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TRANSCRIPT
Bache
BS
BSc
Honou
elor of S
Sc Advan
Medicin
urs in Ch
Science
nced Sc
nal Chem
hemistry
(BSc)
cience
mistry
y 2019
Part A
1
2
3
4
Part B
Part C
A: Welcom
1. Overvie
2. Admiss
3. How to
4. Assess
B: Honou
C: Alterna
me
ew
sion
o Apply / U
sment
rs Supervi
atives for H
seful Inform
sors
Honours
2
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mation …
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Table
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e of Con
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ntents
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12
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4
OVERVIEW OF HONOURS
This booklet provides details for students interested in undertaking an Honours year with a major in chemistry in either the BSc or BSc Advanced programs or undertaking a BSc Medicinal Chemistry (3992). If you are a BSc Nanotechnology (3617) student, please consult the specialised Honours booklet for your degree.
Is the Honours year worth the extra year it takes? The answer is certainly “Yes!” for many people.
The response from potential employers in industry and the public sector is that they will employ a good Honours graduate over someone with a pass degree.
Honours is necessary for anyone contemplating postgraduate study in chemistry. Honours gives you “hands-on” experience in tackling projects, and provides a
rewarding finishing quality to your education. Honours provides you with experience at managing your own project,
independence and time management skills. Most important of all, the Honours year allows you to work closely with the staff in
the School of Chemistry, and it transforms the University for you into a very human organisation that has people who support you.
HONOURS IN THE SCHOOL OF CHEMISTRY
In 2019 the School of Chemistry offers Honours programs that are suitable for students enrolled in Science, Advanced Science, Medicinal Chemistry and Environmental Science. The School of Chemistry also offers projects for Nanoscience students and projects are also accepted in other streams which can be discussed with the respective coordinators. School of Chemistry researchers also supervise or co-supervise the equivalent of a Honours project with colleagues in the Faculty of Science and in other Faculties which are typically made in a case by case basis.
Within the School of Chemistry all programs involve a proportion of coursework. BSc. Science or BSc. Advanced Science students with a major in Chemistry enrol in BSc. Honours (4500). Assessment is based entirely on your record during the Honours year, during which students have the opportunity to demonstrate skills in both research and coursework.
In the UNSW3+ model, the streamlined access to Honours is shown in the figure below. Students enrol in 48 credit points, first term of Honours in CHEM4501, CHEM4502 and CHEM4506, followed by CHEM4518 in your second term and
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9
ASSESSMENT
The Honours degree is graded into Class 1, Class 2 Division 1, Class 2 Division 2, Class 3 or Honours may not be awarded (see below for grade boundaries).
Assessment is on the basis of performance in the various components of the course, including the research project and the formal course work. Note that in order to be awarded Honours, you must achieve a satisfactory performance (>50%) in each component (coursework and research).
CHEM4501 - 6 UoC Research skills
CHEM4502 - 6 UoC Coursework
CHEM4506, CHEM4512 and CHEM4518 - 36 UoC Research
Thesis Grading Committee’s assessment of Thesis Thesis Grading Committee’s assessment of the Final Seminar Thesis Grading Committee’s assessment of the Defence Attendance at School Research Seminars
Research skills (CHEM4501 6 UoC – 12.5%): In order to adequately equip yourself for your research project, you are required to take CHEM4501 which will cover how to write a research proposal, presentation skills, research ethics, managing your research and occupational health and safety.
Course Work (CHEM4502 6 UoC – 12.5%): You are required to take three different short courses during your Honours year. Every term two of these courses are offered and are geared to be advanced level options of undergraduate knowledge. Details are available from the Honours Coordinator (Dr Neeraj Sharma). You will nominate the 3 courses typically when you commence Honours.
Research Component (CHEM4506, CHEM4512, CHEM4518 36 UoC - 75%): The research project is the distinctive feature of the Honours year. It is the major undertaking of the year and is both the most challenging and rewarding aspect of Honours.
Students work on original research projects conceived and overseen by a member of staff. While you will be instructed by your supervisor on the nature of the project and will be given guidance in how to conduct the project, it is expected that you will perform all experimental work independently. You will be expected to prepare and
10
analyse experimental results and work with your supervisor to identify and overcome any problems. At the completion of the year you will present a thesis detailing the background, aims, experimental procedures, results and future directions of your project.
Research Proposal and Presentation: To assist in the preparation of your thesis and to allow your writing style to be improved, you will also be required to submit a research report describing your chosen research project and a review of pertinent literature. You will also do a short presentation on the proposal and your project. This will be in the first term of your Honours year and written feedback will be provided for both aspects.
Thesis Submission: You will write your thesis and submit it during your third term in Honours with the dates made available on your first term. Your thesis is a significant portion of your Honours mark and should be read and edited by numerous people including your supervisor.
You are required to submit a final version of your thesis that incorporates the Thesis Committee’s comments to your supervisor and the School for completion of Honours. Failure to do so will result in your Honours grade being withheld. The thesis accounts for 60% of your research mark.
Honours Seminar: You will be expected to present your work at two seminars during your Honours year; one will be a short overview of your project in your first term which will be graded within your research skills component (see above); and a longer seminar detailing your results to be presented after submitting your thesis; this seminar is typically 15 minutes long plus up to 10 minutes for questions. It comprises 15% of your research mark.
Oral thesis defence (viva-voce): The thesis defence will be shortly after you have submitted your Honours thesis and presented your final seminar and will be a closed examination of around 20-30 minutes with a panel of experts. It will comprise 25% of your research mark.
Attendance at School Research Seminars: Attendance at School Research Seminars is compulsory.
HONOURS DEGREE GRADE BOUNDARIES (%) Class 1 85+
Class 2 Division 1 75 – 84
Class 2 Division 2 65 – 74
Class 3 50 – 64
11
12
HONOURS SUPERVISORS
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16
ON/OFF catalytic activities. One example are spiropyran molecules, which act as ‘photoacids’, being switched between stable acidic and non-acidic states using light stimulus. Photoacids based on spriopyran may be directly incorporated into molecular and supramolecular systems for applications in stimulus-responsible switching with applications ranging from synthetic catalysis to in-situ drug release. New photoacidic molecules are required which are suitable for building into larger structures and membranes, and the tuning their photoswitching properties will be studied using a combination of spectroscopic techniques.
