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BEATING ALZHEIMER’S CHEATER’S GUIDE TO GIADA’S FAVORITE SPICY SHRIMP, P. 14 PLUS SUNDAY, APRIL 8, 2018 | PARADE.COM Friends, fun, fitness!—new research reveals what truly works to delay dementia These Encinitas, Calif., women meet up regularly for surf and sun © PARADE Publications 2018. All rights reserved.

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Page 1: CHEATER’S GUIDE TO BEATING ALZHEIMER’Sthecourier.com/wp-content/uploads/2018/04/Courier-Par… ·  · 2018-04-06ALZHEIMER’S CHEATER’S GUIDE TO GIADA’S FAVORITE SPICY SHRIMP,

BEATING ALZHEIMER’S

CHEATER’S GUIDE TO

GIADA’S FAVORITE SPICY SHRIMP, P. 14

PLUS

S U N DAY, A P R I L 8 , 2 0 1 8 | PA RA D E .CO M

Friends, fun, � tness!—new research reveals what truly works to delay dementia

These Encinitas, Calif., women meet up

regularly for surf and sun

© PARADE Publications 2018. All rights reserved.

Page 2: CHEATER’S GUIDE TO BEATING ALZHEIMER’Sthecourier.com/wp-content/uploads/2018/04/Courier-Par… ·  · 2018-04-06ALZHEIMER’S CHEATER’S GUIDE TO GIADA’S FAVORITE SPICY SHRIMP,

2 | APRIL 8, 2018

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EMAIL YOUR QUESTIONS FOR WALTER SCOTT TO [email protected]

What advice did fellow British actress Emma Thompson give her about playing the role of Margaret? Go to Parade.com/atwell to fi nd out.

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WALTER SCOTT ASKS

WALTER SCOTT’S

Do the themes of How-ards End still resonate?Absolutely. It felt distinctly modern when we were do-ing it, not just because of the relationship between the two sisters being warm and playful and full of con-tradictions and squabbles, but also the idea of class, particularly in England, and the lack of equality in the world. It’s also a love story between Margaret and Henry. I think what makes Margaret remarkable is when [her sister] says about Henry Wilcox, “I don’t know why you would like

someone like that; he represents all the things that the Schlegels despise,” Marga-ret says she sees something fi ne in Henry; she’ll accept him on his own terms. I think as a result of that, it’s a very mature relationship, not one that’s just built on romance or physical de-sire. It’s built on a mutual respect for the differences between each other.You were born in the U.K. but your father’s Ameri-can. I spent my summers in Kansas City [Mo.] looking

at lightning bugs, riding four-wheel bikes through fi elds of hay and eating Kansas City barbecue. It was wonderful because my ancestors are from Kansas City, so I got to learn a lot about my heritage. I feel very proud to be half-American, and I’m close to my grandmother there.

HAYLEY ATWELLThe British actress, 36, who spun her Captain America role as fan-favorite Peggy Carter into its own TV series, now stars as Margaret Schlegel opposite Ma� hew Macfadyen’s Henry Wilcox in Starz’s series Howards End (April 8). Based on the classic E.M. Forster novel about class distinctions, it’s the tale of two independent, unconventional sisters in England at the beginning of the 20th century.

Captain America role as fan-favorite Peggy Carter into its own TV series,

Howards (April 8). Based on the classic E.M. Forster novel

about class distinctions, it’s the tale of two independent,

Helen Hunt’sMiracle MovieThe Mad About You, As Good as It Gets and Cast Away star, 54, has returned to the big screen, play-ing coach Kathy Bresnahan in the just-released Miracle Season. It’s the inspirational true story of an Iowa high school girls’ volleyball team, which after the tragic death of its star player rallies in hopes of winning a championship. Here are fi ve facts about the Oscar- and Emmy-winning California native.

Hunt and Paul Reiser each made $1 million per episode—an unheard-of amount—for Mad About You in the 1998-99 season.

She received her Oscar-winning role in As Good as It Gets after Holly Hunter turned it down.

In 1998, Hunt became the second female performer ever to win an Oscar, an Emmy and a Golden Globe in the same year; the fi rst was Liza Minnelli (1973).

Her exercise routine includes surfi ng and paddle-boarding.

