chronic disease is an environmental issue

Chronic Disease is an Environmental Issue

Isadora Guggenheim, FNP, ND, RN, MS, CNS

1

How Does Ozone Work?

• Ozone has no receptors; its pharmacological mechanism of action is indirect, through its mediators

• The response is dependent on the activation of nuclear transduction mechanisms signals (Nrf2: Nuclear factor (erythroid-derived 2)-like 2) and protein synthesis, e.g. SOD (superoxide dismutase), CAT (catalase), HO1 (hemeoxygenase 1), etc.)

• Ozone therapeutic indications are based on the knowledge that low physiological dose of ozone may play important roles within the cell. Ozone does NOT work through free radical mechanisms

• While ozone itself lasts only microseconds in the blood, the reaction of ozone and blood lipids leads to the production of more stable and still highly reactive oxygen species (such as peroxides), which would react similarly and perhaps mimic the pro-oxidant mechanism of immune system defense

• It does work through the generation of many species of lipid peroxides

Herskowitz, 2017

2

“We are Shaped by Adversity”

• “I have come to the frightening conclusion that I am the

decisive element. It is my personal approach that creates the

climate. It is my daily mood that makes the weather....In all

situations, it is my response that decides whether a crisis is

escalated or de-escalated, and a person is humanized or is

dehumanized.” Johann Wolfgang von Goethe

3

OZONEAs soon as it is dissolved in plasma, or in water present on the skin

surface or in the interstitial fluids, it reacts instantaneously with severalsubstrates (soluble antioxidants, albumin, unsaturated fatty acids)

ErythrocytesImproved O2 delivery

ROSEarly phase

PlateletsRelease of autacoidsand growth factors

Bone marrowMay activate differentiation at theerythropoietic level, favouring the

formation of ¨supergiftederythrocytes¨, with improved

biochemical characteristics, activationof metaloproteinases (MP-9)

that favour the release of stem cells

LeukocytesImmune activation

EndotheliumModulation of NO

LOPLate phase

LOP reach in traceamounts to all organs

and can representmessengers

triggering multiformbiological activities

Other organsUpregulation of

oxidativestress proteins and

antioxidant enzymes (4-

hidroxialkenals, byinduction of glutamate

cysteine ligase expression,

produce an increase ofintracellular GSH)

From Dr. Silvia Menendez’ Ozone Masters Course February 2018

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Sagai, M., & Bocci, V. (2011). Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a

mild oxidative stress? Medical Gas Research, 1, 29. http://doi.org/10.1186/2045-9912-1-29

Nrf2 Pathways to Prevent Cancer

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Biological Responses to Ozone

Therapy• Improves blood circulation and oxygen delivery

• Enhances general metabolism by improving oxygen delivery

• Upregulates cellular antioxidant enzymes and decreases free

radical production

• Activates the immune system and enhances the release of growth

factors, controls viral replication, kills microbes and kills cancer

cells

• Stimulates the neuroendocrine system

• Activates neuroprotective systems

• Helps to liberate heavy metals from tissue storage

• Protects inner mitochondrial membrane and entire electron

transport chain

• Maximal oxygen utilization means better fat burning

• Regulates NAD to NADH -700 to 1

• Oxygen delivery to all tissues

Herskowitz, 2017

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Biological Responses to Ozone

Therapy Cont’d• Increasing the levels of direct antioxidants, such as GSH, CO, and

bilirubin.

• Stimulating GSH regeneration via glutathione and thioredoxin reductase.

• Increasing the levels of enzymes that detoxify oxidants and electrophils (i.e. catalase, SOD, GPx, GSTr, NADPH-quinone oxidoreductase (NQO1), HO-1, HSP70, etc).

• Increasing the levels of phase II enzymes.

• Inhibiting cytokine-mediated inflammation via the induction of leukotriene B4 reductase.

• Reducing iron overload, and subsequent oxidative stress induced via elevated ferritin.

• Recognizing, repairing, and removing damaged proteins.

• Protection from apoptosis induced via oxidative stress*.

• Increasing DNA repair activity*.

Sagai, M., & Bocci, V. (2011). Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress? Medical Gas Research, 1, 29. http://doi.org/10.1186/2045-9912-1-29

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OZONE BIOLOGICAL EFFECTS

OZONE

Maintains the cellularredox balance

Increases Oxygen Metabolism

Metabolic Regulator

Immunologic Modulator

Maintains the cellularredox balance

Germicidal Power


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Nrf2-nuclear factor-erythroid 2-related factor-2

Pharmacological effects of medical ozone

via ozone-produced peroxides (short-chain-

hydroxy-hydroperoxide with its low

tendency to radical reactions). The three

effects: (1) improved oxygen release by the

red blood cells (RBCs); (2)

Immunomodulation through activation of

the white blood cells (WBCs); and, (3)

Regulation of Cellular redox.

Renate et al, OS & Eng, 2012

“Ozone Peroxide” and its second

messenger. Cysteine residue and

glutathione oxidation processes induce

the cytokines – or anti-oxidant regulation

via NFkB or Nrf2, respectively. NrF2,

this important cytoprotective nuclear

transcription factor can suppress NFkB-

activation (Li W et al, Biochem

Pharmacol. 2008)


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Mild/Moderate Oxidative Stress

Antioxidant Response Elements

(ARE)SOD, GPx,

GSTr, CAT,

HO-1, NQO-1,

HSP

Activates hypoxia

inducible factor –

1 & (HIF-1a)

Initiates mild

immune

responses

Nuclear Factor

of Activated T-

cells (NFAT)

Activated

protein-1 (AP-1)

Activates Nrf2

(nuclear factor-

erythroid 2-

releated factor

2)

• Increases the levels of direct antioxidants, such as GSH

• Stimulates GSH regeneration via glutathione and thioredoxin reductase

• Increases the levels of enzymes that detoxify oxidants (i.e., catalase, SOD, GPx,

GSTr, NADH-quinone, oxidoreductase, (NQO1),HO-1, HSP70, etc)

• Increases the levels of phase II enzymes

• Inhibits cytokine-mediated inflammation

• Reduces iron overload, and subsequent oxidative stress induced via elevated ferritin

• Protects from apoptosis induced via oxidative stress

• Increases DNA repair activity

Biological responses induced via the activation

of Nrf2/ARE with mild/moderate oxidative stress

Herskowitz, 2017

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ROS and Neurodegeneration

Sagai, M., & Bocci, V. (2011). Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a

mild oxidative stress? Medical Gas Research, 1, 29. http://doi.org/10.1186/2045-9912-1-29