Skills: organic synthesis, multidimensional NMR spectrometry, mass spectrometry
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(c) Novel ruthenium(II) complexes
Ruthenium(II) complexes are extremely useful complexes with applications ranging from energy storage and light harvesting, to catalysis and drug applications. This project will develop new types of chiral ruthenium(II) complexes which are responsive to their environments to allow these useful properties to be controlled by external stimuli (eg, temperature, chemical reagents, light, redox etc).
Skills: organic and inorganic synthesis, multidimensional NMR spectrometry, mass spectrometry, X-ray crystallography, cyclic voltammetry, X-ray crystallography, photophysical measurements
(d) Molecular rotors
(in collaboration with A/Prof. Jason Harper)
Being able to control motion at the molecular level is a fundamental challenge facing science. Nature uses controlled molecular motion, so called ‘molecular machines’ to control virtually every process in biology. So far, chemists use molecular machines to control nothing! This project involves the synthesis of molecular ‘rotors’ with a ‘propeller’ which can spin spontaneously when appropriate energy is supplied.
Skills: Organic synthesis, multidimensional NMR spectrometry
(e) …or other projects tailored to your interests!
1. Yang, J.; Bhadbhade, M.; Donald, W. A.; Iranmanesh, H.; Moore, E. G.; Yan, H.; Beves, J. E. Chem. Commun. 2015, 51, 4465-4468.
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sis of staAdam Gormle
osis throughpy, and a ns. However, tein for any gheir high cos
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17
Ro
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ell membransign macrom proteins on t
difficult to fire and scree
ese combinatics.
and work Stenzel in ar Design ormley at ontact me ny of the
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r peptide-pey, Rutgers U
cell receptonumber of natural progiven applicatst and poor sg these on
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TORIAL D
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DESIGN
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ustering of et al.[1]
18
breast cancer cell lines. The project will make use of new methods for oxygen tolerant polymer synthesis on microtitre plates that we have recently developed in order to prepare these libraries at low volume and high throughput.[2]
The project will involve the synthesis of several chain transfer agents required to generate the different polymer architectures, the synthesis of peptides for receptor binding, and subsequent polymerisation and polymer analysis by NMR, GPC and associated techniques. Screening of biological activity will be performed in collaboration with Dr Adam Gormley at Rutgers University in the USA, and there is the possibility of visiting his lab in the middle of the year to perform some of this work if you so choose.
(b) Stabilisation of glucose oxidase enzymes in nanocapsules (with Prof. Martina Stenzel)
Despite their extensive use in a range of synthetic, biosensing, and therapeutic applications, enzymes are often highly unstable to heat, pH, and the presence of organic solvents. However, several recent studies have shown that it is possible to protect enzymes against degredation by such environmental factors by encapsulating them within nanocapsules.[3,4]
We recently developed a new methodology for encapsulation of glucose oxidase (GOx) inside a type of nanoparticle known as a polyion complex (PIC) micelle. This gives excellent control over the structure of the nanoparticle, and allows us to crosslink the shell surrounding the enzyme to impart mechanical stability to the enzyme. In this project we will incorporate sugars such as trehalose, mannose, glucose and fructose, which have been shown to have a stabilising effect on enzymes,[3] into our enzyme nanoparticles and compare their effects on enzyme stability. This will be done by first polymerising the sugars into the polymer backbone and then assembling them into the core of the PIC micelle. Enzyme activity will be monitored after exposure to a range of solvent, thermal, and other environmental stresses.
The project will involve controlled polymer synthesis and self-assembly techniques to prepare the enzyme nanocapsules, characterisation by light scattering and electron microscopy, and the use of enzyme activity assays to measure their activity under a range of environmental stresses.
1) J. Lemke, S. von Karstedt, J. Zinngrebe and H. Walczak, Cell Death Differ., 2014, 21, 1350–64.
2) R. Chapman, A. J. Gormley, M. H. Stenzel and M. M. Stevens, Angew. Chemie Int. Ed., 2016, 128, 4576–4579; R. Chapman, A. J. Gormley, K. Herpoldt and M. M. Stevens, Macromolecules, 2014, 47, 8541–8547.
3) A. Beloqui, S. Baur, V. Trouillet, A. Welle, J. Madsen, M. Bastmeyer, G. Delaittre; Small, 2016, 12, 1716–1722
4) E. M. Pelegri-O’Day, S. J. Paluck and H. D. Maynard, J. Am. Chem. Soc., 2017, 139, 1145-1154; R. J. Mancini, J. Lee and H. D. Maynard, J. Am. Chem. Soc., 2012, 134, 8474–9.
Preparation of single enzyme nanogels. Adapted from Beloqui et al [3]
Chen's rnew synsynthesicarbon-b“peapod It would
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19
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20
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NALD ng (F12) w.edu.au
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21
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22
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23
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Honours stu
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24
Leve
YNTHETIC
ound synthetcatalysts thatganic hydrocmations. polymers f
sensitive comination of reaopy (31P, 15
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PROmical Scien385 2700 E:
OMETALL
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OF. LES Fnces Buildin: l.field@unsw
LIC CHEM
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FIELD ng (F10) w.edu.au
MISTRY
(such as ucts, and
molecular
copy, IR
y groups as tal
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25
Alternative Bridging Groups for Organometallic Polymers
The majority of alkyne-bridged organometallic polymers use linear aromatic spacer units, such as 1,4-diethynylbenzene, as the bridge between metal centres. Non-aromatic bridges such as 1,12-diethynyl-p-carborane (C6H12B10) have been described as “3D aromatic systems”. We are interested in the effect of aromatic bridges, as well as non-aromatic bridges such as 1,3-diethynylbenzene, on the chemical and electrochemical behaviour of organometallic polymers.
(b) The Organometallic Chemistry of Carbon Dioxide
Carbon dioxide reacts with many organometallic compounds to give products in which the CO2 is incorporated into the metal complex. A greater understanding of the ways in which CO2 binds and reacts with metal compounds may provide new ways to capture CO2 and utilise this wasted and environmentally dangerous compound.
Our previous work has focused on the stoichiometric insertion of CO2 into metal-hydride and metal-carbon bonds, to give metal formates and acetates, respectively. There have been many reports in the literature of catalytic activation of CO2 to yield formic acid (by hydrogenation), acrylates (by reaction of CO2 with ethylene), and carbonates (by reaction of CO2 with epoxides). We are interested in exploring the ability of novel iron(II) and ruthenium(II) complexes that we have prepared in the lab to catalytically activate CO2.