Hawaii is her favorite get-away destination. “It’s where I feel right,” she says.

A: You’re in luck—and so is the former Grey’s Anatomy actress,

who returns to TV as the star of the new BBC America drama Killing Eve (April 8). Based on the novellas by

Luke Jennings, it’s about a slick psychopathic assassin

(Jodie Comer) and the British MI5 security offi cer (Oh) charged with hunting her down. Oh, 46, says the “frazzledness” of Eve is what at-tracted her to the role. PARADE.COM

A:former

(Jodie Comer) and the British MI5 security offi cer (Oh) charged with hunting her down. Oh, 46, says the “frazzledness” of Eve is what at-tracted her to the role.

Zooey Deschanel Wraps Up New GirlDeschanel, 38, is coy about what changes await the characters in the fi nal season of her comedy series New Girl (April 10 on Fox). Jess (Deschanel) and Nick (Jake Johnson) continue to struggle with the deci-sion of whether or not to marry, complicated by the return of Jess’ ex (Dermot Mulroney). “We’ll see!” says Deschanel, who adds she’ll be “very sad” when the Emmy-nominated show ends.

Deschanel, 38, is coy about what changes await the characters in the fi nal season of her comedy series New Girl(Deschanel) and Nick (Jake Johnson) continue to struggle with the deci-

Robinsons Lost in Space—AgainParker Posey joins the Rob-inson family in a gender-fl ipped role when they fi nd themselves headed toward trouble in Netfl ix’s Lost in Space (April 13), a reimagining of the classic 1960s series. Posey, 49, plays the mys-terious Dr. Smith (played by Jonathan Harris in the original), who possibly—danger! danger!—throws the group’s spaceship light-years off course. The series also stars Toby Stephens, Molly Parker, Taylor Russell and Mina Sundwall.

I liked Sandra Oh in American Crime but would love to see her in a bigger role. Does she have any plans? —Warren B., Burlingame, Calif.

© PARADE Publications 2018. All rights reserved.

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Edited by Alison Abbey | Visit PARADE.COM/PICKS for more

4 | APRIL 8, 2018

Parade

Spring’s brightest craze? Rainbows!

We found them streak-ing across our favorite water bo� le and light-ing up dark corners. You’ll want to follow this trend to the end.

The Rainbow Bud Vase Set is an inspired way to display spring blossoms. $115, uncommongoods.com

You’ll feel like you’re fl oating on cloud nine when you recline on the Love One Another Pool Party Float from Fred Segal’s CB2 outdoor collection. $80, cb2.com

You can’t be in a bad mood when you slip on the cozy Good Vibes Rainbow Sweat-shirt. $58, nordstrom.com

Brighten up some-one’s day with these adorable (and uplift-ing) Future Looks So Bright Cards. Set of 10 for $12, papersource.com

Keep your drinks hot or cold in this colorful 17-oz Boston Warehouse Cantini. $16, amazon.com

Rainbow Connection

Turn on the Rainbow Neon Light for a dazzling display of cheerfulness. $60, bando.comonnectiononnection

THE

You don’t have to look to the sky to fi nd Roy G. Biv! All the colors of the rainbow are right under your nose (or feet) with the Summer Stripe Indoor/Outdoor Rug. Starts at $69, thecompanystore.com

© PARADE Publications 2018. All rights reserved.

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Fiction FanaticIn Emmy-winning Sopranos actor Michael Imperioli’s fi rst novel, The Perfume Burned His Eyes (Akashic Books), $26, a 16-year-old boy comes of age in New York City with a little help from rocker Lou Reed. Here are three of Imperioli’s all-time fi ction favorites.

BOOKS WE LOVE

Frankenstein (MIT Press), $20,by Mary Shelley“This new edition is annotated for scientists, engineers and creators of all kinds. It’s been 200 years since this masterpiece was fi rst released, yet the book is more relevant than ever as we stand at the brink of the A.I. era.”Invisible Man (Vintage Books), $16, by Ralph Ellison“The Great American Novel—period.”

Prison Noir (Akashic Books), $16, edited by Joyce Carol Oates “These are stories authored by current and former inmates of the American prison system. Brutal, raw, honest and intelligent, these tales are written with clarity, cour-age and skill.”

Available in bookstores and online

time fi ction favorites.

