2001 steroids

steroidsU 0300

45 - 199Synthesis and Antiproliferative Activity of Epoxy and BromoCompounds Derived from Estrone. — Steroidal epoxy- and bromo-compounds (II), (III), and (IV) are synthesized stereoselectively in moderateto good yields from epoxyquinol (I) using mild reaction conditions. Significantincrease in the antiproliferative activity is observed by introduction of a furtheroxirane ring and a bromine atom into the A-ring. Cytotoxicity tests revealthat all compounds show a low selectivity between neoplastic and normal cells.— (MILIC, DRAGANA R.; KOP, TATJANA; JURANIC, ZORICA; GASIC,MIROSLAV J.; SOLAJA, BOGDAN A.; Bioorg. Med. Chem. Lett. 11 (2001)16, 2197-2200; Fac. Chem., Univ. Belgrade, YU-11000 Belgrade, Yugoslavia;EN)

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