(c) The Chemistry of ‘CP3’ Complexes
We have recently developed a new type of polydentate ligand for transition metals, which binds to metal centres using three phosphorus donors and an anionic carbon donor. To date, we have only explored the chemistry of this ligand on ruthenium(II). We anticipate that this ligand will form complexes with a wide range of transition metals, and are particularly interested in investigating the synthesis and catalytic properties of new rhodium and iridium complexes.
Selected publications from the group:
1. L. D. Field, A. M. Magill, T. K. Shearer, S. J. Dalgarno, M. M. Bhadbhade, Eur. J. Inorg. Chem., 2011, 23, 3503-3510.
2. L. D. Field, P. M. Jurd, A. M. Magill, M. M. Bhadbhade, Organometallics, 2013, 32, 636-642.
3. O. R. Allen, L. D. Field, A. M. Magill, K. Q. Voung, M. M. Bhadbhade, S. J. Dalgarno, Organometallics, 2011, 30, 6433-6440.
4. L. D. Field N. Hazari, H. L. Li, Inorg. Chem., 2015, 54, 4768-4776.
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27
ethodology scale? (in
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Figure refers The commoorganic solutolution surfacked water dent and wate for preparinmulti-materia
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“Scanning eleRev. 116, 22, 13
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llaie, Y. Zhu, Lm. Sci., vol. 6, n
t-activated elecamatically impro
wish, S. Ciampi,atures”. Submi
Torresi, V. R. Glectrochim. Act
Cu for sensors.
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28
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29
magnetic nannanoporesarefit is the nolves develo
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me. The proof these resud for studentnew methodsmore synthemising isolat
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30
STIC AND
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Catalysis us
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Hawker et al., OJ. Phys. Org. ClusChem 2017,
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rocyclic carb
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Chem. 2015, 13
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J. Phys. Chem.
31
benes: unde
es in organobut not for otmical propertis a series ofg with makinharacterisatiosimple screeationally cho
ionic liquies, UNSW; P
& Prof. Bill P
dynamics sim; this can be eed faster othis and to mhich ionic liquto do this b
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3453, Org. Biom2/poc.3862; S. Ts. Org. Chem. 2
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33
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34
IN MEDIC
punch. Whenecular propeein targets. g such effec
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s within the
eptides nds for the nd malaria. des: (i) their (ii) it is difficu
se their targeistry to solvesise stereosable shape-c
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s, fluorine bility, 3D
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Pasquier,
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rator: Dr Nico
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e/hypnotic ac-rape” drug.of GHB’s
e’s conformamany differenwe are creatrable activity
rator: Prof Ma
Molecular Vunprecedenis a commo
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ult for tumouwith a slowe
rators: Dr Gra
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novel treatmcause of deatoptions are pproach. We natural hypoitude-chambeage-control mel understans hypoxia res
ole Jones, A/
undesirableyrate (GHB)nds to neuro previously b
ments incluunately howctivity, which We believeeffects can ational flexibnt neurotransting conform while editing
ary Collins, D
Velcro: creatnted ways n disease thy is the princ is limited bynventional d
A and weld thr cells to repr developme
aham Ball, A
ects (and othtechnique. Otays; solid-pha
ment for stroth and disabiextremely li
e’re developoxia protectiver-in-a-pill”), mode after a nding of thesponse.
/Prof Renate
e activity out is a molec
otransmitter rbeen prescribding alcoho
wever, GHB has led to ite that the be attribut
bility, which asmitter recepationally-rest
g out the und
Dr Junming H
ting new mo
hat kills 1 in cipal treatme the resistanrugs. We are
he two strandpair. This wilnt of drug res
A/Prof Larry W
hers within thther techniquase peptide s
35
oke ility in Austraimited. We
ping drugs tve mechanis which will stroke. The e proteins t
Griffith
t of illegal dcule with a receptors in bed to treat olism and also has ts abuse as bewildering ted to the allows it to
ptors. In this tricted fluorin
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rugs
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t will stick to
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laser spectrcover new chtribute to inte
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oaming” reactnough energyforming unexs and to exp
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mistry – reydney Univ.
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the atmosphound 500 pa
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here is a trarts per billiot has been r, atmosphe H2. Modelers photochemd application
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36
LASER PR
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models to test
udents on th
at just don’
n state (TS) near the TS etitive, even iously describ
initiated neas influence. Hroject will seeproducts play
ators: Merel Labs, USA
have been mmodels very pecies on airw compound
ace species on. As a lon considered
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PROF. SCLevel 1, Da85 4713 E: s
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ained by curreed atmospher
projects:
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the bedrock reaction bec
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, Sydney Usen, UNSW)
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COTT KAlton Buildin
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ent theories; ric processes
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of chemicalcomes very st few years
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niv; Dwayne)
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ABLE ng (F12) w.edu.au
CTIONS
s;
borators:
reaction slow and we have
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H-atom aromaticcustom-combust
nity to correcresearch, weet light. In thes and workrs is also a po
e of fluorinatee alternativesund widespreave a differened atmosphels thousandshere in the 19re work is urge atmosphereent, or tailore
Radicals in
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all atmoing can releading to
and H2O) og the volatilityformation. T
c emissionsogenic emissunknown. Thfor 2019, for
s from OH at ways: abstd radical. Thyou will invnd (e.g. cycloted in vacuumisomeric and
assumed initia
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ct the weakne have discohis Honours pk out the chossibility.
ed compounds to the chloroead use in cont environme
eric lifetimes rs of times gre990s and willgently needee. This projeced to be almo
the atmosp
key intermedreactions. O
ep in the “proospheric ceduce the fully oxidize
or increase y and leading
The processins (e.g. tersions (e.g. tere are seve
r example:
attack on atmtracting H tohe OH-adduestigate eithohexene) anm and probed electronic sal step in atm
s from commoth cases mar to make itmass selecte
nesses in atmovered that project, you wemical mech
ds (collaboratofluorocarbonommercial proental drawbacranging from
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ct can be tailoost exclusive
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molecular ed products the MW, g to harmful ng of either rpenes) or toluenes) is eral projects
mospheric spo form H2O acted radicals
her a typicad react it witd using laserstructure of t
mospheric pro
on fuels andaking radicalt gain or lod and probed
37
mospheric chmany carbowill make mehanism and
tion with Chrins (CFCs) anoducts, but wck: they abso
m decades to rbon dioxide
r centuries. Tand the pathwored to have
ely experimen
ombustion (C
pecies: OH and a radicas have beenl biogenic cth OH. The er spectroscopthe radical processing of t
d biofuels: Hs. In this pr
ose H. Thed by laser sp
hemistry of Honyls are a easurementsimportance.
ris Hansen): Hnd hydrochlowith no ozoneorb infrared licenturies. Th (CO2). Thes
Their atmosphways by whic a significant ntal in nature
Collaborator
can attack l, or adding n scarcely mcompound (eensuing OH-apy to determroduct. This wthese compo
Hydrogen atoroject you we resulting pectroscopy.
