cheminform abstract: substituent-controlled electrocyclization of 2,4-dienones: synthesis of...

2

ChemInform 2012, 43, issue 09 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Pyran derivatives R 0340 DOI: 10.1002/chin.201209139 Substituent-Controlled Electrocyclization of 2,4-Dienones: Synthesis of 2,3,6-Tri- substituted 2H-Pyran-5-carboxylates and Their Transformations. — Cyclization of disubstituted enals with acetoacetates in the system piperidine—acetic acid provides access towards trisubstituted pyrancarboxylates, e.g. (III) and (IX). The product pyrancarboxylates are hydrogenated to give dihydropyrans (IV) and (X)/(XI) with moderate to excellent cis-selectivity. Oxidation affords endo-peroxides (V), (XII)/(XIII) by sin- glet oxygen cycloaddition. — (PENG, W.; HIRABARU, T.; KAWAFUCHI, H.; INOKUCHI*, T.; Eur. J. Org. Chem. 2011, 28, 5469-5474, http://dx.doi.org/10.1002/ejoc.201100780 ; Dep. Med. Bioeng. Sci., Grad. Sch. Nat. Sci. Technol., Okayama Univ., Okayama 700, Japan; Eng.) — Mischke 09- 139

Upload: wei-peng

Post on 11-Jun-2016

212 views

Category:

Documents

0 download

Report

Download

Embed Size (px):

TRANSCRIPT

Page 1: ChemInform Abstract: Substituent-Controlled Electrocyclization of 2,4-Dienones: Synthesis of 2,3,6-Trisubstituted 2H-Pyran-5-carboxylates and Their Transformations

Pyran derivativesR 0340 DOI: 10.1002/chin.201209139

Substituent-Controlled Electrocyclization of 2,4-Dienones: Synthesis of 2,3,6-Tri-substituted 2H-Pyran-5-carboxylates and Their Transformations. — Cyclization of disubstituted enals with acetoacetates in the system piperidine—acetic acid provides access towards trisubstituted pyrancarboxylates, e.g. (III) and (IX). The product pyran-carboxylates are hydrogenated to give dihydropyrans (IV) and (X)/(XI) with moderate to excellent cis-selectivity. Oxidation affords endo-peroxides (V), (XII)/(XIII) by sin-glet oxygen cycloaddition. — (PENG, W.; HIRABARU, T.; KAWAFUCHI, H.; INOKUCHI*, T.; Eur. J. Org. Chem. 2011, 28, 5469-5474, http://dx.doi.org/10.1002/ejoc.201100780 ; Dep. Med. Bioeng. Sci., Grad. Sch. Nat. Sci. Technol., Okayama Univ., Okayama 700, Japan; Eng.) — Mischke

09- 139

ChemInform 2012, 43, issue 09 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Page 2: ChemInform Abstract: Substituent-Controlled Electrocyclization of 2,4-Dienones: Synthesis of 2,3,6-Trisubstituted 2H-Pyran-5-carboxylates and Their Transformations

ChemInform 2012, 43, issue 09 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

RESEARCHARTICLE OpAccess ......Jiangiet al. J Cheminform Pagej2jofj26 playerindrugabsorption,distribution,metabolism, excretion,andtoxicity(ADMET)[5, 6],andhasalsobeen

Supporting Information for 3-formyl chromene and N-alkyl amino … · 2017-08-11 · S1 Supporting Information for 1,5-Electrocyclization of conjugated azomethine ylides derived from

MER: a shell script and annotation server for minimal named ......Couto and Lamurias J Cheminform Page 5 of 10 common,sandswesempiricallysfoundsthatsmostsofsthestwo-charactersmatchesswereserrors

APPENDIX FOUR The Development and Scope of an Alternate ...thesis.library.caltech.edu/5107/7/06_Tambar_appendix_4.pdf · The Development and Scope of an Alternate Tandem Stille-Oxa-Electrocyclization

Open Access Programming langage in chemiy: a eie of HTML5 ... · Theien J Cheminform Page 3 of 19 HTML5 econtentweviewontheInternetismadepossiblebya unionofseveraltechnologies,mainlyHypertextMarkup

Statistical principle-based approach for gene and protein ... · Lai et al. J Cheminform Page 2 of 9 tobiologicaldatabaserecords.Intheabovecases,“A2A” isasubtypeof“adenosinereceptor”.erefore“A2A

HYDROCARBONS - Morrison's Site · Web view5-ethyl-2,3,6-trtimethyloctane 2,4,5-trimethylheptane (not 2-ethyl-3,6-dimethylhexane) 10. If chains of equal length are competing for selection

Synthetic studies of the Thio-Nazarov Cyclization Biomimetic … · 2018-10-10 · 1 Chapter 1. Progress Towards Thio-Nazarov Electrocyclization 1.1 Introduction Over 60 years ago,

METHODOLOGY Ecientiterativevirtualscreening with … · 2018. 3. 1. · Ahmed et al. J Cheminform Page4of8 10contain‘high-scoring’ligands.eunassignedbin3is excludedfromtraining.Figure

Domino Twofold Heck / 6π-Electrocyclization and ... then Prophet Mohammad (Sallallah ho alai hi wasallam) ... Omer Akravi, Imran Malik, Muhammad Nawaz, S. M. T. Toguem, Ghazwan Ali

