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Undergraduate Research: What, Why, Get Involved Classes are like practice. Research is playing in the game.

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Page 1: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Undergraduate Research: What, Why, Get Involved

Classes are like practice.Research is playing in the game.

Page 2: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

ClassesWhat we know...Learning

ResearchWhat we don't know...Doing (and also learning)

Page 3: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Why get involved in research – pragmatic reasons● Paid research positions available● Looks good on your resume● Better letters of recommendation

Page 4: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Effects of Warming on Stomatal Density and Size in Tropical Rainforest Trees

Filling in the Gaps: Finding the Missing Detrital Zircon Puzzle Pieces to the Magmatic Evolution of the Mt. Princeton Batholith, Colorado

High Spatial and Temporal Resolution Temperature Measurements of Atmospheric Gases Using Noninvasive Raman Spectroscopy

Page 5: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Summer Undergraduate Research Fellowships (SURFs)● Competitively awarded● Two page research proposal (developed with faculty mentor)● Application● Letter of support from faculty mentor● Current stipend: $4000 for 10 weeks

Research: Get involved

See also URIP and MSGC

Page 6: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Research: Get involved

As an undergraduate student at Michigan Tech, it’s simple: if you want to do research, you can. Real research—the kind that creates solutions for industry, gets patented (sometimes with your name on it!), or addresses the problems of our modern

world.

Take the initiative. Ask.Don't wait until you are a senior.Why wait to start the fun part?

Page 7: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Timothy Stone:About Me

• Sustainability Sciences and Society Major

• Houghton Native

• Outside Activities:• Research

• Pavlis Honors College

• EMT

• InterVarsity Christian Fellowship

• Love Sports, Photography, and the Outdoors

Page 8: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Historic School Records Research

Distribution of Children by School

An Example of the Scanned

School Record and its

Corresponding Excel Sheet

Original Record Books

Page 9: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Preliminary Results

Page 10: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Engineered Biomaterials

Preview Day

March 30, 2018

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Kaylee Meyers

2nd year Undergraduate

Department of Biomedical Engineering

Developing materials to re-establish tissue structure and function.

Page 11: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

How I found out about MTU

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

FIRST Robotics Summer Youth Programs:Women In Engineering

Page 12: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Some of my interests

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

• Running/Fitness• Mountain Biking• Cross Country Skiing• Hiking

Kayaking in YellowstoneSkiing at Tech Trails

Trail Running

Page 13: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

How I got involved in research

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Carly JosephPreview Day 2017 Dr. Rupak Rajachar

Fiordland National Park, NZ

Page 14: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

What we work on in the lab for people

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

200µm

Human Tenocytes

Problem: Tendon injury leads to degradation ofthe environment in which cells reside.

Approach: An injectable nitric oxide releasinghydrogel to control ECM structure and function.

Page 15: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

What we work on in the lab for animals

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Problem: Inadequate whale tag design anddeployment techniques.

Approach: Developing antimicrobial coatingsand modeling new tag designs.

Page 16: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

What I do with my lab-mates…outside the lab

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Cross-country skiing at Churning Rapids Lab dinners

Morning trail running

Page 17: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

My SURF project

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

• $4000 award• Proposal writing process• Sharing results at local and

national conferences• Working on publications

Fibrillar collagen (I, III)

Network collagen (IV, VI)

MMPs: Collagen

degrading enzymes

Tendon Tissue

Developing a model system to study the biphasic effects of nitric oxide and substrate stiffness on MMP activity.

SURF Details…

[NO] MMP Activity [NO] MMP Activity

MMP Activation MMP Inhibition

Page 18: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Substrate Model

Developing A Model System

Page 19: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Polyacrylamide (PAM) Gel

+Acrylamide Bis-Acrylamide (MBA)

UV

432,000 µJ/cm2

0

50

100

150

200

0

Mo

du

lus

(kP

a)

PAM Gel Stiffness

0.4 mol%

2.0 mol%

4.0 mol%

*

*

*

Quantifying Matrix Stiffness via Tensile Testing

Mol % Crosslinker PAM Gel Stiffness

Mol % Crosslinker PAM Gel Stiffness

[Shih et al]

[Trappmann et al]

[Chaudhuri et al]

* Statistical Significance (p<0.05)

Substrate Stiffness

Page 20: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

How I had the best summer ever!

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Working with SYPExploring the Keweenaw (Photo: Hiking Mt. Baldy)

Conducting research for my SURF project

+ +

Page 21: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Presenting at the American Society for Matrix Biology

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Red Rock Canyon, Las Vegas, NV Presenting our work My first ½ Marathon

Page 22: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

What I have learned so far

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Me, Amanda, and Carly

• Application of class material• Technical writing skills• Lifelong friends• Mentoring process• Expanding comfort zone

Page 23: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Future plans

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Dr. Valisavljevich and Dr. Holmes

Maureen Hennenfent• Improving whale tag

antimicrobial coatings• Evaluating performance of

hydrogen peroxide releasing microgels

• Continuing work related to my SURF project• Mentoring new students in the lab• Building an ultrasound system at Virginia Tech• Eventually applying for graduate school

Page 24: Classes are like practice. Research is playing in the game. · • Proposal writing process • Sharing results at local and national conferences • Working on publications Fibrillar

Engineered Biomaterials Laboratory Michigan Technological UniversityDepartment of Biomedical Engineering

Advisor:

Dr. Rupak Rajachar

MTU Engineered Biomaterials Lab:

Carly Joseph

Ariana Tyo

Kiaya Caspers

Maria Kwesiga

Kenneth Hubbard

Emil Johnson

Hal Holmes

Margaret Brunette

Jennifer Sanders

Funding:

NIH/NIGMS

(1R15 GM112082-01-RMR)

MTU Summer Undergraduate Research Fellowship (KMM)

MTU Undergraduate Research Internship Program (KMM)

MTU BME Department Collaborators:

Dr. Bruce Lee

Acknowledgements

Slide Photographs: Dr. Rupak Rajachar, Carly Joseph, Maureen Hennenfent, LeAnna Meyers, schmidtsciencefellows.org,

https://catalog.data.gov/organization/noaa-gov, https://news.nationalgeographic.com/2016/09/humpback-whale-delisting-endangered-species-recovery/, Flash Frame Photography