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Circulation Research

SUBJECT INDEX

VOLUME XXI JULY-DECEMBER, 1967

Acetate, 14C-labeIed, incorporation into lipid by foamcells and atherosclerotic arterial intima,593

Acetylcholinemitral valve response to, 9myocardial responses to, 573

Acetylstrophanthidinhemodynamic effects in myocardial infarction, 191role in myocardial oxygen consurnjption, 487

Acid hydrolase, lysosomal, effects' of asphyxia andhypothermia on binding in cardiac muscle,59

Acknowledgment to Reviewers, 935Action potentials

and automaticity in Purkinje fibers, 537cell density and low K effects in chick heart cells,

879ouabain inotropy in canine cardiac muscle, 515sinus node, and atrial fibrillation, 507

Actomyosin, cardiac microsomal calcium binding anduptake, 153

Adenosine triphosphataseand contractility in heart failure, 717and oxidative phosphorylation in mitochondria

from the failing heart, 355Adenosine triphosphate

and calcium uptake in glycerinated cardiac slices,433

formation of in cardiac mitochondria, "competition"between ion transport and, 25

myocardial stores in cardiac hypertrophy and fail-ure, 365

Adenylates, in washout cardiac failure, 263Adrenergic nervous system

enhancement of peripheral a-receptor stimulationby blockade of "silent" /3-receptors, 703

in hypothermic ventricular fibrillation after cate-cholamine depletion, 45

a-receptorsin coronary arteries of the dog, 75norepinepnrine effects, 217role in control of splanchnic circulation in man,

333(3-receptors

blockade in post-countershock arrhythmias, 375in coronary arteries of the dog, 75norepinepnrine effects, 217propranolol effects on coronary vascular resis-

tance, 305role in control of splanchnic circulation in man,

333Alkalosis, respiratory, effects on survival in hemor-

rhagic shock, 461Alpha receptors

in coronary arteries of the dog, 75enhancement of peripheral stimulation by block-

ade of "silent" j3-receptors, 703norepinephrine effects, 217role in control of splanchnic circulation in man, 333

Alveoli, ultrastructural alterations in pulmonary ede-ma, 783

Amino acidsincorporation into proteins by microsomes during

cardiac hypertrophy, 449N-terminal amino acid of angiotensin, 327

Ammonia, cerebral, monitoring methods, 649Anemia, nutritional, nucleic acid synthesis in en-

larged hearts of rats with, 635Angiotensin

and enhancement of a-receptor stimulation byblockade of "silent" /3-receptors, 703

inhibition of production by phospnolipid reninpreinhibitor, 497

response of resistance vessels from mesentery andbrain, 525

tachyphylaxis to aspartyl1 but not to asp.arginyl1

angiotensin II, 327Anoxia

cerebral blood flow and oxygen, glucose, lactate,and ammonia metabolism in, 649

lysosomal enzymes and damage to the heart in, 59Antipyrine

fetal umbilical blood flow measurementsmethod, 163validation of the method, 185

for measurements of fetal and umbilical circula-tory changes, 741

Aortamusculature, viscoelastic properties and microscop-

ic structure, 901stenosis, capacity of terminal vascular bed of car-

diac muscle in, 209 ;Aortic stenosis, capacity of the terminal vascular bed

of cardiac muscle in, 209Arrhythmias. See also Fibrillation

conduction disturbances due to phase-4 depolari-zation in Purkinje fibers as possible cause of,537

post-countershock, in untreated and digitalizeddogs, 375

Arteriesarterial pH and respiratory alkalosis effect in

hemorrhagic shock, 461atherosclerosis

fibrinolytic activity in coronary arteries, 799high molecular weight dextran effects on tissue

cholesterol, 817incorporation of i*C-labeled acetate into lipid

by intima, 593cerebral, resistance and response to drugs, 525coronary

adrenergic receptor activity, 75disease, J-epinephrine effects with and without,

919fibrinolytic activity in human atherosclerosis,

799ligation, myocardial infarction following, 191occlusion, decreased Ca2+ uptake by sarcoplas-

mic reticulum after, 439large, viscoelastic properties and microscopic struc-

ture of, 901

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944 INDEX [Arteries-Blood flow]

mesenterya-receptor stimulation and blockade of "silent"

^-receptors, 703blood flow measured by electromagnetic cathe-

ter-flowmeter, 889resistance and response to drugs, 525

norepinephrine effects on /3-receptors in the dogarterial bed, 217

pulmonary, musculature, viscoelastic propertiesand microscopic structure, 901

renal, blood flow measured by electromagneticcatheter-flowmeter, 889

sinus node, responses of sinoatrial node to pres-sure changes in, 297

venous occlusion pressure plethysmography in hu-man upper limb, 139

Asphyxiaeffects on blood flow in the mature fetal lamb, 229effects on hindlimb circulation in the newborn

calf, 237and hypothermia effects on binding of lysosomal

acid hydrolases, 59Assay, of phospholipid renin preinhibitor, 497Atherosclerosis

effects of high molecular weight dextran on tissuecholesterol, 817

fibrinolytic activity in human coronary arteries, 799incorporation of 14C-labeIed acetate into lipid by

arterial intima, 593ATP. See Adenosine triphosphateATPase. See Adenosine triphosphataseAtrial fibrillation

concealed conduction in, 201sinus node impulses and, 507

Atrial septal defect, myocardial lysosomes in, 17Atrioventricular node, concealed conduction in atrial

fibrillation, 201Atrium

fibrillationconcealed conduction in, 201sinus node impulses and, 507

and mitral valve contraction, 9myocardial lysosomes in atrial septal defects, 17right atrial contractile force and right ventricular

stroke volume, 641Atrophy, cardiac, capacity of the terminal vascular

bed of heart muscle in, 209Automaticity

barium-induced, in right ventricular muscle of thedog, 849

in Purkinje fibers, interrelationships between con-duction and, 537

Autonomic nervous system, control of systemic cir-culation in the newborn calf, 237

Autoregulationof cerebral blood flow, 559of skeletal muscle blood flow in the human fore-

arm, 319, 679

B

Barium, automaticity induced by in right ventricularmuscle of the dog, 849

Baroreceptors, and autoregulation of cerebral bloodflow, 559

Beta panicles, and intra-arterial Kr85, clearance meth-od for measurement of skin blood flow,invalidation of, 281

Beta receptorsblockade

in post-countershock arrhythmias, 375

propranolol effects on coronary vascular resis-tance, 305

of "silent" /3-receptors, enhancement of periph-eral a-receptor stimulation by, 703

in coronary arteries of the dog, 75norepinephrine effects, 217role in control of splanchnic circulation in man,

333Block

atrioventricular, in atrial fibrillation, 201bundle-branch, model; potassium effects on Pur-

kinje network and ventricular conduction, 3Blockade

a-adrenergicin control of splanchnic circulation in man, 333in coronary arteries of the dog, 75