H2 before wesource of H
s of H2 produ Collaborat
Hydrofluorocorofluorocarboe depletion poght very strohis leads to gse compoundheric chemistch these spe computation, or anywher
r: Tim Schm
unsaturated across a -b
measured in e.g. -pinenadducted or aine where thwill provide tunds.
ms can be loill choose suradical, the
e reach this H2 when expuction from a tion with atm
carbons (HFCons (HCFCsotential. How
ongly, and haglobal warminds began entetry is not und
ecies are remnal chemistryre in between
midt)
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BIOI
Inspired chemistrof our wchemicaand biolcellular i1) Dev2) Use
syntOur worchemistr It wouldprojects
(a) J. Kruzic
Hydrogeremodeldynamicof stimulare inveresponseforce. WchemistrRecentlyhydrogeHorizonsconjugatand chelinkages
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INSPIRED
by biologicary to mimic th
work is motival cues (extraogical cues dentity, fate elop model s the output frthetic organork is necessary, materials
d be great tos:
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els in tissue led, and und
c chemistry inli-responsive
estigating chee to stimuli iWe are parry can be moy, we demonl facilitated rs 2016). Thistion tag, and emistry of ss that we are
Directing therials (w/ Pro
ing of cells ation, segregaed printing, d in nature.
D MATERI
al materials, he physical avated by a dacellular matr(paracrine anand function
synthetic platrom 1 to des
oids, model tuarily interdisc fabrication (b
o work with
hemical funcg.)
are viscoeladergo dynamn the laborat
e motifs, or seemical linkagncluding: temrticularly intodulated thronstrated howreaction withs approach represents asoft material interested in
he chemistrof. J. Gooding
and tissues iation of diff
and difficu New metho
ALS, TISS
we integrateand chemicadynamic modrix compositiond juxtacrine. Our broad atforms for celign clinically umours, tissuciplinary; honbioprinting, li
Honours stu
ctionalisatio
astic materiamic changes tory most ofteecondary polges in hydromperature, pHerested in ough applied force-induce an appropris amenablea new route ts. There ar investigating
ry/architectug)
s limited by ferent cell tulty recreatindologies to q
38
SUE ENGI
e nano- andl properties o
del of the mion), physica
e signals) guaims are to: ll biology res relevant biomue repair andnours studenthography), a
udents on th
n of hydrog
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ure of 3D e
issues with ctypes, cell vng complexquickly fabri
LT: 9385 46
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d micro- fabrof the cell anicroenvironml cues (geomides mechan
earch and himaterials tha
d replacemennts will gain and cell and
he following
gels (w/ Prof
continuouslyy. Recreatingincorporationroutines. Wee dynamic inc activity and where the
on or tensionture in a dis
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extruded so
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poly(ethylenaterial (Fig. with the ap
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KILIAN ng (E10) .edu.au
MISTRY
synthetic ent. Much between
pography) influence
elopment. ome (e.g.
synthetic ques.
ne glycol) 1; Mater.
ppropriate
tures disulfides h acceptor
ll-laden chemicv. Mater., 2015)
for
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tissue sttissue ecomposimicrofluico-culturwithin a
(c)
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(d) Stenzel)
Our inteprogresstumour colonizahydrogeof thesestate (Ficells arecauses oof our therapeuin need exploringcell typeJunmin Lee, Mer
Joshua M. Grolm
Amr A. Abdeen, (19), 2536-2544.
Junmin Lee, Am
tructures witengineering. ition (Fig. 2;idics will be ere formulatio3D bulk poly
Magnetoact
n vivo interogical and ics and mvironments ed a compoly modulatedics—to stud by the dyn
osteogenesisealth. Mater. permanent mns in this proversible bonrticles withinvironment fo
Synthetic tu
erests in cesion and me
microenviroation. We mils and were a
e micro-tumoigure 4; Natue believed toof suffering in
model sysutic developmof students g spatiotemp
es. redith N. Silberstein, Amr
man, Douglas Zhang, And
Junmin Lee, N. Ashwin B.
r A. Abdeen, Kathryn L. W
h well-defineWe are exp Advanced Memployed to
ons for transly(ethylene gly
tive hydroge
ract with mpathologica
matrix presin the labor
osite magnetod across thedy temporal amic reversi where stiffe 2016). Thesagnets, whic
oject involvesnds (e.g. H-n the hydror therapeutic
umours for c
ellular “plastietastasis is onment thaicroengineereable to uncovrs in orchest
ure Materials be the root n cancer. Oustems into ment on patieincluding: neporal uptake
r A. Abdeen, Sang Yup K
drew M. Smith, Jeffrey S.
Bharadwaj, Randy H. Ew
Wycislo, Timothy M. Fan,
ed segregateploring the eMaterials 20 establish graation to a 3D
ycol) hydroge
els to drive c
matrices thatal processesentation. Hatory has poactive mate
e full spectrurelationship
bility, we disening guides se materials
ch will broades: 1) the inve-bonding in gel framewo
c developmen
cancer nano
city” has lea conseque
at promote ed small pover an intrigutrating the ac 2016). This cause of rec
ur vision for thautonomous
ent derived cew hydrogel of nanopart
im, and Kristopher A. Kili
Moore, and Kristopher A
woldt, and Kristopher A. K
and Kristopher A. Kilian,
39
ed populationextrusion of m015). By incoadients of mD printer to el.
cell and tiss
t are dynaes governedHowever, rproved challeerial—where um of physios in cell-mascovered crit lineage spe can be ada
en the use ofestigation of
polysacchaork, and 3)nt.
omedicine d
ed us to caence of dyn intravasatiopulations ofuing role for gctivation of a is importantcurrence andhe future of ts tissue-mimcells. We havchemistry anticles, integra
ian, Mechanochemical fu
A. Kilian, Rapid 3D extrus
Kilian, Magnetoactive hyd
, Interfacial geometry dict
ns has the pmultiple hydorporating chultiple cell bidirect write t
sue engineer
amic, with md by chanrecreating tenging. We stiffness ca
ologically releatrix interacttical time pe
ecification (Fapted to muf this techniqustiffening anrides), 2) c) establishin
development
ncer, wherenamic interacon, extravaf melanoma geometry at ta cancer stet because thed metastasisthis work is thmetic architve several nend fabricationation of mult
nctionalization of disulfide
ion of synthetic tumor mic
rogels for temporal modu
tates cancer cell tumorige
potential to brogel materia
hemical handnding ligandsthe cell-laden
ring
many nging these have
an be evant tions.