APRIL 8, 2018 | 5

Visit Parade.com/imperioli to learn about the actor’s connection to Lou Reed.

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With a new, smaller design, the Lively Mobile is easy to carry anywhere you go. And with no landline required, you’re not restricted to your home. It’s also waterproof, so you can even stay protected in the shower. The Lively Mobile has the fastest call response time, and GreatCall owns and operates its own call centers in the U.S. In any emergency, 24/7, simply press the button to speak immediately with a 5Star Medical Alert Agent. The Agent will confirm your location, evaluate your situation and get you the help you need.

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6 | APRIL 8, 2018

Sunday With... DARCI LYNNEAfter taking

home the top prize on

America’s Got Talent, now-13-year-old Oklahoma native Darci Lynne Farmer is headlining her own tour, Darci Lynne and Friends, and she’s bringing along four familiar puppets from the show: Petunia the rabbit, Oscar the mouse, old lady Edna and country girl Katie. Farmer chatted with Paradein Nashville as she prepared to take the stage at the famous Ryman Auditorium. How did you discover ventriloquism? I was super shy, so my mom put me in these little pageants to help that. When I was 8, I went to [one] and met Laryssa Bonacquisti, who was 18 at the time [later she would be crowned Miss Louisiana 2017]. She was a ventriloquist. I was fascinated with what she did. I was like, “Oh my gosh, I have to do that,” so I asked her for pointers. How did you master it? I went home with her tips and practiced in my mirror and taught myself the basics. I already knew I could sing; I just had to master it with my mouth closed. It just came natural after a while. I asked my mom and dad for a puppet. They said, “No. You are a singer, not a ventrilo-quist.” But I was persistent, and they fi nally surprised me with one for my 10th birthday.How did you feel when you won the show? I don’t even remember. I think I was halluci-nating, like, “Wait, it’s real?” It

was kind of a shock, and just the best moment ever.Do you have a favorite song to perform? I love [Smokey Robinson’s] “Who’s Lovin’ You,” because Oscar—he gets all the ladies with that song. He can’t talk to girls, but when he sings, that’s how he speaks to them. He’s like, “Hey, here I am, ladies.” It’s funny.What do you like to do on Sundays? I love hanging out with my friends, because I have the best group of friends ever. In the summer I love to go to the lake with them and water-ski and tube. I love eating Chipotle. Stranger Things is the best TV show ever made, so I love watching that. What do you think your future holds? I want to do it all. I still want to be on a TV show or in a movie or on Broadway. I don’t want to be just known as the puppet girl—I want to be an all-around performer.

What do her brothers think of her success? Visit

Parade.com/darci to fi nd out. JER

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Singer and ventriloquist Darci Lynne Farmer wasn’t even a

teenager when she won season 12 of America’s Got Talent. Now she’s

taking her show on the road.By Alison AbbeyIf you experience painful head-

aches that may pulse or throb, or sensitivity to light and sound, you are not alone. Over 50 million Americans suffer from migraine headaches, and many are not aware of this effective treatment that tar-gets five symptoms of migraines.

MagniLife® Migraine Relief contains ten active ingredients to relieve symptoms, such as Coffea Cruda for piercing headaches and sensitivity to noise. “This is my go to product now when I have a migraine.” - Sandra C. Tablets

dissolve under the tongue. “With-in 15 minutes I felt my headache leave, dizziness was better. Love this product.” - Angel, WV.

MagniLife® Migraine Relief is available at CVS/pharmacy. Order risk free for $19.99 +$5.95 S&H for 90 tablets. Receive a FREE bottle when you order two for $39.98 +$5.95 S&H. Send payment to: MagniLife M-P8, PO Box 6789, McKinney, TX 75071 or call 1-800-532-9177. Satis-faction guaranteed. Order now at www.MLMigraine.com

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MagniLife [gel] is the only thing that gave me relief after my case of shingles.” - Michele G., CA.

