chapter 1. applications of synthetic receptors for biomolecules evan m. peck and bradley d. smith*...

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Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, 46556 IN, USA *Email: [email protected] lementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications e Royal Society of Chemistry 2015

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Page 1: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Chapter 1. Applications of Synthetic Receptors for Biomolecules

Evan M. Peck and Bradley D. Smith*

Department of Chemistry and Biochemistry,

236 Nieuwland Science Hall,

University of Notre Dame, Notre Dame, 46556 IN, USA

*Email: [email protected]

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 2: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.1 Receptor biomolecule association with 1:1 stoichiometry.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 3: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.2 Work flow diagram for supramolecular chemistry research.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 4: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.3 Major categories of synthetic receptors.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 5: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.4 Common scaffolds for organic molecular receptors.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 6: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.5 Receptor scaffolds that incorporate Lewis acids.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 7: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.6 X-ray structure of RNA aptamer complex with 5’-adenosine monophosphate (AMP) guest.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 8: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.7 Molecular imprinted polymer created by non-covalent imprinting.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 9: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.8 Guest encapsulation within the internal cavities of a dendrimer or hyperbranched polymer.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 10: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.9 Nanoparticle with core shell architecture.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 11: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.10 Major applications of receptors for biomolecules.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 12: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.11 Affinity chromatography involves three major steps.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 13: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.12 Synthetic receptors for separations.

Page 14: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.13 Liquid membrane transport.

Page 15: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.14 Supramolecular systems for imaging and sensing.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 16: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.15 Synthetic receptors used for imaging and sensing.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 17: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.16 Supramolecular catalysis of ligation or cleavage reactions.

Page 18: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.17 Synthetic pyridoxamine dendrimer as transaminase mimic.

Page 19: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.18 Synthetic receptors for catalysis.

Page 20: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.19 Pharmaceutically relevant protein biomolecule association systems.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 21: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.20 Synthetic receptors with pharmaceutical activity.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Page 22: Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith* Department of Chemistry and Biochemistry, 236 Nieuwland

Scheme 1.21 Channel and carrier mechanisms for membrane transport.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015