Presented by

B.C.D.A. COLLEGE OF PHARMACY & TECHNOLOGY

University Roll No: 20101913004, 20101913018, 20101913020,

Under the guidance of :

DR. N.N. BALA

4TH YEAR , 7TH SEMESTER

Packaging is the science, art and technology of enclosing or protecting products for distribution, storage, sale, and use.

Packaging also refers to the process of design, evaluation, and production of packages.

Pharmaceutical packaging can be defined as the economical means of providing presentation, protection, identification , information, convenience ,compliance , integrity and stability of the product .

INTRODUCTION

TYPES OF PACKAGING

Primary packaging- is the material that first envelops the product and hold it. This usually is the smallest unit of distribution or use. Ex. Aerosol spray can, blister packs, bottle

Secondary packaging -Is outside the primary packaging perhaps used to group primary package together. Ex. Boxes, cartons

Tertiary packaging- is used to bulk handling and shipping. Ex. Barrel, container, edge protector

GlassPlasticsRubbersPaper/card boardsMetals

TYPES OF PACKAGING MATERIALS USED FOR PHARMACEUTICAL PACKAGING

FUNCTIONS OF PACKAGING

• Product Identification

• Product Protection

• Storage function

• Loading and transport functions

The degree of protection requiredCompatibility with the dosage formCustomer convenience e.g. size, weight of dosage form,Filling methodSterilization method to be employed and cost

THE CHOICE OF PACKAGING MATERIAL WILL DEPEND UPON:

Why packaging development is needed?

In India,pharma packaging today occupies a significant portion of the overall drugs market.

Earlier, the requirement of pharma packaging focused exclusively on preserving the quality of enclosed medication.

Now, they are extended to cover such criteria : • Prevention of product tampering and counterfeiting• Assurance of product dispensing accuracy• Promotion of patient compliance with product dosage

schedules.

Reckitt Benkiser launched the easily portable “Handy tube” version of its popular Strepsils line of sore throat lozenges.

Moov – it was earlier available in tubes, but it is now also available as an aerosol spray which is convenient, easy to apply.

FACTORS INFLUENCING THE CHOICE OF PACKAGE

The product.

The market.

The distribution system.

RECENT TRENDS

Robots in primary packaging Radio-frequency identification(RFID) Electronic-Enabled Packaging Unit-dose packaging for greater dosage

control Packaging against counterfeiting Child-resistant packaging Eco-friendly pharmaceutical packaging The talking packaging : “Self Talk”

ROBOTS IN PRIMARY PACKAGING TECHNOLOGY

Motion control, high speed and robotic dexterity makes it suitable for product orientation, collation, and repetitive tasksCapable of speeds above 40 picks per minute.This can count, stack, load, or unload medical devices, pouches, and other related items.

RADIO- FREQUENCY IDENTIFICATION(RFID)

RFID tagging to simplify shipping, receiving,

inventory location, and control has been mandated

by the Department of defence, several other

retailers, and various hospitals.

Carry and collect the data needed to track and trace

product through the supply chain

Prevent counterfeiting and diversion

ELECTRONIC-ENABLED PACKAGING In February 2011, Finnish packaging company Stora In February 2011, Finnish packaging company Stora

Enso Launched this product.Enso Launched this product.

The removal of pills is tracked and the information The removal of pills is tracked and the information can be sent to an electronic database automatically can be sent to an electronic database automatically via GSM or GPRS and allowing reminders to be sent via GSM or GPRS and allowing reminders to be sent by text.by text.

Catalent’s Delpouch started kit packaging system, designed for topical treatment.

Delpouch measures the right amount of topical cream or ointment to simplify the application process.

Packaging can now connect with computers using sensor technology. Allowing patients to log their feedback on side effect s and treatment efficacy and upload it

UNIT-DOSE PACKAGING FOR GREATER DOSAGE CONTROL

With more of a focus on outpatient care and the self-

regulation of medicine, there’s greater onus on patient to

take the right medications in the right amount.