MagniLife® Pain & Itch Relief Gel is sold at Rite Aid Pharma-cy, located in the first aid section. Order risk free for $19.99 +$5.95 S&H for a 1.8 oz jar. Get a FREE jar when you order two for $39.98 +$5.95 S&H. Send pay-ment to: MagniLife SH-P8, PO Box 6789, McKinney, TX 75071, or call 1-800-532-9177. Mon-ey back guarantee. Order now at www.PainfulRashRelief.com

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MagniLife® Leg & Back Pain Relief is sold at Walgreens, CVS/pharmacy, Rite Aid, Al-bertsons and Walmart. Order risk free for $19.99 +$5.95 S&H for 125 tablets per bottle. Get a FREE bottle when you order two for $39.98 +$5.95 S&H. Send payment to: MagniLife S-P8, PO Box 6789, McKinney, TX 75071 or call 1-800-532-9177. Satis-faction guaranteed. Order now at www.LegBackPain.com

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© PARADE Publications 2018. All rights reserved.

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8 | APRIL 8, 2018

ometimes I walk into a room and can’t remember why. I lose my keys. I blank on names. So I wonder: Could I be heading for

Alzheimer’s, the way my dad and my grandmother did?

Or is there a way I can beat such a fate?

� at’s how I found myself in a New York City doctor’s offi ce one recent winter afternoon, playing com-puter card-matching games and identifying smells like lemon and Play-Doh. � ese brain tests were part of my extensive workup at Weill Cornell Medi-cine’s Alzheimer’s Prevention Clinic, the fi rst of its kind in the U.S. and one of only a handful of centers to focus on the emerging science of dementia risk assessment and prevention strategies.

I came in at a great time, clinic founder Richard S. Isaacson, M.D., a neurologist, tells me. Even fi ve years ago, the idea that Alzheimer’s was preventable was laughed at. “In medical school, I was taught that dementia just starts one day,” Isaacson says. “Today we know diff erently.”

Scientists now think a complex mix of life-

style, genes, age, environment and health conditions leads to the brain changes of Alzheimer’s—up to 20 or 25 years before obvious symptoms. � at’s another reason

I came to the clinic at a good time. At age 57, I’m exactly 25 years younger than the average age of my relatives when their memory loss and odd behaviors fi rst showed up.

“� ere’s been a shift toward changing the progress of disease before symptoms occur that’s really exciting,” says Maria C. Carrillo, Ph.D., chief science offi cer of the Alzheimer’s Association.

“Alzheimer’s is fi nally joining the list of diseases we can have an early eff ect on,” says Harvard neurologist Reisa A. Sperling, M.D. She compares it to heart disease or diabetes, which are treated preventively with a mix of

lifestyle fi xes (like diet) and targeted medica-tions (like statins), and to cancer, for which there are routine screenings.

� e idea of treating Alzheimer’s “upstream,” long before we fail to recognize family or forget what a phone is, was sparked by the ability to fi nally see and track the biomark-ers showing early brain changes. Given that hundreds of drugs have been thrown at cases of full-blown disease, only to wipe out dur-ing testing, starting further back makes sense. As with heart attacks, not every case might be avoided—but what if you could delay the onset for fi ve or 10 years? Or until there were a cure?

Predicting Alzheimer’s RisksAt the Alzheimer’s Prevention Clinic, I step on a large machine that looks like a cross between a fancy scale and a treadmill. As I stand still, it “reads” my body fat, lean body mass, muscle strength and more. A clinician measures my waist and asks how it’s changed since my 20s. (Oops, 4 inches bigger.)

� ese body measures, or “anthropometrics,” represent the A in what the clinic calls the “ABCs of Alzheimer’s prevention.” The B stands for blood biomarkers. Blood tests reveal nutritional, lipid, metabolic, infl am-matory and genetic markers of possible problems—everything from my cholesterol numbers to whether I have one of the genes linked to Alzheimer’s risk. And C stands for

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BEATING ALZHEIMER’S

New research identi� es early signs and prevention breakthroughs. By Paula Spencer Scott

Paula Spencer Scott is the au-thor of Surviving Alzheimer’s: Practical Tips and Soul-Saving

Wisdom for Caregivers. After seeing her father suffer from the disease, she was more than happy to be a guinea pig at Weill Cornell Medicine’s Alzheimer’s Prevention Clinic.

ometimes I walk into a room and can’t remember why. I lose my keys. I blank on names. So I wonder: Could I be heading for

Alzheimer’s, the way my dad and my grandmother did?

