ciplar (propranolol hydrochloride tablets)

Propranolol Hydrochloride Tablets

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Ciplar (Propranolol Hydrochloride Tablets) is a beta adrenergic blocker used for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

Ciplar Tablets


Ciplar Tablets are manufactured by Cipla Ltd. , India (Website: www.cipla.com)

Propranolol Hydrochloride Tablets – Brand Names


Propranolol Hydrochloride tablets are available as Inderal, Avlocardyl, Deralin, Dociton, Inderalici, InnoPran XL, Sumial, Anaprilin, Bedranol SR, Ciplar, Ciplar-LA, Betabloc Forte, Betabloc, Betacap and Provanol.

Active Ingredient


The active ingredient contained in Ciplar tablets is Propranolol Hydrochloride. Each Ciplar tablet contains 10 mg or 40 mg of Propranolol Hydrochloride.

Chemical Structure


The structure of Propranolol Hydrochloride is given below:

Uses of Propranolol Hydrochloride Tablets


Ciplar (Propranolol Hydrochloride Tablets) is used to treat high blood pressure, irregular heartbeats, shaking (tremors), and other conditions. It is used after a heart attack to improve the chance of survival. It is also used to prevent migraine headaches and chest pain (angina). Lowering of high blood pressure helps prevent strokes, heart attacks, and kidney problems. Preventing chest pain can help improve your ability to exercise.

Storage Instructions


Ciplar (Propranolol Hydrochloride Tablets) have to be stored at controlled room temperature i.e. below 25°C (77°F) . Protect from light.Keep this as well as all other medicines away from children and pets.

Warnings


Propranolol Hydrochloride Tablets (Ciplar) must be used with caution in patients with impaired hepatic or renal function. Ciplar is not indicated for the treatment of hypertensive emergencies. There have been reports of exacerbation of angina and, in some cases, myocardial infarction, following abrupt stopping of Propranolol therapy.Hypersensitivity reactions, including anaphylactic/anaphylactoid reactions, have been observed with the administration of Propranolol tablets.

Warnings


Cutaneous reactions, including Stevens-Johnson Syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema ultiforme, and urticaria, have been observed with use of Ciplar tablets.Sympathetic stimulation may be a vital component supporting circulatory function in patients with congestive heart failure, and its inhibition by beta blockade may precipitate more severe failure.Chronically administered beta-blocking therapy must not be routinely stopped prior to major surgery, however the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures.Beta-adrenergic blockade may prevent the appearance of certain premonitory signs and symptoms (pulse rate and pressure changes) of acute hypoglycemia, especially in labile insulin-dependent diabetics.

Warnings


Beta-adrenergic blockade can mask certain clinical signs of hyperthyroidism. Therefore, abrupt stopping of Propranolol tablets can be followed by an exacerbation of symptoms of hyperthyroidism, including thyroid storm.Beta-adrenergic blockade in patients with Wolf-Parkinson-White Syndrome and tachycardia has been associated with severe bradycardia requiring treatment with a pacemaker. In the event of hemorrhage or shock, there is a disadvantage in having both beta and alpha blockade since the combination prevents the increase in heart rate and peripheral vasoconstriction which is needed to maintain blood pressure.

Ciplar Dosage


➢Hypertension: The usual initial adult dosage is Ciplar (Propranolol Hydrochloride Tablets) 40 mg twice daily, whether used alone or added to a diuretic. Dosage can be increased gradually until adequate blood pressure control is achieved. The usual maintenance dosage is 120 mg to 240 mg per day.➢Angina Pectoris: Total daily doses of 80 mg to 320 mg Ciplar, when administered orally, twice a day, three times a day, or four times a day, have been shown to increase exercise tolerance and to reduce ischemic changes in the ECG. If treatment is to be discontinued, dosage has to be gradually reduced over a period of several weeks.

The dosage of Ciplar tablets (Propranolol Hydrochloride) is given below:

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Ciplar Dosage


➢Atrial Fibrillation:The recommended dose is 10 mg to 30 mg Ciplar (Propranolol Tablets) three or four times daily before meals and at bedtime.➢Myocardial Infarction: In the Beta-Blocker Heart Attack Trial (BHAT), the initial dose of Propranolol Tablets was 40 mg three times a day, with titration after 1 month to 60 mg to 80 mg t.i.d. as tolerated. The recommended daily dose is 180 mg to 240 mg Ciplar per day in divided doses.➢Migraine: The initial dose is 80 mg Ciplar tablets daily in divided doses. The usual effective dose range is 160 mg to 240 mg per day. The dosage may be increased gradually to achieve optimum migraine prophylaxis.➢Essential Tremor: The initial dosage is Ciplar (Propranolol Tablets) 40 mg twice daily. Optimum reduction of essential tremor is usually achieved with a dose of 120 mg per day.

The dosage of Ciplar (Propranolol Hydrochloride Tablets) is given below:

Ciplar Tablets


Contraindications

Ciplar is contraindicated in patients with a hypersensitivity to Propranolol Hydrochloride or any other component of this medication. It is also contraindicated in cases of Cardiogenic shock, Sinus bradycardia and greater than first degree block and Bronchial asthma.

Propranolol Hydrochloride Tablets Side Effects


➢Propranolol Hydrochloride tablets are usually well tolerated and side effects are transient in nature, rarely necessitating withdrawal of treatment. The most serious Ciplar side effects observed are congestive heart failure and bronchospasm in susceptible patients. ➢Common adverse reactions include fatigue and/or lassitude (often transient), bradycardia, cold extremities and exacerbation of Raynaud's phenomenon, sleep disturbances including vivid dreams/nightmares. ➢Other less frequently reported side effects include: gastrointestinal disturbances (anorexia, nausea, vomiting, diarrhoea, abdominal pain), congestive heart failure, dizziness, bronchospasm. ➢Rare cases of thrombocytopenia and purpura have also been reported. ➢CNS symptoms including mood changes and hallucinations have been rarely reported.

Propranolol Tablets Overdose


Most overdoses of Propranolol tablets are mild and respond to supportive care. Hypotension and bradycardia have been observed following propranolol overdose and should be treated appropriately.

Ciplar Overdose


Propranolol Hydrochloride (Ciplar Tablets) is not significantly dialyzable. Glucagon can exert potent inotropic and chronotropic effects and could be particularly useful for the treatment of hypotension or depressed myocardial function after a Propranolol overdose. Serious bradycardia may require temporary cardiac pacing.The electrocardiogram, pulse, blood pressure, neurobehavioral status and intake and output balance must be monitored. Isoproterenol and aminophylline may be used for bronchospasm.

Propranolol During Pregnancy


Propranolol Hydrochloride (Ciplar tablets) has been classified by the US FDA as Pregnancy Category C. There are no adequate and well-controlled studies conducted in pregnant women. Intrauterine growth retardation, small placentas, and congenital abnormalities have been reported in neonates whose mothers received Propranolol tablets during pregnancy. Neonates whose mothers received Ciplar tablets at parturition have exhibited bradycardia, hypoglycemia, and/or respiratory depression.

Ciplar Tablets

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Ciplar (Propranolol Hydrochloride Tablets) by Cipla Limited, India.

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ciplar (propranolol hydrochloride tablets)

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