chapter 10 mood disorders ch 10. mood disorders involve a disabling disturbance in emotion...
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Chapter 10 Mood Disorders
Ch 10
• Mood Disorders involve a disabling disturbance in emotion– Depression is an emotional state marked by
• Sadness or loss of pleasure• Feelings of worthlessness and guilt• Withdrawal from others• Reduced sleep, appetite, sexual desire
– Mania is an emotional state marked by• Intense elation• Hyperactivity, talkativeness, distractability
Mood Disorders
Ch 10.1
Diagnosis of Unipolar Depression
• Unipolar depression diagnosis requires presence of 5 of the following:– Sad, depressed daily mood– Loss of interest in usual activities– Difficulties in sleeping– Poor appetite and weight loss– Loss of energy, great fatigue– Negative self-concept– Recurrent thoughts of suicide or death
Ch 10.2
Depression Issues• Depression exists on a continuum• Major depression is quite common
– Lifetime prevalence rates range from 5.2% to 17.1%– Women are twice as likely to develop depression as are
men– Higher rates in young adults and among individuals in lower
socioeconomic groups. – Depression prevalence varies across cultures
• Prevalence of depression has been increasing over the last 50 years
Ch 10.3
Diagnosis of Bipolar Disorder• Bipolar disorder involves
– Alternating episodes of mania and depression– Increase in activity level (work, social, sexual)– Unusual talkativeness, rapid speech– Reduced requirements for sleep– Inflated self-esteem– Distractability– Reckless spending
Ch 10.4
• Chronic Mood Disorder refers to long-term changes in mood that are less severe than that of unipolar or bipolar depression– Cyclothymic disorder refers to frequent periods
of depressed mood and hypomania– Dysthymic disorder involves chronic depression
Chronic Mood Disorder
Ch 10.5
-Recent studies suggest dysthymia may be more debilitating over the long term than depression.
Extremely Depressed Mood– Lasting at Least 2 Weeks
Cognitive Symptoms Anhedonia Vegetative Symptoms Single or Recurrent Episode
– No Manic or Hypomanic Episodes
Extremely Depressed Mood– Lasting at Least 2 Weeks
Cognitive Symptoms Anhedonia Vegetative Symptoms Single or Recurrent Episode
– No Manic or Hypomanic Episodes
Clinical Description Clinical Description
Clinical Description Clinical Description
2 Weeks or More2 Weeks or More
Facts and Statistics Facts and Statistics Mean Age of Onset is 25
Years Length of Episode Varies Remission is Common Risk of Suicide
Mean Age of Onset is 25 Years
Length of Episode Varies Remission is Common Risk of Suicide
2 Years or More2 Years or More
Clinical Description Clinical Description
Facts and Statistics Facts and Statistics Mean Age of Onset Early 20s;
Symptoms can persist unchanged over long periods (e.g., 20 years or more)
Onset Prior to Age 20– Greater Chronicity – Poor Prognosis– Stronger Family Link
Major Depressive Episodes are Common
Mean Age of Onset Early 20s; Symptoms can persist unchanged over long periods (e.g., 20 years or more)
Onset Prior to Age 20– Greater Chronicity – Poor Prognosis– Stronger Family Link
Major Depressive Episodes are Common
Suffer From Both – Major Depression Episodes– Dysthymic Disorder
Dysthymic Usually Begins First Associated With Severe
Pathology A Problematic Future Course
Suffer From Both – Major Depression Episodes– Dysthymic Disorder
Dysthymic Usually Begins First Associated With Severe
Pathology A Problematic Future Course
Clinical Description Clinical Description
DysthymiaDysthymia
MajorDepression
MajorDepression
DysthymiaDysthymia
Clinical Description Clinical Description
Major Features Major Features Experience Both
– Manic Episodes– Major Depressive Episodes
Roller Coaster of Mood
Experience Both– Manic Episodes– Major Depressive Episodes
Roller Coaster of Mood
What are Manic Episodes?What are Manic Episodes?