Or is there a way I can

� at’s how I found myself in a New York

afternoon, playing com-

games and identifying smells like lemon and Play-Doh. � ese brain

Prevention Clinic, the fi rst of its kind in the U.S. and one of only a handful

style, genes, age, environment and health conditions leads to the brain changes of Alzheimer’s—up to 20 or 25 years before obvious symptoms. � at’s another reason

I came to the clinic at a good time. At age 57, I’m exactly 25 years younger than the average age of my relatives when their memory loss and odd behaviors fi rst showed up.

New research identi� es early signs and prevention breakthroughs.

Paula Spencer Scott is the au-thor of Surviving Alzheimer’s: Practical Tips and Soul-Saving

Wisdom for CaregiversAfter seeing her father suffer from the disease, she was more than happy to be a guinea pig at Weill Cornell Medicine’s Alzheimer’s Prevention Clinic.

CHEATER’S GUIDE TO

© PARADE Publications 2018. All rights reserved.

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APRIL 8, 2018 | 9

cognition (thinking skills), measured by 1½ hours of those brain tests.

I also supplied an intensive health history about my diet, exercise, stress level and more. Among the more curious questions: my high school rank (18 in 650), because early achievement has been shown to be protective, and whether I dream (oh, yes!), a sign of good sleep.

� e goal: to assess threats and identify fi xable issues known to aff ect brain health. You can’t do much about some things that raise your risk of Alzheimer’s, like your genes, gender (higher risk for women) or age (about 1 in 3 adults get demen-tia, but by age 85, the odds are 50-50). � e big opportunity lies in modifi able risk factors: what you eat, how you sleep, blood pressure, overall fi tness, even your waistline (abdominal fat raises your risk threefold).

“Genes are not your destiny,” Isaacson says. � e hot word is epigenetics: changing the expres-sion of our genes by changing how we live.

Fish and Wine Are A-OKReviewing my data, Isaacson grades me an A on my A’s, anthropometrics. � ey show 21.9 percent body fat, “pretty darn good,” if short of optimal. My wider waist is still OK but a spot to watch. � ough my legs are superstrong (I walk or run every morning), my core strength is sad (I slouch at a desk all day).

My blood work reveals a few sur-prises. I eat fi sh two to three times a week, but I’m low in DHA, EPA and ALA, omega-3 fatty acids linked to brain and heart health. I’m also low in vitamin D and, despite my “clean and green” diet, continued on page 10

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BEATING ALZHEIMER’S

poorly absorb B vitamins. (My triglycerides rock, though, “so that wine isn’t harming you,” I’m told. Yay!)

At least my cognition scores are great. “I don’t think that extra inch in your waist is aff ecting your cognitive function,” Isaac-son tells me. We all lose keys and forget names due to normal aging, distraction and stress; it’s when mental slips interfere with everyday life that doctors get concerned.

� e ABCs are interconnected. Memory and metabolism (in-dicated by body fat) often go together, for example. � ose with an APOE-4 gene, a type linked to higher risk of Alzheimer’s, re-spond diff erently to certain drugs and nutrients. (I don’t have it.) So Isaacson bases recommendations

for reducing risk on a patient’s in-dividual data picture, an approach called precision medicine.

Up to one-third of dementia cases can be delayed or prevented by steps we already know, found a 2017 Lancetreport. But there’s no single “magic bullet,”

says Mary Butler, Ph.D., of the Minnesota Evidence-Based Practice Center, whose recent reviews showed no single drug, supplement, exercise or brain-training program has been prov-en to do the trick. Scientists are also exploring drugs that could, like statins for heart disease, work preventively in high-risk patients.

“� e body is complicated. � e brain is complicated,” says Isaacson. “� e roads to Alzheimer’s are diff erent in each individual.”

How Worried Should We Be?Relief! My assessment reveals that most of my modifi able risk factors seem under control, with some room for improvement. I could still, of course, get Alzheim-er’s; who knows what genes lurk undiscovered? And what if I’m among the 47 million Americans who, according to a new UCLA study, have no disease symptoms but already have neurodegen-eration or buildups of amyloid protein in their brains?

Normally this protein is rou-tinely cleared away, but if that doesn’t happen it forms clumps that, for some, lead to Alzheimer’s. Increasingly researchers think any brain can become less effi cient at “clearing out the trash” over time.