eriods ig. 3; ltiple hydrogue to virtually
nd softening covalent tethg a 3D ma
t (w/ Prof. M
e we believections in theasation andcells across
the perimetem cell (CSCese CSC-like
s, the primaryhe integrationtectures, foew directionsn techniquestiple differen
e linked hydrogels, Mater
croenvironments, Advanc
ulation of stem cell activity
enicity, Nature Materials,
Fig. iron Hea
be transformaals of tissuedles in the ps. We aim ton extruded h
gel systems, y any laboratin hydrogel
hering of iroagnetoactive
M.
e e d s
er C) e y n
or s s, nt
rials Horizons, 2016, 3, 44
ced Materials, 2015, 27 (3
ty, Advanced Healthcare
2016, 15, 856-862.
3. Cancer cell particles in a h
alth. Mater., 201
Fig. 4. Incurvaturethe activstem-likeMater., 2
ational to e-mimetic polymers, o develop hydrogels
and use tory. New materials on oxide e tumour
47-451
37), 5512-5517
Materials, 2016, 5
adherent to hydrogel (Adv. 16)
nterfacial e will guide ation of a
e state (Nat. 2016)
Climate considerthe fact fluctuatesource rstorage
I am opsystem. principleexpectin
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40
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Earth’s crustcount of its mers a golden
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society to . Despite esources a power g energy
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5. Kim D. J., et a
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es5, the redopoint for dev
. (a) Theoreson between nd. Upon discnic chloroalum in the formatio
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dvanced batteries: Materi
Tarascon J.-M. Building b
Aurbach D. Promise and
al. An overview and future
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r Battery – (
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during redox ode as well lphides throu
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better batteries. Nature 4
reality of post-lithium-ion
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s a promisigh theoreticadue to the for processes. as encapsul
ughout the ba
inger Science & Business
51, 652–657 (2008).
batteries with high energ
um batteries. Adv. Mater.
able batteries. J. Am. Ch
g of li–s rechargeable bat
41
ed rechargeascale energy
cific capacity es. (c) Electr reduced to itated by the a
minium comple
tion with Prof
ng high-peral specific crmation of so In this projlates sulphurattery cycling
s Media, 2008.
gy densities. Nat. Rev. Ma
28, 7564–7579 (2016).
hem. Soc. 139, 6635–664
tteries. Adv. Mater. 25, 65
able AI-ion bay storage app
of Li-ion anrochemical res semiquinon
asymmetric cleex.
f. Do Kyung
rformance bapacity.6 Ho
oluble polysuject, we willr within the e
g process.
ater. 1, 16013 (2016).
3 (2017).
547-6553 (2013).
atteries couldplications.
d Al-ion battedox of quinoe state. Followeavage of dia
Kim at KAIST
attery candiowever, it ha
lphides3, whl design a 1electrode, in
d provide a p
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molecular modscreening. Tf bacterial si
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timicrobial di Prof. David
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42
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43
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Educatospecificateachingdifficultiebased re Are youdifferenyou:
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As part oexpandintested laconcepts
You will following
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Technologreatly entertainalready developilearning
ors have proally in chemisg to provide aes students esearch.
u interested nce on the w
Effects of th
of the excitinng on similaaboratory skis by complet
have the opg research qu
Do students Are studentsDoes this asIs the blende
Developmen
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ning way to lexist [5] bu
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gressed signstry [1-3], hoan outstandilearning che
in doing resway we edu
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pportunity to uestions that
study differes more effectssessment med (online an
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44
the past 50 is still muchnal experiencounter using
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RooT: 9385
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go. When us Game-base
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KIM LAlton Buildinlapere@unsw
CAL EDUC
how studennd implemeno address thbacked by e
o make an immay be just
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CATION
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45
(c) Have your own idea(s)?
If you have your own idea for a project that aligns with our philosophy then we would like to hear from you. Get in contact with me and we can discuss your project idea(s).
References
1. M. M. Cooper and R. L. Stowe, “Chemistry Education Research—From Personal Empiricism to Evidence, Theory, and Informed Practice,” Chem. Rev., vol. 118, no. 12, pp. 6053–6087, 2018.
2. N. Reid, “A scientific approach to the teaching of chemistry. What do we know about how students learn in the sciences, and how can we make our teaching match this to maximise performance?,” Chem. Educ. Res. Pract, vol. 9, no. 1, pp. 51–59, 2008.
3. V. Talanquer and J. Pollard, “Let’s teach how we think instead of what we know,” Chem. Educ. Res. Pract., vol. 11, no. 2, pp. 74–83, 2010.
4. M. K. Seery, “Harnessing technology in chemistry education,” New Directions in the Teaching of Physical Sciences, vol. 0, no. 9, pp. 77–86, 2013.
5. “New app a game changer for chemistry education - RMIT University.” [Online]. Available: https://www.rmit.edu.au/news/all-news/2017/jun/new-app-a-game-changer-for-chemistry-education. [Accessed: 21-Aug-2018].
The UNSof Chemresearchcurriculaand the the projetailored a
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46
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48
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LPINE ng (F12) w.edu.au
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49
would learn how to synthesize molecules, and multiple techniques including how to run reactions in solution and on solid phase. In this project you would learn how to synthesize molecules utilizing solution and solid phase chemistry. You will learn how to run proton and 2-D NMR, LCMS, and column chromatography. You will also have the opportunity to learn how biological assays work on your compounds, including cell death, cell permeability, protein level analysis via western blots, protein folding assays, and protein expression.
(c) Developing prodrugs: a general approach for building cell permeable drug molecules
This project will involve the synthesis of prodrugs that can enter cells and where masking groups are cleaved in cell lysate revealing the active molecule. The approach for this project will involve the incorporation of masking polar side chains with methyl groups, which are easily removed upon cell entry via enzymes. Prodrugs will also incorporate N-methyls on the backbone amide bonds and D-amino acids, both modifications disrupt intramolecular hydrogen bonds within a macrocycle and change the orientation of the side chains in such a way as to improve cell permeability. The prodrug molecules will also include asparagines, where these side chain amides increase transport across the cell membrane. In this project you would learn how to synthesize molecules utilizing solution and solid phase chemistry. You will learn how to run proton and 2-D NMR, LCMS, and column chromatography. You will also have the opportunity to learn how biological assays work on your compounds, including cell death, cell permeability, protein level analysis via western blots, protein folding assays, and protein expression.