/3-adrenergicin control of splanchnic circulation in man, 333in coronary arteries of the dog, 75and post-countershock arrhythmias, 375propranolol effects on coronary vascular resis-

tance, 305"silent," enhancement of peripheral a-receptor

stimulation by, 703Blood

plasmaflow in pericapillary spaces, 925responses of mesenteric and cerebral resistance

vessels to, 525velocity profiles, 925

Blood flowautoregulation

of cerebral blood flow, 559of skeletal muscle blood flow in the human

forearm, 319, 679cerebral

autoregulation and baroreceptor reflexes, 559in the mature fetal lamb, 229measurementinthematurefetallamb, by external monitoring of cesi-

umis i , 8 0 5monitoring methods, 649

coronaryadrenergic receptor activitv, 75endocardial distribution, 65hypertension, ischemia, and vasoactive drug ef-

fects, 65during isoproterenol, 85?-epinephrine effects with and without coronary

artery disease, 919in the mature fetal lamb, 229

fetaleffects of exteriorization of the fetus, 741regional redistribution, 229in utero, 163, 185

forearmautoregulation, 319, 679epinephrine effects, 679

hindlimb, in the newborn calf, 237human upper limb

at low perfusion pressure, 319pressure-flow relations by venous occlusion pleth-

ysmography, 139measurement methods

antipyrine method, 163, 185, 741electromagnetic catheter-flowmeter, 889external monitoring of cesium131, 805inert gas diffusion, 281intra-arterial KrS5 ^-particle clearance, invalida-

tion of. 281venous occlusion plethysmography, 139

monitoring methods, 649plasma flow in pericapillary spaces, 925

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[Blood flow-Cholesterol] INDEX 945

pulmonarychanges evoked by stimulation of the hypo-

thalamic integrative area for the defensereaction, 747

effects of mild chronic hypoxia in reactive pul-monary hypertension, 661

fibrinopeptide effects, 469renal

in the mature fetal lamb, 229measured by electromagnetic catheter-flowme-

ter, 889redistribution produced by furosemide and etha-

crynic acid, 869skeletal muscle, autoregulation in the human fore-

arm, 319, 679skin, measurement methods, 281splanchnic, control of in man, 333umbilical

effects of exteriorization of the fetus, 741of the fetus in utero, 163, 185

Blood pressurehypertension

abnormal norepinephrine storage, 583and coronary now, 65effects of mild chronic hypoxia, 661flbrinopeptide effects, 469left ventricular, 65pulmonary, 469, 661

pressure-flow relations by venous occlusion pleth-ysmography in human upper limb, 139

in the sinus node artery, and rhythmicity, 297Blood vessels

capillariescapacity of the terminal vascular bed of cardiac

muscle, 209fibrinolytic activity in human atherosclerotic cor-

onary arteries, 799plasma flow in pericapillary spaces, 925

from mesentery and brain, responses to drugs, 525technique for microscopic study in living striated

muscle, 823vascular leakage caused by histamine-type medi-

ators, 833Blood volume, respiratory alkalosis in hemorrhagic

shock, 461Books received, 670Bradykinin, vascular leakage caused by, 833Brain. See Cerebral circulationBundle-branch block, model; potassium effects on

Purkinje network and ventricular conduc-tion, 3

Caffeine, and calcium uptake in glycerinated cardiacslices, 433

Calciumin cardiac microsomes, binding and uptake, 153,

767classification of inotropic stimuli, 857effects on inotropic actions of acetvlcholine, 573ionic influence on electrical and mechanical ac-

tivity in rat portal vein, 609role in vascular smooth muscle response to norepi-

nephrine and isoproterenol, 619uptake

in cardiac microsomes, 153, 767decreased Ca2 + uptake by sarcoplasmic rericulum

after coronary artery occlusion, 439by glycerinated cardiac slices, 433

Capillariescapacity of the terminal vascular bed of heart

muscle, 209


fibrinolytic activity in human atherosclerotic coro-nary arteries, 799

plasma flow in pericapillary spaces, 925Carbon black, in microscopic study of blood vessels

in living striated muscle, 823Cardiac denervation, and post-countershock arrhyth-

mias, 375Cardiac depression, myocardial oxygen consumption

in, 123Cardiac failure. See Heart failureCardiac muscle. See also Myocardium and Ventricle

binding of lysosomal acid hydrolases in effectsof asphyxia and hypothermia, 59

capacity of terminal vascular bed of, 209classification of inotropic stimuli, 857collagen in, 33electrophysiological correlate of ouabain inotropy

in, 515glycerinated slices, calcium uptake by, 433length-tension relations, 33mitochondria after exercise, 271in the mitral valve, 9tension-velocity relations in left ventricular func-

tion, 99ultrastructure after exercise, 271

Cardiac outputcalculation by external monitoring of cesium131,

805effects of alterations in right atrial contractile

force, 641of the fetus in utero, 163fibrinopeptide effects, 469

Cardiomegalycapacity of terminaP vascular bed of cardiac mus-

cle in, 209nucleic acid synthesis in, 635

Carotid sinus, denervation effects on cerebral bloodflow autoregulation. 559

Casts, of left ventricular cavity, 409Catecholamines. See also Epinephrine, Isoproterenol,

and Norepinephrineand adrenergic receptor activity in dog coronary

arteries, 75control of ventricular fibrillation during hypo-

thermia after depletion of stores of, 45hemodynamic effects in myocardial infarction, 191post-countershock arrhythmias, 375

Cathepsin, binding in cardiac muscle after asphyxiaand hypothermia, 59

Catheter, electromagnetic catheter-flowmeter, 889Cells

density and low potassium effects on action poten-tials of chick heart cells, 879

foam, incorporation of 14C-labeled acetate intolipid by, 593

hyperplasia, and nucleic acid synthesis in cardiacenlargement and nutritional anemia, 635

myocardial, lengths in the normal dog, 671Cerebral artery, resistance and response to drugs, 525Cerebral circulation

autoregulation and baroreceptor reflexes, 559blood flow measurement by external monitoring

of cesium1'1, 805in the mature fetal lamb, 229monitoring blood flow and oxygen, glucose, lac-

tate, and ammonia metabolism, 649Cesium-131, measurement of total cerebral blood

flow by external monitoring of, 805Cheatham, Owen R., Gold Heart Award, 777, 778Cholesterol, hypercholesterolemia, effect of high

molecular weight dextran, 817


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946 INDEX [Cholesertol ester-Contractility]

Cholesterol ester, incorporation of 14C-labeled ace-tate into fatty acids by atherosclerotic in-tima and foam cells, 593

Cholinergic nerves, in mitral valve contraction, 9Chronotropic response

to pressure changes in the sinus node artery, 297propranolol effects on coronary "vascular resis-

tance, 305Classic pages

Action of ephedrine, the active principle 'of.the Chi-nese drug Ma Huang, The, by K. K. Chenand Carl F. Schmidt, 270

Capillary pressure in frog mesentery as determinedby micro-injection methods, The, by Eu-gene M. Landis, 44

Changes in the cross-striations of muscle duringcontraction and stretch and, their structuralinterpretation, by Hugh Huxley and JeanHanson, 486

Concerning a definite regulatory mechanism ofthe vaso-motor centre which controls bloodpressure during cerebral compression, byHarvey Cushing, 364

Contraction of myosin threads, The, ldy A. Szent-Gyorgyi, 726

Crystalline pressor substance (angiotonin) result-ing from the reaction between renin andrenin-activator, A, by Irvine H. Page andO. M. Helmer, 326

De Venarum Ostiolis, by Hieronymus Fabricius AbAquapendente, 280

Determination of cerebral blood flow in man bythe use of nitrous oxide in low concentra-tions, The, by Seymour S. Kety and CarlF. Schmidt, 766^