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The Herrmann Machine

(n.d.). Retrieved from https://www.h-a-b.de/en/products/ozone/

Ozone Treatments with the Herrmann:

https://www.youtube.com/watch?v=um8JVHb74yU

https://www.youtube.com/watch?v=kjpR7DV8AxI

https://www.youtube.com/watch?v=a4pRTB5DVZc

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https://www.youtube.com/watch?v=um8JVHb74yU

https://www.youtube.com/watch?v=kjpR7DV8AxI

https://www.youtube.com/watch?v=a4pRTB5DVZc

Conclusions and Perspectives

• The application of ozone in medicine represents one of the most intriguing adventures in research. First of all because ozone is too well known as a toxic gas in the troposphere and secondly, in spite of courageous pioneers like Payr, Fisch, Wolff and Auborg, ozone stalled in an empirical phase for almost three decades and it was heavily damaged by the improper use of direct IV infusion by so-called doctors in desperate HIV-AIDS patients. This dangerous and useless application, associated with other deplorable episodes, led the FDA to prohibit the use of ozone in medicine. Today, the basic mechanisms of action of ozone in blood, documenting the existence of a therapeutic window and establishing a framework for understanding and recommending ozone therapy in some diseases have been clarified and we can start to see a faint light at the end of the tunnel. However, owing to the lack of sponsors and funding, the clinical work, fundamental for demonstrating the validity of ozone therapy, proceeds at a snail pace. Furthermore, the urgent need of treating too many patients in poor countries has stimulated the use of “cheap and quick” procedures that hinder progress. Clinical scientists for either prejudice, or lack of knowledge, or exclusive interest in pharmaceutical drugs disregard, if not object, ozone therapy that remains in the hands of practitioners who cannot deliver reliable scientific reports. Thus, optimistically let us say that we are at the end of the beginning but our enthusiasm remains high and we will continue our efforts for allowing the acceptance of ozone therapy as an efficacious approach to be included among the armamentarium of orthodox medicine. (Bocci et al. 2011)

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Conclusions and Perspectives

• Our comparative study showed air plasma and ozone to have

very high bactericidal potency, both producing nearly 99.99%

efficacy. Moreover, both air plasma and ozone inactivated

different bacterial strains P. aeruginosa and S. aureus to the

same extent. (Lunov et al. 2014)

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I.V. Ozone with German

Biologics Homotoxicology

“Anti-homotoxic medicine is an indication-oriented approach.

Homotoxic remedies are mixtures of substances of low to middle

potencies. This practice was scientifically supported by Rudolph

Arndt and Hugo Schulz through a quantitative differentiation of

the medicinal effect on Biosystems. It is known as the Arndt-

Schulz Principle. It states:”

• Weak stimuli stimulate the life functions (retro-action of

homeopathic preparations)

• Moderately strong stimuli accelerate them

• Strong stimuli act as inhibitors

• The strongest stimuli suspend the life functions

Biotherapeutic index: Ordinatio antihomotoxica et materia medica (5th ed.) 2000

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I.V. Ozone with German

Biologics “Dr. Hans-Henrich Reckeweg formulated Homotoxicology in

1952 to provide a holistic perspective on the synthesis of medical

science.”

“According to Homotoxicology all of those processes,

syndromes, and manifestations which we designate as diseases,

are the expression thereof that the body is combatting poisons

and that it wants to neutralize and excrete these poisons. The

body either wins or loses the fight thereby. Those processes,

which we designate as diseases, are always biological, that is

natural teleological processes, which serve poison defense and

detoxification.”

Anti-homotoxic medicine is the connecting link between

allopathic medicine and homeopathy.

Biotherapeutic index: Ordinatio antihomotoxica et materia medica (5th ed.). 2000

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I.V. Ozone with German Biologics • Homotoxins are chemical, biochemical and non-material influences on the

physical/psyche which can cause ill health in humans. Homotoxins can come from the exterior (exogenic) or originate in the body (endogenic).

• Homotoxons are chemical reaction products from compounds of homotoxins with each other or with other substances (products of metabolism) which neutralize the poisonous property of the homotoxins. Liver cells work to neutralize homotoxins and metabolic waste in an effort to detoxify the organism.

• Retoxins are homotoxins with endogenic substances which cannot be eliminated via excretion or irritation and are designated as “residual poisons” or retoxins. One example in the non-enzymatic glucosilization of tissues and cell surfaces in glucose excess or latent diabetes mellitus.

• Homotoxicosis is a non-physiological condition which arises after the reaction of a homotoxins on cells or in tissues. Homotoxicosis presents after humoral or cellular appearance and is followed by morphological changes on the tissues. Homotoxicosis is triggered by a homotoxin and this leads to defensive measures of the organism whose goal is to eliminate the homotoxins and restore the physiological homeostasis when possible.

• Ground Regulation System is composed of the ground substance plus cellular, humoral and nervous components. Ground substance or extracellular matrix is formed of highly polymerized sugars (proteoglycans and glycosaminoglycans) plus structural and meshing glycoproteins.


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Phase Theory• Humoral Phases

1. Excretion Phase – This phase contains manifestations of increased physiological excretion mechanisms.

2. Reaction Phase – Illnesses of the phase are marked by an exudative inflammation, which enables an

accelerated excretion of toxins from the body.

• The Matrix Phases

1. Deposition Phase – In this phase the excretion mechanisms of the body are overworked and toxins are

deposited in the matrix. This phase often progresses with few symptoms.

2. Impregnation Phase – Diseases in this phase are characterized by the presence of toxins which become a

part of the connective tissue and the matrix, along with changes in the structural components as well as

their functions. The typically increasingly severe symptoms and signs of this phase demonstrate damage

of the organ cells.

• The Cellular Phases

1. Degeneration Phase – During this phase, courses of disease cause serious damage, and destruction of larger

cell groups of an organ takes place

2. Dedifferentiation (neoplasm) Phase – Diseases of this phase are characterized by the development of

undifferentiated, non-specialized cell forms. Malignant diseases stand at the end of this phase.

• Biological Division

1. The boundary between the deposition and impregnation phases, demarcates the pure deposition in the

matrix from the integration of toxins into its structural components. Spontaneous endogenic excretion of

the homotoxins is impeded.

• Vicariation

1. Refers to the transition of the indication signs of an illness within one phase to another organ system, or the

change of the fundamental symptoms and signs into another phase, with or without a change of the organ

system

1. Progressive vicariation: Progressive vicariation refers to an aggravation of the total symptoms and signs of

illness.

2. Regressive vicariation: Regressive vicariation refers to an improvement of the total symptoms and signs of

an illness.


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The Principles of Action of Anti-

Homotoxic Medicine• The immune system has memory and regulation systems. The

deposition phase and impregnation phase is characterized by

chronic inflammation and auto-aggression. The humoral area

(via immunoglobulins from B-lymphocytes) and the cellular

area (T-cells, granulocytes, macrophages) still counterbalance

each other in this case. A regressive vicariation is still possible

in these matrix phases.

• This is the greatest opportunity for anti-homotoxic medicine.

• Low dose antigen reactions from D1 to D12 create the

bystander effect. Higher potencies, trace elements and

intermediary catalysts stimulates ground regulation.


