classes are like practice. research is playing in the game. · • proposal writing process •...
TRANSCRIPT
Undergraduate Research: What, Why, Get Involved
Classes are like practice.Research is playing in the game.
ClassesWhat we know...Learning
ResearchWhat we don't know...Doing (and also learning)
Why get involved in research – pragmatic reasons● Paid research positions available● Looks good on your resume● Better letters of recommendation
Effects of Warming on Stomatal Density and Size in Tropical Rainforest Trees
Filling in the Gaps: Finding the Missing Detrital Zircon Puzzle Pieces to the Magmatic Evolution of the Mt. Princeton Batholith, Colorado
High Spatial and Temporal Resolution Temperature Measurements of Atmospheric Gases Using Noninvasive Raman Spectroscopy
Summer Undergraduate Research Fellowships (SURFs)● Competitively awarded● Two page research proposal (developed with faculty mentor)● Application● Letter of support from faculty mentor● Current stipend: $4000 for 10 weeks
Research: Get involved
See also URIP and MSGC
Research: Get involved
As an undergraduate student at Michigan Tech, it’s simple: if you want to do research, you can. Real research—the kind that creates solutions for industry, gets patented (sometimes with your name on it!), or addresses the problems of our modern
world.
Take the initiative. Ask.Don't wait until you are a senior.Why wait to start the fun part?
Timothy Stone:About Me
• Sustainability Sciences and Society Major
• Houghton Native
• Outside Activities:• Research
• Pavlis Honors College
• EMT
• InterVarsity Christian Fellowship
• Love Sports, Photography, and the Outdoors
Historic School Records Research
Distribution of Children by School
An Example of the Scanned
School Record and its
Corresponding Excel Sheet
Original Record Books
Preliminary Results
Engineered Biomaterials
Preview Day
March 30, 2018
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Kaylee Meyers
2nd year Undergraduate
Department of Biomedical Engineering
Developing materials to re-establish tissue structure and function.
How I found out about MTU
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
FIRST Robotics Summer Youth Programs:Women In Engineering
Some of my interests
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
• Running/Fitness• Mountain Biking• Cross Country Skiing• Hiking
Kayaking in YellowstoneSkiing at Tech Trails
Trail Running
How I got involved in research
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Carly JosephPreview Day 2017 Dr. Rupak Rajachar
Fiordland National Park, NZ
What we work on in the lab for people
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
200µm
Human Tenocytes
Problem: Tendon injury leads to degradation ofthe environment in which cells reside.
Approach: An injectable nitric oxide releasinghydrogel to control ECM structure and function.
What we work on in the lab for animals
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Problem: Inadequate whale tag design anddeployment techniques.
Approach: Developing antimicrobial coatingsand modeling new tag designs.
What I do with my lab-mates…outside the lab
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Cross-country skiing at Churning Rapids Lab dinners
Morning trail running
My SURF project
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
• $4000 award• Proposal writing process• Sharing results at local and
national conferences• Working on publications
Fibrillar collagen (I, III)
Network collagen (IV, VI)
MMPs: Collagen
degrading enzymes
Tendon Tissue
Developing a model system to study the biphasic effects of nitric oxide and substrate stiffness on MMP activity.
SURF Details…
[NO] MMP Activity [NO] MMP Activity
MMP Activation MMP Inhibition
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Substrate Model
Developing A Model System
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Polyacrylamide (PAM) Gel
+Acrylamide Bis-Acrylamide (MBA)
UV
432,000 µJ/cm2
0
50
100
150
200
0
Mo
du
lus
(kP
a)
PAM Gel Stiffness
0.4 mol%
2.0 mol%
4.0 mol%
*
*
*
Quantifying Matrix Stiffness via Tensile Testing
Mol % Crosslinker PAM Gel Stiffness
Mol % Crosslinker PAM Gel Stiffness
[Shih et al]
[Trappmann et al]
[Chaudhuri et al]
* Statistical Significance (p<0.05)
Substrate Stiffness
How I had the best summer ever!
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Working with SYPExploring the Keweenaw (Photo: Hiking Mt. Baldy)
Conducting research for my SURF project
+ +
Presenting at the American Society for Matrix Biology
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Red Rock Canyon, Las Vegas, NV Presenting our work My first ½ Marathon
What I have learned so far
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Me, Amanda, and Carly
• Application of class material• Technical writing skills• Lifelong friends• Mentoring process• Expanding comfort zone
Future plans
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Dr. Valisavljevich and Dr. Holmes
Maureen Hennenfent• Improving whale tag
antimicrobial coatings• Evaluating performance of
hydrogen peroxide releasing microgels
• Continuing work related to my SURF project• Mentoring new students in the lab• Building an ultrasound system at Virginia Tech• Eventually applying for graduate school
Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering
Advisor:
Dr. Rupak Rajachar
MTU Engineered Biomaterials Lab:
Carly Joseph
Ariana Tyo
Kiaya Caspers
Maria Kwesiga
Kenneth Hubbard
Emil Johnson
Hal Holmes
Margaret Brunette
Jennifer Sanders
Funding:
NIH/NIGMS
(1R15 GM112082-01-RMR)
MTU Summer Undergraduate Research Fellowship (KMM)
MTU Undergraduate Research Internship Program (KMM)
MTU BME Department Collaborators:
Dr. Bruce Lee
Acknowledgements
Slide Photographs: Dr. Rupak Rajachar, Carly Joseph, Maureen Hennenfent, LeAnna Meyers, schmidtsciencefellows.org,
https://catalog.data.gov/organization/noaa-gov, https://news.nationalgeographic.com/2016/09/humpback-whale-delisting-endangered-species-recovery/, Flash Frame Photography