Further contribution regarding the influence of thedifferent constituents of the blood on thecontraction of the heart, A, by SydneyRinger, 432

Gehirn und Sympathicus: VII. Ueber Beziehungender Hypoihalamuszentren zu Blutdruck undinnerer Sekretion, by J. P. Karplus and A.Kreidl, 746

Identification of the sympathomimetic ergone inadrenergic nerves of cattle (Sympathin N)with laevo-noradrenaline, by U. S. von Euler,690

Lactic acid in amphibian muscles, by W. M. Fletch-er and F. G. Hopkins, 592

Maximal contraction, "staircase" contraction, re-fractory period,, and compensatory pause, ofthe heart, by R. S. Woodworth, 514

Muscular force at different speeds of shortening,by W. O. Fenn and B. S. Marsh, 716

Myosine and Adenosinetriphosphatase, by W. A.Engelhardt and M. N. Ljubimowa, 32

Nature of fibrillary contraction of the heart, The:Its relation to tissue mass and form, byWalter E. Garrey, 200

Niere undWalterE.Garrey,200 Kreislauf, by Robert Tigerstedt andP. G. Bergman, 148

Observations on the mean pressure and the char-acteristics of the pulse wave in the coro-nary arteries of the heart, by H. Newell-Martin and W. T. Sedgwick, 506

On the absorption of fluids from the connectivetissue spaces, by Ernest H. Starling, 116

On the circulation of the blood, by Antoni vanLeeuwenhoek, 16

On the dynamic equilibrium in the heart, by GeorgeRalph Mines, 296

On the mechanical factors which determine theoutput of the ventricles, by S. W. Patter-son and E..H. Starling, 262

Opera Omnia. De Pulmonibus, Epistola II (1661),by Marcelli Malpighii, 402

Physiological action of p-iminazolyl ethylamine,The, by H. H. Dale and P. P. Laidlaw, 460

Physiological effects of extracts of the suprarenalcapsules, The, by George Oliver and E. A.Schafer, 216

Recherches experimentales sur le mouvement desliquides dans les tubes de tres-petits diam-etres, by Jean Leonard Marie Poiseuille, 318

Recherches physiologiques et pharmacodynamiquessur le tete isoles du chien: II. Sur I'in-fluence respiratoire et pneumogastrique etde I'adrSnaline, de Vatropine, de la pitui-trine, de la nicotine et des digitaliques, byJ. F. Heymans and C. Heymans, 228

Researches on the circulation time in organs and onthe influences which affect it: Parts 1-HI,by G. N. Stewart, 776

Rhythmical Pulsation in Scyphomedusae, by Al-fred G. Mayer, 374

Statistical Essays: Containing Haemastaticks, vol. 2,by Stephen Hales, 2

Structural changes in muscle during contraction, byA. F. Huxley and R. Niedergerke, 422

Studies of the consecutive phases of the cardiaccycle: I. The duration of the consecutivephases of the cardiac cycle and the criteriafor their precise determination, by Carl J.Wiggers, 236

Studies on experimental hypertension: I. The pro-duction of persistent elevation of systolicblood pressure by means of renal ischemia,by Harry Goldblatt, James Lynch, RamonF. Hanzal, and Ward W. Summerville, 496

Zur Dynamik des Herzmuskels, by Otto Frank, 634Clearance curves, intra-arterial Kr85 /3-particle method

for measurement of skin blood flow, in-validation of, 281

Cocaine, effects in post-countershock arrhythmias,375

Collagenin cardiac muscle, 33in the mitral valve, 9thermal responses in large arteries. 901

Concealed conduction, in atrial fibrillation, 201Conduction

concealed, in atrial fibrillation, 201diphenylhydantoin effects, 757in Purkinje fibers, interrelationships between au-

tomaticity and, 537ventricular, KC1 and, 3

Constriction. See VasoconstrictionContractility

and cardiac glycosides, 727contractile force in gas-perfused hearts, 263in heart failure

acute cardiac depression, 123congestive, 341depressed ATPase, 717high energy phosphate stores, 365

mitral valve, intrinsic neuromuscular basis for, 9muscular, in large arteries, 901myocardial

and cardiac glycosides, 727ouabain effects, 515oxygen consumption in acute cardiac depres-

sion, 123responses to acetylcholine, 573role of acetylstrophanthidin, 487



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[Contractility-Epinephrine] INDEX 947

ouabain effects in the perfused rabbit heart, 445right atrial contractile force and right ventricular

stroke volume, 641ventricular, and changes in sarcomere length, 423

Coronary arteryadrenergic receptor activity in the dog, 75disease, Z-epinephrine effects with and without,

919fibrinolytic activity in human atherosclerosis, 799myocardial infarction following ligation; isoprote-

renol and acetylstrophanthidin effects, 191occlusion; decreased Ca2 + uptake by sarcoplasmic

reticulum after, 439Coronary circulation

adrenergic receptor activity in dogs, 75endocardial distribution, 65i-epinephrine effects with and without coronary

artery disease, 919in the mature fetal lamb, 229myocardial function and coronary flow during

isoproterenol, 85occlusion, decreased Ca2+ uptake by sarcoplasmic

reticulum after, 439ventricular hypertension, ischemia, and vasoactive

drug effects, 65Coronary vascular resistance, effects of propranolol,

305Corrections, vols. 20 and 21, 936Cortex, juxtamedullary, redistribution of renal blood

flow by furosemide and ethacrynic acid,869

Creatine phosphateand calcium uptake in glycerinated cardiac slices,

433myocardial stores in cardiac hypertrophy and fail-

ure, 365Creep recovery, in large arteries, 901Cremaster muscle

technique for microscopic study of blood vesselsin vivo, 823

vascular leakage caused by histamirie-type media-tors, 833

DDefense reaction, hypothalaniic integrative area for,

stimulation of, 747Denervation

cardiac svmpathetic, and post-countershock ar-rhythmias, 375

carotid sinus, effects on cerebral blood flow auto-regulation, 559

epicardial, and myocardial responses to stimula-tion of cardiac sympathetic nerves, 691

Deoxyribonucleic acid (DNA), synthesis in cardiacenlargement from nutritional anemia, 635

Depolarizationbarium-induced ventricular automaticity, 849diastolic, cell density and low K effects in chick

heart cells, 879phase 4, in Purkinje fibers, 537

Depression, cardiac, myocardial oxygen consump-tion in, 123

Dextran, high molecular weight, effect on hypercho-lesterolemia, 817

Diastolearchitecture of the heart in, 409diastolic depolarization, 537, 879ultrastructure of the heart in, 423

Diffusion processes, inert gas, invalidating the intra-arterial Kr85 /3-particle clearance methodfor measurement of skin blood flow inman, 281


Digitalis..acetylstrophanthidin effects in myocardial infarc-

tion, 191,and contractility in cardiac hypertrophy and fail-

ure, 341electrophysiological correlate of ouabain inotropy

in cardiac muscle, 515post-countershock arrhythmias in untreated and

digitalized dogs, 375Digitalis glycosides, effect on washout cardiac,- fail-

ure, 263Diphenylhydantoin, influence on electrophysiologi-

cal properties of the heart, 757Dipyridamole, and myocardial distribution of coro-

nary flow, 65Diuresis, redistribution of renal blood flow produced

by furosemide and ethacrynic acid, 869,DNA. See Deoxyribonucleic acid

Edema, pulmonary, ultrastructural alterations at thealveolar level in, 783

Editorial announcements, 1Edwards, Jesse E., new American Heart Association

president, 777Elastin, thermal responses in large arteries, 901Electrical activity

portal veininfluence of ionic environment on, 609response to norepinephrine and isoproterenol,