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The Ground Regulation

Every organism requires energy to maintain its vital functions and must be continuously fed by the metabolism. Disorders of energy metabolism impair the energy supply which is controlled by the endogenic regulation. An energetically open system needs suitable energy and unsuitable energy must be evacuated. All reactions of the organism proceed at relatively low temperatures and must be accelerated by catalysts. The prerequisite for an effective catalyst is a suitable substrate between and in the cells. Extracellular is located in front of the cells. Cells can only react as they have been informed via the extracellular space. The dynamic structure of the extracellular space and its ground regulation forms in all cells and cell groups. This has a decisive impact on the effectiveness of extracellular and intracellular catalysts. This creates a molecular sieve of matrix components like highly polymerized PG/GAGs, structural proteins (collagen, elastin) and meshing glycoproteins (fibronectin). The ground substance is connected to the endocrine system via the capillary system and via the axons to the central nervous system. The fibroblast is the metabolically active centers.


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The Ground Regulation

• The connection to the central nervous system is conducted via the autonomic nerve fibers that end in the matrix. The connection to the system of endocrine glands, (pituitary, thyroid, suprarenal glands) are conducted via the capillary system which permeates the matrix. Both systems are connected to each other in the brainstem. The matrix is regulated on site and also under the influence of superimposed control areas. The regulation center in the matrix is the fibroblast corresponding to the glial cell in the central nervous system. It reacts to all incoming information (hormones, neural substances, metabolites, catabolites, pH value changes, etc. ) with a synthesis of bad information (alternative facts). Every surplus or deficit can lead in certain circumstance to detrimental consequences for the total system depending on individually on a circulus vitiosus or viscous circle.

• Connective properties of the PG/GAGs are sieve-like and the matrix can develop latent tissue acidity, increase of free radicals and activation of the proteolytic system turning into a pro-inflammatory situation which can cause damage to all humoral and cellular elements thus progressing to chronic disease states and malignant processes.


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Homeopathy Hoax or Real?

RESULTS:

• The homeopathy RCT literature grew by 309 records in the 18 years that immediately followed Haidvogl's article, with more than a doubling of the proportion that investigated individualized homeopathy. Discounting one prior publication, the entire systematic review literature on homeopathy RCTs post-dates 1994. A total of 36 condition-specific systematic reviews have been identified in the peer-reviewed literature: 16 of them reported positive, or tentatively positive, conclusions about homeopathy's clinical effectiveness; the other 20 were negative or non-conclusive. Reviews typically have been restricted in the strength of their conclusions by the low quality of the original RCT evidence. Three comprehensive systematic reviews concluded, cautiously, that homeopathy may differ from placebo; a fourth such review reached negative conclusions. A recent high-quality meta-analysis concluded that medicines prescribed in individualized homeopathic treatment may have small, specific, effects.

CONCLUSIONS:

• Despite important growth in research activity since 1994, concerns about study quality limit the interpretation of available RCT data. The question whether homeopathic intervention differs from placebo awaits decisive answer.

Homeopathy. 2015 Oct;104(4):328-32. doi: 10.1016/j.homp.2015.05.003.

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Homeopathy Adverse Health Affects• Homeopathy has the potential to harm patients and consumers in both

direct and indirect ways. Clinicians should be aware of its risks and

advise their patients accordingly. (Posadzki et al. 2012)

• An audit of the Bristol Homeopathic Hospital among 116 patients

reported that 11% of them experienced AEs, including headaches,

lethargy or vomiting. This percentage figure is difficult to interpret as

the authors categorize diarrhea, eczema, gastrointestinal upset, hair

loss, infections, nausea, migraines, pains, rash, skin irritation, tension

headaches, tiredness/fatigue as ‘homeopathic aggravations’, new

symptoms and/or return of old symptoms. Our own review of the

evidence for or against the existence of homeopathic aggravations

included 24 placebo‐controlled trials reporting aggravations, and we

came to the conclusion that ‘this systematic review does not provide

clear evidence that homeopathic aggravations exist’ (Posadzki et al.

2012)

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Homeopathy Misreported• Detailed examination of the 37 original articles cited by Posadzki and colleagues has uncovered

numerous striking errors. As there are too many to mention in this comment, we draw your attention to just some examples of our key concerns below.

• In reporting on four cases of AEs published by Ibsen et al., Posadzki and colleagues categorize these as ‘likely’ to have been caused by homeopathy. However, there is actually no reference made to homeopathy whatsoever in the Ibsen article. The word ‘homeopathy’ only appeared in the English abstract as an incorrect translation of the term ‘alternative treatment’.

• Of even greater concern is the reporting of a case report by Geukens of cure by homeopathy, which has been reported by Posadzki et al. as a case of homeopathy causing ‘heart disease and bladder cancer’. In actual fact, the patient was cured from his initial symptoms of vertigo and heart disease using homeopathic medicines; he then presented 7 years later with cancer of the bladder. It is difficult to see how the causality of the cancer could be attributed to the successful treatment of the heart‐condition. The cancer was subsequently treated using conventional treatment, the side‐effects of which were successfully dealt with using homeopathy. The patient recovered, with no further complaint. How does one end up with causality ‘Almost certain’ for homeopathy in a clear case were homeopathy was instrumental in providing cure? (Posadzki et al. 2012)

Differentiating between ordinary standards of homeopathic care and clinical negligence:

• When assessing the safety of a medical intervention it is usual to differentiate between non‐preventable AEs and those which are preventable with ordinary standards of care i.e. cases of clinical negligence. Posadzki et al. have failed to make any such distinction. The four deaths they report as being caused by homeopathy involve either mis-prescribing of poisonous substances or failure to refer the patient for essential conventional medical treatment. As these cases contravene what is considered standard homeopathic care, they should be classified as cases of clinical negligence. (Posadzki et al. 2012) 27

Inaccuracies

• The authors have also shown a lack of consistency in their decision‐making

processes regarding inclusion/exclusion of data. For example, 1070 of the

1159 cases identified by Posadzki et al. come from a single article reporting

calls to a toxicological information center. These comprised calls for

information (e.g. following inadvertent ingestion of a homeopathic remedy)

some of which lead to actual AE cases with a maximum severity of ‘minor’

or ‘mild’. As the article by Zuzak et al. presented 2143 similar cases, it is

unclear why these were omitted. (Tournier et al. 2013)

• Sadly the quality of this review by Posadzki et al. falls short of this standard

by such a large margin, that at best the authors’ results are unreliable, and at

worst we must consider whether the degree of inaccuracy is such that

retraction of this article becomes necessary to preserve the quality of the

peer‐reviewed literature. (Tournier et al. 2013)

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Adverse Health Effects of

Aluminum • Induced formation of oxygen radicals – oxidative damage

• Impaired bone mineralization – Osteomalacia

• Delayed neurological development – Encephalopathy/ Dementia/ Alzheimer’s

• Reduces erythrocyte lifespan and interferes with hemoglobin synthesis – microcytic hypochromic anemia

• Contact allergy

• Adverse reactions to vaccines with Al adjuvants

• Pneumoconiosis after long-term inhalation – (potroom asthma)

• Can effect neurologic, hematopoietic, skeletal, respiratory, gastrointestinal and immunologic systems

