KetonesQ 0350 DOI: 10.1002/chin.201136069

"Greener" Friedel—Crafts Acylations: A Metal- and Halogen-Free Methodology. — Methanesulfonic anhydride promotes the reaction of a wide range of carboxylic acids tolerating steric hindrance and many functional groups. The method is applied to the preparation of intermediate (VI) of COX-2 inhibitor GW406381X. — (WILKINSON, M. C.; Org. Lett. 13 (2011) 9, 2232-2235, http://dx.doi.org/10.1021/ol200482s ; API Chem. Anal., Prod. Dev., GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, UK; Eng.) — R. Steudel

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