cheminform abstract: catalytic asymmetric conjugate addition of grignard reagents to...

ChemInform 2011, 42, issue 26 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Benzopyran derivatives R 0350 DOI: 10.1002/chin.201126146 Catalytic Asymmetric Conjugate Addition of Grignard Reagents to Coumarins— -Synthesis of Versatile Chiral Building Blocks. — The copper-catalyzed conjugate addition of Grignard reagents (II) to coumarins (I) and (VIII) proceeds with good yields and high enantioselectivities in most cases. The intermediate chiral magnesium enolate can be readily trapped with ethanol or propylamine to afford ester (Va) or amide (Vb). — (TEICHERT, J. F.; FERINGA*, B. L.; Chem. Commun. (Cambridge) 47 (2011) 9, 2679-2681, http://dx.doi.org/10.1039/c0cc05160h ; Stratingh Inst. Chem., Univ. Groningen, NL-9747 AG Groningen, Neth.; Eng.) — R. Staver 26- 146

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Page 1: ChemInform Abstract: Catalytic Asymmetric Conjugate Addition of Grignard Reagents to Coumarins—Synthesis of Versatile Chiral Building Blocks

Benzopyran derivativesR 0350 DOI: 10.1002/chin.201126146

Catalytic Asymmetric Conjugate Addition of Grignard Reagents to Coumarins—-Synthesis of Versatile Chiral Building Blocks. — The copper-catalyzed conjugate addition of Grignard reagents (II) to coumarins (I) and (VIII) proceeds with good yields and high enantioselectivities in most cases. The intermediate chiral magnesium enolate can be readily trapped with ethanol or propylamine to afford ester (Va) or amide (Vb). — (TEICHERT, J. F.; FERINGA*, B. L.; Chem. Commun. (Cambridge) 47 (2011) 9, 2679-2681, http://dx.doi.org/10.1039/c0cc05160h ; Stratingh Inst. Chem., Univ. Groningen, NL-9747 AG Groningen, Neth.; Eng.) — R. Staver

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