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SAFETY CHEMISTRY 30121 – First Semester Organic Laboratory (Fall 2019)

Link to TCU CSE Safety: https://chemistry.tcu.edu/current-graduate-students/cse-safety/

All safety rules and regulations from General Chemistry Lab are in force for this semester including the necessity of wearing safety goggles and a lab coat at all times (and avoid wearing contact lenses). Safety glasses are not allowed. Unauthorized visitors are not permitted in the laboratory. No open-toed shoes (no sandals, even with socks). No shorts. Tie long hair back. No eating or drinking, in the laboratory, etc. YOU WILL NOT BE ALLOWED TO ENTER THE LAB UNTIL YOU WEAR THE PROPER ATTIRE. NO EXCEPTION! MISSING A LAB FOR LACK OF PROPER ATTIRE IS NOT GROUND FOR A MAKE-UP LAB.

MATERIAL SAFETY DATA SHEETS (MSDS) MSDS can be found online, for example with major chemical suppliers, and others (e.g. https://chemicalsafety.com/sds-search/). Many links to MSDS can also be found on the above CSE safety web site.

Hazard Communication Safety Data Sheets (MSDS Contents) The Hazard Communication Standard (HCS) requires chemical manufacturers, distributors, or importers to provide Safety Data Sheets (SDSs) (formerly known as Material Safety Data Sheets or MSDSs) to communicate the hazards of hazardous chemical products. As of June 1, 2015, the HCS will require new SDSs to be in a uniform format, and include the section numbers, the headings, and associated information under the headings below: Section 1, Identification includes product identifier; manufacturer or distributor name, address, phone number; emergency phone number; recommended use; restrictions on use. Section 2, Hazard(s) identification includes all hazards regarding the chemical; required label elements. Section 3, Composition/information on ingredients includes information on chemical ingredients; trade secret claims. Section 4, First-aid measures includes important symptoms/effects, acute, delayed; required treatment. Section 5, Fire-fighting measures lists suitable extinguishing techniques, equipment; chemical hazards from fire. Section 6, Accidental release measures lists emergency procedures; protective equipment; proper methods of containment and cleanup. Section 7, Handling and storage lists precautions for safe handling and storage, including incompatibilities. Section 8, Exposure controls/personal protection lists OSHA’s Permissible Exposure Limits (PELs); ACGIH Threshold Limit Values (TLVs); and any other exposure limit used or recommended by the chemical manufacturer, importer, or employer preparing the SDS where available as well as appropriate engineering controls; personal protective equipment (PPE). Section 9, Physical and chemical properties lists the chemical's characteristics. Section 10, Stability and reactivity lists chemical stability and possibility of hazardous reactions. Section 11, Toxicological information includes routes of exposure; related symptoms, acute and chronic effects; numerical measures of toxicity. Section 12, Ecological information* Section 13, Disposal considerations* Section 14, Transport information* Section 15, Regulatory information* Section 16, Other information, includes the date of preparation or last revision. *Note: Since other Agencies regulate this information, OSHA will not be enforcing Sections 12 through 15 (29 CFR 1910.1200(g)(2)). Employers must ensure that SDSs are readily accessible to employees.

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CHEMICAL COMPATIBILITY CHART

Chemical Incompatible with acetic acid chromic acid, nitric acid, perchloric acid, peroxides, permanganates

acetic anhydride Hydroxyl‐containing compounds such as ethylene glycol and perchloric acid

acetylene chlorine, bromine, copper, fluorine, silver, mercury acetone concentrated nitric and sulfuric acid mixtures

alkali and alkaline earth metals water, carbon tetrachloride or other chlorinated hydrocarbons, carbon dioxide, halogens

ammonia (anhydrous) mercury, chlorine, calcium hypochlorite, iodine, bromine, hydrofluoric acid (anhydrous)

ammonium nitrate acids, powdered metals, flammable liquids, chlorates, nitrates, sulfur, finely divided organic or combustible materials

aniline nitric acid, hydrogen peroxide arsenical materials any reducing agent

azides acids bromine see chlorine

calcium oxide water carbon (activated) calcium hypochlorite, all oxidizing agents

carbon tetrachloride sodium

chlorates ammonium salts, acids, powdered metals, sulfur, finely divided organic or combustible materials

chromic acid and chromium trioxide acetic acid, naphthalene, camphor, glycerol, alcohol, flammable liquids in general

chlorine

ammonia, acetylene, butadiene, butane, methane, propane or other petroleum gases, hydrogen, sodium carbide, benzene, finely divided metals, turpentine