• Increased risk of lung and bladder cancer

(Willhite 2014)29

Mechanisms of Action -

Aluminum Air - Water – Food

Low Daily Doses – Systemic Intoxication

• “Mitochondrial metabolism is the main site of the toxicological action of Al due to interference with “Fe-dependent redox sensitive enzymes in the tricarboxylic acid (TCA) cycle and oxidative phosphorylation”

• “Cellular metabolic shift from oxidative ATP production to anaerobic glycolysis –resulting in increased α-ketoglutarate and succinate and reduced L-carnitine”

• “Depletion of mitochondrial iron, H2O2, O2 and OH”

• “Reduced fatty acid β – Oxidation, Increased peroxidation”

• “Al +3 binds with phospholipids in cell membrane altering membrane fluid dynamics through peroxidation”

• “Stress in endoplasmic reticulum leading to cytochrome c release from mitochondria and activation of apoptotic demise”

• “Genomic Effect increased p53 followed by Bax translocation leading to DNA fragmentation at the lowest Al +3 Concentration”

• “Decreases antioxidant enzyme – G-6-PDH, SOD and catalase”

(Willhite 2014)

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Adverse Health Effects of Manganese and CopperManganese:• Neurotoxicity – Brain is main target of Mn intoxication

• Tends to accumulate in the liver, pancreas, bone, kidney and brain

• MOA - oxidative stress, mitochondrial dysfunction, protein misfolding, endoplasmic reticulum stress, autophagy dysregulation, apoptosis and disruption of other metal homeostasis

• Link to Parkinson’s

• Interferes with absorption of dietary iron

• Impairs activity of copper metallo-enzymes

• Impaired thiamin B1 metabolism

(Willhite 2014)

Copper:• Neurotoxicity

• “Cu-induced oxidative damage has been implicated in disorders associated with abnormal Cu metabolism and neurodegenerative changes.” (Gaetke, 2003)

• Associated with Wilson’s disease, liver dysfunction, tremors, involuntary movements, muscle stiffness, muscle spasms, myopathy, gait abnormalities, mood disorders, memory deterioration

• Associated with Alzheimer’s and Parkinson’s

(Gaetke 2003)

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Elevated Aluminum, Manganese

and Copper - Case I: J.E. • 42 y.o. female PTC with 10 year hx of Lyme dz and co-infections. 10

years ago, pt. complained of hot flashes, rashes, clumsiness, loss of balance, vision changes, optic neuritis, gained 70 pounds and went from fully functional 3 time Emmy winner to barely being able to get out of bed.

• Previous labs revealed the following: June 2017

• Platelet count 557 x 10 RR: 144-400

• CRP 1.3 RR: <0.5

• ESR 56 RR: <26

• Ferritin 6 RR: 10-291, Iron, %Sat. 6% RR:20-55%, TIBC 531 RR: 228-428

• Histone Ab IgG 1.0 units RR: 0.0-0.9

• Q Fever Ab+, Lyme Ab+ C6 with bands 18 & 4, Bartonella Ab+, Ehrlichiosis Ab+, Babesia Ab+, Pneumococcal Ab+ and low for Type 4,5,8,9,12,14,19,22,26,34,43,51,54,68,70

• Immunoglobuline G 548RR: 700-1600 Subclass 1 204 RR: 422-1292 32

Elevated Aluminum, Manganese and Copper Cont’d. • Imaging: Stable fatty infiltration of liver, small to moderate size hiatal hernia, CT

of chest – small patch of faint ground glass density and nodularity in the medial segment of the right middle lobe, focal bronchial thickening, possibility of distal bronchial or bronchiolar plugging

• Brain Imaging: Moderate nonspecific white matter signal abnormality involving the periventricular white matter and subcortical white matter DDX: Demyelinating disease and microvascular disease.

• Following contrast: punctate area of enhancement in the right interior basal ganglia in pencaudate location measuring 3mm on axial image.

• PTC with sxs: Fatigue, muscle weakness, H/A (migraine), blurry vision, SOB, asthma, heart palpitations, heartburn/reflux, low grade nausea, abdominal pain, PMS, no libido, joint pain/stiffness, pustular psoriasis on hands and feet with weeping and seeping, restless leg, chronic iron deficiency anemia, numbness/tingling, brain fog, memory issues, balance issues, vertigo, depression/anxiety, excessive stress, hot/cold intolerance, hypothyroid, excessive sweating, pre-diabetes, MCS

• PE: confirmed above, noted continuous eye flutters with Pulse Ox: 94, Ht: 5.1 Wt: 196

• Current Meds: Synthyroid, Pulmicort, Xanax ER/Regular, Celexa, Trinessa (BC), Trofranil, Multivitamin, Vitamin C, Pro Air Albuterol Rescue Inhaler, Prevacid, Zantac, Gaviscon (Ask me for dosages)

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Elevated Aluminum, Manganese and Copper Cont’d. • Assessment: Persistent Lyme/ Co-Infections, Chronic Asthma,

GERD, Fatty Liver, Oxygen Deficiency, Generalized Pain,

Cognitive Impairment, Leaky Gut, Immune Suppression,

Seasonal Allergies, Hypothyroid, Iron Deficiency Anemia,

Metabolic Syndrome, Constipation

• Plan: Clean up Diet, Rebuild immune system with gut repair

protocol, Low dose low Gamma I.V. Ozone with added Rx

Homeopathics, Lab Testing, Advance to Ozone Chelation

(Level 5)

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Elevated Aluminum, Manganese

& Copper in Serum– Case I: J.E.• Empire City Labs– Significant Findings – November 2017

• CBC w Diff

• WBC 11.9 RR:4.0-11.0, RDWCV 15.8 RR: 11.0-15.0, NE# 7.58 RR: 1.40-6.51, IG# 0.04 RR: 0.00-0.03

• %CD8 -/ CD57+ Lymphs 1.9 RR: 2.0-17.0

• Alkaline Phosphatase, ALP 134 RR: 45-129

• Cardiac IQ

• Cholesterol 213 RR: <200, Triglycerides 190 RR: <150, LDL Direct Cholesterol 149.9 RR:<130, LP(a) 139.71 RR: <30, LDL Pattern B

• CRP, High Sensitivity 22.67 RR: <3

• Hemoglobin A1C 6.1 RR: 4.2-5.6

• Pregnenolone <5 RR: 22-237, SHBG 245.5 RR: 18.0-144.0, Dihydrotestosterone <5 RR: 5-46, ACTH, Plasma <5 RR: 6-50

• IGF - 1 86 RR: 101-267

• TNF- Alpha, Highly Sensitive 0.29 RR: 0.56-1.40

• Complement C-3 245 RR: 90-170, Complement C-4 51 RR: 12-36, C3A Level 3115 RR: 0-780

• HH6 1:10 Past Infection, M. Pneumonia 1.11 Past Infection

• Vascular Endothelial GF 511 RR: 31-86

• Food Allergies IgE: Class I RR: 0-10 – Cheese Mold 0.11, Egg White 0.33, Corn 0.14, Milk 0.24, Sesame Seed 0.18