CHILD RESISTANT PACKAGING

Keeping drugs secure from young children is one of the main objectives of pharmaceutical packaging companies.

Child resistant packaging was introduced in late 1960s and is most commonly used as safety cap on bottles that has to be pushed down before being opened.

Packaging company Amcor Flexibles followed suit a few year later and Introduced a CR regulations in Europe and US.

UK packaging producer Burgopak’s sliding CR blister pack Can only be opened by applying pressure at two separatePoints on the packaging . The blister pack and information leaflets are integrated with the outer box.

In 2006 Stora Enso and Bosch packaging launched PharmaSmall hands resistant (SHR) a re closable and tear resistant carton ideal for highly toxic drugs which Test Pak, Inc. Started Using and producing the same year.

ECO FRIENDLY PHARMA PACKAGING

Environmental considerations must not lead to any compromise on a package’s safety or accessibility.

New pharmaceutical packaging concepts are beginning to emerge that address environmental concerns without sacrificing packaging advances made in last decade.

o In August 2011 Keystone Folding Box Company and Legacy Pharmaceutical Packaging launched their Eco slide-RX sustainable compliance packaging.

The pack is made from 100% recycled material using unbleached paper board and a clay coated surface.

Syreen Prefilled Syringe Design

Packaging weight reduction- 30% and volume- 50%, compared to standard packaging

Environmental awareness is even starting to extend to the

syringe market. Syreen syringes replace glass with cyclic olefin polymer

(COP).

Talk Pack-Wipac

Talk packs does not require any microchips.

The dot code is simply printed on top of images and texts using a special varnish.

A special pen shaped reader is used to retrieve the stored information and to replay it as audio files and render speech, music, or sounds audible and thus the consumer can obtain information.

Aeroneb Solo Nebulizer The Aeroneb Solo Nebulizer is designed to

operate in line with standard ventilator circuits and mechanical ventilators.

Operated without changing patient ventilator parameters.

Refilled without interrupting ventilation. Operated on its internal rechargeable battery for up to 45 minutes when fully charged.

RECENT TREND IN PHARMACEUTICAL PACKAGING

CONCLUSION

Packaging should provide protection, identification, information, convenience and compliance for a product during storage, carriage, display and until such time the product is consumed. Pharmaceutical packaging should look into concerned issues like child safety, correct dosage, patient traceability, tampering and diversion of pharmaceutical products. Now, major additional concerns of drug counterfeiting and bring a new sense of urgency to medical packaging manufacturers and hospitals, clinics, assisted living facilities, doctors' offices and, the individual consumer.

REFERENCE

http://www.pg.com:“HelidacTherapyKit”.

Premphase EZ.

http://www.drugs.com/drp/estrogens-conjugated.

html Estrogens,conjugated,“Prempro/DIAL”.

http://www.wyeth.com.

http://www.meadwestvaco.com/HealthcarePackagingSolutions/AdherencePackaging/MWV02Dosepak®Unit-Dose Medication Packaging1898.

http://www.popularmechanics.co.za/sci-tech-news/nfc-aid-for-the-visually-and-hearing-impaired/ NFC aid for the visually and hearing impaired.

http://www.pharmafile.com/news/503156/future-pharma-packaginghttp://www.ijppsjournal.com/Vol6Issue6/9730.pdfhttp://blog.domino-uk.com/8-pharmaceutical-packaging-trends/Packaging Delivers: 2015 Pharma Packaging TrendsFor the pharmaceutical industry, what's on the outside counts as much as what's on the insideBy Steven E. Kuehn, Editor in Chief.http://www.packagingdigest.com/pharmaceutical-packagingHerbert A. Leon Lachman, “The Theory and Practice of Industrial Pharmacy” Third edition.2005:711-32.http://www.iglobalpharma.com/PharmaMarket.aspx India eyes $40 billion global generic market; patents held by MNCs to expire in over 3 years.