chlorine dioxide ammonia, methane, phosphine, hydrogen sulfide copper acetylene, hydrogen peroxide

cumene hydroperoxide acids (organic and inorganic) cyanides acids

flammable liquids ammonium nitrate, chromic acid, hydrogen peroxide, nitric acid, sodium peroxide, halogens

fluorine everything hydrazine hydrogen peroxide, nitric acid, any other oxidant

hydrocarbons (e.g., propane, butane, benzene) fluorine, chlorine, bromine, chromic acid, sodium peroxide

hydrocyanic acid nitric acid, alkali hydrofluoric acid (aqueous or

anhydrous) ammonia (aqueous or anhydrous)

hydrogen peroxide copper, chromium, iron, most metals or their salts, alcohols, acetone, organic materials, aniline, nitromethane, combustible materials

hydrogen sulfide fuming nitric acid, oxidizing gases hypochlorites acids, activated carbon

iodine acetylene, ammonia (aqueous or anhydrous), hydrogen mercury acetylene, fulminic acid, ammonia nitrates sulfuric acid

nitric acid (concentrated) acetic acid, aniline, chromic acid, hydrocyanic acid, hydrogen sulfide, flammable liquids, flammable gases, copper, brass, any heavy metals

nitrites acids nitroparaffins inorganic bases, amines

oxalic acid silver, mercury oxygen oils, grease, hydrogen, flammable liquids, solids, or gases

perchloric acid acetic anhydride, bismuth and its alloys, alcohol, paper, wood, grease, oils

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Chemical Incompatible with

peroxides, organic acids (organic or mineral), avoid friction, store cold phosphorus (white) air, oxygen, alkalis, reducing agents

phosphorus pentoxide alcohols, strong bases, water potassium carbon tetrachloride, carbon dioxide, water

potassium chlorate sulfuric and other acids potassium perchlorate (also see

chlorates) sulfuric and other acids potassium permanganate glycerol, ethylene glycol, benzaldehyde, sulfuric acid

selenides reducing agents silver and silver salts acetylene, oxalic acid, tartaric acid, ammonium compounds, fulminic

acid sodium carbon tetrachloride, carbon dioxide, water

sodium nitrite ammonium nitrate and other ammonium salts

sodium peroxide

ethanol and methanol, glacial acetic acid, acetic anhydride, benzaldehyde, carbon disulfide, glycerin, ethylene glycol, ethyl acetate, methyl acetate, furfural

sulfides acids

sulfuric acid potassium chlorate, potassium perchlorate, potassium permanganate (and similar compounds of light metals such as sodium, lithium)

tellurides reducing agents

EPA Chemical Compatibility Chart Download: https://labsafety.jhu.edu/wp-content/uploads/2017/08/EPAChemicalCompatibilityChartRotated-copy.pdf

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General Laboratory Safety Rules and Procedures for Undergraduate Chemistry Laboratories at Texas Christian University

1. Approved eye protection must be worn at all times in the laboratory. Safety goggles must offer front, top,

bottom, and side protection. Failure to wear approved eye protection will result in ONE warning; after that, you will be expelled from the laboratory for the remainder of that lab period and assigned a grade of 0 (zero) for the day's work.

2. Approved lab coats must be worn at all times in the laboratory. 3. Long pants must be worn in the laboratory. Otherwise, you will be required to leave the lab, change clothes, and

return. In that event, no extra time will be given to complete the lab work. 4. Shoes that protect your feet from broken glass and chemicals are required. You may not wear sandals or shoes with

openings. 5. Long hair must be confined during the laboratory period. 6. No eating, drinking, or chewing is allowed in the laboratory. Deliberately tasting or smelling chemicals is strictly

forbidden. 7. The use of media devices is prohibited in the laboratory. This includes cell phones, MP3 players, and PDA's of all

types. You must be focused on your work without distractions. 8. No visitors may be present in the laboratory without special arrangements or permission. All official visitors are subject

to the same rules as students in the laboratory including wearing eye protection. 9. Horseplay, practical jokes, and/or rowdiness are not allowed in the laboratory. 10. Students are not allowed to work in the laboratory alone. The laboratory instructor or a teaching assistant must be

present at all times. 11. No unauthorized experiments will be performed. 12. Following instruction on the first day of lab. all students are required to know the locations of safety showers, eye

wash fountains, fire extinguishers, and fire blankets in the laboratory. Any non-functioning safety equipment must be reported immediately to your teaching assistant.