• Aluminum Serum 7 RR: <7, Copper 247 RR: 70- 175, Manganese 1.5 RR: <1.2

• Vitamin C <0.1 RR:0.2-1.535

Labs Before and After Treatment WBC 11.9 RR:4.0-11.0

RDWCV 15.8 RR: 11.0-15.0

NE# 7.58 RR: 1.40-6.51

IG# 0.04 RR: 0.00-0.03

Alkaline Phosphatase, ALP 134 RR: 45-129

Hemoglobin A1C 6.1 RR: 4.2-5.6

CRP, High Sensitivity 22.67 RR: <3

Pregnenolone <5 RR: 22-237

Dihydrotestosterone <5 RR: 5-46

IGF - 1 86 RR: 101-267

TNF- Alpha, Highly Sensitive 0.29 RR: 0.56-1.40

Complement C-3 245 RR: 90-170


Aluminum Serum 7 RR: <7

Copper 247 RR: 70- 175

Manganese 1.5 RR: <1.2

LDL Direct Cholesterol 149.9 RR:<130

LP(a) 139.71 RR: <30

Triglycerides 190 RR: <150

M. Pneumonia 1.11

WBC 14.0 RR: 4.0-11.0

RDWCV 13.5 RR: 11.0-15.5

NE# 8.10 RR: 1.40-6.51

IG# 0.21 RR: 0.00-0.03

Alkaline Phosphatase, ALP 130 RR: 45-129

Hemoglobin 11.7 RR: 11.9-15.5g

CRP, High Sensitivity 33 RR: <=3

Pregnenelone <5 RR: 22-237

Dihydrotestosterone, <5 RR: 5-46 ng/dL

IGF-I 138.3 10-1200 ng/mL

TNF- Alpha, Highly Sensitive 1.20 RR: 0.56-1.40



Aluminum Serum 10 RR: <7

COPPER 230 H 70-175 mcg/dL

Manganese 1.8 RR: < 1.2

LDL Direct Cholesterol 145.5 RR: <=130

LP(a) >85 RR: <=30

Triglycerides 200 RR: <=150

M. Pneumonia AB (IGG),EIA 2.67 RR: <=0.90

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Carduus marianus

40

Taraxacum officinale

41

Cyclamen europaeum

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Ozone Chelation Treatment -

Case I: J.E.I.V. Ozone/Chelation Treatment Protocol (Level 5)

• First 6 Treatments

• MAH 500ml-750ml, Heparin 10,000, Gamma 30 with Herrmann

machine

• Biologics:

• Engystol, Hepar N Compositum, Ignatia Homaccord, Cerebrum

Compositum, Traumeel, Bronchus, Drosera, CoEnzyme, Ferrum

Homaccord, Hormeel, Neuro-Injeel, Nux Vomica, Oculus Totalis,

Tonica, Solidago

• Post Labs: Switched to Ozone Chelation 10 Treatments

• Worked up to 1000ml of ozonated blood and gamma remained at 30

• Lowered Heparin to 5000

• Chelation Formula: ½ NS 500ml, Na Bicarb 15ml, Ca-EDTA 3gm,

Ascorbic Acid 3gm, Magnesium 2500mg, B-Complex 4ml, Hydroxy-

B12 5ml, Potassium Chloride 4mEq, Zinc 2ml, Taurine 5ml,

Carnitine 2ml

43

Patient Improvements –

Case I: J.E• Energy , sleep, skin, cognition, digestion, mood, feeling more

in control, more stamina

• Even though this is a documented clinical failure the patient

did receive benefits from ozone chelation

44

Aquilegia vulgaris

45

Adverse Health Effects of Lead• Hypertension

• Peripheral Arterial Disease

• Coronary Heart Disease

• Increased risk of stroke

• Left ventricular hypertrophy

• Cardiac Rhythm Alteration –

AFIB

• Cognitive Degeneration

• Renal Disease

• Mood Disorders (Depression

etc.)

• Systemic Inflammation

• Arthritis

• Associated with ADD and

ADHD

• Impaired Dental Health

• Delayed sexual maturation

• Probably Carcinogenic

• Reduced Fertility

• Nervous System Dysfunction

• Linked to ALS

• Violence and Aggression

Flora, 2012

46

Mechanisms of Action - Lead

• Oxidative Stress

• “Ionic mechanism of action for lead mainly arises due to its ability to substitute other bivalent cations like Ca2+, Mg2+, Fe2+ and monovalent cations like Na+ (though bivalent cations are more readily substituted), affecting various fundamental biological processes of the body (Lidsky & Schneider, 2003). Significant effects have been found on various fundamental cellular processes like intra and intercellular signaling, cell adhesion, protein folding and maturation, apoptosis, ionic transportation, enzyme regulation, release of neurotransmitters, etc. (Garza et al., 2006)”

- Flora, 2012

• “Lead, even in picomolar concentration, can replace calcium, thereby affecting key neurotransmitters like protein kinase C, which regulates long term neural excitation and memory storage. It also affects the sodium ion concentration, which is responsible for numerous vital biological activities like generation of action potentials in the excitatory tissues for the purpose of cell to cell communication, uptake of neurotransmitters (choline, dopamine and GABA) and regulation of uptake and retention of calcium by synaptosomes. This interaction between lead and sodium seriously impairs the normal functioning of the aforementioned sodium dependent processes (Bressler et al., 1999).”

- Flora, 2012 47

Elevated Lead in Tissue Storage

–Case II: S.J. • 54 y.o. male PTC with R knee and hip pain, hx of Lyme, chronic gastrointestinal

upset, headaches (migraines, cluster and tension), muscle spasms, histamine dumping syndrome, irritable bowel with mixed diarrhea/constipation, “aging too quickly”, chronic cold sores, chronic cervical pain/subluxation, hx of HSV1 and 2, joint pain, chronic fatigue and unconfirmed low T.

• Started treatment in July 2016 with Prolozone for R knee and R hip, I.V. Meyer’s with Glutathione (1000mg), 10 pass MAH(2000-2500 ozonated blood) Gamma 70 Heparin 10,000u with Herrmann x 1 session per week for 7 weeks. (Level 5)

• Added Biologics: Traumeel, CoEnzyme, Engystol, Cerebrum Compositum, Testis Compositum, Lymphomyosot, Galium, Glandula Thymi, Herpes Nosode, Hepeel, Spascupreel, Spigelon, Chelidonium, Cimicifuga, Vitamin C, Coloncynthis, NuxVomica, Discus Compositum, Neuralgo-Rheum, Medorrhinum, Injeel, AcidumFumaricum, Acidum DL-Malicum, Zeel, Glyoxal, Ubichinon, Colon-Suis, Duodenum-Suis, ATP, Ignatia-Injeel, Graphites, Mucosa Compositum

• Started with Gut Repair Protocol, Liver support, Joint support, Immune support, Natural support for food cravings (Level 5)

