cheminform abstract: asymmetric addition of nucleophiles to c-1 position of isoquinolines using...
TRANSCRIPT
2002 isoquinoline derivatives
isoquinoline derivativesR 0420
08 - 146Asymmetric Addition of Nucleophiles to C-1 Position of Isoquino-lines Using (S)-Alanine Derivatives as Chiral Auxiliaries. — Thetitle reaction offers a general and highly stereoselective method to prepare1-substituted tetrahydroisoquinolines which are of biological interest. Intro-duction of bromo groups on the substrate efficiently increases both chemicalyield and stereoselectivity. — (ITOH, TAKASHI; NAGATA, KAZUHIRO;MIYAZAKI, MICHIKO; KAMEOKA, KEIKO; OHSAWA, AKIO; Tetrahedron57 (2001) 42, 8827-8839; Sch. Pharm. Sci., Showa Univ., Shinagawa, Tokyo142, Japan; EN)
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