Hsp27 Inactive: forms oligomers
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52
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ORRIS ng (F12) w.edu.au
MISTRY
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53
mediate the phosphorylation. This work originated from earlier work on the synthesis of a natural product. Variolin B is a member of a unique class of marine alkaloids isolated from an extremely rare Antarctic sponge. It is no longer available from its natural source. The Morris group have devised a synthesis of variolin B that has restored access to the material and allowed further biological studies to be carried out. From this work it has been established that variolin B is a potent kinase inhibitor and represents an important scaffold for the development of kinase inhibitors. A range of analogs have been developed that are more selective inhibitors of certain kinases, as well as have better properties (such as solubility).
Our recent publication (ACS Chem. Biol., 2017, 12, 825) describes how we have developed a new class of kinases inhibitor that selectively inhibits the kinase SRPK1 and has led to the identification of a series of molecules that are currently being developed as a treatment for aged macular degeneration, in collaboration with Exonate.
The Morris group is focused on developing selective inhibitors of the various RNA slicing kinases (the CLKs, DYRKs and SRPKs), with appropriate drug-like properties so they can be used as chemical probes to help understand the role these important kinases have on biological systems. A combination of synthesis and structure-based drug design is used to do this work, with students able to use Schrodinger and Cresset software to aid their design work.
(c) Developing the AAL(S) Scaffold for Therapeutic Applications (collaborations with Assoc Prof Nigel Turner (SOMS), Prof Alaina Ammitt (UTS), Dr Nikki Verrills/Dr Matt Dun (Newcastle)
Ceramide synthase (CerS) and protein phosphatase 2A (PP2A) are two enzymes that play a critical role in the regulation of multiple cellular signalling processes. The malfunctioning of these two enzymes has been found to have implications in diseases such as cancer, diabetes, asthma and neurological diseases including Alzheimer’s disease and stroke. Little is known about the biological mechanism of these enzymes and in particular, how they cause such diseases. To gain insight into these biological processes, the CerS and PP2A binders, FTY720 and AAL(S), will be used to explore the binding site of both enzymes and allow the identification of chemical probes which can be used to develop an understanding of the biological mechanisms of these complex diseases.
Development of the AAL(S) scaffold will allow for analog production which along with key biological testing will provide key information towards revealing the biochemical pathways and proteins involved regulating both enzymes at a molecular level. With Prof Ammitt, work is focused on using these molecules for the development of therapeutics for the treatment of asthma, whereas with Asoc Prof Turner we are developing molecules to elucidate the role of CerS in fat metabolism (see Turner et al, Nature Communications, 2018, 9: 3165 | DOI: 10.1038/s41467-018-05613-7)
Our resemoleculaswitchingtemperadistinct display a
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54
COOR
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VILLE ng (F12) w.edu.au
MISTRY
develop molecular essed by anied by storage,
ANSTO)
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55
lexes
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molecular buicks (metals ae on includinemperature, state (aka be
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s project ich show nsitive to s that are X-ray and
Nguyen’systems
(a) TropyliumRecent sunderstochemistrcan be umaterialsencoura
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s group hass or unusual m
Project NTVm ion is an usynthetic advood, allowingry[2-5] and phused as a ves for metal ged to discus
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56
CATALYS
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VINH NGUlton Buildin
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RY OF UNUMOLEC
novel organoistry.
arbon-ring strmore accessns in organoindings that dyes and lumfidential, stud
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UYEN ng (F12) w.edu.au
USUAL CULES
ocatalytic
ructure.[1] sible and ocatalytic tropylium
minescent dents are
valuable veniently ted as a
nteresting
57
compound family. Due to the donating ability of the two nitrogen atoms, the exocyclic C-C double bond is very electron-rich and strongly polarized. This interesting feature of NHOs offers multinucleophilic reactivity over the ketene aminal frameworks.[6] Due to the strong nucleophilicity of the -carbon, NHOs can act as strong Lewis/Bronsted bases.[7-9] This project will focus on synthesizing a family of NHOs, estimating their basicity and applying them as organocatalysts to promote environmentally friendly chemical processes. Students are encouraged to discuss with Vinh in person about this project.
(c) Project NTV3 - Tropylium-Based Host-Guest (collaboration with A/Prof Pall Thordarson) This project will explore the potential of tropylium-bearing systems in host-guest chemistry in collaboration with A/ProfPall Thordarson’s group. The electron-deficient nature of tropylium moiety makes it particularly attractive for the binding and sensing of small and medium-sized biologically importantanions such as chloride, phosphate and carbonates. Wepropose the synthesis of tropylium-based macrocycles (see figure) as the starting point for this project, which will representa new platform in supramolecular chemistry. Please also see Thordarson’s Honours projects for more details.
References [1] D. J. M. Lyons, R. D. Crocker, M. Blümel, T. V. Nguyen,* Angew. Chem. Int. Ed. 2017, 56, 1466-1484. http://dx.doi.org/10.1002/anie.201605979
[2] T. V. Nguyen,* A. Bekensir, Org. Lett. 2014, 16, 1720-1723. http://dx.doi.org/10.1021/ol5003972 [3] T. V. Nguyen,* M. Hall, Tetrahedron Lett. 2014, 55, 6895-6898. http://dx.doi.org/10.1016/j.tetlet.2014.10.100 [4] T. V. Nguyen,* D. J. M. Lyons, Chem. Commun. 2015, 51, 3131-3134. http://dx.doi.org/10.1039/C4CC09539A
[5] Demelza J. M. Lyons, Reece D. Crocker, Dieter Enders, Thanh V. Nguyen,* Green Chem. 2017, in press (DOI = 10.1039/C7GC01519D). http://dx.doi.org/10.1039/C7GC01519D
[6] R. D. Crocker, T. V. Nguyen,* Chem. Eur. J. 2016, 22, 2208-2213. http://dx.doi.org/10.1002/chem.201503575
[7] M. Blümel, J.-M. Noy, D. Enders, M. H. Stenzel, T. V. Nguyen,* Org. Lett. 2016, 18, 2208-2211.
http://dx.doi.org/10.1021/acs.orglett.6b00835
[8] M. Blümel, R. D. Crocker, J. B. Harper, D.Enders, T. V. Nguyen,* Chem. Commun. 2016, 52, 7958-7961.
http://dx.doi.org/10.1039/c6cc03771b
[9] Ugur Kaya, Uyen P. N. Tran, Dieter Enders, Junming Ho, Thanh V. Nguyen,* Org. Lett. 2017, 19, 1398–1401. http://dx.doi.org/10.1021/acs.orglett.7b00306
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very strongLewis/Bronsted base
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NHOs = NOVEL CATALYSTSon organocatalytic chemistry
Potential guests: Cl, HnPO4(3-n),
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anding the ing the bottom-ar units in ispectrometers-like molecul
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58
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59
Unique techniques used in the group include:
-advanced mass spectrometry and ion-mobility mass spectrometry,
-robotic analysis of dynamic combinatorial solutions, with screening of large chemical data sets,
-electronic structure and trajectory methods of computation for structure and function,
along with a variety of kinetic, wet chemistry and chemical characterisation techniques.