• Later added Cardiac support48

Vitex agnus-castus

49

Conium maculatum

50

Damiana

51

Elevated Lead in Tissue Storage

–Case II: S.J. • Empire City Labs– Significant Findings

• NE#% 76.50 RR: 39-71

• LY% 15 RR: 19-53

• Abs. CD8-CD57+ Lymphs 46 RR: 60-360

• LDL Peak Size 216.8 RR:>218

• Homocysteine 16.4 RR: 3.7-13.9

• Cholesterol 161.7 RR:<130

• Pregnenolone 11 RR: 22-237

• Progesterone 0.21 RR: 0.28-1.22

• ACTH

• Plasma <5 RR: 6-50

• TNF-Alpha 2.25 RR 0.56-1.40

• ANA screen 0.9 RR: 0.0-0.7

• C3A Level 1904 RR: 0-780

• EBV IGG 226.0 RR: <18.0

• HSV-1 IGG 31.2 RR: <0.9

• HSV-2 IGG RR: 9.5

• HH 6 AB IGG 1:40 RR:<1.20

• M. Pneum. IGG 3.46 RR:<0.9

• VEGF Vascular Endothelial GF 194 RR: 31-86

• Lead in Serum 1.57 RR: 0-5

• Aluminum 5 RR: <7

• Cadmium 0.52 RR:1.7ug/L or less for non-smokers

• Mercury 0.79 RR: 0-10

• Arsenic 1.00 RR: 0-23

• Copper 91 RR: 70-175

• Vitamin C 0.1 RR: 0.2 – 1.5

• Vitamin D 25-Hydroxy 27.73 RR: 33.0-100.00

• LDL Pattern B

• LDL Small 246 RR: <161

• LDL Medium 331 RR: <200

• HDL Large 4410 RR: >9387

• Omega-3 1.5 RR:>3.2

52

Urine Toxic Metals Provocative

Challenge – Case II: S.J. • EDTA 3000mg

• DMSA 3000mg

• 6 Hour Urine Challenge

• Results:

• Al 48 RR: <25

• Cadmium 1.7 RR: <0.8

• Cesium 21 RR: <9

• Lead 40 RR:<2

• Mercury 2.9 RR: <3

• Nickel 11 RR: <8

• Thallium 0.7 RR: <0.5

• Creatinine 26.5 RR: 35-240 mg/dL56

Ozone Chelation Treatment –

Case II: S.J.Follow up Results: Urine Toxic Metals

• Al 9.3 RR: <25

• Cadmium 0.4 RR: 0.8

• Cesium 7.1 RR: <9

• Lead 5.1 RR: <2

• Mercury : Undetected

• Nickel 4.2 RR: <8

• Thallium 0.1 RR: <0.5

• Creatinine 52.5 RR: 35-240

57

Ozone Chelation Treatment –

Case II: S.J.• Switched to Ozone Chelation post results

• 10 Pass MAH followed by Chelation protocol

• EDTA 3gm as in first case plus Zinc 3ml, Taurine 5ml,

Carnitine 2-3ml x 12 tx: One tx per month as Pt. could not

come weekly due to distance

• Tx #10 Pt. had eye infection

• Used an eye cup to insufflate direct ozone for 1 minute into R eye

• Applied Ozone cream on affected eyelid as well

Level 558

Patient Improvements – Case II:

S.J. • Patient has improved daily function

• Improved gastrointestinal system

• Not as sensitive to foods

• Significant reduction in headaches

• Significant reduction in systemic inflammation

• Feels younger

• Able to do 100 mile bike rides

• No R knee or R hip complaints

• Brain fog cleared/ Cognition improved

• Improved coping mechanisms

• Great Sense of Humor! 59

Arnica montana

60

Calendula officinalis

61

Elevated Aluminum, Mixed Connective Tissue Disease & Oxygen Deficiency – Case III S.P.

• 69 y.o female, PTC with HTN, Scoliosis, Mixed Connective Tissue Disease, Metabolic Syndrome, Raynaud’s, Rosacea, Missing Fat Pad in Left Foot, Poor Methylation and Oxygen Deficiency

• Current Medications: Chlorthalidone 25mg/day, Labetalol 50mg twice/day, Irbesartan 150mg/day

• Started treatment 4/23/2018, MAH blood 650ml, ozone gamma 55, heparin u 5000

• German Biologics: ATP, Glyoxal, Ubichinon

• 3rd – 9th Session: Added Engystol

• Recommended Endoscopy to r/o H. Pylori

• Recommended Ketogenic Diet

• Oral Nutraceuticals: Resveratrol, Alpha-Lipoic Acid, Biotin, Arginine, Alpha-Ketoglutarate, Whey Peptide, Quercetin, L-Glutamic Acid, Betaine HCI, Pepsin, Gentian

• 6/12/2018 – Added Nutraceuticals Cardio Protection, 5-MTHFR, Liver Protection, Andrographis

• Recommended Coronary Calcium Artery Score62

Elevated Aluminum, Mixed Connective Tissue Disease & Oxygen Deficiency – Case III S.P.

• 10th Session – Started Ozone Chelation

• 500ml of half normal saline, NA bicarb 10ml, Ca-EDTA 1gm, Mg Sulfate 2500mg, B Complex 1ml, Dexpanthenol 4ml, Pyridoxine 2ml, Hydroxy – B12 5mg, Potassium Chloride 4 mEq, Zinc 1ml, Carnitine 1ml, Taurine 3ml

• Empire City Labs – 6/5/2018 – Abnormals

• Blood Type: B+

• ESR 36 H <=30 mm/hr

• ALKALINE PHOSPHATASE, ALP 163 H 45-129 U/L

• MANGANESE,SERUM 1.2 H < 1.2 mcg/L

• HOMOCYSTEINE 24.6 H 3.7-13.9 umol/L

• CHOLESTEROL 265 H <=200 mg/dL

• LDL DIRECT CHOLESTEROL 161.1 H <=130 mg/dL

• LP(a) 99.53 H <=30 mg/dL

• T3 REVERSE, LC/MS/MS 26 H 8-25 ng/dL

• PREGNENOLONE,LC/MS/MS

• SHBG 79 H 14-73 nmol/L

• DIHYDROTESTOSTERON,LCMSMS

• TNF-ALPHA,HIGHLY SENSITIVE 2.42 H 0.56-1.40 pg/mL

• ANA Screen(Symphony) 0.8 H 0-0.7 Ratio63

• EPSTEIN-BARR VIRUS EA(D)IGG 72.0 H <=9.0 U/mL

• EPSTEIN-BARR VIRUS IGG >750.0 H <=18.0 U/mL

• EBV NUCLEAR ANTIGEN,AB(IGG) 360.0 H <=18.0 U/mL

• LYME DISEASE (IGG,IGM) WB

• 41 kDa (IGG) BAND Reactive Nonreactive 39 kDa (IGG) BAND Reactive Nonreactive

• HERPES SIMPLEX VIRUS-1 IGG 58.3 H <=0.9 INDEX

• HERPESVIRUS 6 AB IGG,IFA 1:80 H

• CYTOMEGALOVIR, CMV AB IGG >10 H 0.0-0.6 U/mL

• M.PNEUMONIAE AB (IGG),EIA 2.99 H <=0.90

• VASCULAR ENDOTHELIAL GF 518 H 31-86 pg/mL

• ALUMINUM 17 H < 7 mcg/L

• BIOTIN (VITAMIN B7) >3600.0 H 221.0- 3004.0 pg/mL

64

The Source of Aluminum

68

September 2018 Aluminum in serum zero.69

Case V: P.R.