It’s impossible—too costly—to scan every brain for amyloid right now.

Luckily what’s already known about prevention is cheap and safe. Isaacson employs a “tech team” ex-ploring digital ways to spread this info and more quickly train more doctors how to do assessments.

Meanwhile, I’m really motivated to tweak what I can. A supple-ment skeptic, I’m giving omega-3s and my prescribed vitamins a trial run. Since tests show I’m an over-absorber of cholesterol, I’ve cut back on cheeses and switched my beloved whole-milk vanilla Greek yogurt for nonfat plain (with ber-ries, it’s still sweet!). I haven’t tried sitting on a balance ball while working, but at least I’ve located the muscles to strengthen my core. I’m determined to shrink my waistline to “optimal” size.

My No. 1 takeaway: � e little things we do add up—for our bod-ies and our brains. So why wait?

Do you love music?There’s growing research

on the brain benefi ts of music. Listening is great but playing it or singing is even more benefi cial.

Up to one-third

of dementia cases can be delayed or prevented

What was your high school rank?Being an early achiever actually helps protect against Alzheimer’s, new research shows.

How big is your waist?

If it’s dramatically bigger than it was in your 20s—that raises your risk of Alzheimer’s.

Do you dream?Dreamers are good sleepers. Getting a good night’s sleep helps prevent Alzheimer’s.

© PARADE Publications 2018. All rights reserved.

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10 | APRIL 8, 2018

Beating Alzheimer’s is not one size fi ts all, says Weill Cornell’s Alzheimer’s Prevention Clinic director Richard Isaacson. About 40 percent of risk-reduction strategies depend on factors unique to you, like genetics and physical condition. “Some people can do everything right and still get Alzheimer’s,” he says.

Still, the other 60 percent of ways to lower your risk apply to everyone. Start here:Know your “numbers.” Get basic blood tests to fi nd out your cholesterol (including HDL, LDL and triglycerides), blood glucose and homocysteine. Learn your blood pressure (hypertension in midlife is a key dementia risk), body-mass index (BMI) and waist circumference.

The good news: All are risk factors you can change if you’re outside normal ranges; any doctor can show you how. Take a cognitive test. It’s useful to have a baseline of your current thinking skills, to compare over time. There’s no single best test, though it ideally should be less simplis-tic than the basic mini-mental state exam (MMSE) used to screen for AD. One you can try at home: the 15-minute SAGE test (for a link, go to alzu.org).Hang on to your muscle. We lose 1 percent of muscle mass a year if we don’t do anything about it. A mix of aerobic and resistance/weight training helps burn the fat that leads to a more risky apple-shaped body. Maintain a healthy weight. There may be no such thing as “fat but fi t,” recent studies say. Eat “green, lean and clean.” Almost every brain benefi ts from a plant-heavy diet (veg-gies, beans, whole grains, nuts, seeds) with

lean protein (fi sh, especially) and low-fat dairy. Sourcing seems to mat-ter: Grass-fed dairy and meat have less fat, and more of it is healthy. Use

extra-virgin olive oil for everything.Go fi shing. It really is brain food. Fatty

fi sh to eat twice a week include salmon, alba-core tuna, mackerel, lake trout and sardines. Some people benefi t from omega-3 supple-ments with DHA and EPA; they’re pricey and are best used under a doctor’s supervision.Pass on late-night eating. At least a few times a week, try to hold out from after din-ner until breakfast for 12 to 14 hours of no eating, or at least no carbs. This helps your body burn stored fats.Put devices to bed. Sleep is likely as infl uen-tial as diet and exercise, researchers think. Hit the hay in time to get at least 8 hours. Stop texting, checking email and watching TV at least 30 to 45 minutes before bedtime.Balance stress with downtime. Every 4.5 years of work stress lead to one additional year of brain aging, Isaacson says. Yoga, acu-puncture and regular vacations all help.