619Electrocardiogram

aberrant QRS complexes in atrial fibrillation, 201P-P interval, and post-countershock arrhythmias,

375Electromagnetic flowmeter

compared with antipyrine method for measurementof fetal umbilical blood flow, 185

fetal blood flow and cardiac output measurements,163, 185

incorporated into a catheter, 889Electron microscope, alterations at the alveolar level

in pulmonary edema, 783Embryonic heart cells, effects of cell density and' low

K on action potentials of, 879Endocardium, distribution of left coronary blood

flow in, 65Endothelium

fibrinolytic activity in human atherosclerotic coro-nary arteries, 799

and vascular leakage caused by histamine-typemediators, 833

Energymyocardial stores in cardiac hypertrophy and fail-

ure, 365myocardial utilization in acute cardiac depression,

123Enzymes

lysosomal, and asphyxic damage to the' heart, 59protein synthesis during cardiac hypertrophy, 449

Epicardiumdenervation, and myocardial responses to stimula-

tion of cardiac sympathetic "nerves, 691distribution of coronary flow, 65

Epilepsy, cerebral blood flow and oxygen, glucose,lactate, and ammonia metabolism in, 649

Epinephrineand adrenergic receptor activity in ;36g coronary

arteries, 75and calcium uptake in glycerinated cardiac slices,

433


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948 INDEX [ Epinephrine-Heart]

effects on coronary circulation with and withoutcoronary artery disease, 919

effects on oxygen consumption, 679, 919iontophoresis

human upper limb blood flow, 319metabolic and vasodilator effects of epineph-

rine in human forearm muscle, 679phase-4 depolarization in Purkinje fibers, 537pressor effects on isolated mesenteric arteries, 703response of mesenteric and cerebral resistance ves-

sels, 525Ethacrynic acid, redistribution of renal blood flow

produced by, 869Excitation-contraction coupling

cardiac microsomal calcium binding and uptake,153

and ischemia effects on the sarcoplasmic reticulum,439

Exercise, fine structure of myocardial mitochondriaafter, 271

Exteriorization of the fetus, effect on cardiovascularfunction, 741

External monitoring, of cesium131, measurement oftotal cerebral blood flow by, 805

Fatty acidslipid synthesis bv foam cells and atherosclerotic

intima, 593myocardial metabolism, ouabain effects, 445

Fenn, Wallace O., Research Achievement Award,777, 778

Fetal circulationeffects of exteriorization of the fetus on, 741regional redistribution in the mature fetal lamb,

229umbilical blood flow, 163, 185in utero, blood flow distribution, organ blood flow,

and cardiac output, 163Fetus, exteriorization, effect on cardiovascular func-

tion, 741Fibrillation

atrialconcealed conduction in, 201sinus node impulses and, 507

ventricularcontrol in hypothermia after depletion of cate-

cholamine stores, 45vulnerability induced by 60 cps alternating cur-

rent, 601Fibrin, fibrinolytic activity in human atherosclerotic

coronary arteries, 799Fibrinogen, pulmonary and circulatory effects of

fibrinopeptides, 469Fibrinopeptides, pulmonary and circulatory effects,

469Fixation, rapid technique for analysis of left ven-

tricular diameter, 409Flow. See Blood flowFlowmeter. See Electromagnetic flowmeterFoam cells, incorporation of 14C-labeled acetate into

lipid by, 593Force-velocity relation

in cardiac hypertrophy and failure, 341left ventricular myocardial function in sedated

dogs, 99myocardial, role of acetylstrophanthidin, 487

Furosemide, redistribution of renal blood flow pro-duced by, 869

Gasinduction of failure in gas-perfused hearts, 263inert, diffusion process invalidating the intra-

arterial Kr85 /3-particle clearance mediod formeasuring skin blood flow in man, 281

Glucose, cerebral consumption, monitoring methods,649

/3-Glucuronidase, binding in cardiac muscle afterasphyxia and hypothermia, 59

Glutaraldehyde, rapid fixation technique for leftventricular geometry, 409

Glycerol, calcium uptake in glycerinated cardiacslices, 433

Glycosidesacetylstrophanthidin effects in myocardium, 487digitalis, effect on washout cardiac failure, 263and heart contractions, 727

Gracilis muscle, intracellular POo and its regulation

in, 251

H

Hamster, hereditary myocardiopathy, work perfor-mance of beating heart in, 391

Heartarchitecture in systole and diastole, 409arrhythmias. See also Fibrillation

conduction disturbances in Purkinje fibers aspossible cause of, 537

post-countershock, 375calcium binding and uptake in microsomes, 153cells, embryonic, effects of cell density and low K

on action potentials of, 879conduction

and automaticity in Purkinje fibers, 537concealed, in atrial fibrillation, 201diphenylhydantoin effects, 757ventricular, KC1 and, 3

contractilityacetylcholine effects, 573acetylstrophanthidin effects, 487and cardiac glycosides, 727and depressed ATPase in failure, 717in failure, 123, 341, 365, 717in gas-perfused hearts, 263high energy phosphate stores in hypertrophy

and failure, 365mitral valve, 9myocardial O2 consumption in acute depression,

123ouabain effects, 445, 515right atrial contractile force and right ventricular

stroke volume, 641sarcomere length changes, 423

denervation, and post-countershock arrhythmias,375

diphenylhydantoin effects on electrophysiologicalproperties of, 757

electrocardiogramaberrant QRS complexes in atrial fibrillation, 201P-P interval, and post-countershock arrhythmias,

375enlargement, nucleic acid synthesis in nutritional

anemia, 635ial,role

contractility of cardiac muscle in, 341Circulation Research, Vol. XXI, December 1967


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[ Heart-Hypoxia] INDEX 949

depressed ATPase and reduced contractility in,717

effect of digitalis glycosides, 263induction in gas-perfused hearts with Krebs

solution, 263myocardial high energy phosphate stores in, 365myocardial Os consumption in acute cardiac de-

pression, 123normal oxidative phosphorylation in, 355

fibrillationatrial, 201, 507ventricular, 45, 601

fibrinopeptide effects, 469hypertrophy

contractile state of cardiac muscle, 341high energy phosphate stores in, 365nucleic acid synthesis with nutritional anemia,