• 52 y.o male PTC with HPV related condyloma acuminatum

(AIN 1) had surgery to remove warts saw Dr. Robins NYC

four times for DIV 50 gamma 30-45cc

• Supplements: Vitamin C and probiotics

• Patient wanted comprehensive systemic treatment to prevent

recurrence

• Recommended weekly MAH treatment with German Biologic

and Immune Support

70

Treatment - Case V: P.R.

• Patient did 10 Pass MAH gamma 70 first treatment with Thuja

• Treatments 2-16 multi-pass 650ml- 1000ml with Thuja

• Patient cleaned diet, exercises daily, always in good mood and

enjoys his life

• No Recurrence

71

Case VI: D.C.

• 60 y.o. female PTC with HSV II (dx 4 y.o.), HPV (LEEP

1991), depression d/t dx, hypothyroidism, adrenal

hypofunction, Transphenoidal Rathke’s Cyst removal 12/09

• Current Meds: Hydrocortisone, Synthroid, Valtrex, Premarin,

Vitamin D, Calcium

• Supplements: Propolis, Cordyceps, Lysine, Flax Seed Oil,

Liposomal Vitamin C, Olive Leaf Extract, Immulox,

Monolaurin, Argentyn 23, CoQ 10, Pekana Desbro

Comprehensive Detox, Methyl Protect, B12, Immunotix

• Family Hx: Father- deceased, heart event 53 y.o., Mother-

deceased, Parkinson’s 87 y.o.

73

Treatment- Case VI: D.C.

• 10 Sessions: 10 pass MAH 2000-2500ml gamma 70 with German Biologics• Herpes Simplex Nosode

• Injeel

• Neuro-injeel

• Cerebrum Compositum

• Lymphomyosot

• Traumeel

• Galium

• Glandula – Thymi

• Glandula – Thyroidea

• Chelidonium

• Engystol

• Hepeel

• Hepar Suis – Injeel

• Glyoxal Compositum

• Ubichinon Compositum

74

Labs : Case VI: D.C.After Session 7, Empire City Labs

• RBC 3.4 RR: 3.9-5.0 10(6)/uL

• Hemoglobin 10.8 RR:11.9-15.5g/dL

• Hematocrit 32.4 RR: 35.0-45.0%

• MPV 9.4 RR:9.7-13.0fL

• ESR 130 RR: <30

• Abs.CD8-CD57+Lymphs 50 RR:60-360/uL

• Thyroglobulin IgG 81 RR: 0-40 IU/ml

• Thyroid Peroxidase IgG 61 RR: 0-25IU/ml

• Pregnenelone,LC/MS/MS<5 RR: 22-237ng/dL

• SHBG 95 RR:14-73nmol/L

• Sex Hormone Binding Globulin 168 RR:18.0-144.0nmol/L

• Cortisol Total Serum 2.8 RR:3.09-25.0ug/dL

• DHEA-SO4 6.2 RR: 18-391ug/dl

• ACTH,PLASMA <5 RR: 6-50pg/mL

• Epstein-Barr Virus EA(D)IGG 18.4 RR: <=9.0 U/mL

• Epstein-Barr Virus IGG 104.0 RR: <=18.0U/mL

• EBV Nuclear Antigen ,AB(IGG) 196.0 RR:

<=18.0 U/mL

• Fibrinogen 219 RR: 244.8-463.4mg/dL

• Blood Urea Nitrogen 6 RR: 9-23 mg/dL

• Gamma Glutamyl Transferas 7 RR: 10-38 U/L

• LDL Particle Number 987 L 1016-2185nmol/L

75

Labs: Case VI: D.C. Cont’d.

• Epstein-Barr Virus IGG 104.0 RR: <=18.0U/mL

• EBV Nuclear Antigen ,AB(IGG) 196.0 RR: <=18.0 U/mL

• Fibrinogen 219 RR: 244.8-463.4mg/dL

• Blood Urea Nitrogen 6 RR: 9-23 mg/dL

• Gamma Glutamyl Transferas 7 RR: 10-38 U/L

• LDL Particle Number 987 L 1016-2185nmol/L

• HDL LARGE 4048 RR: 5038-17886 nmol/L

• Testosterone Bioavailable 0.4 RR:0.5-8.5 ng/dL

• Dihydrotestosterone,LCMSMS

<5 RR: 5-46ng/dL

• DHEA-SO4 9 RR: 18-391 ug/dl

• IGF-1 71 L 81-225 ng/mL

• Complement C-3 88 RR: 90-170mg/dl

• Herpes Simplex Virus-2 IgG 1.2 RR <=0.9

• Herpes Virus 6 AB IGG,IFA 1:40

• M. Pneumoniae AB (IGG),EIA 3.01 RR: <=0.90

• Vitamin B12 2343 RR: 211-911pg/mLCoenzymeE Q10 2.21 RR: 0.44-1.64mg/L

• RMSF IGG Detected76

Passiflora

78

Post Lab Recommendations – Case VI: D.C. • Liver Support

• DHEA

• IG 26 DF

• Pregnenelone

• Adrenal Support

79

Patient Progress- Case VI: D.C

• Will switch to Naturethroid

• Feeling much better, no suicidal ideation, has more energy,

learned BOD breathing dynamic, better color, improved

digestion, no outbreaks, feels stronger

80

Chelidonium

81

Treatment Failures

82

Case III: J.P.• 57 y.o. female massage therapist PTC with stage 2-3 infiltrating

ductal carcinoma poorly differentiated hypoechoic nodule with focal

apocrine features 2.1 cm ER+ PR+ HER- breast cancer. Diagnosed

April 2015. Lumpectomy July 2015. Suggested mastectomy. August

2016 Dx invasive ductal. Patient decided not to do Tamoxifen 1 year

later recurrence tumor behind right nipple and positive lymph nodes.

• Family Hx: Mother – deceased colon cancer 86 y.o., Father –

deceased heart attack 59 y.o, Sister – deceased Colon Cancer 55 y.o,

Brother - deceased Melanoma 39 y.o.

