cheminform abstract: novel conformationally restricted tetracyclic analogues of...

1999 benzopyran derivatives benzopyran derivatives R 0350 46 - 146 Novel Conformationally Restricted Tetracyclic Analogues of Δ 8 - Tetrahydrocannabinol. — The novel compounds are tested for their cannabinoid receptor binding activity. It is shown that the desired activity depends on the orientation of the side chain and also on the distance to phenol ring with (IX) being the most active compound. — (KHANOLKAR, AT- MARAM D.; LU, DAI; FAN, PUSHENG; TIAN, XIAOYU; MAKRIYANNIS, ALEXANDROS; Bioorg. Med. Chem. Lett. 9 (1999) 15, 2119-2124; Dep. Pharm. Sci., Sch. Pharm., Univ. Conn., Storrs, CT 06269, USA; EN) 1

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Page 1: ChemInform Abstract: Novel Conformationally Restricted Tetracyclic Analogues of Δ8-Tetrahydrocannabinol

1999 benzopyran derivatives

benzopyran derivativesR 0350

46 - 146Novel Conformationally Restricted Tetracyclic Analogues of ∆8-Tetrahydrocannabinol. — The novel compounds are tested for theircannabinoid receptor binding activity. It is shown that the desired activitydepends on the orientation of the side chain and also on the distance to phenolring with (IX) being the most active compound. — (KHANOLKAR, AT-MARAM D.; LU, DAI; FAN, PUSHENG; TIAN, XIAOYU; MAKRIYANNIS,ALEXANDROS; Bioorg. Med. Chem. Lett. 9 (1999) 15, 2119-2124; Dep.Pharm. Sci., Sch. Pharm., Univ. Conn., Storrs, CT 06269, USA; EN)

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