635protein synthesis during, 449ventricular, 341, 365, 449

ischemiaand decreased Ca2+ uptake by the sarcoplasmic

reticulum after, 439effects on coronary flow, 65

lysosomal enzymes and asphyxic damage to, 59mitochondria, potassium ion transport in, 25muscle. See also Myocardium and Ventricle

binding of lysosomal acid hydrolases in, 59capacity of terminal vascular bed of. 209classification of inotropic stimuli, 857collagen in, 33electrophysiological correlate of ouabain ino-

tropy in, 515glycerinated, calcium uptake by, 433length-tension relations, 33the mitochondria after exercise, 271in the mitral valve, 9tension-velocity relations, 99ultrastructure after exercise, 271

myocardium. See Myocardiumoutput

calculation by external monitoring of cesium131,805

effects of alterations in right atrial contractileforce, 641

of the fetus in utero, 163fibrinopeptide effects, 469

pacemakersbarium-induced automaticity in ventricular mus-

cle, 849and concealed conduction in atrial fibrillation,

201in Purkinje fibers. 537and ventricular fibrillation threshold, 601

premature beats, sinus node impulses and, 507rate, regulation; sinus node arterial pressure and

rhythmicity, 297relaxation, calcium binding and uptake, 153ultrastructure

after exercise. 271in systole and diastole, 423

ventricles. See Ventriclework performance in hereditary myocardiopathy,

391Heart failure

contractilityof cardiac muscle, 341reduced, and depressed ATPase, 717

effect of digitalis glycosides, 263induction in gas-perfused hearts with Krebs solu-

tion, 263myocardial high energy phosphate stores in, 365


myocardial OJ consumption in acute cardiac de-pression, 123

normal oxidative phosphorylation in, 355Heart muscle. See also Myocardium and Ventricle

binding of lysosomal acid hydrolases in, effects ofasphyxia and hypothermia, 59

capacity of terminal vascular bed of, 209classification of inotropic stimuli, 857collagen in, 33electrophysiological correlate of ouabain inotropy

in, 515glycerinated, calcium uptake by, 433length-tension relations, 33the mitochondria after exercise, 271in the mitral valve, 9tension-velocity relations in left ventricular func-


Heart rate, regulation; sinus node arterial pressureand rhythmicity, 297

Hemorrhagic shock, effects of respiratory alkalosison survival in, 461

Hexamethonium, in control of splanchnic circulationin man, 333

High energy phosphate, myocardial stores in cardiachypertrophy and failure, 365

High molecular weight dextran, effect on hyper-cholesterolemia, 817

Histamine-type mediators, vascular leakage causedby, 833

Histone, and cardiac mitochondrial potassium iontransport, 25

Hypercholesterolemia, effect of high molecular weightdextran on, 817

Hyperplasia, and nucleic acid synthesis in rats withcardiac enlargement and nutritional anemia,635

Hypertensionabnormal norepinephrine storage, 583left ventricular, and coronary flow, 65pulmonary

fibrinopeptide effects, 469reactive, effects of mild chronic hypoxia, 661

Hypertrophycardiac; nucleic acid synthesis in nutritional anemia,

635ventricular

contractile state of cardiac muscle, 341high energy phosphate stores in, 365protein synthesis during, 449

Hyperventilationcerebral blood flow and oxygen, glucose, lactate,

and ammonia metabolism, 649epinephrine effects in human forearm muscle, 679

Hypothalamus, changes in the pulmonary circulationevoked by stimulation of the hypothalamicintegrative area for the defense reaction,747

Hypothermiaand asphyxia effects on binding of lysosomal acid

nydrolases in cardiac muscle. 59control of ventricular fibrillation after depletion of

catecholamine stores, 45Hypoxia

cerebral blood flow and oxygen, glucose, lactate,and ammonia metabolism in, 649

effects on oxidative phosphorylation in the failingheart, 355

effects on pulmonary circulation in reactive pul-monary hypertension, 661

lysosomal enzymes and damage to the heart in, 59


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950 INDEX [Impulses-Methoxamine]

Impulses, sinus node, and atrial fibrillation, 507Inert gas, diffusion processes, invalidation of the

intra-arterial Kr85 j3-particle clearance meth-od for measurement of skin blood flow inman, 281

Inotropic responseacetylcholine effects on myocardium, 573of cardiac glycosides, and heart contractility, 727classification of inotropic stimuli, 857and myocardial energetics in acute cardiac de-

pression, 123of ouabain in canine cardiac muscle, 515of substance isolated in washout cardiac failure,

263

Intracellular P and its regulation in resting skele-

tal muscle, 251Ion transport, potassium ion in cardiac mitochon-

diac miIonic environment, influence on electrical and

mechanical activity of rat portal vein, 609Iontophoresis

epinephrinehuman upper limb blood flow, 319metabolic and vasodilator effects of epinephrine

in human forearm muscle, 679Ischemia

cerebral; blood flow and oxygen, glucose, lactate,and ammonia metabolism, 649

decreased Ca2+ uptake by sarcoplasmic reticulumafter, 439

effects on coronary flow, 65Isoproterenol

hemodynamic effects in myocardial infarction, 191and reduced coronary blood flow effects on myo-

cardial function, 85vascular smooth muscle response to, 619

Joseph, Frank E., Gold Heart Award, 777, 778Juxtamedullary cortex, redistribution of renal blood

flow by furosemide and ethacrynic acid,869

KKidney. See also Renal circulation

furosemide and ethacrynic acid effects on renalblood flow, 869

renininactivation of, 149preinhibitor, 497tachyphylaxis, 327

Krebs solution, induction of failure in gas-perfusedhearts by intermittent administration of, ef-fect of digitalis glycosides, 263

Krypton-85, intra-arterial ^-particle clearance meth-od for measurement of skin blood flow inman, invalidation of, 281

Lactate, cerebral metabolism, monitoring methods,649

Leakage, vascular, caused by histamine-type media-tors, 833

Left-to-right shunt, and myocardial lysosomes inatrial septal defects, 17

Length-tension relationsin the mitral valve, 9myocardial, 33

Light photomicroscopy, myocardial cell and sarco-mere lengths in the normal dog, 671

Limb circulationautoregulation in human forearm, 319, 679epinephrine effects in the human forearm muscle,

679human hand and forearm at low perfusion pres-

sure, 319Lipids. See also Phospholipids

synthesis by foam cells and atherosclerotic ar-terial intima, 593

Livereffect of high molecular weight dextran on choles-

terol levels in, 817renin inactivation, 149

Lungs. See also Pulmonary circulationedema, ultrastructural alterations at the alveolar

level in, 783fibrinopeptide effects, 469hyperventilation, 649, 679hypoxia

cerebral blood flow and oxygen, glucose, lactate,and ammonia metabolism, 649

effects on oxidative phosphorylation in the fail-ing heart, 355

effects on pulmonary circulation in reactivepulmonary hypertension, 661

lysosomal enzymes and damage to the heart in,59

Lysophospholipid, renin preinhibitor, assay, 497Lysosomes

acid hydrolases, effects of asphyxia and hypother-mia on binding of, 59

myocardial, in atrial septal defects, 17

M

Mechanical activityportal vein

influence of ionic environment on, 609response to norepinephrine and isoproterenol, 619

Medulla, blood flow redistribution produced by furos-emide and ethacrynic acid, 869

Membrane potentials. See also Transmembrane po-tentials

diastolic, in Purkinje fibers, 537portal vein

effects of changes in ionic environment, 609response to norepinephrine and isoproterenol,

619Mesenteric artery

a-receptor stimulation and blockade of "silent"|3-receptors, 703

blood flow measured by electromagnetic catheter-flowmeter, 889

resistance and response to drugs, 525Metabolism

cerebral oxygen, glucose, lactate, and ammonia,monitoring methods, 649

myocardialin acute cardiac depression, 123and coronary flow during isoproterenol, 85of free fatty acids, ouabain effects, 445and performance in hereditary myocardiopathy,