Mania and Hypomania Mania and Hypomania
Elevated Mood Elevated Mood
Grandiosity Grandiosity
Increased Activity Increased Activity
Varied Impairment Varied Impairment
1 Week1 Week
4 Days4 Days
Major Depressive Episodes
Alternate With Full Manic Episodes
Major Depressive Episodes
Alternate With Full Manic Episodes
Clinical Description Clinical Description
MajorDepression
MajorDepression
ManiaMania
Clinical Description Clinical Description
Major Depressive Episodes
Alternate With Hypomanic Episodes Only 10 to 13% of cases
progress to full bipolar I disorder
Major Depressive Episodes
Alternate With Hypomanic Episodes Only 10 to 13% of cases
progress to full bipolar I disorder
Clinical Description Clinical Description
MajorDepression
MajorDepression
HypomaniaHypomania
Clinical Description Clinical Description
Milder Depressive Episodes
Alternate With Hypomanic Episodes
– Average age of onset is about 12 or 14 years– Cyclothymia tends to be chronic and lifelong– Most are female– High risk for developing bipolar I or II disorder
Milder Depressive Episodes
Alternate With Hypomanic Episodes
– Average age of onset is about 12 or 14 years– Cyclothymia tends to be chronic and lifelong– Most are female– High risk for developing bipolar I or II disorder
Clinical Description Clinical Description
Clinical Description Clinical Description
DysthmiaDysthmia
HypomaniaHypomania
General Facts and Statistics General Facts and Statistics Bipolar I
– Onset Around 18 Years
Bipolar II – Onset Around 22 Years
16% Commit Suicide Cyclothymia
– Typically Chronic
Bipolar I– Onset Around 18 Years
Bipolar II – Onset Around 22 Years
16% Commit Suicide Cyclothymia
– Typically Chronic
Recent Episode and Pattern Recent Episode and Pattern
Psychotic– Hallucinations and Delusions– Very Rare but Serious Condition– Poor Treatment Response
Psychotic– Hallucinations and Delusions– Very Rare but Serious Condition– Poor Treatment Response
Recent Episode and Pattern Recent Episode and Pattern
Postpartum– Major Depression and Mania– Four Weeks Following Birth– Mood Episodes of a Psychotic
Nature– Relatively Rare
Postpartum– Major Depression and Mania– Four Weeks Following Birth– Mood Episodes of a Psychotic
Nature– Relatively Rare
Course and Pattern Course and Pattern Longitudinal Course Longitudinal Course
Rapid-Cycling Rapid-Cycling Seasonal Pattern
– Bipolar and Recurrent Major Depression
– Episodes During Certain Seasons
Seasonal Pattern– Bipolar and Recurrent Major
Depression– Episodes During Certain Seasons
Facts and Statistics Facts and Statistics 7.8% Lifetime Prevalence Females > Males
– Major Depression and Dysthymia
Females = Males– Bipolar Disorders
Similar in Children and Adults
7.8% Lifetime Prevalence Females > Males
– Major Depression and Dysthymia
Females = Males– Bipolar Disorders
Similar in Children and Adults
Psychological Theories of Depression
• Psychoanalytic theory views grief over object loss as the basis for depression
• Cognitive views of depression include– Beck’s theory of depression: the way depressed
people think is biased towards negative interpretations – Learned helplessness: depressed people are passive
because they have been unable in the past to control traumatic events
Ch 10.6
Depression and Positive Emotion
• Depressed individuals: – Display fewer positive expressions– Report experiencing less pleasant emotion in
response to pleasant stimuli– Physiologically less responsive to positive, but
not negative, stimuli
Negative Cognitive Biases Beck’s Cognitive Triad
Negative Cognitive Biases Beck’s Cognitive Triad
Negative Schema About
Self,
World,
& Future
Negative Schema About
Self,
World,
& Future
Cognitive Biases in Depression
• Arbitrary influence refers to a conclusion drawn in the absence of sufficient evidence
• Selective abstraction refers to a conclusion drawn on one of many elements in a situation
• Overgeneralization refers to an overall sweeping conclusion drawn on a basis of a trivial event
• Magnification of trivial events
Ch 10.7
Learned Helplessness• Learned helplessness view is that depression is a
response to a history of failing to control traumatic life events
• The Attribution-Learned helplessness view is that depressed people make global, stable and internal attributions
• Hopelessness view is that depressed persons expect that desired outcomes will not occur, their actions will have no effect
Ch 10.8
Stressful Life Events Learned Helplessness Attributional Style
Stressful Life Events Learned Helplessness Attributional Style
– Internal attributions – Negative outcomes are one’s own fault– Stable attributions – Believing future negative outcomes will be one’s fault– Global attribution – Believing negative events will disrupt many life activities – All three domains contribute to a sense of hopelessness
– Internal attributions – Negative outcomes are one’s own fault– Stable attributions – Believing future negative outcomes will be one’s fault– Global attribution – Believing negative events will disrupt many life activities – All three domains contribute to a sense of hopelessness
Helplessness Theories of Depression
Ch 10.9
Mood Disorders: Social & Cultural Dimensions
• Marriage and Interpersonal Relationships– Marital dissatisfaction is strongly related to depression– This link is particularly strong in males
• Gender Imbalances– Occur across all mood disorders, except bipolar disorders– Gender imbalance likely due to socialization (i.e., perceived
uncontrollability and more rumination in women)• Social Support
– Extent of social support is related to depression– Presence of social support delays onset of depression– High expressed emotion and/or family conflict predicts relapse– Substantial social support predicts recovery from depression but
not from mania
Interpersonal Theory of Depression
• Interpersonal relations are altered in depression– Depressed people have limited social support networks– Depressed people elicit rejection from others– Depressed people are low in social skills across a wide