Projects and collaborations include:
-Assembly and reactivity of n-confused porphyrins (P. Weis, KIT)
-Dynamic combinatorial solutions and self-assembly of bis-β-diketonates (J. Clegg, UQ)
-Unusual complexation behaviours of cyclotricatechylene clusters (B. Abrahams, UoM)
-Encapsulation of ions by cyclophanes in solution (T. Brotin, ENS Lyon)
-Effect of fluorine on catalytic and metal mediated reactions
-Development of ion mobility and mass spectrometric techniques for analysis of reaction intermediates in solution (W. A. Donald, UNSW)
Potential students are highly encouraged to discuss their research interests with Dr Rijs.
We are modificatranslatio(a) Devehard tis
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60
ATERIALSENERATIO
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61
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63
(c) Laser Spectroscopy of Isolated Radicals and Ions (with Prof. Scott Kable)
The new Molecular Photonics Laboratory houses sophisticated lasers and equipment with which we can discover new transient chemical species of importance in the gas phase chemistries of our atmosphere and the interstellar medium.
Atmospheric Radicals
One of the greatest scientific challenges of our time is to understand the complex chemistry of the atmosphere. Plants and human activity are responsible for >1000 Tg (1012 kg) of volatile organic compounds being emitted into the atmosphere each year. These molecules are processed into less volatile compounds which then find their way into secondary organic aerosols, which are a major natural impactor on public health and climate. In this project, we will develop laser-based spectroscopic methods to detect and characterize intermediates formed on the way from the plant to the aerosol particle.
Interstellar Molecules and Ions
As stars die, they eject complex organic molecules into the interstellar medium, where they live out millennia before being incorporated into new stars and planetary systems. These organic molecules are the seeds of life, but, as yet, we do not know the chemical make up of the interstellar medium from which planetary systems are formed.
Using a star as a lamp, we can peer into this medium using telescopes by observing molecular absorption spectra. However, despite there being hundreds of nibbles taken out of the visible stellar spectra of stars occluded by diffuse clouds, only a few molecules have been unambiguously detected by their visible spectra. The unidentified features are known as the diffuse interstellar bands, and are the longest standing mystery in astrophysical spectroscopy.
In this project, we will develop techniques to capture the spectra of isolated, never-seen-before aromatic cations which the leading candidates for carrying the DIBs, and (hopefully) solve this long standing problem.
(d) Advanced Spectroscopy for Complex Functional Materials (with Dr Dane McCamey, School of Physics)
Complex functional materials are employed in a range of applications, the development of which is motivated by the future technological needs of society. Organic solar cells, organic light emitting diodes and organic electronics all employ materials characterized by a complex relationship between morphology and function which can only be elucidated by advanced spectroscopic techniques.
Combining lasers and magnetic resonance, we will develop and apply new advanced spectroscopic techniques to complex functional materials, revealing the dynamical behaviour of charge carriers and excited states.
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mic arrangemh as energy shniques to ch
at the Austnce analysis,ise materials
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projects:
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RAJ SHAlton Buildinharma@unsw
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such as batte
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materials
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ative therma
erials expand per year in parts (e.g. intings, electror expands n
achieve this, pansion (NTEvibrations o
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cooperative rerials.
solid-state e
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mbient condit0C as the electrolyte. Ievelopment aures adoptednd oxide-ion rtantly, variabon (from star formation pr
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st investigatehow poor petanding their ation of devic
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operating tn both examand use of thd by the eleconducting mble temperatrting reagentsrocesses and
ther solid steeraj for furth
65
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n to produce
ting via therme, re-manufas turbines), azero thermals upon heatite extreme oerty exhibited
by underst
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tate projectsher details.
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mal expansiocture and re
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anding thei
Using a solidhat are comgenerally loweme, solid os are esseolyte ionic cogies. The io
nd how they l be synthes
solved neutroonic conduct
nditions requi
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m-ion batteryon batteries. ersible sodium
mal expansio
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ents that are (ZTE) mate
uld dramaticaare considegroup of ma
r formation
d-state electmercially ava
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process is resosts due to w designed to
erial can be ally reduce ered in this aterials predo
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66
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ri silk fibroin
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with Honours
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llence in we have synthetic) students
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o have a plore the all know, tries and ry.
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netto and Kap
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ecurity is one which mean
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of this projee and the tea field trial in f
plan, New Op
nalized Silk B
re based mag, UNSW, Un
e of the grandns food produation of resouduce the bes
ct is to invesam in UGM farms such a
pportunities f
Biomaterials f
aterial (chitoniversitas Gad
d challengesuction needs urces that thet we can.
tigate the us towards fors strawberrie
67
for Ancient M
for Wound He
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s of our time. to increase be world have
se of chitosanrmulation thaes, chilies, or
Material, Scie
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servatives fUGM), and S
World popuby 70% to be (land, financ
n as natural pat is safe, er other fruits.
ence, 2010, 3
Health. Mat.,
or fresh fooSalim Agro Gr
lation is proje compared tce, human, e
preservativesconomical, s
329, 528-533
, 2013, 2, 20
od (in collaboroup Compa
jected to be to the food deetc) we need
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polymers: Le
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68
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A PROF. L
T: 9385 4
LORED P
the drug intond can be pus polymers
while the she
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he following
m the succes
carriers descs. Interestnano-objectsExample is thm-like morphoups that allo In this pros that will si
understands into cells,tness as we ter. The stuate the prop
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within the f biological lammation, d by them. m, the use
apeutics for ortant step diseases.