391Metaraminol, in control of hypothermic ventricular

fibrillation, 45Methoxamine, pressor effects in isolated mesenteric

artery, 703



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[Microscope-Nerves] INDEX 951

Microscope. See Electron microscopeMicrosomes

cardiac, calcium binding and uptake, 153, 767protein synthesis during cardiac hypertrophy, 449

Microspheres, nuclide-labeled, for study of fetal cir-culation in utero, 163

Mitochondriaenlargement, replication, and protein synthesis af-

ter exercise, 271in the failing heart, normal oxidative phosphoryla-

tion, 355potassium ion transport in, 25

Mitral valvecontraction, intrinsic neuromuscular basis for, 9orifice area in systole and diastole, 409

MJ-1999, cardiac effects and peripheral actions of,703

Monitoring methodscerebral blood flow and oxygen, glucose, lactate,

and ammonia metabolism, 649external, cesium131, total cerebral blood flow, 805

Monkey, total cerebral blood flow, measured by ex-ternal monitoring of cesium131, 805

Muscarinic receptor, effects of acetylcholine, 573Muscle

aortic, viscoelastic properties and microscopic struc-ture, 901

cardiac. See also Myocardium and Ventriclebinding of lysosomal acid hydrolases in, 59capacity of terminal vascular bed of, 209classification of inorropic stimuli, 857collagen in, 33electrophysiological correlate of ouabain inotropy

in, 515glycerinated, calcium uptake by, 433length-tension relations, 33the mitochondria after exercise, 271in the mitral valve, 9tension-velocity relations in left ventricular func-


contraction in large arteries, 901cremaster

technique for microscopic study of blood ves-sels in vivo, 823

va.scular leakage caused by histamine-type me-diators, 833

in the mitral valve, 9papillary

acetylcholine effects, 573acetylstrophanthidin effects on contraction, 487contractile state in hypertrophied and failing

hearts, 341high energy phosphate stores in cardiac hyper-

trophy and failure, 365length-tension relations, 33volume in systole and diastole, 409

pulmonary artery, viscoelastic properties and mi-croscopic structure, 901

right ventricular, barium-induced automaticity,849

skeletalautoregulation of blood flow in the human fore-

arm, 319, 679collagen content, 33intracellular PQ and its regulation in, 251metabolic and vasodilator effects of epinephrine

in human forearm, 679smooth

influence of ionic environment on rat portalvein, 609

response to norepinephrine and isoproterenol,619

Circulation Research, Vol. XX/; Dece-mber 1967

responses of mesenteric and cerebral resistancevessels to drugs, 525

thermal responses in large arteries, 901striated, technique for microscopic study of blood

vessels in vivo, 823Myocardial infarction, hemodynamic effects of iso-

proterenol and acetylstrophanthidin, 191Myocardiopathy, hereditary, in the Syrian hamster,

work performance of the beating heart, 391Myocardium

acetylstrophanthidin effects, 191, 487calcium binding and uptake in microsomes, 153cell and sarcomere lengths in the normal dog heart,

671classification of inotropic stimuli, 857contractility

and cardiac glycosides, 727in cardiac hypertrophy and failure, 341, 365ouabain effects, 445, 515oxygen consumption in acute cardiac depression,

123responses to acetylcholine, 573role of acetylstrophanthidin, 487

and coronary flowdistribution of, 65isoproterenol effects, 85

energystores in cardiac hypertrophy and failure, 365utilization in acute cardiac depression, 123

functionforce-velocity relations in sedated dogs, 99limitation by reduced coronary flow during iso-

proterenol, 85high energy phosphate stores in cardiac hypertrophy

and failure, 365infarction, hemodynamic effects of isoproterenol

and acetylstrophanthidin, 191isoproterenol effects, 85, 191length-tension relations, 33localized responses to stimulation of cardiac sym-

pathetic nerves, 691lysosomes in atrial septal defects, 17metabolism

in acute cardiac depression, 123and coronary flow during isoproterenol, 85of free fatty acids, ouabain effects, 445and performance in hereditary myocardiopathy,

391mitochondrial fine structure after exercise, 271ouabain effects, 445, 515oxygen consumption

in acute cardiac depression, 123Z-epinephrine effects with and without coronary

artery disease, 919role of acetylstrophanthidin, 487

oxygen extraction, 85responses to acetylcholine, 573

Myofibrils, depressed ATPase and reduced contrac-tility in heart failure, 717

NNerves

adrenergico-receptors, 75, 217, 333, 703/3-receptors, 75, 217, 305, 333, 375, 703enhancement of peripheral a-receptor stimula-

tion by blockade of "silent" /3-receptors, 703in hypothermic ventricular fibrillation after

catecholamine depletion, 45in mitral valve contraction, 9

autonomic, control of systemic circulation in new-born calves, 237


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952 INDEX [Nerves-Phospholipids]

carotid sinus, and cerebral blood flow autoregu-lation, 559

cholinergic, in mitral valve contraction, 9denervation

cardiac sympathetic, and post-eountershock ar-rhythmias, 375

carotid sinus, effects on autoregulation of cere-bral blood flow, 559

epicardial, and myocardial responses to stimula-tion of cardiac sympathetic nerves, 691

neuromuscular basis for mitral valve contraction,9

sciatic, section of, and hindlimb circulation in new-born calves, 237

sympatheticdefect in norepinephrine storage in experimental

hypertension, 583denervation, and post-countershock arrhythmias,

375myocardial responses to stimulation of, 691

Nodeatrioventricular, concealed conduction in atrial fibril-

lation, 201sinoatrial, responses to pressure change in the sinus

artery, 297sinus

impulses, and atrial fibrillation, 507pressure change in artery, responses of sino-

atrial node to, 297Norepinephrine

abnormal storage in hypertension, 583and adrenergic receptor activity in dog coronary

arteries, 75and calcium uptake in glycerinated cardiac slices,

433classification of inotropic stimuli, 857and contractility in cardiac hypertrophy and fail-

ure, 341in control of hypothermic ventricular fibrillation, 45effects on /3-receptors, 217in the mitral valve, 9myocardial

distribution of coronary flow, 65responses to stimulation of cardiac sympathetic

nerves, 691and post-countershock arrhythmias, 375pressor effects on isolated mesenteric arteries, 703response of mesenteric and cerebral resistance ves-

sels, 525vascular smooth muscle response to, 619

Nucleic acidprotein synthesis during cardiac hypertrophy, 449synthesis in enlarged hearts with nutritional anemia,

635Nutritional anemia, nucleic acid synthesis in, 635

oOcclusion, coronary artery, decreased Ca2 + uptake

by sarcoplasmic reticulum after, 439Oligomycin, and calcium uptake in glycerinated

cardiac slices, 433Organelle, intracellular, myocardial lysosomes in atri-

al septal defects, 17Ouabain

and calcium uptake in glycerinated cardiac slices,433

effects on contractile force in gas-perfused hearts, 263effects in post-countershock arrhythmias, 375inotropic effects

in canine cardiac muscle, 515positive, contraction dependency of, 727

myocardial effects, 445, 515

Oxidative phosphorylation, in mitochondria fromthe failing heart, 355

Oxygencerebral, monitoring methods, 649consumption

epinephrine effects, 679, 919myocardial, 123, 487, 919ouabain effects in the perfused rabbit heart, 445role of acetylstrophanthidin in augmenting in

the myocardium, 487splanchnic, 333

extraction, by myocardium, 85intracellular P and its regulation in resting skele-

tal muscle, 251

Pacemakersbarium-induced automaticity in the right ventricu-

lar muscle of the dog, 849and concealed conduction in atrial fibrillation, 201in Purkinje fibers. 537and ventricular fibrillation threshold, 601