13. Never use mouth suction to fill a pipet. Pipet bulbs are always available in the laboratory. 14. In case of fire or spillage, call your teaching assistant at once. Accidents involving the spillage of mercury require

special handling by your laboratory instructor. 15. In the event that your skin (hands, arms, face, etc.) comes into contact with laboratory chemicals, wash the affected

area quickly and thoroughly with soap and water. Use the eye wash fountain to flush chemicals from the eyes and face. GET HELP IMMEDIATELY! Do not rub the affected area with your hands before washing, especially the face or eyes.

16. Chemical spillage over a large part of the body requires IMMEDIATE action. Flood the affected area for at least five (5) minutes using the safety shower. Remove contaminated clothing if necessary. Use a mild detergent and water only (no salves, creams, lotions, etc.). Get medical attention IMMEDIATELY!

17. Acid and base spills must be neutralized (sodium bicarbonate solution for acids; 1% acetic acid for bases) followed by washing the affected surface with plenty of water. Organic chemical spills and mercury spills must be reported IMMEDIATELY to your laboratory instructor, who will be responsible for directing the clean-up procedure.

18. Maintain an orderly arrangement of the apparatus, glassware, and materials in your work area. 19. Your laboratory instructor must be notified at once of any accident or injury even if it appears to be minor.

TCU departmental policy requires that you visit the student Health Center for all cuts, burns, or inhalation of fumes sustained in the laboratory. Your laboratory instructor will arrange for transportation and call ahead to alert the Health Center.

20. Anytime that a student is taken to the health center, the laboratory instructor must notify the Department Chair immediately. In turn, the Chair will so notify the CSE Dean's Office by e-mail and then send a follow-up report as soon as the student's condition is assessed by the Health Center.

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Special Safety Rules

Each laboratory instructor may add additional safety rules that are specific for each laboratory course.

YES NO I have completed the TCU online GENERAL SAFETY TRAINING: ☐ ☐

I, THE UNDERSIGNED, HAVE READ THESE LABORATORY SAFETY RULES AND AGREE TO OBSERVE THEM IN MY CHEMISTRY LABORATORY COURSE. Printed Name _____________________________________ Signed _____________________________________ Date _____________________________________

Return a signed copy of these rules to your laboratory instructor and retain for your own records the electronic copy that was provided to you in the syllabus. Laboratory quizzes and/or exams, including final exams will often include questions regarding laboratory safety.

General Laboratory Rules for Organic Chemistry (CHEM 30121) 1. Avoid wasting gas, water, acetone, filter paper, litmus paper and other materials. 2. Do not carry reagent bottles to your hood unless authorized. Measure out the quantity that you need and always

replace the bottle cap. Do not pour excess reagents back into the supply bottle. 3. All organic waste materials must be discarded in designated waste bottles located in Hoods A and N. Read the

label to avoid putting the wrong material in the wrong waste bottle. 4. Waste inorganic acids and bases should be diluted with a large amount of water and discarded in a sink under the

hood. 5. Acid and base spills must be neutralized (sodium bicarbonate solution for acids; 1% acetic acid for bases) followed

by washing the affected surface with plenty of water. Organic chemical spills and mercury spills must be reported immediately to your teaching assistant, who will be responsible for directing the clean-up procedure.

6. Balance pans and the balance areas must be left clean when you are finished working. 7. Maintain an orderly arrangement of the apparatus and materials in your desk and equipment drawer. 8. When leaving the laboratory, make certain that water, gas, and vacuum taps have been turned off. Electrical

appliances in the hoods must be turned off and unplugged. Special Safety Rules 1. Approved eye protection must be worn at all times in the laboratory. Safety goggles must offer front, top, bottom,

and side protection. Failure to wear approved eye protection will result in ONE warning; but after that, you will be expelled from the laboratory for the remainder of that lab period.

2. No unauthorized experiments will be performed. 3. In case of fire or accident, call your teaching assistant at once! Accidents involving the spillage of mercury require

special handling by your instructor. 4. Departmental policy requires that you visit the student health center for all cuts, burns, or inhalation of fumes

sustained in a laboratory course no matter how minor the problem may seem. Your instructor will arrange for transportation if needed.

5. Do not taste anything in the laboratory. 6. Never use mouth suction to fill a pipette. Pipette bulbs are always available in the lab. 7. Long hair must be confined during the laboratory period. 8. Short pants and garments with loose, floppy sleeves are not suitable for working in the lab. You will be asked to

leave the lab, change clothes, and return. 9. Shoes that protect your feet from broken glass and chemicals are required. NO sandals or open-toed shoes. 10. No eating, drinking, chewing is allowed. The use of cell phones and related devices is not permitted. No visitors

during the lab period.