METHODOLOGY Molecularstructuresenumeration and ......Koch et al. J Cheminform Page5of17 changing4bonds,sinceweaimtondminimaltransfor - mations.Letuscall a 13 and a 24 thetwoﬁxedbonds,with

Domino Twofold Heck / 6π-Electrocyclization and

Crystal Structure of Tetrakis( μ-2,3,6-trimethoxybenzoato

UNIVERSITI PUTRA MALAYSIA IN- VITRO … · kaya dengan alkaloid tetapi tiada laporan mengenai sifat perubatan traditionalnya dilaporkan. Sebatian N-methyl-2,3,6, trimethoxymorphinan-7-one

Database fingerprint (DFP): an approach to represent ... · Fernández‑de Gortari et al. J Cheminform DOI 10.1186/s13321‑017‑0195‑1 PRELIMINARY COMMUNICATION Database fingerprint

Preparatory Problems & SOLUTIONS1. Pericyclic reactions (Cycloaddition and electrocyclization reactions). 2. Nucleophilic substitution reactions at sp2 carbon centers. 3. Spectroscopy:

SmartGraph: a network pharmacology investigation platform · 2020. 1. 21. · Zahoránszky‑Kőhalmi et al. J Cheminform Page 5 of 11 isolatethenearestneighbors.ethird,bottom(infor-mation)panelisusedtovisualizeselectednodeandedge

GitHub Pages › static › papers › 7 Detection of Forwarding-Ba… · phish sites or create malicious threads in a simulation browser [2,3,6] and attackers have ways of disguising

ChemInform Sheet A4on chemo-, regio-, and stereo-selective reactions. The RefLib database is included with CIRX and provides reactions abstracted from Theilheimer’s Synthetic Methods

Twofold Heck / 6π-Electrocyclization and Regioselective ...rosdok.uni-rostock.de/.../Dissertation_TenghoToguem_2012.pdf · Twofold Heck / 6π-Electrocyclization and Regioselective

Open Access CSgator:kanjintegratedkwebkplatformk forjcompoundksetkanalysis · 2019. 3. 4. · Parkjet al. J Cheminform Pagek6kofk8 currentlackofenoughcompound-targetdataevenafter

ChemInform Sheet A4 · 2013. 9. 13. · The ChemInform Reaction Library (CIRX) helps to deal with the enormous number of published reactions as it does not cover all information available

A CELEBRATION OF PRAISE, TESTIMONIES, AND PRAYERpmcdata.s3.amazonaws.com/pmc-pdfs/Web_Bulletin_03-17-2018.pdf · 3/17/2018 · Scripture Isaiah 55:2,3,6,& 12 • Russell and Cynthia

GPURFSCREEN: a GPU based virtual screening tool …people.cse.nitc.ac.in/jayaraj/files/gpurfscreen...Jayaraj et al. J Cheminform DOI 10.1186/s13321-016-0124-8 SOFTWARE GPURFSCREEN:

A AWMFonline Augenärztliche Screening-Untersuchungen von · Verfügung, die die Häufigkeit eines ungünstigen Ausgangs der Erkrankung zu reduzieren vermag [2,3,6] (A1). Die Laserkoagulation

spyrmsd: symmetry-corrected RMSD calculations in Python · 2020. 8. 31. · Meli and Biggin J Cheminform Page 3 of 7 usingtheNewton-Raphsonmethod[7]startingfromthe initialguess (GA

Pericyclic Reactions Title Cycloaddition Electrocyclization

Filtered circular fingerprints improve either prediction ... · Gütlein and Kramer J Cheminform () DOI 10.1186/s13321-016-0173-z RESEARCH ARTICLE Filtered circular fingerprints improve

ChemDoodle Web Components: HTML5 toolkit for …...Burger. J Cheminform DOI 10.1186/s13321-015-0085-3 REVIEW ChemDoodle Web Components: HTML5 toolkit for chemical graphics, interfaces,

Eﬃcient NiII LnIII Electrocyclization Catalysts for the ...sro.sussex.ac.uk/61632/6/acs%2Einorgchem%2E6b00720.pdf · Kieran Griﬃths,† Prashant Kumar,† James D. Mattock,†

An Approach to Catalytic Asymmetric Electrocyclization · 2012-07-24 · 2 Project aims 46 3 Results and discussion 47 3.1 Preparation of monomer units 47 3.1.1 Ester desymmetrization

Microwave-Enhanced Synthesis of 2,3,6-Trisubstituted ... · Microwave-Enhanced Synthesis of 2,3,6-Trisubstituted Pyridazines: Application to Four-Step Synthesis of Gabazine (SR-95531)

rosdok.uni-rostock.derosdok.uni-rostock.de/file/rosdok_derivate... · Domino Twofold Heck / 6π-Electrocyclization and Regioselective Palladium(0)-Catalyzed Reactions of Brominated

THE TOTAL SYNTHESIS OF INDOLOCARBAZOLE ......A synthesis of the aglycon portion of the indolocarbazoles is described, wherein Rh (II) mediated C-C bond formation precedes electrocyclization

Classification System for Solid Supports Used ... - FIZ CHEMIE › fileadmin › user_upload › Cheminform › Spore › _… · FIZ CHEMIE BERLIN - 5 (23) - The remainder of the