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OLYMERS
o nanoparticprepared usi to create corll makes the
synthesis to ve meeting w
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cribed in litetingly, natu, viruses, h
he by now wehology. In adow fast recogoject, we wilmulate the sding of th we will ma have found
udent will theperties of the
ar antennae
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INA STElton Buildin
stenzel@unsw
S FOR CATREAT
cles. Nanopaing various re-shell nano particles so
polymer nanwith clinicians
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ENZEL ng (F12) w.edu.au
ANCER TMENT
rticles for materials oparticles luble and
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spherical highly elongated bola virus ses carry host and elongated ruses. To of these rticles of
ould be a nd some le before
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Learning mration with Dr
lock copolym, it is wide
ate has a cortransition ber, we do noe is and howrticle. Thesehe biological cellent tools and why diffeyou would spen spend a datical mo
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size and ohis knowledgmortal cances do not reser cells mayd in with cachool of ched a model thand cells of en geometries on of these icles by varction of nano
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Australian SyStudents s2/honours_s
69
f our core acrization of ge loaded withedia such as
ancer stem
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morigenicity os and stars r
h nanoparticltypes simultd help us ide.
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ctivities over lycomonomeh anti-cancer proteins
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taneously. Tentify what ty
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ring (SANS) nce we und and why som and apply th
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This can helypes of nano
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and small aderstand theme of them dhe technique Prerequisiteapply for
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A/Prof Kris K
e. Cells are ge with a steme the rate olp us evaluaoparticles are
analysis at
angle X-ray se structure, do not perfore. If time pere is some inr a sc
polymers zation of
earn how
Kilian
grown on m-cell-like of cellular ating the e suitable
ANSTO
scattering we also
m. In this mits, you nterest in holarship
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(a)
Over theapproaccoordinaorderingrange of
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This resfaced infacile stoexcellentuning theffectiveshown h
Quantum
Magneticrole to ppretty usfascinatiunderstawhen disingle cembeddideal maquantum
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mple inter-moes in order to
d be great to
Metal organ
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search projecn industry - orage of gaset host materheir propertiee gas-selectihere.
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o work with H
nic framewo
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na in magneti
have revolutioum computinuring notes tre that weaviour of sucy is constrain or sheets on-magnetic ich to study t
nt.
MAT
d understanday: energy, nd neutron scal emergen
eractions; wew materials di
Honours stu
rks (MOFs):
nic chemistryated the subFs. These toional flexibiling up many
how to sele
cally targetedparations of uch as H2. Hall moleculesn become efnes such as
ic materials
onised the wng; they haveto the fridge e still do ch materials, ned. MOFs (2D) of m matrix, mathe effects of
70
TERIALS
ding new mawater and scattering in tt properties
e aim for a isplaying nov
udents on th
coordinatio
ry has takenbject – one aopologically bty, along witpotential app
ect for one m
d at very re mixed gas
Highly porouss such as CHfficient storags the H2 se
way in which e also been door. It is not fully
especially can have
metal ions king them f magnetic
A/PL
T: 938
CHEMIST
aterials that asustainabilitytruly multi-diand complexgreater und
vel properties
he following
on chemistry
n on board area showingbeautiful matth structural plications.
molecule ove
al challengestreams an
s MOFs makH4 or H2. Bge vessels oelecting MO
we store anda navigation
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PROF. JLevel 1, Da85 4672 E: j
TRY AT TH
are often focy. We makesciplinary proxity - the worerstanding os.
projects:
y of the 21st
a number og particular terials displayrigidity; they
er
s d e y
or F
d use informnal aid for ce
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ve spectrum ng inelastic n
JOHN STlton Buildinj.stride@unsw
HE NANOS
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mation and haenturies and
the
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TRIDE ng (F12) w.edu.au
SCALE
me of the range of to these s derives damental
epts and polymeric ng range osts for a
ave a key are even
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Solid stastructureorder givplay imparomaticapproximdimensiointeractiosystemscomputa
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s to studyational simula
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disorder in m
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ogen-bonding
Pauling arounsis of biologyhen it comese of solid staollaborative, ly to student
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odes. Complactions of si to moleculaproduced th
onduction unand A molecue in their cer it be for ange absorpt also suited
n terms of th.
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molecular m
though of in upon phase
elcome to theng the behavar interest iscs, their es their inte
They are big, ameitous and ver
g
nd 80 years ay and our ws to H-bondinte NMR, X-ra requiring higts with an inq
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71
materials
n terms of te transitions we world of phviour of mole
in that reduced ermolecular
also ideal enable to ry stable.
ago, the hydwatery world. ng - we have ay and neutrgh-end reseaquisitive mind
voltaics to mo
cient electronct as organic transfers canstacks whilsIn this way, emarkable a load. Withe, these matebe tuned fo
n the visible Being relat
ational studiec interactions
hemistry, nanored to you
he long rangwhen molecuase transitiocular motifs.
rogen bond However t been lookingron diffractionarch infrastrud, seeking de
olecular mag
n donors (D)c semiconducn result in bust modifying self-healing
anisotropy, h the wide erials have or specific spectrum ively small
es that are s and -
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is the champhere is a lotg at a numben and inelastcture and so
eep insights i
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phase
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ophisticated ninto the fund
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, crystallograo come and
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optically oelectrics
We aim to l groups,
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e
Lanthanknow evincrediblcycles, ldevices are explthat cou
Skills yo
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Recent potentiaany 3d-environmcompouprofoundthere hasynthesito exploi
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devices & iquantum comnthesis and cn the technolo
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Inorganic sy
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SYNTHETI
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actions to sta
72
Ro
IC INORG
ea of coordiw they reactpotential app
magnetic props is where thtion of new lature.
nsitive compo
mistry
oscopy (1H,
udents on th
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ggested that in the mag
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nation chemt”… This isnplications. Laperties that he research ianthanide co
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EMISTRY RDINATIO
istry – peopn’t so, lanthaanthanides hcould be utin the Sulway
ontaining coo
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taining compriers to magne changes viour of lanto the meta
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T A. SULlton Buildinsulway@unsw
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mun., 2015, 51, 1012.
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73
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c Prof Cliff W
research in ed matter and
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85
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Woodward
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86
JOINT PROJECTS AND COLLABORATIVE PROJECTS WITH OTHER SCHOOLS ACROSS UNSW
School of Chemistry researchers collaborate broadly with researchers in other Schools, Faculties and Institutes. If you are a Chemistry major or are eligible for Honours and wish to do a project aligned between Chemistry and another discipline, please contact the Honours coordinator.