chapter 14 ans - sp10
TRANSCRIPT
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Chapter 14
Autonomic Nervous System
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The Autonomic Nervous System
• Regulates activity of smooth
muscle, cardiac muscle &certain glands
• Structures involved – general visceral afferent neurons
– general visceral efferent neurons
– integration center within the brain
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The Autonomic Nervous System
• Receives input from limbic system and
other regions of the cerebrum
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Autonomic versus Somatic NS
• Autonomic nervous system
– unconsciously perceived visceral sensations
– involuntary inhibition or excitation of smooth
muscle, cardiac muscle or glandular secretion
– two neurons needed to connect CNS to organ• preganglionic and postganglionic neurons
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Autonomic versus Somatic NS
• Notice that the ANS pathway is a 2 neuron pathway
while the Somatic NS only contains one neuron.
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Basic Anatomy of ANS
• Preganglionic neuron
– cell body in brain or spinal cord
– axon is myelinated type B fiber that extends to autonomic
ganglion• Postganglionic neuron
– cell body lies outside the CNS in an autonomic ganglion
– axon is unmyelinated type C fiber that terminates in a visceral
effector
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Divisions of the ANS
• 2 major divisions
– parasympathetic
– sympathetic• Dual innervation
– one speeds up organ
– one slows down organ
– Sympathetic NS
increases heart rate
– Parasympathetic NS
decreases heart rate
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Divisions of the ANS
• Parasympathetic
• D division
– digestion – defecation
– diuresis (urination)
• Sympathetic
• E division
– exercise – excitement
– emergency
– embarrassment
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Sources of Dual Innervation
• Sympathetic
(thoracolumbar) division
– preganglionic cell bodies
in thoracic and first 2lumbar segments of spinal
cord
• Parasympathetic
(craniosacral) division – preganglionic cell bodies in
nuclei of 4 cranial nerves
and the sacral spinal cord
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Locations of Autonomic Ganglia
• Sympathetic Ganglia
– trunk (chain) ganglia near
vertebral bodies
– prevertebral ganglia near
large blood vessel in gut
• celiac
• superior mesenteric
• inferior mesenteric
• Parasympathetic Ganglia
– terminal ganglia in wall of
organ
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Autonomic Plexuses
• Cardiac plexus
• Pulmonary plexus
• Celiac (solar) plexus
• Superior mesenteric
• Inferior mesenteric
• Hypogastric
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Organs Innervated by Sympathetic NS
• Structures innervated by each spinal nerve
– sweat glands, arrector pili mm., blood vessels to skin &
skeletal mm.
• Thoracic & cranial plexuses supply: – heart, lungs, esophagus & thoracic blood vessels
– plexus around carotid artery to head structures
• Splanchnic nerves to prevertebral ganglia supply: – GI tract from stomach to rectum, urinary & reproductive
organs
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Circuitry of Sympathetic NS
• Divergence = each preganglionic cell
synapses on many postganglionic cells
• Mass activation due to divergence
– multiple target organs
– fight or flight response explained
• Adrenal gland
– modified cluster of postganglionic cell bodies that
release epinephrine & norepinephrine into blood
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Anatomy of Parasympathetic NS
• Preganglionic cell bodies found in
– 4 cranial nerve nuclei
in brainstem – S2 to S4 spinal cord
• Postganglionic cell
bodies very near or inthe wall of the target
organ in a terminal
ganglia
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Parasympathetic Cranial Nerves
• Oculomotor nerve
– ciliary ganglion in orbit
– ciliary muscle & pupillary constrictor muscle inside
eyeball
• Facial nerve – pterygopalatine and submandibular ganglions
– supply tears, salivary & nasal secretions
• Glossopharyngeal
– otic ganglion supplies parotid salivary gland
• Vagus nerve
– many brs supply heart, pulmonary and GI tract as far as
the midpoint of the colon
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Parasympathetic Sacral Nerve Fibers
• Form pelvic
splanchnic nerves
• Preganglionic fibers
end on terminalganglia in walls of
target organs
• Innervate smooth
muscle and glands in
colon, ureters, bladder
& reproductive organs
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ANS Neurotransmitters• Classified as either cholinergic or adrenergic