Palmitate-l-^Cmetabolism in myopathic hamster hearts, 391ouabain effects on extraction ratio and oxidation,

445Papillary muscle

acetylcholine effects, 573acetylstrophanthidin effects on contraction, 487in cardiac hypertrophv and failure

contractile state, 341high energy phosphate stores, 365

length-tension relations. 33volume in systole and diastole, 409

Peptides, pulmonary and circulatory effects of fibrin-opeptides, 469

Perfusion pressurecoronary

and left ventricular hypertension, ischemia, andvasoactive drugs, 65

propranolol effects on coronary vascular resis-tance, 305

resistance and response to drugs of mesentericand cerebral vessels, 525

and sinus node rhythmicity, 297Pericapillary spaces, plasma flow in, 925Peripheral resistance, role of /3-adrenergic receptors,

norepinephrine effects, 217pH, arterial, and respiratory alkalosis in hemorrhagic

shock, 461Phase-4 depolarization, and conduction in Purkinje

fibers, 537Phenoxybenzamine

in control of splanchnic circulation in man, 333and vascular smooth muscle response to norepineph-

rine, 619Phenylephrine, and adrenergic receptor activity in

dog coronary arteries, 75Phosphate

creatine phosphateand calcium uptake in glycerinated cardiac

slices. 433myocardial stores in hypertrophy and failure,

365high-energy, myocardial stores in cardiac hyper-

trophy and failure, 365Phospholipids

effect of high molecular weight dextran in hyper-cholesterolemia, 817

incorporation of 14C-labeled acetate into fatty acidsby foam cells and atherosclerotic intima, 593



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[Phospholipids-Renal circulation] INDEX 953

renin preinhibitor, 497Photomicroscopy, light, myocardial cell and sarco-

mere lengths in the normal dog, 671Plasma

flow in pericapillary spaces, 925responses of mesenteric and cerebral resistance

vessels to, 525Plasminogen activator, and fibrinolytic activity in

human atherosclerotic coronary arteries, 799Plethysmography, venous occlusion pressure, in hu-

man upper limb, 139P0 o , intracellular, and its regulation in resting skeletal

muscle, 251Portal vein

influence of ionic environment on, 609response to norepinephrine and isoproterenol, 619

Post-countershock arrhythmias, in untreated anddigitalized dogs, 375

Potassiumand cell density effects on action potentials of

chick heart cells, 879effects on cardiac microsomal calcium uptake and

binding, 767ion transport in heart mitochondria, 25ionic influence on electrical and mechanical ac-

tivity in rat portal vein. 609response of mesenteric and cerebral resistance

vessels to KC1, 525and ventricular conduction disturbances, 3

Potentialsaction potentials

and automaticity in Purkinje fibers, 537cell density and low K effects in ohjck heart

cells, 879ouabain inotropy in canine cardiac muscle, 515sinus node, and atrial fibrillation, 507

membrane 'diastolic, in Purkinje fibers, 537effects of changes in ionic environment on,

609in the rat portal vein, 609, 619response to norepinephrine and isoproterenol,

619threshold, in Purkinje fibers, 537transmembrane

cell density and low K effects in chick heart cells,879

in Purkinje fibers, 537P-P interval, and post-countershock arrhythmias, 375Preinhibitor, renin, chemical assay, 497Premature beats, sinus node impulses and, 507Prenylamine, control of hypothermic ventricular fi-

brillation after depletion of catecholaminestores with, 45

Pressure. See also Blood pressure-flow relations, venous occlusion plethysmography

in human upper limb, 139perfusion

coronary, 65, 305resistance and response to drugs of mesenteric

and cerebral vessels, 525and sinus node rhythmicity, 297

venous occlusion pressure plethysmography in hu-man upper limb, 139

ventricular, and coronary flow, 65Propranolol

cardiac effects and peripheral actions, 703ejfects on coronary vascular resistance, 305and myoeardial distribution of coronary flow, 65role in control of splanchnic circulation in man, 333and vascular smooth muscle response to isopro-

terenol, 619


Protein, in washout cardiac failure, 263Protein synthesis

in cardiac enlargement in rats with nutritionalanemia, 635

during cardiac hypertrophy, 449mitochondrial, after exercise, 271

Pulmonary artery, musculature, viscoelastic proper-ties and microscopic structure, 901

Pulmonary circulationchanges evoked by stimulation of the hypothalamic

integrative area for the defense reaction,747

edema, ultrastructural alterations at the alveolarlevel in, 783

fibrinopeptide effects, 469hypertension

fibrinopeptide effects, 469reactive, effects of mild chronic hypoxia, 661

hyperventilation, 649, 679hypoxia

cerebral blood flow and oxygen glucose, lactate,and ammonia metabolism in, 649

effects in calves with reactive pulmonary hyper-tension, 661

effects on oxidative phosphorylation in the failingheart, 355

lysosomal enzymes and damage to the heart in, 59Pulmonary edema, ultrastructural alterations at the

alveolar level in, 783Pulmonary hypertension

fibrinopeptide effects, 469reactive, effects of mild chronic hypoxia on pul-

monary circulation, 661Purkinje fibers

interrelationships between automaticity and con-duction in, 537

potassium action on, and ventricular conduction, 3Pyruvate-3-}4C, metabolism in myopathic hamster

hearts, 391

QRS complex, aberrance in atrial fibrillation, 201

R

Receptorsa-adrenergic

in''coronary arteries of the dog, 75norepinephrine effects, 217role in control of splanchnic circulation in man,

333baroreceptors, and autoregulation of cerebral blood

flow, 559/3-adrenergic

blockade, 305, 375, 703in ,coronary arteries of the dog, 75norepinephrine effects, 217role in control of splanchnic circulation in man,

333enhancement of peripheral o-receptor stimulation

by blockade of "silent" |9-receptors, 703muscarjnie, acetylcholine effects, 573

Reflexes, baroreceptor, and autoregulation of cere-bral blood flow, 559

Relaxation, heart; calcium binding and uptake incardiac microsomes, 153

Renal artery, flow measured by electromagnetic cath-eter-flowmeter, 889

Renal 'circulationblood flow measured by electromagnetic catheter-

flowmeter, 889


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954 INDEX [Renal circulation-Ultrastructure]

in the mature fetal lamb, 229redistribution of blood flow produced by furosemide

and ethacrynic acid, 869Renin

hepatic inactivation of, 149preinhibitor in canine and human blood, 497tachyphylaxis, 327

