1997 protection, deprotection

protection, deprotectionO 0345

20 - 064Neopentyl Ester Protecting Groups for Arylsulfonic Acids. —Neopentyl is used as a protecting group for brominated arylsulfonic acids. Itspotentials are the high compatibility with a wide range of organic reagents suchas vinyl-MgBr, CrO3, NBS/benzoyl peroxide, H2/ Raney-Ni, NaI, aqueousHBr or NaOH, HONH2 and NaH and the easy cleavage in high yields. Inaddition the Boc-protected N-neopentyl group present in (XII) is developed asprotecting group in solid phase synthesis. — (ROBERTS, J. C.; GAO, H.;GOPALSAMY, A.; KONGSJAHJU, A.; PATCH, R. J.; Tetrahedron Lett. 38(1997) 3, 355-358; Dep. Ration. Drug. Des., Procept Inc., Cambridge, MA02139, USA; EN)

1