Keep busy and connected. Hobbies and friendships both relax and challenge the brain to learn new things. Social contact protects it. The word on brain games and crosswords is mixed—

remember there’s no one magic bullet. Visit the dentist and eye doctor. Sur-prise: Untreated tooth and gum problems

can cause problematic infl ammation. And if you’re having vision or hearing loss, treatment can spare you the resulting social isolation that is its own risk.Take up the ukulele. Isaacson swears by the growing body of research on music’s benefi ts to the brain (he joined a band himself). Even listening revs you up for exercise and calms stress, but playing or singing is even better.Don’t smoke. But you knew that. Consider genetic testing. Let’s be clear: It won’t tell you whether you’ll get the dis-ease. Only a few genes have been linked to Alzheimer’s so far. The best studied is APOE, which helps regulate fats. We get one copy of it from each parent. The rarest variation, APOE-2, is protective against Alzheimer’s. APOE-3 is neutral. APOE-4 slightly elevates your risk. But you can have two copies of APOE-4 and still avoid Alzheimer’s, or not have any and get it.

So why fi nd out? It can be a good motivator. “Our preliminary, unpublished data suggests that when people fi nd out, their compliance to interventions increases,” Isaacson says. “Knowledge is power.” Doctors also use this info to shape treatments.Join a clinical trial. Early-intervention re-search is “our best chance to cure the disease,” says Harvard neurologist Reisa A. Sperling. “The fi rst person cured of Alzheimer’s disease will be in a clinical trial.” Search for studies you might qualify for at clinicaltrials.gov.

—Paula Spencer Scott

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Beating Alzheimer’s is not one size fi ts all, says Weill Cornell’s Alzheimer’s Prevention Clinic

To Lower Your Risk, Start Here

Alzheimer’s Prevention Clinic

reduction strategies depend

lean protein (fi sh, especially) and low-fat dairy. Sourcing seems to mat-ter: Grass-fed dairy and meat have

is not one says Weill Cornell’s

Alzheimer’s Prevention Clinic

Your Risk,Your Risk,

Keep busy and connected. friendships both relax and challenge the brain to learn new things. Social contact protects it. The word on brain games and crosswords is mixed—

can cause problematic infl ammation. And if you’re having vision or hearing loss, treatment can spare you the resulting social isolation that

In June, enrollment starts for the largest-ever lifestyle study on preventing cognitive decline. The Alzheimer’s Association–funded U.S. POINTER study is looking for 2,500 symptom-free participants who are at risk for Alzheimer’s, ages 60 to 79. In a brand-new twist in clinical trials, local Alzheimer’s Association offi ces, the YMCA and other commu-nity groups will work with researchers to evaluate the impact of two lifestyle interventions on brain health in participants across fi ve U.S. regions. (First up: Wake Forest, N.C., and Northern California.) Visit alz.org/us-pointer to ask about enrolling.

Take Action

Go to “Alzheimer’s University” Visit alzu.org to take an Alzheimer’s course, fi nd links to the SAGE cognitive test, get loads of info and more.

© PARADE Publications 2018. All rights reserved.

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THE FIRST SURVIVOR OF

ALZHEIMER’SDISEASE IS

OUT THERE.

They’re out there, and they’re going to hold on to

everything the disease steals away. And the Alzheimer’s

Association is going to make it happen by funding

research, advancing public policy and spurring scientific

breakthroughs.

 

And by providing local support to those living with the

disease and their caregivers, we’re easing the burden for

all those facing it until we accomplish our goal.

 

But we won’t get there without you.

Visit alz.org to join the fight.

© PARADE Publications 2018. All rights reserved.

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Send questions tomarilyn @ parade.com

Ask MarilynBy Marilyn vos Savant

Since we have two ears, I can understand how we can tell whether sounds are coming from our left or right. But how can we tell if they’re coming from our front or back?

—Don Phillips, Cypress, Calif.

As those two ears are on opposite sides of our heads, they provide us with a great many clues about the location of the source. Even the tiniest differences in volume, timing, frequency and reverbera-tion give us data. And all of our senses are in play: Anything we can see or feel adds to what our brains perceive from our hear-ing. Also, without giving it a moment’s thought, we simply turn or tilt our heads to pick up even more information.

Visit Parade.com/numbrix for more Marilyn vos Savant Numbrix puzzles

and today’s solution.

Numbrix®

Complete 1 to 81 so the numbers follow a horizontal or

vertical path—no diagonals.

7

39

3

41

57

45

59

63

79

77

75

11

13

21

25

37

12 | APRIL 8, 2018

“I can watch TV as loud as I want without disturbing my wife. The dialog is clear and it’s good to hear my favorite shows again!”

