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Quinoline derivativesR 0410 DOI: 10.1002/chin.201033148

Hafnium (IV) Bis(perfluorooctanesulfonyl)imide Complex Catalyzed Synthesis of Polyhydroquinoline Derivatives via Unsymmetrical Hantzsch Reaction in Fluo-rous Medium. — The four-component condensation of dimedone (I), aldehydes (II), active methylene compounds (III), and ammonium acetate is conducted in the presence of the title catalyst in perfluorodecalin to produce the polyhydroquinoline derivatives (IV) in good to very good yields. Aromatic aldehydes containing both electron-with-drawing and electron-donating groups as well as heterocyclic systems react smoothly. Additionally, aromatic aldehydes with electron-withdrawing groups show an increased reaction rate. Furthermore, simple work-up and the use of a nontoxic solvent make this procedure a useful process for the synthesis of polyhydroquinoline derivatives. — (HONG, M.; CAI*, C.; YI, W.-B.; J. Fluorine Chem. 131 (2010) 1, 111-114, DOI:10.1016/j.jfluchem.2009.10.009 ; Sch. Chem. Eng., Nanjing Univ. Sci. Technol., Nanjing 210094, Peop. Rep. China; Eng.) — H. Hoennerscheid

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ChemInform 2010, 41, issue 29 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim