Clinical Case # 3 Respiratory SystemChronic Obstructive Pulmonary Disease in Acute Exacerbation

Guide Questions:Discuss COPD (Emphysema) in terms of:

1. Mechanism of underlying airflow limitation

2. Respiratory muscles involved during an exacerbation

3. Work of Breathing 4. Physical properties that affect lung function5. Pulmonary Lung Volumes and Capacities6. Pulmonary Function Test (spirometry) with pre and post bronchodilator7. Lung diffusing capacity8. Ventilation-Perfusion Ratio9. O2-Hgb Dissociation Curve 10. Automatic control of respiration and inspiratory ramp signal11. Central and peripheral chemoreceptors