Reserpine, effects in post-countershock arrhythmias,375

Resistancecoronary vascular, propranolol effects, 305in isolated mesenteric and cerebral vessels, 525peripheral, role of /3-adrenergic receptors, norepi-

nephrine effects, 217Respiratory alkalosis, effects on survival in hemor-

rhagic shock, 461Rhythmicity, sinus node; blood pressure and heart

rate, 297Ribonucleic acid (RNA)

and protein synthesis during cardiac hypertrophy,449

synthesis in enlarged hearts in rats with nutritionalanemia, 635

Ribosomes, protein synthesis during cardiac hyper-trophy, 449

RNA. See Ribonucleic acidRubidium-86, coronary flow and pressure studies,

65Ryanodine, and calcium uptake in glycerinated car-

diac slices, 433

Salyrgan, and calcium uptake in glycerinated cardiacslices, 433

Sampson, John J., Gold Heart Award, 777, 778Sarcomeres

lengthin cardiac muscle, 33changes in systole and diastole, 423myocardial, in the normal dog, 671

Sarcoplasmic reticulumcardiac microsomal calcium binding and uptake,

153decreased Ca2+ uptake after coronary artery oc-

clusion, 439and calcium uptake in glycerinated cardiac slices,

433sodium and potassium effects on calcium binding

and uptake, 767Sciatic nerve, section of, and vasomotor responses in

the hindlimbs of newborn calves, 237Segontin. See PrenylamineSerotonin

response of mesenteric and cerebral resistance ves-sels, 525

vascular leakage caused by, 833Shock

hemorrhagic, effects of respiratory alkalosis onsurvival in, 461

post-countershock arrhythmias in untreated anddigitalized dogs, 375

Shunts, left-to-right, and myocardial lysosomes inatrial septal defect, 17

Sinoatrial node, responses to pressure change in thesinus node, artery, 297

Sinus codeimpulses, and atrial fibrillation, 507pressure change in artery, responses of sinoatrial

node to, 297Skeletal muscle

autoregulation of blood flow in the human fore-arm, 319, 679

collagen content, 33intracellular P 0 o and its regulation in, 251metabolic and vasodilator effects of epinephrine in

human forearm, 679Skin blood flow, invalidation of intra-arterial Kr83

/3-particle clearance method for measurementof, 281

Smooth muscleinfluence of ionic environment on rat portal vein,

609response to norepinephrine and isoproterenol, 619responses of mesenteric and cerebral resistance

vessels to drugs, 525thermal responses in large arteries, 901

Sodiumeffects on cardiac microsomal calcium uptake and

binding, 767effects on inotropic actions of acetylcholine, 573

Splanchnic circulation, role of /3-adrenergic receptorsin control of in man, 333

Stenosis, aortic, capacity of terminal vascular bed ofcardiac muscle in, 209

Stiles, Merritt H., Gold Heart Award, 777, 779Striated muscle, technique for microscopic study

of blood vessels in vivo, 823Stroke volume, right ventricular,, and right atrial con-

tractile force, 641Sympathetic nervous system

defect in norepinephrine storage in experimentalhypertension, 583

denervation, and post-countershock arrhythmias,375

localized myocardial responses to stimulation of,691

Syrian hamster, hereditary myocardiopathy, workperformance of the beating heart in, 391

Systemic circulation, autonomic control of in new-born calves, 237

Systolearchitecture of the heart in, 409ultrastructure of the heart in, 423

Tachyphylaxis, to aspartyl1 but not to asparginyl1

angiotensin II, 327Tension

acetylcholine effects in myocardium, 573classification of inotropic stimuli, 857length-tension relations

in the mitral valve, 9myocardial, 33

-velocity relationsin the left ventricle, 99myocardial O» consumption and cardiac depres-

sion, 123Threshold potential, in Purkinje fibers, 537Transmembrane potentials

cell density and low K effects in chick heart cells,879

in Purkinje fibers, 537Triglycerides, effect of high molecular weight dex-

tran in hypercholesterolemia, 817Tyramine, mitral valve response to, 9

uUltrastructure

alveolar alterations in pulmonary edema, 783of cardiac muscle after exercise, 271of the heart in systole and diastole, 423



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[Umbilical flow-Washout cardiac failure] INDEX 955

Umbilical blood floweffects of exteriorization of the fetus on, 741measurement by antipyrine infusion, 163, 185

Valinomycin, and cardiac mitochondrial potassiumion transport, 25

Vascular bedcoronary, responses to propranolol and its stereo-

isomers, 305in human upper limb, at low perfusion pressure,

319terminal, capacity during normal growth, cardio-

megaly, and cardiac atrophy, 209Vascular resistance

coronary, effects of propranolol, 305splanchnic, in man, 333

Vascular smooth muscleinfluence of ionic environment on rat portal vein,

609response to norepinephrine and isoproterenol, 619responses of mesenteric and cerebral resistance

vessels to drugs, 525thermal responses in large arteries, 901

Vasoactive drugsand hindlimb circulation in newborn calves, 237and myocardial distribution of coronary flow, 65responses of mesenteric and cerebral resistance

vessels to, 525Vasoconstriction, pulmonary, elicited by stimula-

tion of the hypothalamic integrative areafor the defense reaction, 747

Vasomotor responses, of the hindlimb circulation inthe newborn calf, 237

Vasopressinand myocardial distribution of coronary flow, 65response of mesenteric and cerebral resistance ves-

sels, 525Veins

portalinfluence of ionic environment on, 609response to isoproterenol and norepinephrine,

619vascular leakage caused by histamine-type media-

tors, 833venous occlusion plethysmography in human up-

per limb, 139Velocity

force-velocity relationin cardiac hypertrophy and failure, 341left ventricular myocardial function in sedated

d 99dogs, 99ycardial

profiles, 925i l

g ,myocardial, role of acetylstrophanthidin, 487fil 925p ,

tension-velocity relationin the left ventricle, 99

myocardial O2 consumption and cardiac depres-sion, 123

Ventilation. See HyperventilationVentricle

architecture in systole and diastole, 409conduction, KC1 and, 3contractility, and changes in sarcomere length, 423dysrhythmia in atrial fibrillation, concealed con-

duction, 201failure, normal oxidative phosphorylation in, 355fibrillation

control in hypothermia after depletion of cate-cholamine stores, 45

threshold, 601vulnerability induced by 60 cps alternating cur-

rent, 601function

in myocardial infarction, 191and ultrastructure, 423

hypertension, and coronary flow, 65hypertrophy

contractile state of cardiac muscle in, 341high energy phosphate stores in, 365protein synthesis during, 449casts of cavity, 409force-velocity relations in sedated dogs, 99

leftfunction, 99hypertension, and pressure effects on coronary

flow, 65rapid fixation and analysis of geometry of, 409ultrastructure and function relations, 423

myocardial cell and sarcomere lengths in the normaldog, 671

myocardial lysosomes in atrial septal defects, 17right

automaticity, barium-induced, 849stroke volume, and right atrial contractile force,

641sarcomere length changes, 423

Ventricular fibrillationcontrol in hypothermia after depletion of catechola-

mine stores, 45threshold, 601vulnerability induced by 60 cps alternating cur-

rent, 601Vessels. See Blood vesselsVolume

blood volume and respiratory alkalosis in hemor-rhagic shock, 461

of papillary muscle in systole and diastole, 409right ventricular stroke volume and right atrial

contractile force, 641

WWashout cardiac failure, induced by Krebs solution

administration, effects of digitalis glyco-sides, 26.3

Circulation Reiearch, Vol. XXI, December 1967


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Subject Index

Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 1967 American Heart Association, Inc. All rights reserved.is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231Circulation Research

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