CENTER FOR PROCESS ANALYTICAL CHEMISTRY

UNIVERSITY OF WASHINGTON,UNIVERSITY OF WASHINGTON, SEATTLESEATTLE

Provides a Forum for Multidisciplinary Participation in Process Analytical Technology Definition, Creation, and Utilization

Established in 1984, the Objective of the Center is to Address Challenges in Real-Time and Continuous Process Monitoring and Control

CPAC is a Consortium of Industrial Sponsors, National Laboratories and

Government Agencies

CPAC ActivitiesCPAC Activities•Semiannual Sponsor Meetings•Graduate Education•Summer Institute•Industry Segment Meetings•Technical Workshops•Visiting Scientist Program•Pittcon, IFPAC, TAS

Core Research Areas

Chemometrics

Sensors

Spectroscopy / Imaging

Chromatography

MicroFlow Analysis

Process Control

Multidisciplinary Chemistry

Chemical Engineering

Electrical Engineering

Bioengineering

Applied Physics

Forestry

Mechanical Engineering

Food Science & Engineering

Health Sciences

PEER COMMUNICATION

BENCHMARKING

CLEARING HOUSE

FOCUS GROUPS

CPAC Industrial Sponsors

•Air Products•Amgen •Amersham Bioscience•Ashland•Aventis •Baxter Healthcare •Boeing•Bristol-Myers Squibb•Cargill•CPC Systems•Chevron Texaco

•Dow Chemical•Dupont •ExxonMobil Chemical•Genentech•Goodyear Tire & Rubber•Honeywell Inc.•ICI•Kaiser Optical Systems•Kimberly-Clark •Kraft Foods

•Master Foods •Merck & Co.•Metso Automation•Parker Hannifin•Pharmacia•Phillips Petroleum •Rohm & Haas •Rosemount Analytical •Swagelok •Systematix Controls •ThermoONIX•3M

CPAC Government Sponsors

• National Institute of Standards & Technology

• Pacific Northwest National

• Westinghouse Savannah River Co.

Sponsor Focus Groups

Oil & Petrochemicals

Chemicals & Materials

Food & Consumer Products

Bio Tech / Pharmaceuticals

National Labs & Agencies

Instrument Companies

REVOLUTIONARY ADVANCES THAT ARE AFFECTING MEASUREMENT

SCIENCE

• MEASUREMENT INFORMATION PROCESSING

• MINIATURIZATION

• ENGINEERED MATERIALS

• ELECTRO-OPTICS

Advances in Microtechnology.

•Electronics computers, communications

•MEMS microfluidics, microoptics, bulk micromachining

•Nanotechnology new materials and interface control

CPAC STRATEGIC RESEARCH AREAS

SURFACE AND INTERFACIAL CHARACTERIZATION AND CONTROL

MULTICOMPONENT MATERIALS CHARACTERIZATION AND CONTROL

VERSATILE MICROANALYTICAL SYSTEMS

PROCESS MONITORING, MODELING AND CONTROL

PROBLEMS

SYSTEMS

1996 Summer Institute

with special emphasis on:

VERSATILE MICRO-

ANALYTICAL SYSTEMS

and

PROCESS MONITORING,

MODELING AND CONTROL

JULY 17-19, 1996

TOPICS IN PROCESS ANALYSIS AND CONTROL

CPAC INITIATIVES

OPEN- NEW SAMPLING AND SENSOR INITIATIVE

(NeSSI)- CONNECTIVITY INTIATIVE (ConnI)- CHEMOMETRICS ON-LINE INITIATIVE (COPA)

CLOSED- MICRO-INSTRUMENTATION FOR HIGH

THROUGHPUT EXPERIMENTATION PLATFORM- FERMENTATION MONITORING AND CONTROL

PLATFORM (FermI)

2002 Summer Institute

IMPROVING HIGH

THROUGHPUT

EXPERIMENTATION

via

MICRO-ANALYTICAL SYSTEMS

and

PROCESS MONITORING,

MODELING AND CONTROL

JULY 17-19, 2002

Prospects for Improving Process Optimization using Miniaturization Technology

MICRO-INSTRUMENTATION AND

MICRO-REACTORS

THE DRIVER IS THE NEED FOR HIGH THROUGHPUT

EXPERIMENTAION

• DISCOVERY

• SCREENING

• PROCESS DEVELOPMENT

• PROCESS CONTROL

MICROREACTORS

• BATCH

• CONTINOUS

SOME RELEVANT CURRENT CPAC RESEARCH EFFORTS

MICRO-LCSURFACE TENSION DETECTIONGCxGCFRINGE FIELD SENSORSVAPOCHROMIC SENSORSRAMANGRATED LIGHT REFLECTIVE SPECTROSCOPYREFLECTOMETRYFLOW-THROUGH PARTICLE ANALYZERSURFACE PLASMON RESONANCEMINI-MASS SPECTROMETERDATA HANDLING

NeSSI has become an Enabling technology for...

– Miniature physical sensors

– Miniature chemical composition sensors

Courtesy of Panametrics & SwagelokCourtesy of Rosemount Analytical

Courtesy of Applied Analytics

Porter Instruments and the Swagelok Co.

Micro-reactor / NeSSI connection being planned at

CPACC o urte s y o f A u to flo w

NeSSI with Analytical will Impact

• Process Optimization

• Process Control

• Analytical Method Development

• Product Development