83

Treatment – Case III: J.P.• GoodGut Shake Protocol

• Aromatase Inhibitor

• Multivitamin with Vitamin D and broccoli seed extract

• Turmeric

• Liver Support Herbs

• Melatonin

• Oral Homeopathics – Staphysagria, Carcinosum Miasm, Lymph Stim Liq

• Essiac Botanical Elixer

• Organic Iodine

• Frankincense oil

• 30 minute cardio 6 days per week

• Infrared sauna 120 degrees 2x per week84

Treatment – Case III: J.P.• 4 – 10 Pass MAH treatments Gamma 70 with German Biologics in 2017

• Tonsilla

• Chelidonium

• Ignatia

• Carcinoma-Coli

• Ubichinon

• Galium

• Hepar comp

• Hormeel

• Lymphomyosot

• Glandula lymphatica

• Selenium

• After 3rd MAH treatment we added in Scorpio Venom for 250 days – 5ml per day

• Patient moved and contracted sinus infection which turned into Pneumonia as evidenced by X-Ray on right lung

• PET Scan revealed metastatic tumors in lymphatic chain – no biopsies, pneumonia treatment –prednisone and Levaquin for 7 days

• Patient switched to cephalosporin because of difficulty breathing

• Came in for a 10 Pass MAH Gamma 70 with added German Biologics • Sinusitis nosode

• Drosera

• Traumeel

• Phosphor

• Grippe

• Funiculus-Umbilicus

85

Treatment – Case III: J.P.

• Two of the treatments injected sodium bicarb 8.4% 3ml and 20

Gamma Ozone 20ml direct into tumor

• Will Redo PET scan in 3 months

• Patient is able to massage 5 patients per day

Patient transcended May 2018.

86

Case IV: L.J.

• 96 y.o male patient PTC with Stage 4 Squamous Cell Cancer in

left lateral pharyngeal wall with submandibular Para-

pharyngeal infiltration – Tonsillar Cancer with metastatic

lymphadenopathy within the left submandibular and left

jugulodigastric lymph nodes

• Current Meds- Doxazosin 2mg, Naltrexone 3mg, Testosterone

cream

• Supplements – Vitamin D3, 5K, Betaine HCL, DIM, Sun

Chlorella, Melatonin, Salvestrols, Cyto-Control, Myco-

Control, Coconut oil, Prostabel, Vitamin A 5000iu, Lugol’s

Solution Iodine, ARG Pancreas, Macuguard, 4 Sight, EZ Flo

Tea, Oncoplex ES, Daily Essential Nutrients, Modified Citrus

Pectin 87

Case IV: L.J.

• Significant Findings – Empire City Labs

• Pregnenelone LC/MS/MS 15 RR:22-237ng/dL

• Sex Hormone Binding Globulin 165.4 RR:10.0-57.0nmol/L

• FSH(Follicle Stimulating Hormone) 29.6 RR: 1.4-

18.1mIU/mL

• Cortisol Total Serum 26.5 RR: 3.09-25.0 ug/dL

• IGF-1 83 RR:163-584ng/mL

• Carnitine Total 28 RR:30-70umol/L

• Carnitine Free 22 RR:23-59umol/L

• Homocysteine 16 RR:3.7-13.9umol/L

• Cortisol Free 2nd Void U 189.5 RR: 3.5-87.1 88

Case IV: L.J. After Labs

• L-Carnitine 500 mg BID, Pregnenelone 30 mg in AM, Methyl Protect, IG 26DF

• Ketogenic Diet

• 14 Multi-Pass Treatments with Herrmann Machine Gamma 55 500-1000ml and German Biologics

• Tonsilla Compositum

• Sabal Homaccord

• Solidago Compositum

• Heppar Compositum

• Chelidonium

• Lymphomyosot

• Momordica Compositum

• Glyoxal

• CoEnzyme

• Engystol

• Herpes Nosode

• Mucosa Compositum

• ATP

• Occulis Totalis

• Tumor injection x9 sodium bicarb 8.4% 5ml Ozone 20 ml gamma 39

• Patient does C drips with another doctor every week

• “Overall I think L.J. is doing very well. His cancer seems to be reasonably stabile over the last 14 months

and his quality of life is reasonably good. But there is some evidence that the local condition is worse.”

Dr.S

• At this time L.J. manages pain with tramadol, morphine and medical marijuana, he is on hospice and

continues to come weekly for multi-pass treatment

• Patient transcended June 2018.

90

Finnish Sauna Was Recommended in all Three Cases

“In the control group, neither summed stress score (SSS) nor summed

difference score (SDS) of myocardial scintigraphy changed. However, Waon

therapy improved both SSS (16±7 to 9±6, p<0.01) and SDS (7±4 to 3±2,

p<0.01), and the improvement was greater in patients with higher SSS and SDS

scores at the baseline. Waon therapy extended treadmill exercise time (430±185

to 511±192 s, p<0.01) and improved flow-mediated dilation of the brachial

artery (4.1±1.3 to 5.9±1.8%, p<0.05), but tended to decrease the number of

circulating CD34-positive bone marrow-derived cells.” LOE 4

Repeated sauna therapy improves myocardial perfusion in patients with chronically occluded coronary artery-related

ischemia Sobajima, Mitsuo et al. International Journal of Cardiology , Volume 167 , Issue 1 , 237 - 24391

LOE 392

Low Dose Naltrexone • Naltrexone is an FDA-approved drug

• Inhibits Opioid receptors

• Reduces pain

• Targets same receptors that respond to morphine, heroine and

other opioids

• Small doses 0.5 – 4.5mg profoundly affects the immune

system

• LDN attaches to opioid receptors and temporarily blocks

endorphin attachment

• This signals the body to increase endorphin production,

orchestrates the activity of stem cells, macrophages and other

immune cells

Brown N, Panksepp J. Low-dose naltrexone for disease preventionand quality of

life. Med Hypothesis. 209; 72: 333-337

93

Low Dose Naltrexone

• Effective therapy for conditions ranging from autoimmune disorders, allergies, cancer and autism

• Some conditions LDN may help:• ALS

• Alzheimer’s

• Autism

• Celiac Disease

• Crohn’s Disease

• Emphysema

• Endometriosis

• HIV/AIDS

• Lupus

• Inflammatory Bowel Disease

• Multiple Sclerosis

• Psoriasis

• Rheumatoid Arthritis

• Sarcoidosis

• Scleroderma

Brown N, Panksepp J. Low-dose naltrexone for disease preventionand quality of life. Med Hypothesis.

209; 72: 333-337

94

In Conclusion

I strongly encourage environmental medicine providers to incorporate ozone

chelation into clinical practice, as in my opinion and evidenced by clinical cases,

ozone chelation is a safe, effective and time efficient protocol to reduce and

eliminate heavy metal toxicity. Join me in the Ozonosphere!

95

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2014, www.nature.com/articles/srep07129

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Cardiology , Volume 167 , Issue 1 , 237 - 243

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http://doi.org/10.1186/2045-9912-1-29

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Viebahn-Hänsler, R., Fernández, O.S.L. & Fahmy, Z. Ozone in Medicine: The Low-Dose Ozone Concept. Guidelines and Treatment Strategies. Ozone Science & Engineering34,

408-424 (2012).

Viviana, C. & Gabriele, T. Exposure to low ozone concentrations induces cytoskeletal reorganization, mitochondrial activity and nuclear transcription in epithelial human cells. in

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Willhite, C. C., Karyakina, N. A., Yokel, R. A., Yenugadhati, N., Wisniewski, T. M., Arnold, I. M., . . . Krewski, D. (2014). Systematic review of potential health risks posed by

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chronic disease is an environmental issue

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