che5480 summer 2005
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CHE5480 Summer 2005. Dendrimers June 14, 2005. Starburst Dendrimers. What is a dendrimer? Branched polymers ( dendron = tree in Greek) Functionality = 3 (Nitrogen). Silicon, Si, functionalty f=4. Rose bengal inside PPI dendrimer. Dendrimers:. 1. Manufacture 2. Structure - PowerPoint PPT PresentationTRANSCRIPT
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CHE5480 Summer 2005CHE5480 Summer 2005
Dendrimers
June 14, 2005
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Starburst DendrimersStarburst Dendrimers
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What is a dendrimer? What is a dendrimer? Branched polymersBranched polymers
((dendron dendron = tree in Greek)= tree in Greek)
Functionality = 3 (Nitrogen)= 3 (Nitrogen)
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Silicon, Si,
functionalty f=4
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Rose bengal inside PPI dendrimer.Rose bengal inside PPI dendrimer.
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Dendrimers:Dendrimers:
1. Manufacture2. Structure3. Characterization4. Applications
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Manufacture:Manufacture:
(i) Divergent Method(ii) Convergent Method
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Methods of Synthesis:Methods of Synthesis:
(i) Divergent Growth(i) Divergent Growth
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Methods of Synthesis:Methods of Synthesis:
(ii) Convergent Growth(ii) Convergent Growth
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Comparison: Comparison: Divergent vs. ConvergentDivergent vs. Convergent
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Structure:Structure:
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Generations of DendrimersGenerations of Dendrimers
2nd gen.
4th gen.
5th gen.
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PAMAM Dendrimer PAMAM Dendrimer (polyamidoamine)(polyamidoamine)
Alternating
(B)-AB-AB-AB-...Ethylenediamine (B)H2N-C-C-NH2
Methylacrylate (A)C=C-CO-OCH3
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PAMAM Moieties:PAMAM Moieties:
Acryla
te
Diami
ne
NH3 or
Diamin
e
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Characterization:Characterization:
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f=3 fc=3
Spacer b
123
generations
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Construction of Generations:Construction of Generations:
Core: Ethylenediamine (Moiety B = D)
“Michael Addition” of 4 Methylacrylates (A= O)
Amidization: add 4 ethyldiamines (D)
Result: Generation “0”
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Continue Branching:Continue Branching:Generation “1”:
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Generation “2”:Generation “2”:
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Calculations:Calculations:Note that Core functionality (2
nitrogens): fc = 4 Branch functionality
(nitrogen): f=3
No. of Spacers (A+B): b=2
Generation = G
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Number of Branches: Number of Branches: NNbrbr
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Number of Mers (A+B): Number of Mers (A+B): NNmermer
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Applications of DendrimersApplications of Dendrimers
Gas and chemical sensorsCatalystsDrug delivery and gene therapySurface modifiers (tribology, and
information storage)Bio compatible materialsElectronic devices and antennae
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Size of PAMAM DendrimersSize of PAMAM Dendrimers
Generation M.W. Angstrom (dia.) End GpsGeneration M.W. Angstrom (dia.) End Gps
(1 nm = 10 Angstroms)
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Equivalent Sizes with Cells:Equivalent Sizes with Cells:
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Dendrimer: PAMAMDendrimer: PAMAM
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2. Nanostructured materials: 2. Nanostructured materials: Gas adsorption in dendrimersGas adsorption in dendrimers