— Pat Boone, Singer/Songwriter

Voice Clarifying ProductsTV Ears is a trademark of TV Ears, Inc. © 2018 TV Ears, Inc. All Rights Reserved

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The Doctor Recommended TV•EARS® headset has helped millions of people hear television dialog clearly while eliminating concerns about loud volume or the need to buy expensive hearing aids. Put on your TV•Ears headset and turn it up as loud as you want while others listen to the television at a comfortable volume. You can even put the TV on mute and listen through the headset only. Others in the room won’t hear a thing, but we guarantee you will. Imagine watching television with your family again without fi ghting over the TV volume or listening in private while a loved one sleeps or reads. As thousands of our customers have said, “TV•Ears has

changed our lives!”

Voice Clarifying Circuitry® The TV•Ears headset contains proprietary Voice Clarifying Circuitry that automatically adjusts the audio curve to increase the clarity of television dialog while decreasing the volume of background sounds such as music and sound effects. The words seem to jump out of the audio track, making even whispers and accents understandable.

Fast, Safe and Simple. TV•Ears transmitters use Speed of Light Infrared Technology™ (SoLIT) to send the television’s audio to the headset. Unlike slower Bluetooth or Radio Frequency, SoLIT does not need to be paired or adjusted, is completely safe with pacemakers, and will not interfere with your telephone.

Twice the Power with 120 decibels. The TV•Ears headsets are classifi ed as “Assistive Listening Devices” for hearing-impaired individuals. This special designation permits the TV•Ears headset to have twice the maximum volume compared to all other wireless headsets.

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© PARADE Publications 2018. All rights reserved.

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EatsWhat America

14 | APRIL 8, 2018

CELEBRITY KITCHEN

Made with fi ery peppers from the toe of Italy's “boot,” Calabrian chile paste adds bright heat to all manner of pasta, salad dressing and more.

De Laurentiis’ favorite is Tutto Calabria Crushed Hot Chili Peppers ($8,

supermarketitaly.com).RE

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F iery Calabrian chiles lend this easy appe-

tizer a nice kick. The recipe is from celebrity chef Giada De Laurentiis’ beautiful new cookbook, Giada’s Italy, shot on location in her native Rome and featuring her lighter, healthier spin on classic Italian fare.

—Alison Ashton

SPICY SHRIMP

CALABRIAN SHRIMPPreheat oven to 425°F. In a medium bowl, whisk together ½ cup freshly grated Parmigiano-Reggiano cheese, 2 Tbsp olive oil, 2 tsp Calabrian chile paste or red pepper fl akes, 1 tsp grated lemon zest, ¼ tsp dried oregano and ¼ tsp kosher salt. Add 1 lb large shrimp, peeled and deveined (tails intact); toss to coat. Marinate 10 minutes at room temperature. Spread shrimp evenly on a rimmed baking sheet. Bake 8–10 minutes or until shrimp are pink and opaque all the way through. Sprinkle with 1 Tbsp lemon juice and 1 Tbsp chopped fresh basil. Serve with lemon wedges. Serves 4–6.

GIADA IN THE KITCHEN

First thing she remembers cooking: “Pizza!”

Lesson she wants to share with her 10-year-old daughter, Jade: “My grandfather taught me to grate Parmigiano-Reggiano cheese onto hot pasta before tossing

it with the sauce. The cheese sticks to the pasta and the sauce sticks to the cheese, creating a perfectly delicious bite—every bite.”

Her must-have kitchen tools: A Williams Sonoma grater; a sharp

chef's knife, such as one by Berti; and a “perfect” wooden spoon. “I like

one that has a � at edge so it gets into the corners of pans to make sure noth-ing sticks.”

Food trend she loves: dra� la� es (a co� ee-milk drink served on tap with a head of foam). “I love how creamy and frothy they are.”

Crushed Hot Chili Peppers ($8, supermarketitaly.com).

Go to Parade.com/pasta for De Laurentiis’ spicy, speedy linguine recipe.

“I use Calabrian chile paste in many

of my recipes—it’s kind of like the Italian

version of sriracha.” —Giada De Laurentiis

GIADA’S

© PARADE Publications 2018. All rights reserved.