1999 antibiotics

antibioticsU 1200

44 - 288Synthesis and in vitro Evaluation of Novel Highly Potent CoumarinInhibitors of Gyrase B. — Starting from L-arabinose (I) a series ofpotent gyrase B inhibitors, e.g. (XX), containing coumarin is prepared.Synthesis includes a novel reaction sequence to obtain noviose (X) whichallows modifications at different points of the sugar moiety. — (LAURIN,PATRICK; FERROUD, DIDIER; KLICH, MICHEL; DUPUIS-HAMELIN,CLAUDINE; MAUVAIS, PASCALE; LASSAIGNE, PATRICE; BONNEFOY,ALAIN; MUSICKI, BRANISLAV; Bioorg. Med. Chem. Lett. 9 (1999) 14,2079-2084; Dep. Med. Chem., Res. Cent., Hoechst Marion Roussel, F-93230Romainville, Fr.; EN)

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