neurons based upon the neurotransmitter released
• Adrenergic
• Cholinergic
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Cholinergic Neurons and Receptors
• Cholinergic neurons release acetylcholine from
preganglionic neurons & from parasympathetic
postganglionic neurons
– Excites or inhibits depending upon
receptor type and organ involved
– Nicotinic receptors are found on dendrites & cell bodies of
autonomic NS cells and at NMJ
– Muscarinic receptors are found on plasma membranes of all
parasympathetic effectors
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Adrenergic Neurons and Receptors
• Adrenergic neurons release norepinephrine (NE)
– from postganglionic
sympathetic neurons only
– Excites or inhibits organs depending on receptors
– Alpha1 and Beta1 receptors produce excitation – Alpha2 and Beta2 receptors cause inhibition
– Beta3 receptors(brown fat) increase thermogenesis
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Adrenergic Neurons and Receptors
• NE lingers at the synapse until
enzymatically inactivated by monoamine
oxidase (MAO) or catechol-O-
methyltransferase (COMT)
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Physiological Effects of the ANS
• Most body organs receive dual innervation
– innervation by both sympathetic & parasympathetic
• Hypothalamus regulates balance (tone) between
sympathetic and parasympathetic activity levels
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Physiological Effects of the ANS
• Some organs have only sympathetic
innervation
– sweat glands, adrenal medulla, arrector pili mm
& many blood vessels
– controlled by regulation of the “tone” of the
sympathetic system
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Sympathetic Responses
• Dominance by the sympathetic system is caused by physical or emotional stress -- “E situations”
– emergency, embarrassment, excitement, exercise
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Sympathetic Responses
• Alarm reaction = flight or fight response
– dilation of pupils
– increase of heart rate, force of contraction & BP – decrease in blood flow to nonessential organs
– increase in blood flow to skeletal & cardiacmuscle
– airways dilate & respiratory rate increases
– blood glucose level increase
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Sympathetic Responses
• Long lasting due to lingering of NE in
synaptic gap and release of norepinephrine by the adrenal gland
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Parasympathetic Responses
• Enhance “rest-and-digest” activities
• Mechanisms that help conserve and restore body energy
during times of rest• Normally dominate over sympathetic impulses
• SLUDD type responses = salivation, lacrimation,
urination, digestion & defecation and 3 “decreases”---
decreased HR, diameter of airways and diameter of pupil
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Parasympathetic Responses
• Paradoxical fear when there is no escape
route or no way to win
– causes massive activation of parasympathetic
division
– loss of control over urination and defecation
– deer in head lights
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Regulation of the ANS:
• Without the regulatory activity of the ANS,
an individual has limited ability to maintain
homeostasis and readily succumbs tosudden changes in environmental
conditions.
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Controlling Factors:
1. Autonomic reflexes
• Example: baroreceptors – located in arteries
– sensitive to pressure changes
– results in changes in heart rate
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Autonomic reflexes
• These reflexes control most of the activity
of visceral organs, glands, and bloodvessels.
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Controlling Factors:
2. Cerebrum
3. Hypothalamus
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Functional Generalizations about the ANS
• 1. Both divisions produce stimulatory and
inhibitory effects.
• 2. Most organs are innervated by both
divisions.
• 3. Usually each division produces an
opposite effect on a given organ.
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Functional Generalizations about the ANS
• 4. Either division alone or both working
together can coordinate the activities of
different structures.
• 5. The sympathetic division produces more
generalized effects than the parasympathetic
division.
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Functional Generalizations about the ANS
• 6. Sympathetic activity generally prepares
the body for physical activity.
• 7. Parasympathetic activity is more
important for vegetative functions like
sitting through an Anatomy and Physiologylecture.