanna C. Bendell, Julian R. Molina,Raoul Tibes, Ramesh K. Ramanathan,Karen Lewandowski, Suzanne F. Jones,Mario E. Lacouture, Virginia K. Langmuir,Hank Lee, Stew Kroll, and Howard A. Burris , III

3005 Close and Stable Relationshipbetween Proliferation and a HypoxiaMetagene in Aromatase Inhibitor–Treated ER-Positive Breast CancerZara Ghazoui, Francesca M. Buffa, Anita K.Dunbier, Helen Anderson, Tim Dexter, SimoneDetre, Janine Salter, Ian E. Smith, Adrian L.Harris, and Mitchell Dowsett

PREDICTIVE BIOMARKERS ANDPERSONALIZED MEDICINE

3013 The Role of Serum ImmunoglobulinFree Light Chain in Response andProgression in WaldenstromMacroglobulinemiaXavier Leleu, Wanling Xie, Meghan Bagshaw,Ranjit Banwait, Renee Leduc, Nitin Roper,Edie Weller, and Irene M. Ghobrial

3019 Pharmacometabonomic Profiling asa Predictor of Toxicity in Patientswith Inoperable Colorectal CancerTreated with CapecitabineAlexandra Backshall, Rohini Sharma,Stephen J. Clarke, and Hector C. Keun

3029 Overexpression of miR-200c InducesChemoresistance in EsophagealCancers Mediated ThroughActivation of the Akt SignalingPathwayRie Hamano, Hiroshi Miyata,Makoto Yamasaki, Yukinori Kurokawa,Johji Hara, Jeong hoMoon, Kiyokazu Nakajima,Shuji Takiguchi, Yoshiyuki Fujiwara,Masaki Mori, and Yuichiro Doki

3039 Pretreatment TranscriptionalProfiling for Predicting Response toNeoadjuvant Chemoradiotherapy inRectal AdenocarcinomaKate H. Brettingham-Moore, Cuong P. Duong,Danielle M. Greenawalt, Alexander G. Heriot,Jason Ellul, Christopher A. Dow,William K. Murray, Rodney J. Hicks,Joe Tjandra, Michael Chao, Andrew Bui,Daryl Lim Joon, Robert J. S. Thomas,and Wayne A. Phillips

LETTER TO THE EDITOR

3048 Reporting the Capture Efficiency of aFilter-Based Microdevice: A CTC IsNot a CTC Unless It Is CD45Negative—LetterGerhardt Attard, Mateus Crespo, Ai Chiin Lim,Lorna Pope, Andrea Zivi, andJohann S. de Bono

3050 Reporting the Capture Efficiency of aFilter-Based Microdevice: A CTC IsNot a CTC Unless It Is CD45Negative—ResponseAnthony Williams, Henry Lin, Ram Datar, andRichard J. Cote

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ABOUT THE COVER

Fibroblast growth factor receptor 2B (FGFR2) in mouse submandibular glands.Immunofluorescence staining shows the presence of FGFR2 in mousesubmandibular glands. FGFR2 staining is shown in red and nuclear stainingwith DAPI (� 400) is shown in blue. Ductal cells show stronger FGFR2-positivestaining than acinar cells. For further details, please see Zheng and coworkerson page 2842 in this issue.

viii Clinical Cancer Research

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2011;17:2603-3050. Clin Cancer Res     17 (9)

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