ChronicGlomerulonephritis

Benisha Julian

Poststreptococcal GN, 1%

Membranous GN, 30%

IgA nephropathy, 30%

Idiopathic, 20%

Membranoproliferative GN

50%

Focal Segmental

Glomerulosclerosis80%-50%

Rapidly Progressive

GN 90%

Causes

Normal sized kidney

Contracted,granular

kidney

Gross FeaturesSmall size

Contracted, diffuse granular kidneys

Cortical Atrophy

Microscopic Features• Glomerulus: hyalinized

• Tubules: Atrophied & contains hyalinized casts.

• Interstitium: Fibrosed with lymphocytic infiltration

• Vessels: Arterial or aterioral sclerosis

1

2

4

3

2. Proteinuria 3. Edema

4.Azotemia and Uraemia

Clinical Features

Uraemic frost

1. Hypertension

Other symptoms of renal degeneration• Anemia• Weight loss• Drowsiness• Fatigue• Muscle cramps• Nausea, vomitting

Prognosis

Acute GN

Chronic GN

Chronic Kidney Failure

Treatment

Kidney Transplant

Dialysis

Thank you!