variety of situations– Depressed people seek reassurance from others, but
this reassurance is temporary
Ch 10.10
Biological Theories of Mood Disorder
• Genetic factors for bipolar disorder are supported by adoption, family and twin studies– The role of genetic factors in unipolar depression
is not as strong as bipolar disorder
• Neurochemistry studies link norepinephrine (NE) to mania/depression and serotonin (5-HT) to depression
Ch 10.11
Biological Dimensions Biological Dimensions Family Studies Twin Studies
– As Severity Increases, so Does the Genetic Connection
No Single Genetic Link
Family Studies Twin Studies
– As Severity Increases, so Does the Genetic Connection
No Single Genetic Link
Sleep and Circadian Rhythms Sleep and Circadian Rhythms Sleep Disturbances are Common REM Sleep and Depression Diminished Deep Sleep Disruption of Circadian Rhythms
Sleep Disturbances are Common REM Sleep and Depression Diminished Deep Sleep Disruption of Circadian Rhythms
Neurochemistry of Mood Disorders
• Tricyclic drugs and MAO inhibitors relieve depression and increase levels of NE and 5-HT by blockade of reuptake
• Measurement of NE/5-HT metabolites in urine and blood does not assess brain activity
• CSF levels of 5-HIAA (5-HT metabolite) are related to depression
• Relief of depression takes 2 weeks or longer, but NE and 5-HT levels may have to previous state
Ch 10.13
Integrative Model of Mood Disorders
• Shared Biological Vulnerability– Overactive neurobiological response to stress
• Exposure to Stress– Activates hormones that affect neurotransmitter systems– Turns on certain genes– Affects circadian rhythms– Activates dormant psychological vulnerabilities (i.e., negative
thinking)– Contributes to sense of uncontrollability– Fosters a sense of helplessness and hopelessness
• Social and Interpersonal Relationships/Support are Moderators
Therapies for Mood Disorders
• Psychoanalysis is not an effective treatment for depression
• Beck’s cognitive-behavioral approach involves changing thought patterns and activity levels– Beck’s approach is an effective therapy for depression– Behavioral activation component may be crucial
• Social skills training involves improving social interactions so as to lift depression
Ch 10.14
Psychological Treatment of Mood Disorders
• Cognitive Therapy– Addresses cognitive errors in thinking– Also includes behavioral components (“activation”)
• Behavioral Activation– Involves helping depressed persons make increased
contact with reinforcing events• Interpersonal Psychotherapy
– Focuses on problematic interpersonal relationships • Outcomes with Psychological Treatments Are
Comparable to Medications
• Electroconvulsive therapy (ECT) involves the induction of brain seizures by the application of electrical current to the skull – ECT is an effective therapy for severe depression, but its
mechanism of action is unknown
• Drug therapy involves ingestion of tricyclic drugs, MAO inhibitor drugs and selective serotonin reuptake inhibitor (SSRI) drugs, or mood stabilizers (e.g., Lithium, Tegretol, Depakote, Topamax) for bipolar disorder
Biological Therapies for Mood Disorders
Ch 10.15
Treatment of Mood Disorders: Lithium
Percentage of patients with bipolar disorder recovered after standard drug treatment or drug treatment plus family therapy (Miklowitz et al., 2001; from Barlow/Durand, 3rd. Edition)
Psychological Treatment of Mood Disorders: Relapse Prevention
Data from Teasdale (2000) study on patients treated with severe depression (from Barlow/Durand, 3rd. Edition)
Suicide
• Suicide is the intentional ending of one’s own life– Suicide is often related to depression, to drug use and
to borderline personality disorder– Suicide is the 9th leading cause of death in the US– There are gender differences in the methods of suicide
(men choose guns, women choose drugs)
Ch 10.16
In the United States In the United States 300,000 Kill Themselves 9th Leading Cause of Death Increasing in Adolescents & Elderly Males > Females in Killing
Themselves Females > Males in Attempts
300,000 Kill Themselves 9th Leading Cause of Death Increasing in Adolescents & Elderly Males > Females in Killing
Themselves Females > Males in Attempts
Ten Commonalities of Suicide The common purpose of suicide is to seek a solution The common goal of suicide is the cessation of consciousness The common stimulus in suicide is intolerable psychological pain The common stressor in suicide is frustrated psychological needs The common emotion in suicide is hopelessness-helplessness The common cognitive state in suicide is ambivalence The common perceptual state in suicide is constriction The common action in suicide is egression The common interpersonal act in suicide is communication of
intention The common consistency in suicide is with lifelong coping patterns
Ch 10.17
Suicide Myths• People who talk about suicide won’t do it• Suicide has no warning• Only people of a certain class commit suicide• All who commit suicide are depressed• Suicide is a lonely event• Suicidal people clearly want to die• Thinking about suicide is rare
Ch 10.18
The Nature of Suicide: Risk Factors
• Suicide in the Family Increases Risk• Low Serotonin Levels Increase Risk• A Psychological Disorder Increases Risk• Alcohol Use and Abuse• Past Suicidal Behavior Increases Subsequent Risk• Experience of a Shameful/Humiliating Stressor Increases
Risk• Hopelessness is a strong predictor of suicide (Beck et al.)• Publicity About Suicide and Media Coverage Increase
Risk
Preventing Suicide
• Reduce the intense psychological pain and suffering
• “Lift the blinders” (expand the constricted view by helping the person see other options other than the extremes of continued suffering or nothingness)
• Encourage the person to pull back even a little from the self-destructive act.